{"id":"https://openalex.org/W2011106727","doi":"https://doi.org/10.1016/s0750-7658(88)80143-6","title":"Evaluation de l'efficacit\u00e9 et de la tol\u00e9rance du flumaz\u00e9nil dans l'antagonisme des effets du flunitraz\u00e9pam sur le syst\u00e8me nerveux central","display_name":"Evaluation de l'efficacit\u00e9 et de la tol\u00e9rance du flumaz\u00e9nil dans l'antagonisme des effets du flunitraz\u00e9pam sur le syst\u00e8me nerveux central","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2011106727","doi":"https://doi.org/10.1016/s0750-7658(88)80143-6","mag":"2011106727","pmid":"https://pubmed.ncbi.nlm.nih.gov/3129969"},"language":"fr","primary_location":{"id":"doi:10.1016/s0750-7658(88)80143-6","doi":"https://doi.org/10.1016/s0750-7658(88)80143-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0750-7658(88)80143-6","pdf_url":null,"source":{"id":"https://openalex.org/S59157177","display_name":"Annales Fran\u00e7aises d Anesth\u00e9sie et de R\u00e9animation","issn_l":"0750-7658","issn":["0750-7658","1769-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annales Fran\u00e7aises d'Anesth\u00e9sie et de R\u00e9animation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049489416","display_name":"Claude Winckler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154623","display_name":"Centre Hospitalier Universitaire de Rouen","ror":"https://ror.org/04cdk4t75","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210154623"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"C. Winckler","raw_affiliation_strings":["D\u00e9partement d'Anesth\u00e9sie-R\u00e9animation Chirurgicale, CHU, Rouen","Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement d'Anesth\u00e9sie-R\u00e9animation Chirurgicale, CHU, Rouen","institution_ids":["https://openalex.org/I4210154623"]},{"raw_affiliation_string":"Rouen, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077579152","display_name":"M Cavellat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Cavellat","raw_affiliation_strings":["Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Angers, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"J.P. Dupeyron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.P. Dupeyron","raw_affiliation_strings":["Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Strasbourg, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542223","display_name":"Georges Fran\u00e7ois","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Fran\u00e7ois","raw_affiliation_strings":["Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marseille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075237407","display_name":"A. Lienhart","orcid":"https://orcid.org/0000-0003-0294-6214","observed_orcids":["https://orcid.org/0000-0003-0294-6214"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Lienhart","raw_affiliation_strings":["Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067021908","display_name":"Jean P. Motin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Motin","raw_affiliation_strings":["Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"J.P. Richard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.P. Richard","raw_affiliation_strings":["Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toulouse, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109150663","display_name":"B Roquefeuil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Roquefeuil","raw_affiliation_strings":["Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Montpellier, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010658062","display_name":"M Sabathi\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Sabathi\u00e9","raw_affiliation_strings":["Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bordeaux, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112075898","display_name":"P Scherpereel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Scherpereel","raw_affiliation_strings":["Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lille, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112142592","display_name":"Remy Souron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Souron","raw_affiliation_strings":["Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes, France","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"M. Wilkening","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Wilkening","raw_affiliation_strings":["Dijon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dijon, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049489416"],"corresponding_institution_ids":["https://openalex.org/I4210154623"],"apc_list":null,"apc_paid":null,"fwci":2.4355,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.86914181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"2","first_page":"145","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flumazenil","display_name":"flumazenil","score":0.9549999833106995},{"id":"https://openalex.org/keywords/flunitrazepam","display_name":"flunitrazepam","score":0.972000002861023},{"id":"https://openalex.org/keywords/benzodiazepine-antagonism","display_name":"benzodiazepine antagonism","score":0.8799999952316284},{"id":"https://openalex.org/keywords/central-nervous-system-depression","display_name":"central nervous system depression","score":0.6389999985694885},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.4300000071525574},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.40299999713897705},{"id":"https://openalex.org/keywords/time-orientation","display_name":"time orientation","score":0.3700000047683716},{"id":"https://openalex.org/keywords/spatial-orientation","display_name":"spatial orientation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/drug-tolerance","display_name":"drug tolerance","score":0.5360000133514404},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.5130000114440918},{"id":"https://openalex.org/keywords/neuromuscular-blockade","display_name":"neuromuscular blockade","score":0.6629999876022339},{"id":"https://openalex.org/keywords/vecuronium","display_name":"vecuronium","score":0.7390000224113464},{"id":"https://openalex.org/keywords/pancuronium","display_name":"pancuronium","score":0.996999979019165},{"id":"https://openalex.org/keywords/fentanyl","display_name":"fentanyl","score":0.7149999737739563},{"id":"https://openalex.org/keywords/anesthesia","display_name":"anesthesia","score":0.3440000116825104},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2778409475","wikidata":"https://www.wikidata.org/wiki/Q421920","display_name":"Flumazenil","level":4,"score":0.8957605361938477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8197470903396606},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7281168699264526},{"id":"https://openalex.org/C2781442855","wikidata":"https://www.wikidata.org/wiki/Q62947","display_name":"Flunitrazepam","level":4,"score":0.6733653545379639},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.5933262705802917},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5577300190925598},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.4290100038051605},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.28967341780662537},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15361732244491577},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000762","descriptor_name":"Anesthesia Recovery Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005442","descriptor_name":"Flumazenil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005445","descriptor_name":"Flunitrazepam","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D005445","descriptor_name":"Flunitrazepam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0750-7658(88)80143-6","doi":"https://doi.org/10.1016/s0750-7658(88)80143-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0750-7658(88)80143-6","pdf_url":null,"source":{"id":"https://openalex.org/S59157177","display_name":"Annales Fran\u00e7aises d Anesth\u00e9sie et de R\u00e9animation","issn_l":"0750-7658","issn":["0750-7658","1769-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annales Fran\u00e7aises d'Anesth\u00e9sie et de R\u00e9animation","raw_type":"journal-article"},{"id":"pmid:3129969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3129969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annales francaises d'anesthesie et de reanimation","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W7519788","https://openalex.org/W1898404641","https://openalex.org/W2010450802","https://openalex.org/W2073121554","https://openalex.org/W2148654856","https://openalex.org/W2267777397"],"related_works":["https://openalex.org/W2083966195","https://openalex.org/W3035395154","https://openalex.org/W2404782505","https://openalex.org/W2397810085","https://openalex.org/W2082589788","https://openalex.org/W2011704660","https://openalex.org/W2038912180","https://openalex.org/W2400531801","https://openalex.org/W1988667910","https://openalex.org/W2412043814"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
