{"id":"https://openalex.org/W2011201627","doi":"https://doi.org/10.1107/s1744309105007748","title":"Crystallization and preliminary X-ray analysis ofNa-ASP-1, a multi-domain pathogenesis-related-1 protein from the human hookworm parasiteNecator americanus","display_name":"Crystallization and preliminary X-ray analysis ofNa-ASP-1, a multi-domain pathogenesis-related-1 protein from the human hookworm parasiteNecator americanus","publication_year":2005,"publication_date":"2005-03-24","ids":{"openalex":"https://openalex.org/W2011201627","doi":"https://doi.org/10.1107/s1744309105007748","mag":"2011201627","pmid":"https://pubmed.ncbi.nlm.nih.gov/16511050","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1952415"},"language":"en","primary_location":{"id":"doi:10.1107/s1744309105007748","doi":"https://doi.org/10.1107/s1744309105007748","is_oa":false,"landing_page_url":"https://doi.org/10.1107/s1744309105007748","pdf_url":null,"source":{"id":"https://openalex.org/S4210231712","display_name":"Acta Crystallographica Section F Structural Biology and Crystallization Communications","issn_l":"1744-3091","issn":["1744-3091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section F Structural Biology and Crystallization Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1952415","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063830805","display_name":"Oluwatoyin Ajibola Asojo","orcid":"https://orcid.org/0000-0002-4043-2700","observed_orcids":["https://orcid.org/0000-0002-4043-2700"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oluwatoyin A. Asojo","raw_affiliation_strings":["Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198-7696, USA. oasojo@unmc.edu","Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198-7696, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198-7696, USA. oasojo@unmc.edu","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]},{"raw_affiliation_string":"Eppley Institute for Research in Cancer and Allied Diseases, 987696 Nebraska Medical Center, Omaha, NE 68198-7696, USA","institution_ids":["https://openalex.org/I1307117695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024270822","display_name":"Alex C. Loukas","orcid":"https://orcid.org/0000-0002-0896-8441","observed_orcids":["https://orcid.org/0000-0002-0896-8441"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]},{"id":"https://openalex.org/I217937681","display_name":"QIMR Berghofer Medical Research Institute","ror":"https://ror.org/004y8wk30","country_code":"AU","type":"facility","lineage":["https://openalex.org/I217937681"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Alex Loukas","raw_affiliation_strings":["Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA","Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, Brisbane, QLD 4006, Australia","institution_ids":["https://openalex.org/I217937681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045318991","display_name":"Mehmet \u0130nan","orcid":"https://orcid.org/0000-0003-1806-7927","observed_orcids":["https://orcid.org/0000-0003-1806-7927"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehmet Inan","raw_affiliation_strings":["Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003697748","display_name":"Rick Barent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rick Barent","raw_affiliation_strings":["Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jicai Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jicai Huang","raw_affiliation_strings":["Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044333313","display_name":"Bradley A. Plantz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brad Plantz","raw_affiliation_strings":["Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026066353","display_name":"Amber Swanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber Swanson","raw_affiliation_strings":["Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021845325","display_name":"Mark A. Gouthro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Gouthro","raw_affiliation_strings":["Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015947780","display_name":"Michael M. Meagher","orcid":"https://orcid.org/0000-0003-0300-3349","observed_orcids":["https://orcid.org/0000-0003-0300-3349"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Meagher","raw_affiliation_strings":["Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The University of Nebraska\u2013Lincoln, Lincoln, NE 68588-0643, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087704375","display_name":"Peter Jay Hotez","orcid":"https://orcid.org/0000-0001-8770-1042","observed_orcids":["https://orcid.org/0000-0001-8770-1042"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Hotez","raw_affiliation_strings":["Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0426,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.74196721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"61","issue":"4","first_page":"391","last_page":"394"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.7821999788284302,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.7821999788284302,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.19200000166893005,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necator-americanus","display_name":"Necator americanus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hookworm","display_name":"hookworm","score":0.8270000219345093},{"id":"https://openalex.org/keywords/multidomain-proteins","display_name":"multidomain proteins","score":0.6880000233650208},{"id":"https://openalex.org/keywords/protein-crystallization","display_name":"protein crystallization","score":0.6489999890327454},{"id":"https://openalex.org/keywords/x-ray-crystallography","display_name":"X-ray crystallography","score":0.7429999709129333},{"id":"https://openalex.org/keywords/molecular-replacement","display_name":"molecular replacement","score":0.6830000281333923},{"id":"https://openalex.org/keywords/vaccine-antigens","display_name":"vaccine antigens","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2777047024","wikidata":"https://www.wikidata.org/wiki/Q2433913","display_name":"Necator americanus","level":4,"score":0.9826431274414062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6134563684463501},{"id":"https://openalex.org/C2908979412","wikidata":"https://www.wikidata.org/wiki/Q11679861","display_name":"Hookworm