{"id":"https://openalex.org/W2011085165","doi":"https://doi.org/10.1158/1538-7445.am2014-lb-87","title":"Abstract LB-87: Analysis of JAZF1 loss-of-function reveals its role in regulation of genes relevant for prostate cancer","display_name":"Abstract LB-87: Analysis of JAZF1 loss-of-function reveals its role in regulation of genes relevant for prostate cancer","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2011085165","doi":"https://doi.org/10.1158/1538-7445.am2014-lb-87","mag":"2011085165"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-lb-87","doi":"https://doi.org/10.1158/1538-7445.am2014-lb-87","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-lb-87","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036803309","display_name":"Helen Gharwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Gharwan","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047700839","display_name":"Tamara L. Jones","orcid":"https://orcid.org/0000-0002-4854-0968","observed_orcids":["https://orcid.org/0000-0002-4854-0968"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara Jones","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024110359","display_name":"Wei Tang","orcid":"https://orcid.org/0000-0002-7089-4391","observed_orcids":["https://orcid.org/0000-0002-7089-4391"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Tang","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027170042","display_name":"Stefan Ambs","orcid":"https://orcid.org/0000-0001-7651-9309","observed_orcids":["https://orcid.org/0000-0001-7651-9309"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Ambs","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009724115","display_name":"Ludmila Prokunina\u2010Olsson","orcid":"https://orcid.org/0000-0002-9622-2091","observed_orcids":["https://orcid.org/0000-0002-9622-2091"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ludmilla Prokunina","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052362487","display_name":"Natasha J. Caplen","orcid":"https://orcid.org/0000-0002-0001-9460","observed_orcids":["https://orcid.org/0000-0002-0001-9460"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha Caplen","raw_affiliation_strings":["National Cancer Institute, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"LB","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jazf1","display_name":"JAZF1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9120000004768372},{"id":"https://openalex.org/keywords/loss-of-function","display_name":"loss of function","score":0.7670000195503235},{"id":"https://openalex.org/keywords/transcriptional-repressor","display_name":"transcriptional repressor","score":0.7490000128746033},{"id":"https://openalex.org/keywords/id1","display_name":"Id1","score":0.7059999704360962},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9200000166893005},{"id":"https://openalex.org/keywords/map2k4","display_name":"MAP2K4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/met","display_name":"MET","score":0.9959999918937683},{"id":"https://openalex.org/keywords/prostate-cancer-susceptibility","display_name":"prostate cancer susceptibility","score":0.5559999942779541},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6299999952316284},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.6890000104904175},{"id":"https://openalex.org/keywords/lentiviral-shrna","display_name":"lentiviral shRNA","score":0.675000011920929},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C2776438761","wikidata":"https://www.wikidata.org/wiki/Q5206280","display_name":"DU145","level":5,"score":0.861361563205719},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.695257842540741},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6702176332473755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6347029805183411},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.6145749688148499},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5978990793228149},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5410396456718445},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5054042339324951},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49439024925231934},{"id":"https://openalex.org/C205003668","wikidata":"https://www.wikidata.org/wiki/Q17113442","display_name":"Chromoplexy","level":5,"score":0.49357306957244873},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47574281692504883},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.20775872468948364},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.06514260172843933}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-lb-87","doi":"https://doi.org/10.1158/1538-7445.am2014-lb-87","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-lb-87","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089110008","https://openalex.org/W2093064866","https://openalex.org/W2153824703","https://openalex.org/W2946144155","https://openalex.org/W2945013268","https://openalex.org/W2460679135","https://openalex.org/W3167513512","https://openalex.org/W2935791182","https://openalex.org/W1983235475","https://openalex.org/W6908225836"],"abstract_inverted_index":{"Abstract":[0],"Genome-wide":[1],"association":[2],"studies":[3,77],"(GWAS)":[4],"have":[5],"mapped":[6],"one":[7],"of":[8,24,53,64,82,93,99,113