{"id":"https://openalex.org/W2011133686","doi":"https://doi.org/10.1097/01.shk.0000127683.26493.e4","title":"REMOTE TRAUMA SENSITIZES HEPATIC MICROCIRCULATION TO ENDOTHELIN VIA CAVEOLIN INHIBITION OF eNOS ACTIVITY","display_name":"REMOTE TRAUMA SENSITIZES HEPATIC MICROCIRCULATION TO ENDOTHELIN VIA CAVEOLIN INHIBITION OF eNOS ACTIVITY","publication_year":2004,"publication_date":"2004-07-07","ids":{"openalex":"https://openalex.org/W2011133686","doi":"https://doi.org/10.1097/01.shk.0000127683.26493.e4","mag":"2011133686","pmid":"https://pubmed.ncbi.nlm.nih.gov/15257084"},"language":"en","primary_location":{"id":"doi:10.1097/01.shk.0000127683.26493.e4","doi":"https://doi.org/10.1097/01.shk.0000127683.26493.e4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.shk.0000127683.26493.e4","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048966072","display_name":"Jean H. Ashburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean H Ashburn","raw_affiliation_strings":["Department of Biology, University of North Carolina, Charlotte, North Carolina 28223, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Charlotte, North Carolina 28223, USA","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054126384","display_name":"Rajiv Baveja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rajiv Baveja","raw_affiliation_strings":["Department of Biology, University of North Carolina, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Charlotte, North Carolina","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052226290","display_name":"Nicole Kresge","orcid":"https://orcid.org/0000-0003-1551-6627","observed_orcids":["https://orcid.org/0000-0003-1551-6627"]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicole Kresge","raw_affiliation_strings":["Department of Biology, University of North Carolina, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Charlotte, North Carolina","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055025148","display_name":"Katarzyna Korneszczuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katarzyna Korneszczuk","raw_affiliation_strings":["Department of Biology, University of North Carolina, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Charlotte, North Carolina","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111904070","display_name":"Steve A. Keller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802101240","display_name":"Carolinas Medical Center","ror":"https://ror.org/0483mr804","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334069289","https://openalex.org/I2802101240"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Keller","raw_affiliation_strings":["Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina","institution_ids":["https://openalex.org/I2802101240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033755527","display_name":"Amel Karaa","orcid":"https://orcid.org/0000-0001-5781-9824","observed_orcids":["https://orcid.org/0000-0001-5781-9824"]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amel Karaa","raw_affiliation_strings":["Department of Biology, University of North Carolina, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Charlotte, North Carolina","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052829488","display_name":"Yukihiro Yokoyama","orcid":"https://orcid.org/0000-0003-2385-5610","observed_orcids":["https://orcid.org/0000-0003-2385-5610"]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yukihiro Yokoyama","raw_affiliation_strings":["Department of Biology, University of North Carolina, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Charlotte, North Carolina","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008636125","display_name":"Jian X. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian X Zhang","raw_affiliation_strings":["Department of Biology, University of North Carolina, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Charlotte, North Carolina","institution_ids":["https://openalex.org/I102149020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102987627","display_name":"Toan T. Huynh","orcid":"https://orcid.org/0009-0003-4502-353X","observed_orcids":["https://orcid.org/0009-0003-4502-353X"]},"institutions":[{"id":"https://openalex.org/I2802101240","display_name":"Carolinas Medical Center","ror":"https://ror.org/0483mr804","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334069289","https://openalex.org/I2802101240"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toan Huynh","raw_affiliation_strings":["Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina","institution_ids":["https://openalex.org/I2802101240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104993174","display_name":"Mark G. Clemens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102149020","display_name":"University of North