{"id":"https://openalex.org/W2011161975","doi":"https://doi.org/10.1111/j.1365-3083.1992.tb02877.x","title":"Preferential Interaction of the CD4+29+/45RA\u2010 Subset of Human CD4+ T Lymphocytes with an Antibody against the Cell\u2010Membrane Ganglioside GD3","display_name":"Preferential Interaction of the CD4+29+/45RA\u2010 Subset of Human CD4+ T Lymphocytes with an Antibody against the Cell\u2010Membrane Ganglioside GD3","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W2011161975","doi":"https://doi.org/10.1111/j.1365-3083.1992.tb02877.x","mag":"2011161975","pmid":"https://pubmed.ncbi.nlm.nih.gov/1373001"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-3083.1992.tb02877.x","doi":"https://doi.org/10.1111/j.1365-3083.1992.tb02877.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-3083.1992.tb02877.x","pdf_url":null,"source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062887811","display_name":"Mariusz A. Wasik","orcid":"https://orcid.org/0000-0002-1988-3670","observed_orcids":["https://orcid.org/0000-0002-1988-3670"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. A. WASIK","raw_affiliation_strings":["Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA","Division of Tumor Immunology, Dana-Farber Cancer Institute and the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA","Present address: Mariusz A. Wasik, MD, Department of Pathology, Beth Israel Hospital and Department of Pathology, Harvard Medical School, 330 Brookline Ave., Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Division of Tumor Immunology, Dana-Farber Cancer Institute and the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Present address: Mariusz A. Wasik, MD, Department of Pathology, Beth Israel Hospital and Department of Pathology, Harvard Medical School, 330 Brookline Ave., Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062887811"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.09425684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"4","first_page":"421","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cd45ra","display_name":"CD45RA","score":0.996999979019165},{"id":"https://openalex.org/keywords/gd3-ganglioside","display_name":"GD3 ganglioside","score":0.9549999833106995},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.6940000057220459},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6449999809265137},{"id":"https://openalex.org/keywords/calcium-flux","display_name":"calcium flux","score":0.6669999957084656},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.8029999732971191},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9950000047683716},{"id":"https://openalex.org/keywords/t-cell-surface-molecules","display_name":"T cell surface molecules","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2777331542","wikidata":"https://www.wikidata.org/wiki/Q419287","display_name":"Ganglioside","level":2,"score":0.8279745578765869},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6034524440765381},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5346646904945374},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5264585614204407},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5056331157684326},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5032424330711365},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.43093299865722656},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.4270781874656677},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4046379327774048},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4033958613872528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35986754298210144},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23590612411499023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2093334197998047}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005732","descriptor_name":"Gangliosides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006649","descriptor_name":"Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017493","descriptor_name":"Leukocyte Common Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019012","descriptor_name":"Integrin beta1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-3083.1992.tb02877.x","doi":"https://doi.org/10.1111/j.1365-3083.1992.tb02877.