{"id":"https://openalex.org/W2011111542","doi":"https://doi.org/10.1172/jci106188","title":"Plasma insulin: fluctuations in the \u201cbig\u201d insulin component in man after glucose and other stimuli","display_name":"Plasma insulin: fluctuations in the \u201cbig\u201d insulin component in man after glucose and other stimuli","publication_year":1969,"publication_date":"1969-12-01","ids":{"openalex":"https://openalex.org/W2011111542","doi":"https://doi.org/10.1172/jci106188","mag":"2011111542","pmid":"https://pubmed.ncbi.nlm.nih.gov/4311236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/297479"},"language":"en","primary_location":{"id":"doi:10.1172/jci106188","doi":"https://doi.org/10.1172/jci106188","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci106188","pdf_url":"http://www.jci.org/articles/view/106188/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/106188/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070064147","display_name":"Phillip G\u00f6rden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip Gorden","raw_affiliation_strings":["From the Diabetes Section , Clinical Endocrinology Branch , National Institute of Arthritis and Metabolic Diseases , National Institutes of Health , Bethesda , Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Diabetes Section , Clinical Endocrinology Branch , National Institute of Arthritis and Metabolic Diseases , National Institutes of Health , Bethesda , Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112097822","display_name":"Jesse Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse Roth","raw_affiliation_strings":["From the Diabetes Section, Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Diabetes Section, Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":18.3484,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.99230648,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"48","issue":"12","first_page":"2225","last_page":"2234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proinsulin","display_name":"proinsulin","score":0.7649999856948853},{"id":"https://openalex.org/keywords/insulin-like-substance","display_name":"insulin-like substance","score":0.5699999928474426},{"id":"https://openalex.org/keywords/plasma-insulin","display_name":"plasma insulin","score":0.7910000085830688},{"id":"https://openalex.org/keywords/oral-glucose-tolerance","display_name":"oral glucose tolerance","score":0.6729999780654907},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.652999997138977},{"id":"https://openalex.org/keywords/starvation","display_name":"starvation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":1.0},{"id":"https://openalex.org/keywords/arginine-stimulation","display_name":"arginine stimulation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tolbutamide","display_name":"tolbutamide","score":0.9259999990463257},{"id":"https://openalex.org/keywords/islet-cell-carcinoma","display_name":"islet cell carcinoma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.8649916052818298},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8284764885902405},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8090132474899292},{"id":"https://openalex.org/C2776054734","wikidata":"https://www.wikidata.org/wiki/Q414275","display_name":"Tolbutamide","level":3,"score":0.7508251070976257},{"id":"https://openalex.org/C90061646","wikidata":"https://www.wikidata.org/wiki/Q426173","display_name":"Proinsulin","level":3,"score":0.6576303243637085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5273474454879761},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.48271414637565613}],"mesh":[{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007456","descriptor_name":"Iodine Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007516","descriptor_name":"Adenoma, Islet Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013851","descriptor_name":"Thinness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci106188","doi":"https://doi.org/10.1172/jci106188","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci106188","pdf_url":"http://www.jci.org/articles/view/106188/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:297479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/297479","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:4311236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4311236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci106188","doi":"https://doi.org/10.1172/jci106188","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci106188","pdf_url":"http://www.jci.org/articles/view/106188/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2011111542.pdf","grobid_xml":"https://content.openalex.org/works/W2011111542.