{"id":"https://openalex.org/W2011195559","doi":"https://doi.org/10.1249/01.mss.0000386475.25547.76","title":"Stroke Volume Response to Low Dose Beta Blockade during Exercise Under Normothermic and Hyperthermic Conditions","display_name":"Stroke Volume Response to Low Dose Beta Blockade during Exercise Under Normothermic and Hyperthermic Conditions","publication_year":2010,"publication_date":"2010-05-01","ids":{"openalex":"https://openalex.org/W2011195559","doi":"https://doi.org/10.1249/01.mss.0000386475.25547.76","mag":"2011195559"},"language":"en","primary_location":{"id":"doi:10.1249/01.mss.0000386475.25547.76","doi":"https://doi.org/10.1249/01.mss.0000386475.25547.76","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000386475.25547.76","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035467273","display_name":"Joel Douglas Trinity","orcid":"https://orcid.org/0000-0001-8271-6536","observed_orcids":["https://orcid.org/0000-0001-8271-6536"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel D. Trinity","raw_affiliation_strings":["The University of Texas at Austin, Austin, TX","(No disclosure reported)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"(No disclosure reported)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089801940","display_name":"Matthew D. Pahnke","orcid":"https://orcid.org/0000-0002-4660-2918","observed_orcids":["https://orcid.org/0000-0002-4660-2918"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew D. Pahnke","raw_affiliation_strings":["The University of Texas at Austin, Austin, TX","(No disclosure reported)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"(No disclosure reported)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056615553","display_name":"Joshua F. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua F. Lee","raw_affiliation_strings":["The University of Texas at Austin, Austin, TX","(No disclosure reported)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"(No disclosure reported)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034844182","display_name":"Edward F. Coyle","orcid":"https://orcid.org/0000-0002-4329-8287","observed_orcids":["https://orcid.org/0000-0002-4329-8287"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward F. Coyle","raw_affiliation_strings":["The University of Texas at Austin, Austin, TX","(No disclosure reported)","Email: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"(No disclosure reported)","institution_ids":[]},{"raw_affiliation_string":"Email: [email\u00a0protected]","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19381644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"5","first_page":"800","last_page":"800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.5971999764442444,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.40209999680519104,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stroke-volume","display_name":"stroke volume","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/beta-adrenergic-blockade","display_name":"beta-adrenergic blockade","score":0.7149999737739563},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.6499999761581421},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.9959999918937683},{"id":"https://openalex.org/keywords/skin-blood-flow","display_name":"skin blood flow","score":0.8579999804496765},{"id":"https://openalex.org/keywords/forearm-blood-flow","display_name":"forearm blood flow","score":0.9860000014305115},{"id":"https://openalex.org/keywords/skin-temperature","display_name":"skin temperature","score":0.6430000066757202},{"id":"https://openalex.org/keywords/core-body-temperature","display_name":"core body temperature","score":0.7689999938011169},{"id":"https://openalex.org/keywords/thermoregulation","display_name":"thermoregulation","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.9411782026290894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7446236610412598},{"id":"https://openalex.org/C2776525901","wikidata":"https://www.wikidata.org/wiki/Q411325","display_name":"Atenolol","level":3,"score":0.5884256362915039},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5563291907310486},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5244172811508179},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.5154033899307251},