{"id":"https://openalex.org/W2011199799","doi":"https://doi.org/10.1111/jnc.12159","title":"Chondroitin sulfate, a major component of the perineuronal net, elicits inward currents, cell depolarization, and calcium transients by acting on AMPA and kainate receptors of hippocampal neurons","display_name":"Chondroitin sulfate, a major component of the perineuronal net, elicits inward currents, cell depolarization, and calcium transients by acting on AMPA and kainate receptors of hippocampal neurons","publication_year":2013,"publication_date":"2013-01-25","ids":{"openalex":"https://openalex.org/W2011199799","doi":"https://doi.org/10.1111/jnc.12159","mag":"2011199799","pmid":"https://pubmed.ncbi.nlm.nih.gov/23350646"},"language":"en","primary_location":{"id":"doi:10.1111/jnc.12159","doi":"https://doi.org/10.1111/jnc.12159","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.12159","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051238542","display_name":"Marcos Maroto","orcid":"https://orcid.org/0000-0003-4020-9688","observed_orcids":["https://orcid.org/0000-0003-4020-9688"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marcos Maroto","raw_affiliation_strings":["Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051049983","display_name":"Jos\u00e9\u2010Carlos Fern\u00e1ndez\u2010Morales","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9\u2010Carlos Fern\u00e1ndez\u2010Morales","raw_affiliation_strings":["Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049586965","display_name":"Juan Fernando Pad\u00edn","orcid":"https://orcid.org/0000-0003-4585-9401","observed_orcids":["https://orcid.org/0000-0003-4585-9401"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Fernando Pad\u00edn","raw_affiliation_strings":["Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055259148","display_name":"Jose Gonzalez","orcid":"https://orcid.org/0000-0003-4612-1943","observed_orcids":["https://orcid.org/0000-0003-4612-1943"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 C. Gonz\u00e1lez","raw_affiliation_strings":["Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091046880","display_name":"Jes\u00fas Miguel Hern\u00e1ndez-Guijo","orcid":"https://orcid.org/0000-0002-7011-5351","observed_orcids":["https://orcid.org/0000-0002-7011-5351"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jes\u00fas M. Hern\u00e1ndez\u2010Guijo","raw_affiliation_strings":["Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040132868","display_name":"E. Montell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146139","display_name":"Bioib\u00e9rica (Spain)","ror":"https://ror.org/057p4eb38","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210146139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eulalia Montell","raw_affiliation_strings":["Pre\u2010Clinical R&amp;D Area Pharmascience Division Bioib\u00e9rica Barcelona Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pre\u2010Clinical R&amp;D Area Pharmascience Division Bioib\u00e9rica Barcelona Spain","institution_ids":["https://openalex.org/I4210146139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085904915","display_name":"Josep Verg\u00e9s","orcid":"https://orcid.org/0000-0003-4228-9263","observed_orcids":["https://orcid.org/0000-0003-4228-9263"]},"institutions":[{"id":"https://openalex.org/I4210146139","display_name":"Bioib\u00e9rica (Spain)","ror":"https://ror.org/057p4eb38","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210146139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josep Verg\u00e9s","raw_affiliation_strings":["Pre\u2010Clinical R&amp;D Area Pharmascience Division Bioib\u00e9rica Barcelona Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pre\u2010Clinical R&amp;D Area Pharmascience Division Bioib\u00e9rica Barcelona Spain","institution_ids":["https://openalex.org/I4210146139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109846806","display_name":"Antonio M. G. de Diego","orcid":"https://orcid.org/0000-0002-3557-3330","observed_orcids":["https://orcid.org/0000-0002-3557-3330","https://orcid.org/0000-0002-6517-3565"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio M. G. de Diego","raw_affiliation_strings":["Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109846806","display_name":"Antonio M. G. de Diego","orcid":"https://orcid.org/0000-0002-3557-3330","observed_orcids":["https://orcid.org/0000-0002-3557-3330","https://orcid.org/0000-0002-6517-3565"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Antonio G. Garc\u00eda","raw_affiliation_strings":["Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","Instituto de Investigaci\u00f3n Sanitaria Servicio de Farmacolog\u00eda Cl\u00ednica Hospital Universitario de la Princesa. Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacolog\u00eda y Terap\u00e9utica Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto Te\u00f3filo Hernando Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Servicio de Farmacolog\u00eda Cl\u00ednica Hospital Universitario de la Princesa. Facultad de Medicina Universidad Aut\u00f3noma de Madrid Madrid Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109846806"],"corresponding_institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":0.7277,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.65964457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"125","issue":"2","first_page":"205","last_page":"213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.2888000011444092,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":1.0},{"id":"https://openalex.org/keywords/perineuronal-nets","display_name":"perineuronal nets","score":0.859000027179718},{"id":"https://openalex.org/keywords/proteoglycans","display_name":"proteoglycans","score":0.9309999942779541},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/kainate-receptors","display_name":"kainate receptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/membrane-depolarization","display_name":"membrane depolarization","score":0.9700000286102295},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.871999979019165},{"id":"https://openalex.org/keywords/cyclothiazide","display_name":"cyclothiazide","score":0.9620000123977661},{"id":"https://openalex.org/keywords/positive-allosteric-modulation","display_name":"positive allosteric