{"id":"https://openalex.org/W2011234972","doi":"https://doi.org/10.1097/00001756-199910190-00002","title":"D3 receptor knockdown through antisense oligonucleotide administration supports its inhibitory role in locomotion","display_name":"D3 receptor knockdown through antisense oligonucleotide administration supports its inhibitory role in locomotion","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2011234972","doi":"https://doi.org/10.1097/00001756-199910190-00002","mag":"2011234972","pmid":"https://pubmed.ncbi.nlm.nih.gov/10574548"},"language":"en","primary_location":{"id":"doi:10.1097/00001756-199910190-00002","doi":"https://doi.org/10.1097/00001756-199910190-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-199910190-00002","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058804618","display_name":"Liliana Menalled","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Liliana B. Menalled","raw_affiliation_strings":["Instituto de Investigaciones Farmacol\u00f3gicas-CONICET, Buenos Aires, Argentina","Instituto de Investigaciones Farmacol\u00f3gicas\u2013CONICET, Junin 956 Piso 5, 1113 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Farmacol\u00f3gicas-CONICET, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"Instituto de Investigaciones Farmacol\u00f3gicas\u2013CONICET, Junin 956 Piso 5, 1113 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027942207","display_name":"Gustavo Dziewczapolski","orcid":"https://orcid.org/0000-0003-1393-485X","observed_orcids":["https://orcid.org/0000-0003-1393-485X"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Gustavo Dziewczapolski","raw_affiliation_strings":["Instituto de Investigaciones Farmacol\u00f3gicas\u2013CONICET, Junin 956 Piso 5, 1113 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Farmacol\u00f3gicas\u2013CONICET, Junin 956 Piso 5, 1113 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria C. Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Maria C. Garcia","raw_affiliation_strings":["Instituto de Investigaciones Farmacol\u00f3gicas\u2013CONICET, Junin 956 Piso 5, 1113 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Farmacol\u00f3gicas\u2013CONICET, Junin 956 Piso 5, 1113 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012299131","display_name":"Marcelo Rubinstein","orcid":"https://orcid.org/0000-0002-7500-7771","observed_orcids":["https://orcid.org/0000-0002-7500-7771"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marcelo Rubinstein","raw_affiliation_strings":["Instituto de Investigaciones en Ingenier\u00eda Gen\u00e9tica y Biolog\u00eda Molecular, CONICET and Departimento Qu\u00edmica Biol\u00f3gica, FCEyN, Universidad de Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones en Ingenier\u00eda Gen\u00e9tica y Biolog\u00eda Molecular, CONICET and Departimento Qu\u00edmica Biol\u00f3gica, FCEyN, Universidad de Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087800987","display_name":"Oscar S. Gershanik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Oscar S. Gershanik","raw_affiliation_strings":["Corresponding Author: Oscar S. Gershanik","Instituto de Investigaciones Farmacol\u00f3gicas\u2013CONICET, Junin 956 Piso 5, 1113 Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding Author: Oscar S. Gershanik","institution_ids":[]},{"raw_affiliation_string":"Instituto de Investigaciones Farmacol\u00f3gicas\u2013CONICET, Junin 956 Piso 5, 1113 Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087800987"],"corresponding_institution_ids":["https://openalex.org/I151201029"],"apc_list":null,"apc_paid":null,"fwci":0.8407,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.66539337,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"15","first_page":"3131","last_page":"3136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-d3-receptor","display_name":"dopamine D3 receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.8339999914169312},{"id":"https://openalex.org/keywords/receptor-knockdown","display_name":"receptor knockdown","score":0.7009999752044678},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.7910000085830688},{"id":"https://openalex.org/keywords/apomorphine","display_name":"apomorphine","score":0.8669999837875366},{"id":"https://openalex.org/keywords/islands-of-calleja","display_name":"islands of Calleja","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C2777525119","wikidata":"https://www.wikidata.org/wiki/Q269111","display_name":"Apomorphine","level":4,"score":0.7051461338996887},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6852464079856873},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.6848169565200806},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.6274154186248779},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5815755724906921},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.48545628786087036},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47384506464004517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44910547137260437},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.44681575894355774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4431934952735901},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4215373992919922},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.413038969039917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3952987790107727},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.17819708585739136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16337504982948303},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1112578809261322},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012110","descriptor_name":"Reserpine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016375","descriptor_name":"Antisense Elements (Genetics)","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018759","descriptor_name":"Adrenergic Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020670","descriptor_name":"Islands of Calleja","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020670","descriptor_name":"Islands of Calleja","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050637","descriptor_name":"Receptors, Dopamine D3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00001756-199910190-00002","doi":"https://doi.org/10.1097/00001756-199910190-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-199910190-00002","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},{"id":"pmid:10574548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10574548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroreport","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1987577062","https://openalex.org/W2016754165","https://openalex.org/W2021620079","https://openalex.org/W2037767456","https://openalex.org/W2048174585","https://openalex.org/W2071072403","https://openalex.org/W2319440068"],"related_works":["https://openalex.org/W2013983233","https://openalex.org/W2025653842","https://openalex.org/W1980878415","https://openalex.org/W7099455037","https://openalex.org/W2043365964","https://openalex.org/W1995164636","https://openalex.org/W2000413640","https://openalex.org/W2319440068","https://openalex.org/W2052497807","https://openalex.org/W2260665813"],"abstract_inverted_index":{"To":[0],"study":[1],"the":[2,6,11,28,49,55,58,67,72,98,104,128],"specific":[3],"contribution":[4],"of":[5,13,100,106,130],"D3":[7,29,91,101,118],"dopamine":[8],"receptor":[9,30],"in":[10,43,48,66,71,97,103],"generation":[12],"locomotor":[14,33,44,68,125],"activity,":[15,126],"total":[16],"or":[17,85],"partially":[18,73],"dopamine-depleted":[19,51,74],"rats":[20,52,75],"were":[21],"pretreated":[22,53],"with":[23,54,77,81,109],"an":[24,121],"antisense":[25],"oligodeoxynucleotide":[26,84],"for":[27,90],"(D3R-as)":[31],"and":[32,133],"activity":[34,45],"induced":[35],"by":[36],"apomorphine":[37],"was":[38,46],"measured.":[39],"A":[40],"35.7%":[41],"increase":[42,65],"seen":[47],"totally":[50],"D3R-as,":[56],"whereas":[57],"same":[59],"antisense,":[60],"caused":[61],"a":[62,82,94],"significantly":[63],"greater":[64],"response":[69],"(95%)":[70],"compared":[76,108],"control":[78,83,110],"groups":[79],"(pretreated":[80],"vehicle).":[86],"In":[87],"situ":[88],"autoradiography":[89],"receptors":[92,102,119],"showed":[93],"27%":[95],"fall":[96],"density":[99],"islands":[105],"Calleja":[107],"animals.":[111],"Our":[112],"results":[113],"seem":[114],"to":[115],"confirm":[116],"that":[117],"exert":[120],"inhibitory":[122],"effect":[123],"on":[124],"through":[127],"stimulation":[129],"both":[131],"pre-":[132],"postsynaptic":[134],"components.":[135]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}