{"id":"https://openalex.org/W2011199373","doi":"https://doi.org/10.1007/bf02899530","title":"Locally applied GM-CSF induces the accumulation of \u03b1-smooth muscle act in containing myofibroblasts","display_name":"Locally applied GM-CSF induces the accumulation of \u03b1-smooth muscle act in containing myofibroblasts","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W2011199373","doi":"https://doi.org/10.1007/bf02899530","mag":"2011199373","pmid":"https://pubmed.ncbi.nlm.nih.gov/1675512"},"language":"en","primary_location":{"id":"doi:10.1007/bf02899530","doi":"https://doi.org/10.1007/bf02899530","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02899530","pdf_url":null,"source":{"id":"https://openalex.org/S5406927145","display_name":"Virchows Archiv B Cell Pathology Including Molecular Pathology","issn_l":"0340-6075","issn":["0340-6075","0042-6431"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virchows Archiv B Cell Pathology Including Molecular Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073307450","display_name":"Laura Rubbia\u2010Brandt","orcid":"https://orcid.org/0000-0002-3173-3376","observed_orcids":["https://orcid.org/0000-0002-3173-3376"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Laura Rubbia-Brandt","raw_affiliation_strings":["Department of Pathology, University of Geneva, Switzerland","Dept of Pathology, University of Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Dept of Pathology, University of Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111810645","display_name":"Andr\u00e9\u2010Pascal Sappino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andr\u00e9-Pascal Sappino","raw_affiliation_strings":["Division of Onco-Hematology, University Hospital of Geneva, CH-1211, Geneva 4, Switzerland","Division of Onco-Hematology, University Hospital of Geneva, Geneva 4, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Onco-Hematology, University Hospital of Geneva, CH-1211, Geneva 4, Switzerland","institution_ids":["https://openalex.org/I4210106256"]},{"raw_affiliation_string":"Division of Onco-Hematology, University Hospital of Geneva, Geneva 4, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091042751","display_name":"Giulio Gabbiani","orcid":"https://orcid.org/0000-0001-7773-1061","observed_orcids":["https://orcid.org/0000-0001-7773-1061"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Giulio Gabbiani","raw_affiliation_strings":["Department of Pathology, University of Geneva, CMU, 1 rue Michel-Servet, CH-1211, Geneva 4, Switzerland","Department of Pathology, University of Geneva, Geneva 4, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Geneva, CMU, 1 rue Michel-Servet, CH-1211, Geneva 4, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"Department of Pathology, University of Geneva, Geneva 4, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.6867,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.99244332,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"60","issue":"1","first_page":"73","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.051500000059604645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8870000243186951},{"id":"https://openalex.org/keywords/alpha-smooth-muscle-actin","display_name":"alpha-smooth muscle actin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fibroblast-accumulation","display_name":"fibroblast accumulation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7599999904632568},{"id":"https://openalex.org/keywords/interleukin-1-alpha","display_name":"interleukin-1 alpha","score":0.953000009059906},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9959999918937683},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":1.0},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9509999752044678},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/leukocyte-infiltration","display_name":"leukocyte infiltration","score":0.703000009059906},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8320000171661377},{"id":"https://openalex.org/keywords/connective-tissue","display_name":"connective tissue","score":0.5370000004768372},{"id":"https://openalex.org/keywords/microfilament-bundles","display_name":"microfilament bundles","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.6961507797241211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5378270745277405},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5058915019035339},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4698095917701721},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.45182886719703674},{"id":"https://openalex.org/C2776055305","wikidata":"https://www.wikidata.org/wiki/Q1543255","display_name":"Granulation tissue","level":3,"score":0.4489153027534485},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.44662177562713623},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.4132785201072693},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.41121456027030945},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3765828311443329},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3517845869064331},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23396539688110352},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.16149890422821045},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14606916904449463},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.12838494777679443},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006097","descriptor_name":"Granulation Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf02899530","doi":"https://doi.org/10.1007/bf02899530","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02899530","pdf_url":null,"source":{"id":"https://openalex.org/S5406927145","display_name":"Virchows Archiv B Cell Pathology Including Molecular Pathology","issn_l":"0340-6075","issn":["0340-6075","0042-6431"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virchows Archiv B Cell Pathology Including Molecular Pathology","raw_type":"journal-article"},{"id":"pmid:1675512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1675512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virchows Archiv. B, Cell pathology including molecular pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W65810411","https://openalex.org/W263572369","https://openalex.org/W1218841746","https://openalex.org/W1244955178","https://openalex.org/W1557168106","https://openalex.org/W1599392598","https://openalex.org/W1631150466","https://openalex.org/W1732198201","https://openalex.org/W1969696386","https://openalex.org/W1973312385","https://openalex.org/W1981200245","https://openalex.org/W1982093100","https://openalex.org/W1983031935","https://openalex.org/W1986311374","https://openalex.org/W1994090580","https://openalex.org/W1995255507","https://openalex.org/W2003178930","https://openalex.org/W2012244701","https://openalex.org/W2013993175","https://openalex.org/W2016710605","https://openalex.org/W2045401603","https://openalex.org/W2047377654","https://openalex.org/W2047908260","https://openalex.org/W2055037877","https://openalex.org/W2056544931","https://openalex.org/W2072224250","https://openalex.org/W2074532891","https://openalex.org/W2081596799","https://openalex.org/W2104628127","https://openalex.org/W2111803376","https://openalex.org/W2112138377","https://openalex.org/W2113497740","https://openalex.org/W2114242966","https://openalex.org/W2122805183","https://openalex.org/W2143461429","https://openalex.org/W2148371225","https://openalex.org/W2151376215","https://openalex.org/W2168476587","https://openalex.org/W2170202796","https://openalex.org/W2239006518","https://openalex.org/W2296890825","https://openalex.org/W2325284571","https://openalex.org/W2397769233","https://openalex.org/W2404057244","https://openalex.org/W2412609849","https://openalex.org/W2437594851","https://openalex.org/W2461169750","https://openalex.org/W2886308690","https://openalex.org/W2935273799","https://openalex.org/W3140216262"],"related_works":["https://openalex.org/W2071149119","https://openalex.org/W2096280264","https://openalex.org/W2052258952","https://openalex.org/W2000843185","https://openalex.org/W7098816371","https://openalex.org/W3021250953","https://openalex.org/W2013105546","https://openalex.org/W2402239629","https://openalex.org/W2082076151","https://openalex.org/W1486248937"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}