{"id":"https://openalex.org/W2011145014","doi":"https://doi.org/10.1046/j.1365-2249.1999.00775.x","title":"Hypoxia augments cytokine (transforming growth factor-beta (TGF-\u03b2) and IL-1)-induced vascular endothelial growth factor secretion by human synovial fibroblasts","display_name":"Hypoxia augments cytokine (transforming growth factor-beta (TGF-\u03b2) and IL-1)-induced vascular endothelial growth factor secretion by human synovial fibroblasts","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2011145014","doi":"https://doi.org/10.1046/j.1365-2249.1999.00775.x","mag":"2011145014","pmid":"https://pubmed.ncbi.nlm.nih.gov/9933439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1905193"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2249.1999.00775.x","doi":"https://doi.org/10.1046/j.1365-2249.1999.00775.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1999.00775.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1905193","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075594049","display_name":"Brygida Berse","orcid":"https://orcid.org/0000-0002-0735-2792","observed_orcids":["https://orcid.org/0000-0002-0735-2792"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B BERSE","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Boston University, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Boston University, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103556833","display_name":"Jane A. Hunt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210118357","display_name":"White River Junction VA Medical Center","ror":"https://ror.org/02et65004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095851","https://openalex.org/I4210118357","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A HUNT","raw_affiliation_strings":["Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210118357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090237888","display_name":"Roger J. Diegel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210118357","display_name":"White River Junction VA Medical Center","ror":"https://ror.org/02et65004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095851","https://openalex.org/I4210118357","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R J DIEGEL","raw_affiliation_strings":["Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210118357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081914657","display_name":"Peter M. Morganelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210118357","display_name":"White River Junction VA Medical Center","ror":"https://ror.org/02et65004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095851","https://openalex.org/I4210118357","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P MORGANELLI","raw_affiliation_strings":["Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210118357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111646972","display_name":"K T Yeo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210118357","display_name":"White River Junction VA Medical Center","ror":"https://ror.org/02et65004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095851","https://openalex.org/I4210118357","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K -T YEO","raw_affiliation_strings":["Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210118357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048568861","display_name":"Forst E. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039337","display_name":"Dartmouth Health","ror":"https://ror.org/01pa9ed26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F BROWN","raw_affiliation_strings":["Department of Surgery, Dartmouth Medical School, Hanover, NH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Dartmouth Medical School, Hanover, NH","institution_ids":["https://openalex.org/I4390039337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066089494","display_name":"Roy A. Fava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I4210118357","display_name":"White River Junction VA Medical Center","ror":"https://ror.org/02et65004","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I107672454","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210095851","https://openalex.org/I4210118357","https://openalex.org/I4390039337"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R A FAVA","raw_affiliation_strings":["Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, White River Jct, VT and Department of Medicine","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210118357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066089494"],"corresponding_institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I4210118357"],"apc_list":{"value":2894,"currency":"GBP","value_usd":3816},"apc_paid":null,"fwci":11.1841,"has_fulltext":false,"cited_by_count":199,"citation_normalized_percentile":{"value":0.98962634,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"115","issue":"1","first_page":"176","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8529999852180481},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.996999979019165},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9449999928474426},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":1.0},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.921999990940094},{"id":"https://openalex.org/keywords/synovium","display_name":"synovium","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.9010000228881836},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.796999990940094},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.7144603729248047},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6746398210525513},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.6705277562141418},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6016091108322144},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5263246893882751},{"id":"https://openalex.org/C87313946","wikidata":"https://www.wikidata.org/wiki/Q18031970","display_name":"Transforming