{"id":"https://openalex.org/W2011198767","doi":"https://doi.org/10.1113/jphysiol.1969.sp008898","title":"Effect of barbiturates on \u2018quantal\u2019 synaptic transmission in spinal motoneurones","display_name":"Effect of barbiturates on \u2018quantal\u2019 synaptic transmission in spinal motoneurones","publication_year":1969,"publication_date":"1969-09-01","ids":{"openalex":"https://openalex.org/W2011198767","doi":"https://doi.org/10.1113/jphysiol.1969.sp008898","mag":"2011198767","pmid":"https://pubmed.ncbi.nlm.nih.gov/4310944","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1351593"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1969.sp008898","doi":"https://doi.org/10.1113/jphysiol.1969.sp008898","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1969.sp008898","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2011198767"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1351593/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034096285","display_name":"J. N. Weakly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. N. Weakly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034096285"],"corresponding_institution_ids":[],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":3.3024,"has_fulltext":false,"cited_by_count":432,"citation_normalized_percentile":{"value":0.92178583,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"204","issue":"1","first_page":"63","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/barbiturates","display_name":"barbiturates","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thiopental","display_name":"thiopental","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pentobarbital","display_name":"pentobarbital","score":1.0},{"id":"https://openalex.org/keywords/spinal-motoneurons","display_name":"spinal motoneurons","score":0.8220000267028809},{"id":"https://openalex.org/keywords/triceps-surae","display_name":"triceps surae","score":0.8240000009536743},{"id":"https://openalex.org/keywords/monosynaptic-excitatory-postsynaptic-potentials","display_name":"monosynaptic excitatory postsynaptic potentials","score":0.8980000019073486},{"id":"https://openalex.org/keywords/quantum-content","display_name":"quantum content","score":0.7170000076293945},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.8809999823570251},{"id":"https://openalex.org/keywords/neurotransmitter-release","display_name":"neurotransmitter release","score":0.8140000104904175},{"id":"https://openalex.org/keywords/afferent-nerve-stimulation","display_name":"afferent nerve stimulation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.8143690228462219},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.6103816032409668},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.609551191329956},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.5550379157066345},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.4240131974220276},{"id":"https://openalex.org/C2779263132","wikidata":"https://www.wikidata.org/wiki/Q2215671","display_name":"Afferent","level":2,"score":0.419028639793396},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.4177379012107849},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4046436846256256},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38058245182037354},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.30710166692733765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20199915766716003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14294040203094482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12095069885253906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07516801357269287},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06840389966964722}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010424","descriptor_name":"Pentobarbital","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012023","descriptor_name":"Reflex, Monosynaptic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013874","descriptor_name":"Thiopental","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1969.sp008898","doi":"https://doi.org/10.1113/jphysiol.1969.sp008898","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1969.sp008898","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:4310944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4310944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1351593","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1351593/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1351593","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1351593/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1648825372","https://openalex.org/W1976561710","https://openalex.org/W1982614140","https://openalex.org/W1991416239","https://openalex.org/W1997696502","https://openalex.org/W2013659331","https://openalex.org/W2028276159","https://openalex.org/W2030430694","https://openalex.org/W2030845649","https://openalex.org/W2033898792","https://openalex.org/W2050969248","https://openalex.org/W2086552052","https://openalex.org/W2086916200","https://openalex.org/W2093752082","https://openalex.org/W2106081526","https://openalex.org/W2159427135","https://openalex.org/W2161923991","https://openalex.org/W2262297987","https://openalex.org/W2301339089","https://openalex.org/W2346742684","https://openalex.org/W2396446279","https://openalex.org/W2399792522","https://openalex.org/W2402310641","https://openalex.org/W2414693601"],"related_works":["https://openalex.org/W2013543202","https://openalex.org/W2014343523","https://openalex.org/W2090748465","https://openalex.org/W1972255009","https://openalex.org/W2041916509","https://openalex.org/W2031860542","https://openalex.org/W2414560629","https://openalex.org/W2025836171","https://openalex.org/W2271453272","https://openalex.org/W1972079617"],"abstract_inverted_index":{"1.":[0],"Monosynaptic":[1],"excitatory":[2],"post-synaptic":[3],"potentials":[4],"(EPSPs)":[5],"produced":[6,99],"in":[7,20,95,102,111,134,147,150],"triceps":[8],"surae":[9],"motoneurones":[10],"of":[11,16,34,41,54,106,130,153],"the":[12,21,32,42,52,55,96,103,107,112,122,128,135,141,151],"cat":[13],"by":[14,78,88,116,156],"stimulation":[15],"single":[17],"afferent":[18,157],"fibres":[19],"muscle":[22],"nerve":[23,143],"were":[24],"recorded":[25],"with":[26],"intracellular":[27],"electrodes":[28],"before":[29,71],"and":[30,48,83,90,132,145],"after":[31,51],"administration":[33,53],"thiopentone":[35,79,131],"or":[36,110],"pentobarbitone.2.":[37],"The":[38,74,93],"average":[39],"amplitude":[40],";unit'":[43],"EPSP":[44],"was":[45,76],"0.11-0.21":[46],"mV":[47],"remained":[49],"unchanged":[50],"barbiturates":[56],"(10":[57,80,85],"mg/kg,":[58,81,86],"I.V.).3.":[59],"Mean":[60],"quantum":[61],"content":[62],"(m)":[63],"ranged":[64],"from":[65],"1.9":[66],"to":[67,140],"more":[68],"than":[69],"5":[70],"drug":[72],"administration.":[73],"m":[75],"reduced":[77],"I.V.)":[82,87],"pentobarbitone":[84],"23.1":[89],"24.7%":[91],"respectively.4.":[92],"barbiturates,":[94],"doses":[97,136],"employed,":[98],"no":[100],"alterations":[101],"input":[104],"resistance":[105],"motoneurone":[108],"membrane":[109],"strength-duration":[113],"relation":[114],"obtained":[115],"passing":[117],"depolarizing":[118],"current":[119],"pulses":[120],"through":[121],"micro-electrode.5.":[123],"It":[124],"is":[125,138],"concluded":[126],"that":[127],"action":[129],"pentobarbitone,":[133],"used,":[137],"confined":[139],"presynaptic":[142],"terminals":[144],"results":[146],"a":[148],"reduction":[149],"amount":[152],"transmitter":[154],"released":[155],"impulses.":[158]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}