,171,218,231,237,279,302,313,334,369,383,391,405,428,447,455,464,469],"the":[9,25,51,61,65,79,91,212,232,242,267,299,465,470],"prostate":[10,54,87,101,116,180,282,326,414,459],"cancer":[11,55,102,117,181,283,415,420],"susceptibility":[12,66],"regions":[13],"to":[14,36,49,59,130,315,365,410],"a":[15,30,75,146,208,223,252,275,288,324,386,403,407],"single":[16],"nucleotide":[17],"polymorphism":[18],"(SNP)":[19],"rs10486567":[20],"within":[21],"intron":[22],"2":[23],"gene":[26,156,268,284],"that":[27,44,227,258,416],"encodes":[28],"JAZF1,":[29,305],"putative":[31,205,300],"transcriptional":[32,209,225,387],"co-factor.":[33],"In":[34,246],"order":[35],"translate":[37],"GWAS":[38],"findings":[39,395],"into":[40],"clinically":[41],"relevant":[42,457],"information":[43],"will":[45],"ultimately":[46],"enable":[47],"us":[48],"improve":[50],"management":[52],"it":[56],"is":[57,222,241,417],"essential":[58],"identify":[60],"biological":[62,80],"role":[63,206,452],"variant":[67],"in":[68,86,105,123,155,165,198,254,264,356,413,453],"cells":[69,249],"and":[70,84,121,188,292,306,323,349,379,423],"tissues.":[71],"To":[72,89,296],"date,":[73],"only":[74],"few":[76],"address":[78],"function":[81,92],"JAZF1":[83,94,107,132,140,196,291,336,371,384,400,448],"none":[85],"cancer.":[88,460],"investigate":[90],"we":[95,250,309,338],"generated":[96],"expression":[97,257,285,294,342],"profiles":[98],"several":[100],"cell":[103,118,167,200,329,377,421],"lines,":[104,119,201],"which":[106,124],"was":[108,259],"silenced.":[109],"We":[110],"conducted":[111],"RNA-Seq":[112],"two":[114,191],"metastatic":[115],"LNCaP":[120],"DU145,":[122],"siRNA-mediated":[125,370],"RNAi":[126],"had":[127],"been":[128],"employed":[129],"induce":[131],"loss-of-function":[133,449],"(LOF).":[134],"For":[135],"this":[136,361,373],"study,":[137],"three":[138],"different":[139],"siRNAs":[141],"were":[142,161,193],"used,":[143],"along":[144],"with":[145,179,203,261,399,419],"siRNA":[147,216],"(siNeg)":[148],"serving":[149],"as":[150,163,207,229,343,385,402],"control":[151],"for":[152,176,458,473],"transfection-related":[153],"changes":[154],"expression.":[157,393],"Approximately":[158],"1,500":[159],"genes":[160,173,177,192,213,240,456],"identified":[162],"deregulated":[164],"both":[166,199],"lines.":[168,359],"Computational":[169],"analysis":[170,348],"these":[172],"showed":[174],"enrichment":[175],"associated":[178,418],"(p=2.4x10-6,":[182],"Ingenuity":[183],"Pathway":[184],"Analysis),":[185],"including":[186],"MAP2K4":[187],"MET.":[189],"These":[190,394],"up-regulated":[194],"following":[195,215],"LOF":[197,337],"consistent":[202,397],"JAZF1's":[204],"repressor.":[210],"Among":[211],"down-regulated":[214],"silencing":[217],"JAZF1was":[219],"ID1.":[220],"ID1":[221,255,293,303,341,392],"negative":[224],"regulator":[226,404],"functions":[228],"part":[230],"mitotic":[233],"checkpoint":[234],"machinery.":[235],"One":[236],"ID1's":[238],"target":[239],"cell-cycle":[243],"inhibitor":[244],"p21.":[245],"JAZF1-silenced":[247],"DU145":[248,318],"observed":[251,339],"decrease":[253],"mRNA":[256],"correlated":[260],"an":[262,271],"increase":[263],"CDKN1A":[265],"expression,":[266],"encoding":[269],"p21;":[270],"observation":[272,368],"confirmed":[273],"at":[274],"protein":[276,354,408],"level.":[277],"Examination":[278],"publically":[280],"available":[281],"data":[286],"indicated":[287],"correlation":[289],"between":[290],"(p<0.001).":[295],"further":[297],"analyze":[298],"regulation":[301,454],"by":[304,345],"thus":[307],"p21,":[308],"used":[310],"lentivirus-mediated":[311],"delivery":[312],"JAZF1-shRNAs":[314],"stably":[316],"transduce":[317],"cells,,":[319],"OPCN-1":[320],"non-tumorigenic":[321],"cells,":[322],"non-metastatic":[325],"tumor":[327],"epithelium":[328],"line,":[330],"OPCT-1.":[331],"Under":[332],"conditions":[333],"long-term":[335],"increased":[340],"measured":[344],"Western":[346],"Blot":[347],"concurrent":[350],"decreases":[351],"in,":[352],"p21":[353],"levels":[355],"all":[357],"three-cell":[358],"Although":[360],"result":[362],"appears":[363],"contradictory":[364],"our":[366],"initial":[367],"silencing,":[372],"difference":[374],"may":[375],"reflect":[376],"line":[378],"temporal":[380],"specific":[381],"activity":[382],"activator":[388],"or":[389],"repressor":[390],"are":[396],"though":[398],"functioning":[401],"ID1,":[406],"reported":[409],"be":[411],"over-expressed":[412],"proliferation":[422],"metastasis":[424],"formation":[425],"through":[426],"activation":[427],"various":[429],"oncogenic":[430],"pathways.":[431],"Citation":[432],"Format:":[433],"Helen":[434],"Gharwan,":[435],"Tamara":[436],"Jones,":[437],"Wei":[438],"Tang,":[439],"Stefan":[440],"Ambs,":[441],"Ludmilla":[442],"Prokunina,":[443],"Natasha":[444],"Caplen.":[445],"Analysis":[446],"reveals":[450],"its":[451],"[abstract].":[461],"In:":[462],"Proceedings":[463],"105th":[466],"Annual":[467],"Meeting":[468],"American":[471],"Association":[472],"Cancer":[474,485],"Research;":[475],"2014":[476],"Apr":[477],"5-9;":[478],"San":[479],"Diego,":[480],"CA.":[481],"Philadelphia":[482],"(PA):":[483],"AACR;":[484],"Res":[486],"2014;74(19":[487],"Suppl):Abstract":[488],"nr":[489],"LB-87.":[490],"doi:10.1158/1538-7445.AM2014-LB-87":[491]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