growth factor, beta 3","level":5,"score":0.5246199369430542},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.4591035842895508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4580248296260834},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4330638647079468},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4214558005332947},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.41817498207092285},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.414205402135849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3600606620311737},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35178589820861816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24843677878379822},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23498889803886414},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.221693754196167},{"id":"https://openalex.org/C125555471","wikidata":"https://www.wikidata.org/wiki/Q14908037","display_name":"TGF alpha","level":4,"score":0.19507020711898804},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.13653582334518433},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001168","descriptor_name":"Arthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D013583","descriptor_name":"Synovial Membrane","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2249.1999.00775.x","doi":"https://doi.org/10.1046/j.1365-2249.1999.00775.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2249.1999.00775.x","pdf_url":null,"source":{"id":"https://openalex.org/S11896317","display_name":"Clinical & Experimental Immunology","issn_l":"0009-9104","issn":["0009-9104","1365-2249"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1905193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1905193","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:9933439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9933439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1905193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1905193","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306237","display_name":"Arthritis Foundation","ror":"https://ror.org/04zk9fe75"},{"id":"https://openalex.org/F4320306383","display_name":"Hitchcock Foundation","ror":"https://ror.org/00d1dhh09"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W32167704","https://openalex.org/W56717304","https://openalex.org/W1494416455","https://openalex.org/W1670891845","https://openalex.org/W1985712533","https://openalex.org/W1992380657","https://openalex.org/W1999223106","https://openalex.org/W2001412491","https://openalex.org/W2022490022","https://openalex.org/W2026393226","https://openalex.org/W2032894856","https://openalex.org/W2042663666","https://openalex.org/W2043850275","https://openalex.org/W2062594120","https://openalex.org/W2067055586","https://openalex.org/W2093498435","https://openalex.org/W2100311816","https://openalex.org/W2101840353","https://openalex.org/W2108145145","https://openalex.org/W2123840402","https://openalex.org/W2141962274","https://openalex.org/W2160578379","https://openalex.org/W2166784415","https://openalex.org/W2168014904","https://openalex.org/W2418661392","https://openalex.org/W4247664461"],"related_works":["https://openalex.org/W56717304","https://openalex.org/W2061520029","https://openalex.org/W2087466296","https://openalex.org/W2134260905","https://openalex.org/W2032062578","https://openalex.org/W2035623316","https://openalex.org/W1804526638","https://openalex.org/W1670891845","https://openalex.org/W2017902437","https://openalex.org/W2059979102"],"abstract_inverted_index":{"Vascular":[0],"endothelial":[1],"growth":[2,42,52],"factor":[3,43,48,53],"(VEGF)":[4],"is":[5],"abundant":[6],"in":[7,21,31,177,185,195,207],"synovium":[8],"and":[9,19,60,103,117,148,152,160,163],"synovial":[10,70,153,165,183],"fluids,":[11],"where":[12],"it":[13],"probably":[14,202],"contributes":[15,203],"to":[16,62,189,197,205],"vascular":[17],"permeability":[18],"angiogenesis":[20,206],"arthritic":[22],"joints.":[23],"To":[24],"investigate":[25],"the":[26,35,74,138,145,180,186,208],"probable":[27],"sources":[28],"of":[29,37,65,77,110,115,140,182,193],"VEGF":[30,66,78,83,120,129,141,171,194],"synovium,":[32],"we":[33],"compared":[34],"ability":[36],"several":[38],"cytokines":[39,146,161,198],"(TGF-beta,":[40],"platelet-derived":[41],"(PDGF),":[44],"IL-1,":[45],"tumour":[46],"necrosis":[47],"(TNF),":[49],"basic":[50],"fibroblast":[51],"(bFGF)":[54],"that":[55],"are":[56],"associated":[57],"with":[58],"arthritis":[59],"angiogenesis,":[61],"stimulate":[63,107],"secretion":[64,109,121,142],"protein":[67],"by":[68,90,95,144,158],"human":[69],"fibroblasts.":[71,175],"TGF-beta":[72,91,116,147,201],"was":[73,84],"strongest":[75],"inducer":[76],"secretion;":[79],"six":[80],"times":[81,169],"more":[82,132,170],"secreted":[85,167],"when":[86,93],"cells":[87],"were":[88,122,155],"stimulated":[89,94,128,143,156],"than":[92,172],"PDGF":[96],"or":[97],"IL-1":[98,118],"for":[99],"24":[100],"h.":[101],"TNF-alpha":[102],"bFGF":[104],"did":[105,173],"not":[106],"any":[108],"VEGF.":[111],"The":[112],"stimulatory":[113],"effects":[114],"on":[119],"additive.":[123],"Hypoxic":[124],"culture":[125,135],"alone":[126],"also":[127],"secretion,":[130],"but":[131],"importantly,":[133],"hypoxic":[134,187],"conditions":[136],"doubled":[137],"rate":[139],"IL-1.":[149],"When":[150],"dermal":[151,174],"fibroblasts":[154,166,184],"identically":[157],"hypoxia":[159],"(TGF-beta":[162],"IL-1),":[164],"four":[168],"Thus":[176],"rheumatoid":[178],"arthritis,":[179],"capacity":[181],"environment":[188],"secrete":[190],"large":[191],"amounts":[192],"response":[196],"such":[199],"as":[200],"significantly":[204],"synovium.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}