{"id":"https://openalex.org/W2011102403","doi":"https://doi.org/10.1007/s11805-008-0326-6","title":"Pharmacokinetics and pharmacodynamics of subcutaneous single doses of pegylated human G-CSF mutant (PEG30-rhG-CSF) in beagle dogs","display_name":"Pharmacokinetics and pharmacodynamics of subcutaneous single doses of pegylated human G-CSF mutant (PEG30-rhG-CSF) in beagle dogs","publication_year":2008,"publication_date":"2008-09-13","ids":{"openalex":"https://openalex.org/W2011102403","doi":"https://doi.org/10.1007/s11805-008-0326-6","mag":"2011102403"},"language":"en","primary_location":{"id":"doi:10.1007/s11805-008-0326-6","doi":"https://doi.org/10.1007/s11805-008-0326-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11805-008-0326-6","pdf_url":null,"source":{"id":"https://openalex.org/S4210175664","display_name":"Chinese Journal of Clinical Oncology","issn_l":"1672-7118","issn":["1672-7118","1993-5145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101693959","display_name":"Yongming Cai","orcid":"https://orcid.org/0000-0002-5507-0693","observed_orcids":["https://orcid.org/0000-0002-5507-0693"]},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongming Cai","raw_affiliation_strings":["State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","Tianjin Institute of Pharmaceutical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","institution_ids":["https://openalex.org/I4210105139"]},{"raw_affiliation_string":"Tianjin Institute of Pharmaceutical Research","institution_ids":["https://openalex.org/I4210105139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090877353","display_name":"Zhengmin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengmin Chen","raw_affiliation_strings":["State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","Tianjin Institute of Pharmaceutical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","institution_ids":["https://openalex.org/I4210105139"]},{"raw_affiliation_string":"Tianjin Institute of Pharmaceutical Research","institution_ids":["https://openalex.org/I4210105139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112253057","display_name":"Ling Jiang","orcid":"https://orcid.org/0009-0004-1072-3461","observed_orcids":["https://orcid.org/0009-0004-1072-3461"]},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Jiang","raw_affiliation_strings":["State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","Tianjin Institute of Pharmaceutical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","institution_ids":["https://openalex.org/I4210105139"]},{"raw_affiliation_string":"Tianjin Institute of Pharmaceutical Research","institution_ids":["https://openalex.org/I4210105139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351484","display_name":"Ming Li","orcid":"https://orcid.org/0000-0002-9242-7735","observed_orcids":["https://orcid.org/0000-0002-9242-7735","https://orcid.org/0000-0001-6471-2769"]},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Li","raw_affiliation_strings":["State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","Tianjin Institute of Pharmaceutical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","institution_ids":["https://openalex.org/I4210105139"]},{"raw_affiliation_string":"Tianjin Institute of Pharmaceutical Research","institution_ids":["https://openalex.org/I4210105139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077854313","display_name":"Changxiao Liu","orcid":"https://orcid.org/0000-0003-3034-2522","observed_orcids":["https://orcid.org/0000-0003-3034-2522"]},"institutions":[{"id":"https://openalex.org/I4210105139","display_name":"Tianjin Institute of Pharmaceutical Research (China)","ror":"https://ror.org/01g9y2x13","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105139"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changxiao Liu","raw_affiliation_strings":["State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","Tianjin Institute of Pharmaceutical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300193, China","institution_ids":["https://openalex.org/I4210105139"]},{"raw_affiliation_string":"Tianjin Institute of Pharmaceutical Research","institution_ids":["https://openalex.org/I4210105139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077854313"],"corresponding_institution_ids":["https://openalex.org/I4210105139"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15636191,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"5","first_page":"326","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pegylated-g-csf","display_name":"pegylated G-CSF","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.796999990940094},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutrophil-count","display_name":"neutrophil count","score":0.7350000143051147},{"id":"https://openalex.org/keywords/absolute-neutrophil-count","display_name":"absolute neutrophil count","score":0.7789999842643738},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.7129999995231628},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.7009999752044678},{"id":"https://openalex.org/keywords/relative-bioavailability","display_name":"relative bioavailability","score":0.7689999938011169},{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.7319999933242798},{"id":"https://openalex.org/keywords/beagle","display_name":"beagle dogs","score":0.8619999885559082},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.42100000381469727},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"area under the curve","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2776820430","wikidata":"https://www.wikidata.org/wiki/Q21102","display_name":"Beagle","level":2,"score":0.952292799949646},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.907759964466095},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7497076392173767},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.71247798204422},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6802970767021179},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.6286423206329346},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6244887709617615},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5133742094039917},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47809502482414246},{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.4702143967151642},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4609798192977905},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2524794340133667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16440820693969727},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s11805-008-0326-6","doi":"https://doi.org/10.1007/s11805-008-0326-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11805-008-0326-6","pdf_url":null,"source":{"id":"https://openalex.org/S4210175664","display_name":"Chinese Journal of Clinical Oncology","issn_l":"1672-7118","issn":["1672-7118","1993-5145"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5400000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W130297679","https://openalex.org/W202042235","https://openalex.org/W305838808","https://openalex.org/W1535197869","https://openalex.org/W1556377850","https://openalex.org/W2011370547","https://openalex.org/W2030163254","https://openalex.org/W2032414164","https://openalex.org/W2050383104","https://openalex.org/W2158530870","https://openalex.org/W2164470216"],"related_works":["https://openalex.org/W2354875722","https://openalex.org/W2378266540","https://openalex.org/W1993820209","https://openalex.org/W3012698092","https://openalex.org/W2401279245","https://openalex.org/W2411406125","https://openalex.org/W2390221855","https://openalex.org/W1530166373","https://openalex.org/W2327615024","https://openalex.org/W1647379185"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-10-10T00:00:00"}