modulation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/nbqx","display_name":"NBQX","score":0.7919999957084656},{"id":"https://openalex.org/keywords/cnqx","display_name":"CNQX","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.8684647083282471},{"id":"https://openalex.org/C189184402","wikidata":"https://www.wikidata.org/wiki/Q3454536","display_name":"Kainate receptor","level":5,"score":0.825336217880249},{"id":"https://openalex.org/C2780076171","wikidata":"https://www.wikidata.org/wiki/Q972076","display_name":"NBQX","level":5,"score":0.6281699538230896},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6194384098052979},{"id":"https://openalex.org/C129987498","wikidata":"https://www.wikidata.org/wiki/Q7168586","display_name":"Perineuronal net","level":3,"score":0.5985532999038696},{"id":"https://openalex.org/C2779803574","wikidata":"https://www.wikidata.org/wiki/Q4386534","display_name":"CNQX","level":5,"score":0.5833106637001038},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.566274106502533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5285232067108154},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.5090531706809998},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4812716841697693},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.4419528841972351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3615974187850952},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28208398818969727},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23879802227020264},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.11571985483169556}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018092","descriptor_name":"Kainic Acid Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018092","descriptor_name":"Receptors, Kainic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018092","descriptor_name":"Receptors, Kainic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jnc.12159","doi":"https://doi.org/10.1111/jnc.12159","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jnc.12159","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:23350646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23350646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W151635768","https://openalex.org/W269137301","https://openalex.org/W1500029814","https://openalex.org/W1535136623","https://openalex.org/W1636225847","https://openalex.org/W1706245649","https://openalex.org/W1824808675","https://openalex.org/W1966724696","https://openalex.org/W1984746596","https://openalex.org/W1985114553","https://openalex.org/W1987632300","https://openalex.org/W1999968276","https://openalex.org/W2004785268","https://openalex.org/W2007162991","https://openalex.org/W2009667219","https://openalex.org/W2012928251","https://openalex.org/W2016466873","https://openalex.org/W2019730170","https://openalex.org/W2029527028","https://openalex.org/W2032148058","https://openalex.org/W2033779398","https://openalex.org/W2040720937","https://openalex.org/W2050337384","https://openalex.org/W2053191670","https://openalex.org/W2058953761","https://openalex.org/W2061497228","https://openalex.org/W2066287275","https://openalex.org/W2066520425","https://openalex.org/W2068608417","https://openalex.org/W2069575340","https://openalex.org/W2074562018","https://openalex.org/W2078340394","https://openalex.org/W2080442263","https://openalex.org/W2082808714","https://openalex.org/W2082833517","https://openalex.org/W2084275244","https://openalex.org/W2085689721","https://openalex.org/W2087057046","https://openalex.org/W2087612255","https://openalex.org/W2089941152","https://openalex.org/W2091551183","https://openalex.org/W2099134671","https://openalex.org/W2102677257","https://openalex.org/W2104968232","https://openalex.org/W2106489369","https://openalex.org/W2110534885","https://openalex.org/W2127947811","https://openalex.org/W2129770670","https://openalex.org/W2147528917","https://openalex.org/W2158241217","https://openalex.org/W2167208176"],"related_works":["https://openalex.org/W2072170831","https://openalex.org/W2050792525","https://openalex.org/W1991610391","https://openalex.org/W2031167339","https://openalex.org/W2064760334","https://openalex.org/W2088499230","https://openalex.org/W2062793260","https://openalex.org/W2062150034","https://openalex.org/W2063461600","https://openalex.org/W2086817748"],"abstract_inverted_index":{"Chondroitin":[0],"sulfate":[1],"(CS)":[2],"proteoglycans":[3],"(CSPGs)":[4],"are":[5],"the":[6,11,33,149],"most":[7],"abundant":[8],"PGs":[9],"of":[10,35,115,151],"brain":[12],"extracellular":[13],"matrix":[14],"(ECM).":[15],"Free":[16],"CS":[17,36,51,140],"could":[18,145],"be":[19,146],"released":[20],"during":[21],"ECM":[22,143],"degradation":[23,144],"and":[24,39,64,80,87,94,99,103,135,159],"exert":[25],"physiological":[26],"functions;":[27],"thus,":[28],"we":[29],"aimed":[30],"to":[31,74,148],"investigate":[32],"effects":[34,71,153],"on":[37],"voltage-":[38],"current-clamped":[40],"rat":[41],"embryo":[42],"hippocampal":[43],"neurons":[44],"in":[45],"primary":[46],"cultures.":[47],"We":[48],"found":[49],"that":[50,59],"elicited":[52,76],"a":[53,65,111],"whole-cell":[54],"Na(+)-dependent":[55],"inward":[56],"current":[57],"(ICS)":[58],"produced":[60],"drastic":[61],"cell":[62],"depolarization,":[63],"cytosolic":[66],"calcium":[67],"transient":[68],"([Ca(2+)]c).":[69],"Those":[70],"were":[72,82,89,95,106],"similar":[73],"those":[75],"by":[77,85,92,97,109],"\u03b1-amino-3-hydroxy-5-methylisoxazole-4-propionate":[78],"(AMPA)":[79],"kainate,":[81],"completely":[83],"blocked":[84,91],"NBQX":[86],"CNQX,":[88],"partially":[90],"GYKI,":[93],"unaffected":[96],"MK801":[98],"D-APV.":[100],"Furthermore,":[101],"ICS":[102],"AMPA":[104,116,158],"currents":[105],"similarly":[107],"potentiated":[108],"cyclothiazide,":[110],"positive":[112],"allosteric":[113],"modulator":[114],"receptors.":[117,161],"Because":[118],"CSPGs":[119],"have":[120],"been":[121],"attributed":[122],"Ca(2)":[123],"(+)":[124],"-dependent":[125],"roles,":[126],"such":[127],"as":[128],"neural":[129],"network":[130],"development,":[131],"axon":[132],"pathfinding,":[133],"plasticity":[134],"regeneration":[136],"after":[137,142],"CNS":[138],"injury,":[139],"action":[141],"contributing":[147],"mediation":[150],"these":[152],"through":[154],"its":[155],"interaction":[156],"with":[157],"kainate":[160]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