Infections","level":3,"score":0.5519197583198547},{"id":"https://openalex.org/C2779192670","wikidata":"https://www.wikidata.org/wiki/Q2490891","display_name":"Ancylostoma","level":3,"score":0.5019688606262207},{"id":"https://openalex.org/C2776677957","wikidata":"https://www.wikidata.org/wiki/Q11679861","display_name":"Hookworm infection","level":3,"score":0.47561436891555786},{"id":"https://openalex.org/C2777683361","wikidata":"https://www.wikidata.org/wiki/Q2520810","display_name":"Ancylostoma duodenale","level":5,"score":0.4547140598297119},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4293457269668579},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.38924312591552734},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3574450612068176},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.2724294662475586},{"id":"https://openalex.org/C2777364306","wikidata":"https://www.wikidata.org/wiki/Q468771","display_name":"Ascaris lumbricoides","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000947","descriptor_name":"Antigens, Helminth","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000947","descriptor_name":"Antigens, Helminth","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000947","descriptor_name":"Antigens, Helminth","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017221","descriptor_name":"Necator americanus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1107/s1744309105007748","doi":"https://doi.org/10.1107/s1744309105007748","is_oa":false,"landing_page_url":"https://doi.org/10.1107/s1744309105007748","pdf_url":null,"source":{"id":"https://openalex.org/S4210231712","display_name":"Acta Crystallographica Section F Structural Biology and Crystallization Communications","issn_l":"1744-3091","issn":["1744-3091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section F Structural Biology and Crystallization Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1952415","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1952415","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallogr Sect F Struct Biol Cryst Commun","raw_type":"Text"},{"id":"pmid:16511050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16511050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta crystallographica. Section F, Structural biology and crystallization communications","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.unl.edu:chemengall-1024","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/chemengall/25","pdf_url":"https://digitalcommons.unl.edu/chemengall/25","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Chemical and Biomolecular Engineering: Faculty Publications","raw_type":"text"},{"id":"pmh:oai:digitalcommons.unl.edu:chemengbiochemeng-1002","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.unl.edu/chemengbiochemeng/3","pdf_url":"https://digitalcommons.unl.edu/chemengbiochemeng/3","source":{"id":"https://openalex.org/S4306400577","display_name":"Lincoln (University of Nebraska)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114395901","host_organization_name":"University of Nebraska\u2013Lincoln","host_organization_lineage":["https://openalex.org/I114395901"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Papers in Biochemical Engineering","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1952415","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1952415","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallogr Sect F Struct Biol Cryst Commun","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G19645674","display_name":"Structural Basis of Novel Hookworm Vaccines","funder_award_id":"R03AI065990","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011201627.pdf","grobid_xml":"https://content.openalex.org/works/W2011201627.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W144189955","https://openalex.org/W156929183","https://openalex.org/W188891551","https://openalex.org/W1545357297","https://openalex.org/W1832305427","https://openalex.org/W1982479137","https://openalex.org/W2065721403","https://openalex.org/W2080476827","https://openalex.org/W2090919316","https://openalex.org/W2108819608","https://openalex.org/W2118006267","https://openalex.org/W2151473667","https://openalex.org/W2154644113","https://openalex.org/W2156188380","https://openalex.org/W2170217346","https://openalex.org/W4234297355"],"related_works":["https://openalex.org/W2156188380","https://openalex.org/W2008034188","https://openalex.org/W2038115176","https://openalex.org/W2065721403","https://openalex.org/W2010015760","https://openalex.org/W2736468315","https://openalex.org/W7099725778","https://openalex.org/W4391196948","https://openalex.org/W2134897517","https://openalex.org/W2079773088"],"abstract_inverted_index":{"Human":[0,23],"hookworm":[1,20,112],"infection":[2],"is":[3,64,103],"a":[4,42,83,104,126,139],"major":[5],"cause":[6],"of":[7,38,44,56,82],"anemia":[8],"and":[9,86,100],"malnutrition":[10],"in":[11,87,163],"the":[12,22,33,39,50,57,109,131,164],"developing":[13],"world.":[14],"In":[15,61],"an":[16,88],"effort":[17,89],"to":[18,90,119,130],"control":[19],"infection,":[21],"Hookworm":[24],"Vaccine":[25],"Initiative":[26],"has":[27,96,157],"identified":[28],"candidate":[29],"vaccine":[30],"antigens":[31],"from":[32,108,125],"infective":[34],"larval":[35],"stage":[36],"(L3)":[37],"parasite,":[40],"including":[41],"family":[43],"pathogenesis-related-1":[45],"(PR-1)":[46],"proteins":[47,52],"known":[48,80],"as":[49],"ancylostoma-secreted":[51],"(ASPs).":[53],"The":[54],"functions":[55],"ASPs":[58,68],"are":[59,78],"unknown.":[60],"addition,":[62],"it":[63],"unclear":[65],"why":[66],"some":[67],"have":[69,73,122],"one":[70,161],"while":[71],"others":[72],"multiple":[74],"PR-1":[75],"domains.":[76],"There":[77],"no":[79],"structures":[81],"multi-domain":[84,106],"ASP":[85,107],"remedy":[91],"this":[92],"situation,":[93],"recombinant":[94],"Na-ASP-1":[95,102],"been":[97,123,158],"expressed,":[98],"purified":[99],"crystallized.":[101],"406-amino-acid":[105],"prevalent":[110],"human":[111],"parasite":[113],"Necator":[114],"americanus.":[115],"Useful":[116],"X-ray":[117],"data":[118],"2.2":[120],"A":[121],"collected":[124],"crystal":[127],"that":[128],"belongs":[129],"monoclinic":[132],"space":[133],"group":[134],"P2(1)":[135],"with":[136,160],"unit-cell":[137],"parameters":[138],"=":[140,143,146,150],"67.7,":[141],"b":[142],"74.27,":[144],"c":[145],"84.60":[147],"A,":[148],"beta":[149],"112.12":[151],"degrees.":[152],"An":[153],"initial":[154],"molecular-replacement":[155],"solution":[156],"obtained":[159],"monomer":[162],"asymmetric":[165],"unit.":[166]},"counts_by_year":[{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}