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-3083.1992.tb02877.x","pdf_url":null,"source":{"id":"https://openalex.org/S79173686","display_name":"Scandinavian Journal of Immunology","issn_l":"0300-9475","issn":["0300-9475","1365-3083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1373001","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1373001","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W7695055","https://openalex.org/W36144156","https://openalex.org/W62447273","https://openalex.org/W205401375","https://openalex.org/W1484629663","https://openalex.org/W1486831515","https://openalex.org/W1504600626","https://openalex.org/W1553835608","https://openalex.org/W1554177941","https://openalex.org/W1559971535","https://openalex.org/W1561072490","https://openalex.org/W1573797130","https://openalex.org/W1594898695","https://openalex.org/W1627093987","https://openalex.org/W1632209833","https://openalex.org/W1662473501","https://openalex.org/W1665894543","https://openalex.org/W1666818122","https://openalex.org/W1818805711","https://openalex.org/W1830776040","https://openalex.org/W1877478601","https://openalex.org/W1922102737","https://openalex.org/W1986097431","https://openalex.org/W1988791393","https://openalex.org/W1999168221","https://openalex.org/W2004106131","https://openalex.org/W2012852738","https://openalex.org/W2012962241","https://openalex.org/W2013381560","https://openalex.org/W2014383722","https://openalex.org/W2016292927","https://openalex.org/W2037456347","https://openalex.org/W2038374182","https://openalex.org/W2063572572","https://openalex.org/W2067004325","https://openalex.org/W2068457755","https://openalex.org/W2074614649","https://openalex.org/W2081266951","https://openalex.org/W2087774304","https://openalex.org/W2088689097","https://openalex.org/W2095672355","https://openalex.org/W2096746473","https://openalex.org/W2097755535","https://openalex.org/W2112464982","https://openalex.org/W2127977816","https://openalex.org/W2129625054","https://openalex.org/W2133880058","https://openalex.org/W2166833626","https://openalex.org/W2170076907","https://openalex.org/W2172937773","https://openalex.org/W2262779158","https://openalex.org/W2397213684","https://openalex.org/W4244757991"],"related_works":["https://openalex.org/W2049875552","https://openalex.org/W1666818122","https://openalex.org/W1518732479","https://openalex.org/W1553835608","https://openalex.org/W2130488553","https://openalex.org/W1824306396","https://openalex.org/W2184566787","https://openalex.org/W1561072490","https://openalex.org/W2169880807","https://openalex.org/W2077488824"],"abstract_inverted_index":{"This":[0],"study":[1],"shows":[2],"that":[3,42,180],"the":[4,14,20,35,43,52,59,64,71,77,88,109,119,122,137,141,146,150,156,159,163,168,178,181,187,195,201],"two":[5,127],"major":[6],"subpopulations":[7],"of":[8,16,19,58,99,121,177,198,200],"CD4+":[9,202],"T":[10,203],"lymphocytes":[11],"defined":[12],"on":[13,49],"basis":[15],"differential":[17],"expression":[18],"CD29":[21],"and":[22,73,102,132],"CD45RA":[23],"antigens,":[24],"show":[25,95],"significant":[26,97],"differences":[27],"in":[28,85,175],"reactivity":[29],"with":[30,63,108],"a":[31,96],"monoclonal":[32],"antibody":[33],"against":[34],"GD3":[36,44,164],"ganglioside.":[37],"Double":[38],"staining":[39],"studies":[40],"showed":[41],"ganglioside":[45,165],"is":[46],"predominantly":[47],"expressed":[48],"cells":[50],"from":[51,186],"CD4+29+/45RA":[53,60],"subsets.":[54,205],"The":[55],"preferential":[56,196],"interaction":[57],"cell":[61],"subset":[62,80],"anti-GD3":[65,89,110,142],"MoAb":[66,90],"was":[67,81,152],"further":[68,173],"confirmed":[69],"by":[70],"proliferative":[72],"calcium-flux":[74],"studies.":[75],"Accordingly,":[76],"reciprocal,":[78],"CD4+(29-)/45RA+":[79],"unable":[82],"to":[83,87,104,139,154,194],"proliferate":[84],"response":[86,113],"alone.":[91],"Although":[92,158],"it":[93],"did":[94],"mobilization":[98],"calcium":[100],"ions":[101],"proliferation":[103],"IL-2":[105],"when":[106,126],"stimulated":[107],"MoAb,":[111],"these":[112],"were":[114,134],"much":[115],"less":[116],"pronounced":[117],"than":[118],"responses":[120],"CD4+29+/45RA-":[123],"subset.":[124],"Finally,":[125],"T-cell":[128,182,188],"stimulating":[129],"monokines,":[130],"IL-1":[131],"IL-6,":[133],"tested":[135],"for":[136,162],"ability":[138],"modulate":[140],"mediated":[143],"proliferation,":[144],"only":[145],"former,":[147],"but":[148],"not":[149],"latter":[151],"able":[153],"enhance":[155],"proliferation.":[157],"natural":[160],"ligand":[161],"remains":[166],"unknown,":[167],"data":[169],"presented":[170],"here":[171],"provide":[172],"evidence":[174],"support":[176],"notion":[179],"surface":[183],"molecules":[184],"different":[185],"receptor":[189],"MHC-antigen":[190],"complex":[191],"may":[192],"contribute":[193],"activation":[197],"one":[199],"lymphocyte":[204]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