Carolina at Charlotte","ror":"https://ror.org/04dawnj30","country_code":"US","type":"education","lineage":["https://openalex.org/I102149020"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark G Clemens","raw_affiliation_strings":["Department of Biology, University of North Carolina, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina, Charlotte, North Carolina","institution_ids":["https://openalex.org/I102149020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008636125","https://openalex.org/A5033755527","https://openalex.org/A5048966072","https://openalex.org/A5052226290","https://openalex.org/A5052829488","https://openalex.org/A5054126384","https://openalex.org/A5055025148","https://openalex.org/A5104993174"],"corresponding_institution_ids":["https://openalex.org/I102149020"],"apc_list":null,"apc_paid":null,"fwci":4.4036,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.94060876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"22","issue":"2","first_page":"120","last_page":"130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.4814000129699707,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.4814000129699707,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.2020999938249588,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.15800000727176666,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/femoral-fracture","display_name":"femoral fracture","score":0.734000027179718},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.8600000143051147},{"id":"https://openalex.org/keywords/endothelin-b-receptor","display_name":"endothelin B receptor","score":0.8730000257492065},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.949999988079071},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatic-microcirculation","display_name":"hepatic microcirculation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sinusoidal-flow","display_name":"sinusoidal flow","score":0.7860000133514404},{"id":"https://openalex.org/keywords/red-blood-cell-velocity","display_name":"red blood cell velocity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.5619999766349792},{"id":"https://openalex.org/keywords/endothelin-receptors","display_name":"endothelin receptors","score":0.41499999165534973},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.5860000252723694},{"id":"https://openalex.org/keywords/intravital-microscopy","display_name":"intravital microscopy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/liver-perfusion","display_name":"liver perfusion","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.775599479675293},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6088228225708008},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6051429510116577},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.5977833271026611},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.5778782963752747},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5238616466522217},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.45980989933013916},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4561883211135864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4037434160709381},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.388771653175354},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21776902675628662}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005596","descriptor_name":"Fractures, Closed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018715","descriptor_name":"Microscopy, Video","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022461","descriptor_name":"Caveolins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/01.shk.0000127683.26493.e4","doi":"https://doi.org/10.1097/01.shk.0000127683.26493.e4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.shk.0000127683.26493.e4","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:15257084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15257084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G314167107","display_name":null,"funder_award_id":"DK-38201","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7367876553","display_name":"Regulation of sinusoidal perfusion in