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1603688983","https://openalex.org/W1974904969","https://openalex.org/W1976459980","https://openalex.org/W1977408796","https://openalex.org/W1990126254","https://openalex.org/W2000184187","https://openalex.org/W2009580551","https://openalex.org/W2010985011","https://openalex.org/W2019832137","https://openalex.org/W2024253268","https://openalex.org/W2079938927","https://openalex.org/W2083250005","https://openalex.org/W2083606604","https://openalex.org/W2089811173","https://openalex.org/W2093477186","https://openalex.org/W2095490600","https://openalex.org/W2095745349","https://openalex.org/W2122277944","https://openalex.org/W2156476745","https://openalex.org/W2156782959","https://openalex.org/W2164252720","https://openalex.org/W2319180293","https://openalex.org/W2321975356","https://openalex.org/W2338145542","https://openalex.org/W3023173633","https://openalex.org/W4242324471","https://openalex.org/W6655246955"],"related_works":["https://openalex.org/W2019969085","https://openalex.org/W2419313331","https://openalex.org/W2118133551","https://openalex.org/W2075407967","https://openalex.org/W1990126254","https://openalex.org/W2051808761","https://openalex.org/W2010985011","https://openalex.org/W2111755638","https://openalex.org/W7098179671","https://openalex.org/W2034811834"],"abstract_inverted_index":{"Plasma":[0],"was":[1,54,65,111,166,177,200,224,233,253],"filtered":[2],"on":[3],"G50":[4],"Sephadex,":[5],"and":[6,14,35,80,159,197,212,238],"two":[7,243],"components":[8],"of":[9,50,86,102,108,119,174,218],"circulating":[10],"insulin,":[11,16,27,104],"\"little\"":[12],"insulin":[13,52,56,110,186],"\"big\"":[15],"were":[17,130],"measured":[18],"by":[19,81],"immunoassay.":[20],"The":[21,172],"former":[22],"component":[23],"is":[24],"indistinguishable":[25],"from":[26,41],"whereas":[28],"the":[29,36,42,48,77,87,127,138,148,162,175,183,191,201,206,229,249,255],"latter":[30],"more":[31,144],"closely":[32],"resembles":[33],"proinsulin":[34],"other":[37],"insulin-like":[38],"substances":[39],"isolated":[40],"pancreas.":[43],"In":[44,90,113,242],"thin":[45,92,114,170,207],"normal":[46,100,260],"subjects,":[47,161],"fraction":[49],"plasma":[51,88,103,185],"that":[53,223],"big":[55,71,109,122,151,165,194,232,252],"(per":[57],"cent":[58,70,121,150,164,193,231,251],"\"big\").":[59],"15-30":[60],"min":[61,83,125],"after":[62,154,236],"oral":[63,227],"glucose,":[64],"less":[66],"than":[67,168],"5%;":[68],"per":[69,120,149,163,192,230,250],"rose":[72],"2-":[73],"to":[74,157,226],"8-fold":[75],"over":[76],"next":[78],"hour":[79],"90-120":[82,124,189],"represented":[84],"5-29%":[85],"insulin.":[89,152],"young":[91],"subjects":[93,115,219],"with":[94,99,180,240,245],"idiopathic":[95],"glucose":[96,139,155],"intolerance":[97],"associated":[98],"concentrations":[101],"an":[105],"identical":[106],"pattern":[107],"observed.":[112],"in":[116,142,147,169,182,195,205,214,254,259],"whom":[117],"elevations":[118,181],"at":[123],"during":[126],"standard":[128],"test":[129],"only":[131],"modest,":[132],"starvation":[133],"for":[134],"48":[135],"hr":[136],"before":[137],"administration":[140,156],"resulted":[141],"a":[143,215,221],"pronounced":[145],"rise":[146],"Early":[153],"obese":[158,196],"acromegalic":[160,198],"higher":[167],"subjects.":[171,208,261],"magnitude":[173],"elevation":[176],"roughly":[178],"correlated":[179],"fasting":[184],"concentration.":[187],"By":[188],"min,":[190],"patients":[199,244],"same":[202,256],"range":[203,257],"as":[204,258],"Intravenously":[209],"administered":[210],"arginine":[211],"tolbutamide":[213],"small":[216],"number":[217],"yielded":[220],"response":[222],"similar":[225],"glucose;":[228],"low":[234],"early":[235],"stimulation":[237],"increased":[239],"time.":[241],"islet":[246],"cell":[247],"carcinomas,":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}