{"id":"https://openalex.org/W2011129052","doi":"https://doi.org/10.1158/0008-5472.can-05-2198","title":"N-myc Can Substitute for Insulin-Like Growth Factor Signaling in a Mouse Model of Sonic Hedgehog\u2013Induced Medulloblastoma","display_name":"N-myc Can Substitute for Insulin-Like Growth Factor Signaling in a Mouse Model of Sonic Hedgehog\u2013Induced Medulloblastoma","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W2011129052","doi":"https://doi.org/10.1158/0008-5472.can-05-2198","mag":"2011129052","pmid":"https://pubmed.ncbi.nlm.nih.gov/16510586"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-05-2198","doi":"https://doi.org/10.1158/0008-5472.can-05-2198","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-2198","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089342646","display_name":"Samuel R. Browd","orcid":"https://orcid.org/0000-0003-2376-9421","observed_orcids":["https://orcid.org/0000-0003-2376-9421"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel R. Browd","raw_affiliation_strings":["1Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah;","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010874181","display_name":"Anna Marie Kenney","orcid":"https://orcid.org/0000-0001-8323-0618","observed_orcids":["https://orcid.org/0000-0001-8323-0618"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna M. Kenney","raw_affiliation_strings":["2Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York; and","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046972525","display_name":"Oren N. Gottfried","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oren N. Gottfried","raw_affiliation_strings":["1Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah;","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031007294","display_name":"Joon Won Yoon","orcid":"https://orcid.org/0000-0003-3875-3641","observed_orcids":["https://orcid.org/0000-0003-3875-3641"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joon Won Yoon","raw_affiliation_strings":["3Department of Pediatrics; Northwestern University Feinberg Medical School and the Children's Memorial Hospital Research Center; Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pediatrics; Northwestern University Feinberg Medical School and the Children's Memorial Hospital Research Center; Chicago, Illinois","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077144940","display_name":"David Otto Walterhouse","orcid":"https://orcid.org/0000-0002-1067-0900","observed_orcids":["https://orcid.org/0000-0002-1067-0900"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Walterhouse","raw_affiliation_strings":["3Department of Pediatrics; Northwestern University Feinberg Medical School and the Children's Memorial Hospital Research Center; Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Pediatrics; Northwestern University Feinberg Medical School and the Children's Memorial Hospital Research Center; Chicago, Illinois","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054284592","display_name":"Carolyn A. Pedone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn A. Pedone","raw_affiliation_strings":["1Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah;","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057487004","display_name":"Daniel W. Fults","orcid":"https://orcid.org/0000-0001-8141-0519","observed_orcids":["https://orcid.org/0000-0001-8141-0519"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel W. Fults","raw_affiliation_strings":["1Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah;","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8105,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.93917943,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"66","issue":"5","first_page":"2666","last_page":"2672"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.9247999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.07150000333786011,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sonic-hedgehog-signaling","display_name":"Sonic hedgehog signaling","score":0.9120000004768372},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-signaling","display_name":"insulin-like growth factor signaling","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gli1","display_name":"Gli1","score":0.800000011920929},{"id":"https://openalex.org/keywords/granule-neuron-precursors","display_name":"granule neuron precursors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cerebellar-development","display_name":"cerebellar development","score":0.8679999709129333},{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3beta","display_name":"glycogen synthase kinase-3\u03b2","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-models","display_name":"tumor models","score":0.47099998593330383},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.9239691495895386},{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.9051740765571594},{"id":"https://openalex.org/C2779933373","wikidata":"https://www.wikidata.org/wiki/Q14886430","display_name":"GLI1","level":4,"score":0.8670138120651245},{"id":"https://openalex.org/C2779477247","wikidata":"https://www.wikidata.org/wiki/Q18030895","display_name":"PTCH1","level":4,"score":0.7199240922927856},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6626419425010681},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5449532270431519},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.526740550994873},{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.4417238235473633},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.426044762134552},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.42172834277153015},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.41919535398483276},{"id":"https://openalex.org/C2777994357","wikidata":"https://www.wikidata.org/wiki/Q24781250","display_name":"Patched","level":4,"score":0.41297444701194763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3551484942436218},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11907744407653809},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08363917469978333}],"mesh":[{"descriptor_ui":"D000071676","descriptor_name":"Zinc