shock","funder_award_id":"R01DK038201","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1544252040","https://openalex.org/W1967396537","https://openalex.org/W1967910591","https://openalex.org/W1971328499","https://openalex.org/W1987213472","https://openalex.org/W1987551469","https://openalex.org/W1987709121","https://openalex.org/W1990856194","https://openalex.org/W1998474168","https://openalex.org/W2005978449","https://openalex.org/W2014806005","https://openalex.org/W2016893185","https://openalex.org/W2022683053","https://openalex.org/W2023145731","https://openalex.org/W2026008412","https://openalex.org/W2031292559","https://openalex.org/W2040235989","https://openalex.org/W2040698802","https://openalex.org/W2044847181","https://openalex.org/W2052607851","https://openalex.org/W2064946616","https://openalex.org/W2065592034","https://openalex.org/W2067448001","https://openalex.org/W2069189623","https://openalex.org/W2070913408","https://openalex.org/W2074215405","https://openalex.org/W2079561461","https://openalex.org/W2124334318","https://openalex.org/W2133662506","https://openalex.org/W2164576604","https://openalex.org/W2167042104","https://openalex.org/W2399316545","https://openalex.org/W2414350339","https://openalex.org/W2415088294","https://openalex.org/W2416679012","https://openalex.org/W4246066765"],"related_works":["https://openalex.org/W157153433","https://openalex.org/W2195353940","https://openalex.org/W34835444","https://openalex.org/W2146022929","https://openalex.org/W2000216349","https://openalex.org/W572082392","https://openalex.org/W2356259288","https://openalex.org/W2016374074","https://openalex.org/W2128841229","https://openalex.org/W2289626993"],"abstract_inverted_index":{"This":[0,358],"study":[1],"addresses":[2],"the":[3,17,121,228,259,303,318,321,339,352,368],"microvascular":[4],"mechanisms":[5],"by":[6,65,135,346],"which":[7],"a":[8,37,83,118,177,288,334],"remote,":[9],"mild":[10],"stress":[11],"such":[12],"as":[13,333],"blunt":[14],"trauma":[15,316],"sensitizes":[16,317],"liver":[18,319],"to":[19,47,146,154,320,367],"injury.":[20],"Rats":[21],"received":[22],"closed":[23],"femur":[24],"fracture":[25],"(FFx),":[26],"and":[27,34,59,90,97,99,104,111,164,218,274,279,350],"24":[28],"h":[29],"later":[30],"livers":[31,72],"were":[32,63,225,270],"isolated":[33],"perfused":[35],"at":[36,159],"similar":[38],"starting":[39],"flow":[40,52,182],"rate":[41],"for":[42,195],"assessment":[43],"of":[44,173,261,291,305,325,336,338,348,370],"vascular":[45,359],"response":[46],"endothelin-1":[48],"(ET-1).":[49],"Sinusoidal":[50],"volumetric":[51],"(QS),":[53],"red":[54],"blood":[55],"cell":[56],"velocity":[57],"(VRBC),":[58],"sinusoidal":[60,181,322],"diameter":[61],"(Ds)":[62],"determined":[64],"intravital":[66],"microscopy.":[67],"Baseline":[68],"portal":[69],"resistance":[70],"in":[71,95,109,120,123,137,141,162,180,183,193,207,227,235,241,247,253,272,299,302],"from":[73,342],"FFx":[74,80,142,165,184,208,229,300,364],"rats":[75],"was":[76,133,176,189,296],"not":[77],"changed.":[78],"The":[79,170,293],"group":[81,230],"showed":[82,281],"lower":[84],"baseline":[85],"VRBC":[86,122],"(322.9":[87],"+/-":[88,92,102,106,144,148,152,156,233,239,245,251],"26.4":[89],"207.3":[91],"17.2":[93],"microm/s":[94],"sham":[96,110,124,138,163,236,248],"FFx,)":[98],"QS":[100],"(28.4":[101],"4.2":[103],"17.6":[105],"2.1":[107],"pL/s":[108],"FFx,":[112,273],"P":[113,167,255],"<":[114,168,256],"0.05).":[115,169],"ET-1":[116,136],"caused":[117],"decrease":[119,179],"but":[125,139],"no":[126,190],"change":[127,192],"after":[128,363],"FFx.":[129],"In":[130],"contrast,":[131],"Ds":[132],"unchanged":[134],"decreased":[140],"(10.3":[143],"0.4":[145,153,157],"10.7":[147],"0.5":[149],"vs.":[150,237,249],"10.6":[151],"9.0":[155],"microm":[158],"10":[160],"min":[161],"groups,":[166],"overall":[171],"result":[172,335],"these":[174,262,285,311],"changes":[175],"greater":[178],"compared":[185,209],"with":[186,210,276,284,355],"sham.":[187,211],"There":[188],"significant":[191],"mRNA":[194,217,224],"ET-1,":[196],"endothelin":[197,213],"A":[198],"(ETA)":[199],"receptor,":[200],"or":[201],"iNOS":[202],"(inducible":[203],"nitric":[204,221],"oxide":[205,222],"synthase)":[206,223],"However,":[212],"B":[214],"(ETB)":[215],"receptor":[216,341,354],"eNOS":[219,280,294,343,349],"(endothelial":[220],"increased":[226,282,306,356],"(ETB,":[231],"54.81":[232],"8.08":[234],"83.28":[238],"8.19":[240],"FFx;":[242,254],"eNOS,":[243],"56.11":[244],"2.53":[246],"83.31":[250],"5.51":[252],"0.05)":[257],"while":[258],"levels":[260,269],"proteins":[263],"remained":[264],"unchanged.":[265],"Caveolin-1":[266],"(cav-1)":[267],"protein":[268],"elevated":[271],"coimmunoprecipitation":[275],"both":[277],"ETB":[278,340,353],"associations":[283],"proteins,":[286],"suggesting":[287],"possible":[289],"inactivation":[290],"eNOS.":[292],"activity":[295,344],"also":[297],"blunted":[298],"animals":[301],"presence":[304],"cav-1":[307],"expression.":[308],"Taken":[309],"together,":[310],"results":[312],"demonstrate":[313],"that":[314,329,361],"remote":[315],"constrictor":[323],"effect":[324],"ET-1.":[326],"We":[327],"propose":[328],"this":[330],"hyperresponsiveness":[331],"occurs":[332,362],"uncoupling":[337],"mediated":[345],"interaction":[347],"possibly":[351],"caveolin-1.":[357],"sensitization":[360],"may":[365],"contribute":[366],"exacerbation":[369],"injury":[371],"during":[372],"subsequent":[373],"stresses.":[374]},"counts_by_year":[{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