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5108773112297058},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.49758055806159973},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.43957772850990295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3969542980194092},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3474004566669464},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.2968100905418396},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.17348790168762207},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07087761163711548},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1249/01.mss.0000386475.25547.76","doi":"https://doi.org/10.1249/01.mss.0000386475.25547.76","is_oa":false,"landing_page_url":"https://doi.org/10.1249/01.mss.0000386475.25547.76","pdf_url":null,"source":{"id":"https://openalex.org/S14544163","display_name":"Medicine & Science in Sports & Exercise","issn_l":"0195-9131","issn":["0195-9131","1530-0315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine &amp; Science in Sports &amp; Exercise","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2167997199","https://openalex.org/W2943853217","https://openalex.org/W2618287717","https://openalex.org/W147784604","https://openalex.org/W1855360891","https://openalex.org/W2072817121","https://openalex.org/W2415002011","https://openalex.org/W2274765440","https://openalex.org/W2786367044","https://openalex.org/W2043284375"],"abstract_inverted_index":{"The":[0,147],"effect":[1],"of":[2,11,14,28,44,49,61],"hyperthermia":[3,26,80,84,134,206,238],"during":[4,35,110,159,242,249],"exercise":[5,45,184,250],"on":[6],"stroke":[7],"volume":[8],"(SV)":[9],"independent":[10,27],"the":[12,62,178,229,245,260],"elevation":[13,30],"heart":[15],"rate":[16],"(HR)":[17],"has":[18],"not":[19,186,225],"been":[20],"described.":[21],"PURPOSE:":[22],"To":[23],"determine":[24],"if":[25],"an":[29],"in":[31,102,149,181,231,247,262],"HR":[32,104,106,182],"reduces":[33],"SV":[34,127,150,190,241,248],"exercise.":[36,243],"METHODS:":[37],"Eleven":[38],"active":[39],"men":[40],"performed":[41],"60":[42,109],"min":[43],"at":[46,107],"\u223c":[47],"57%":[48],"VO2peak":[50],"after":[51],"receiving":[52],"placebo":[53,75],"control":[54],"(PL)":[55],"or":[56],"a":[57,154],"low":[58],"dose":[59],"(0.2mg/kg)":[60],"b1":[63],"adrenoreceptor":[64],"beta":[65],"blocker":[66],"(bB),":[67],"atenolol.":[68],"Four":[69],"experimental":[70],"conditions":[71,161,256],"were":[72,121,224],"performed;":[73],"normothermia":[74,77],"(NormoPL),":[76],"bB":[78,85],"(NormobB),":[79],"PL":[81],"(HyperPL),":[82],"and":[83,91,96,115,195,199,212,254],"(HyperbB).":[86],"RESULTS:":[87],"Hyperthermia":[88],"increased":[89,129,207],"skin":[90],"core":[92],"temperature":[93],"by":[94,130,133,188,193,217],"4.3\u00b0C":[95],"0.8\u00b0C,":[97],"respectively.":[98],"Beta-blockade":[99],"was":[100,128,151,185,191],"successful":[101],"matching":[103],"as":[105],"minute":[108],"NormoPL":[111,139,198],"(154.6":[112],"\u00b1":[113,118,166,171],"11.0)":[114],"HyperbB":[116,137],"(153.8":[117],"13.3":[119],"bpm)":[120],"similar":[122],"(p":[123,202,219],"=":[124,145],"0.82).":[125],"However,":[126],"6":[131],"%":[132],"when":[135],"comparing":[136],"to":[138,228,259],"(treatment":[140],"x":[141],"time":[142],"interaction,":[143],"p":[144,174],"0.03).":[146],"increase":[148,180,261],"associated":[152],"with":[153],"higher":[155],"cardiac":[156],"output":[157],"(CO)":[158],"hyperthermic":[160,255],"(minute":[162],"60:":[163],"Hyper;":[164],"21.0":[165],"2.5":[167],"vs.":[168],"Normo":[169],"18.9":[170],"2.6":[172],"L/min,":[173],"<":[175,203,220],"0.01).":[176,204],"When":[177,234],"progressive":[179],"throughout":[183],"prevented":[187],"bB,":[189],"reduced":[192],"9%":[194],"14%":[196],"for":[197,236],"HyperPL,":[200],"respectively":[201],"Although":[205],"cutaneous":[208],"blood":[209,214],"flow":[210,215],"(CBF)":[211],"forearm":[213],"(FBF)":[216],"\u223c40%":[218],"0.05),":[221],"these":[222],"increases":[223,240],"temporally":[226],"related":[227],"decrease":[230],"SV.":[232],"CONCLUSION:":[233],"matched":[235],"HR,":[237],"slightly":[239],"Furthermore,":[244],"reduction":[246],"under":[251],"both":[252],"normothermic":[253],"is":[257],"due":[258],"HR.":[263]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}