Finger Protein GLI1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071676","descriptor_name":"Zinc Finger Protein GLI1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071676","descriptor_name":"Zinc Finger Protein GLI1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013002","descriptor_name":"Somatomedins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-05-2198","doi":"https://doi.org/10.1158/0008-5472.can-05-2198","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-05-2198","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:16510586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16510586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.332.7911","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.332.7911","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/66/5/2666.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7099999785423279}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2140472678","display_name":"Multidisciplinary Cancer Research Training Program","funder_award_id":"T32CA093247","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3115554531","display_name":null,"funder_award_id":"CA108622","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8275937298","display_name":"Somatic Cell Transfer to Model Medulloblastoma in Mice","funder_award_id":"R01CA108622","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1531753146","https://openalex.org/W1538085254","https://openalex.org/W1584833644","https://openalex.org/W1826261498","https://openalex.org/W1936178817","https://openalex.org/W1950889666","https://openalex.org/W1968825318","https://openalex.org/W1968996432","https://openalex.org/W1970864607","https://openalex.org/W1973251215","https://openalex.org/W1980110416","https://openalex.org/W1983341583","https://openalex.org/W1986283384","https://openalex.org/W1987145582","https://openalex.org/W1987290581","https://openalex.org/W1991895682","https://openalex.org/W2007648282","https://openalex.org/W2011325803","https://openalex.org/W2011855173","https://openalex.org/W2012526118","https://openalex.org/W2027113588","https://openalex.org/W2028933307","https://openalex.org/W2041795984","https://openalex.org/W2045667786","https://openalex.org/W2048121649","https://openalex.org/W2058106363","https://openalex.org/W2066672792","https://openalex.org/W2082178034","https://openalex.org/W2088851040","https://openalex.org/W2103694596","https://openalex.org/W2107031745","https://openalex.org/W2109214564","https://openalex.org/W2110496051","https://openalex.org/W2112050795","https://openalex.org/W2112672557","https://openalex.org/W2114702304","https://openalex.org/W2117490484","https://openalex.org/W2117492061","https://openalex.org/W2119657716","https://openalex.org/W2124009292","https://openalex.org/W2126735009","https://openalex.org/W2137279272","https://openalex.org/W2141078839","https://openalex.org/W2143860664","https://openalex.org/W2150788754","https://openalex.org/W2151665764","https://openalex.org/W2158496649","https://openalex.org/W2163307259","https://openalex.org/W2169346737","https://openalex.org/W2418005520"],"related_works":["https://openalex.org/W1987290581","https://openalex.org/W4247222618","https://openalex.org/W2097109659","https://openalex.org/W2129859375","https://openalex.org/W1584833644","https://openalex.org/W7100207544","https://openalex.org/W2146865659","https://openalex.org/W2035716151","https://openalex.org/W2099689873","https://openalex.org/W7096217416"],"abstract_inverted_index":{"Medulloblastoma":[0],"is":[1,54],"a":[2,27,107],"malignant":[3],"brain":[4],"tumor":[5,159],"that":[6,32],"arises":[7],"in":[8,11,20,100,113,120,129,150],"the":[9,35,44,76,137],"cerebellum":[10],"children,":[12],"presumably":[13],"from":[14],"granule":[15],"neuron":[16],"precursors":[17],"(GNP).":[18],"Advances":[19],"patient":[21],"treatment":[22],"have":[23],"been":[24],"hindered":[25],"by":[26,81],"paucity":[28],"of":[29,38,43,64,91,95,110,118,125,154,174],"animal":[30],"models":[31],"accurately":[33],"reflect":[34],"molecular":[36],"pathogenesis":[37],"human":[39,57],"tumors.":[40,144],"Aberrant":[41],"activation":[42],"Sonic":[45],"hedgehog":[46],"(Shh)":[47],"and":[48,88,97,156,169],"insulin-like":[49],"growth":[50],"factor":[51,79],"(IGF)":[52],"pathways":[53,60],"associated":[55],"with":[56,122,131,136],"medulloblastomas.":[58],"Both":[59],"are":[61],"essential":[62],"regulators":[63],"GNP":[65],"proliferation":[66],"during":[67],"cerebellar":[68],"development.":[69],"In":[70],"cultured":[71],"GNPs,":[72],"IGF":[73,98,132],"signaling":[74,133],"stabilizes":[75],"oncogenic":[77],"transcription":[78],"N-myc":[80,155],"inhibiting":[82],"glycogen":[83],"synthase":[84],"kinase":[85],"3beta-dependent":[86],"phosphorylation":[87],"consequent":[89],"degradation":[90],"N-myc.":[92,123],"However,":[93],"determinants":[94],"Shh":[96,119,138,146],"tumorigenicity":[99],"vivo":[101],"remain":[102],"unknown.":[103],"Here":[104],"we":[105],"report":[106],"high":[108],"frequency":[109],"medulloblastoma":[111,167],"formation":[112],"mice":[114],"following":[115],"postnatal":[116],"overexpression":[117],"cooperation":[121],"Overexpression":[124],"N-myc,":[126],"alone":[127],"or":[128,135],"combination":[130],"mediators":[134],"target":[139],"Gli1,":[140],"did":[141],"not":[142],"cause":[143],"Thus,":[145],"has":[147],"transforming":[148],"functions":[149],"addition":[151],"to":[152],"induction":[153],"Gli1.":[157],"This":[158],"model":[160],"will":[161],"be":[162],"useful":[163],"for":[164],"testing":[165],"novel":[166],"therapies":[168],"providing":[170],"insight":[171],"into":[172],"mechanisms":[173],"hedgehog-mediated":[175],"transformation.":[176]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
