{"id":"https://openalex.org/W2011104206","doi":"https://doi.org/10.1046/j.1471-4159.1995.65041499.x","title":"Light\u2010Induced CREB Phosphorylation and Gene Expression in Rat Retinal Cells","display_name":"Light\u2010Induced CREB Phosphorylation and Gene Expression in Rat Retinal Cells","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2011104206","doi":"https://doi.org/10.1046/j.1471-4159.1995.65041499.x","mag":"2011104206","pmid":"https://pubmed.ncbi.nlm.nih.gov/7561843"},"language":"en","primary_location":{"id":"doi:10.1046/j.1471-4159.1995.65041499.x","doi":"https://doi.org/10.1046/j.1471-4159.1995.65041499.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1995.65041499.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036304615","display_name":"Kazuhiko Yoshida","orcid":"https://orcid.org/0000-0002-3834-0153","observed_orcids":["https://orcid.org/0000-0002-3834-0153"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiko Yoshida","raw_affiliation_strings":["Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078318891","display_name":"Junko Imaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Junko Imaki","raw_affiliation_strings":["Department of Anatomy, Nippon Medical School, Tokyo; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Nippon Medical School, Tokyo; and","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113445965","display_name":"Hidehiko Matsuda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidehiko Matsuda","raw_affiliation_strings":["Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022179217","display_name":"Masatoshi Hagiwara","orcid":"https://orcid.org/0000-0003-1193-7571","observed_orcids":["https://orcid.org/0000-0003-1193-7571"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masatoshi Hagiwara","raw_affiliation_strings":["Department of Anatomy, Nagoya University School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Nagoya University School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022179217"],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":4.5984,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.94495134,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"65","issue":"4","first_page":"1499","last_page":"1504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.968999981880188},{"id":"https://openalex.org/keywords/light-induced-gene-expression","display_name":"light-induced gene expression","score":0.7979999780654907},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.972000002861023},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cyclic-amp-response-element","display_name":"cyclic AMP response element","score":0.7979999780654907},{"id":"https://openalex.org/keywords/calcium-calmodulin-dependent-protein-kinase-ii","display_name":"calcium/calmodulin-dependent protein kinase II","score":0.8059999942779541},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.7549999952316284},{"id":"https://openalex.org/keywords/bay-k-8644","display_name":"Bay K 8644","score":0.9869999885559082},{"id":"https://openalex.org/keywords/amacrine-cells","display_name":"amacrine cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/inner-nuclear-layer","display_name":"inner nuclear layer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/rat-retina","display_name":"rat retina","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.8617365956306458},{"id":"https://openalex.org/C2777506830","wikidata":"https://www.wikidata.org/wiki/Q4113799","display_name":"Inner nuclear layer","level":3,"score":0.6908597946166992},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6419639587402344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5040087103843689},{"id":"https://openalex.org/C2780188069","wikidata":"https://www.wikidata.org/wiki/Q4133186","display_name":"Ganglion cell layer","level":3,"score":0.497882604598999},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.49701789021492004},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.48963266611099243},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4819355010986328},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.38308876752853394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36570021510124207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35103729367256165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15757158398628235},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.13414660096168518},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12091156840324402}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001498","descriptor_name":"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1471-4159.1995.65041499.x","doi":"https://doi.org/10.1046/j.1471-4159.1995.65041499.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1471-4159.1995.65041499.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:7561843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7561843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1530351217","https://openalex.org/W2016192229","https://openalex.org/W2030483758","https://openalex.org/W2061911673","https://openalex.org/W2056805727","https://openalex.org/W1996135882","https://openalex.org/W2016121300","https://openalex.org/W2041497541","https://openalex.org/W1987186800","https://openalex.org/W2005144279"],"abstract_inverted_index":{"The":[0],"signal":[1],"pathway":[2],"for":[3],"light-induced":[4],"expression":[5],"of":[6,70,81,86,125],"c-fos":[7,22,38],"and":[8,23,31,39,68,90,113,130],"the":[9,27,32,71,84,87,91,123,135],"neuropeptide":[10],"somatostatin":[11],"(SS)":[12],"in":[13,26,49,56,83,134],"rat":[14],"retinal":[15,57],"cells":[16,58,89,93,100],"was":[17,59],"investigated.":[18],"Flashing":[19],"light":[20,67],"induced":[21,79],"SS":[24,40],"mRNA":[25],"inner":[28],"nuclear":[29],"layer":[30],"ganglion":[33,92],"cell":[34],"layer.":[35],"As":[36],"both":[37],"genes":[41],"have":[42],"a":[43,62],"cyclic":[44],"AMP":[45],"response":[46],"element":[47],"(CRE)":[48],"their":[50],"promoters,":[51],"CRE-binding":[52],"protein":[53],"(CREB)":[54],"phosphorylation":[55,80],"examined":[60],"with":[61,104],"phospho-CREB-specific":[63,114],"antibody.":[64],"Both":[65],"flashing":[66],"administration":[69],"L-type":[72],"Ca2+":[73],"channel":[74],"activator":[75],"Bay":[76,118],"K":[77,119],"8644":[78,120],"CREB":[82,127],"nuclei":[85],"amacrine":[88],"where":[94],"c-fos/SS":[95],"mRNAs":[96],"were":[97],"expressed.":[98],"These":[99],"could":[101],"be":[102],"double-stained":[103],"anti-calmodulin":[105],"kinase":[106,109,132],"II":[107,133],"(anti-CaM":[108],"II)":[110],"monoclonal":[111],"antibody":[112],"polyclonal":[115],"antiserum":[116],"after":[117],"administration,":[121],"indicating":[122],"colocalization":[124],"phosphorylated":[126],"at":[128],"Ser133":[129],"CaM":[131],"neural":[136],"retina.":[137]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}