{"id":"https://openalex.org/W2011080294","doi":"https://doi.org/10.1016/s0959-437x(99)80065-3","title":"Extracellular modulation of the Hedgehog, Wnt and TGF-\u03b2 signalling pathways during embryonic development","display_name":"Extracellular modulation of the Hedgehog, Wnt and TGF-\u03b2 signalling pathways during embryonic development","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2011080294","doi":"https://doi.org/10.1016/s0959-437x(99)80065-3","mag":"2011080294","pmid":"https://pubmed.ncbi.nlm.nih.gov/10449357"},"language":"en","primary_location":{"id":"doi:10.1016/s0959-437x(99)80065-3","doi":"https://doi.org/10.1016/s0959-437x(99)80065-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-437x(99)80065-3","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics &amp; Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109918410","display_name":"Javier Capdevila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Capdevila","raw_affiliation_strings":["The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050690657","display_name":"Juan Carlos Izpis\u00faa Belmonte","orcid":"https://orcid.org/0000-0003-0557-8875","observed_orcids":["https://orcid.org/0000-0003-0557-8875"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Juan Carlos Izpis\u00fca Belmonte","raw_affiliation_strings":["The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, California 92037, USA","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050690657"],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.4046,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.40159046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"9","issue":"4","first_page":"427","last_page":"433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.17759999632835388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.15549999475479126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.953000009059906},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9869999885559082},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pattern-formation","display_name":"pattern formation","score":0.5910000205039978},{"id":"https://openalex.org/keywords/positional-information","display_name":"positional information","score":0.9769999980926514},{"id":"https://openalex.org/keywords/secreted-factors","display_name":"secreted factors","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8455649614334106},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8405568599700928},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7753064036369324},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.6996581554412842},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6576210856437683},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.639612078666687},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.6325286626815796},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5648090839385986},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.506784975528717},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.47550541162490845},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45750856399536133},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.44768738746643066},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.3988223075866699},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2594905197620392},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07669302821159363}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019476","descriptor_name":"Insect Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0959-437x(99)80065-3","doi":"https://doi.org/10.1016/s0959-437x(99)80065-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-437x(99)80065-3","pdf_url":null,"source":{"id":"https://openalex.org/S116174365","display_name":"Current Opinion in Genetics & Development","issn_l":"0959-437X","issn":["0959-437X","1879-0380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Genetics &amp; Development","raw_type":"journal-article"},{"id":"pmid:10449357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10449357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in genetics & development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W326368786","https://openalex.org/W1511048586","https://openalex.org/W1564357553","https://openalex.org/W1566448969","https://openalex.org/W1585922331","https://openalex.org/W1598742335","https://openalex.org/W1603468729","https://openalex.org/W1631692643","https://openalex.org/W1659265739","https://openalex.org/W1967719403","https://openalex.org/W1968263279","https://openalex.org/W1969910714","https://openalex.org/W1971125032","https://openalex.org/W1973768914","https://openalex.org/W1976551834","https://openalex.org/W1981718544","https://openalex.org/W1982709013","https://openalex.org/W1984288177","https://openalex.org/W1984696112","https://openalex.org/W1988350691","https://openalex.org/W1988404865","https://openalex.org/W1990938412","https://openalex.org/W1990944246","https://openalex.org/W1994620081","https://openalex.org/W2000646745","https://openalex.org/W2001372468","https://openalex.org/W2005849699","https://openalex.org/W2008777486","https://openalex.org/W2010863761","https://openalex.org/W2012743416","https://openalex.org/W2015892335","https://openalex.org/W2017668082","https://openalex.org/W2024279589","https://openalex.org/W2025019677","https://openalex.org/W2027255572","https://openalex.org/W2028497134","https://openalex.org/W2030382396","https://openalex.org/W2030943228","https://openalex.org/W2034964406","https://openalex.org/W2039541905","https://openalex.org/W2044384686","https://openalex.org/W2044615295","https://openalex.org/W2045655335","https://openalex.org/W2046597024","https://openalex.org/W2047165320","https://openalex.org/W2047854255","https://openalex.org/W2056206121","https://openalex.org/W2056504726","https://openalex.org/W2056994384","https://openalex.org/W2058016050","https://openalex.org/W2064537289","https://openalex.org/W2067967789","https://openalex.org/W2068760238","https://openalex.org/W2071130833","https://openalex.org/W2079276277","https://openalex.org/W2081939122","https://openalex.org/W2083540431","https://openalex.org/W2088256061","https://openalex.org/W2091670449","https://openalex.org/W2093150604","https://openalex.org/W2098726225","https://openalex.org/W2103031848","https://openalex.org/W2103484049","https://openalex.org/W2106441070","https://openalex.org/W2109922541","https://openalex.org/W2110022036","https://openalex.org/W2113780941","https://openalex.org/W2115340713","https://openalex.org/W2121936687","https://openalex.org/W2125068279","https://openalex.org/W2127280898","https://openalex.org/W2131304500","https://openalex.org/W2132584224","https://openalex.org/W2140932241","https://openalex.org/W2141367941","https://openalex.org/W2141906259","https://openalex.org/W2142344672","https://openalex.org/W2143366342","https://openalex.org/W2147257521","https://openalex.org/W2148158930","https://openalex.org/W2157493750","https://openalex.org/W2158939849","https://openalex.org/W2164310262","https://openalex.org/W2165061154","https://openalex.org/W2165459158","https://openalex.org/W2165781463","https://openalex.org/W2169009865","https://openalex.org/W2169483492","https://openalex.org/W2183101699","https://openalex.org/W2184547682","https://openalex.org/W2188362237","https://openalex.org/W2947204387","https://openalex.org/W6684107985"],"related_works":["https://openalex.org/W86122165","https://openalex.org/W2953286732","https://openalex.org/W2086509258","https://openalex.org/W2077395272","https://openalex.org/W2108707301","https://openalex.org/W2015272152","https://openalex.org/W1522864600","https://openalex.org/W2088256061","https://openalex.org/W2059205089","https://openalex.org/W1527103851"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
