{"id":"https://openalex.org/W2011050800","doi":"https://doi.org/10.1073/pnas.1300392110","title":"Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells","display_name":"Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells","publication_year":2013,"publication_date":"2013-02-27","ids":{"openalex":"https://openalex.org/W2011050800","doi":"https://doi.org/10.1073/pnas.1300392110","mag":"2011050800","pmid":"https://pubmed.ncbi.nlm.nih.gov/23447566","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3607057"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1300392110","doi":"https://doi.org/10.1073/pnas.1300392110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1300392110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3607057","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045647243","display_name":"Amy S. McKee","orcid":"https://orcid.org/0000-0002-9268-5574","observed_orcids":["https://orcid.org/0000-0002-9268-5574"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy S. McKee","raw_affiliation_strings":["Clinical Immunology Division, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;","Integrated Department of Immunology and","Clinical Immunology Division, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Immunology Division, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Integrated Department of Immunology and","institution_ids":[]},{"raw_affiliation_string":"Clinical Immunology Division, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077448887","display_name":"Matthew A. Burchill","orcid":"https://orcid.org/0000-0003-3118-2962","observed_orcids":["https://orcid.org/0000-0003-3118-2962"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew A. Burchill","raw_affiliation_strings":["Integrated Department of Immunology and","bIntegrated Department of Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Department of Immunology and","institution_ids":[]},{"raw_affiliation_string":"bIntegrated Department of Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020676135","display_name":"Michael W. Munks","orcid":"https://orcid.org/0000-0002-0335-7238","observed_orcids":["https://orcid.org/0000-0002-0335-7238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael W. Munks","raw_affiliation_strings":["Integrated Department of Immunology and","bIntegrated Department of Immunology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Department of Immunology and","institution_ids":[]},{"raw_affiliation_string":"bIntegrated Department of Immunology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066665904","display_name":"Lei Jin","orcid":"https://orcid.org/0000-0001-6836-1142","observed_orcids":["https://orcid.org/0000-0001-6836-1142"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Jin","raw_affiliation_strings":["Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]},{"raw_affiliation_string":"cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040853234","display_name":"John W. Kappler","orcid":"https://orcid.org/0000-0002-5827-6240","observed_orcids":["https://orcid.org/0000-0002-5827-6240"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Kappler","raw_affiliation_strings":["Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","Integrated Department of Immunology and","Program in Biomolecular Structure and","cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]},{"raw_affiliation_string":"Integrated Department of Immunology and","institution_ids":[]},{"raw_affiliation_string":"Program in Biomolecular Structure and","institution_ids":[]},{"raw_affiliation_string":"cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027358643","display_name":"Rachel Sharon Friedman","orcid":"https://orcid.org/0000-0001-7549-6387","observed_orcids":["https://orcid.org/0000-0001-7549-6387"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel S. Friedman","raw_affiliation_strings":["Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]},{"raw_affiliation_string":"cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076736469","display_name":"Jordan Jacobelli","orcid":"https://orcid.org/0000-0001-6612-6704","observed_orcids":["https://orcid.org/0000-0001-6612-6704"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan Jacobelli","raw_affiliation_strings":["Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]},{"raw_affiliation_string":"cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044329784","display_name":"Philippa Marrack","orcid":"https://orcid.org/0000-0003-1883-3687","observed_orcids":["https://orcid.org/0000-0003-1883-3687"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]},{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philippa Marrack","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, University of Colorado Health Science Center, Aurora, CO 80045","Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","Integrated Department of Immunology and","cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","eDepartment of Biochemistry and Molecular Genetics, University of Colorado Health Science Center, Aurora, CO 80045"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Colorado Health Science Center, Aurora, CO 80045","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I51713134"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]},{"raw_affiliation_string":"Integrated Department of Immunology and","institution_ids":[]},{"raw_affiliation_string":"cHoward Hughes Medical Institute, National Jewish Health, Denver, CO 80206; and","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I3019586173"]},{"raw_affiliation_string":"eDepartment of Biochemistry and Molecular Genetics, University of Colorado Health Science Center, Aurora, CO 80045","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.2155,"has_fulltext":false,"cited_by_count":142,"citation_normalized_percentile":{"value":0.98227305,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"110","issue":"12","first_page":"E1122","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aluminium-adjuvants","display_name":"alum adjuvant","score":0.9890000224113464},{"id":"https://openalex.org/keywords/host-dna","display_name":"host DNA","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mhc-class-ii-antigen-presentation","display_name":"MHC class II antigen presentation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cd4-t-cell-priming","display_name":"CD4+ T cell priming","score":0.8690000176429749},{"id":"https://openalex.org/keywords/dendritic-cell-t-cell-interaction","display_name":"dendritic cell-T cell interaction","score":0.7549999952316284},{"id":"https://openalex.org/keywords/dnase","display_name":"DNase","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cytosolic-dna-sensing","display_name":"cytosolic DNA sensing","score":0.8669999837875366},{"id":"https://openalex.org/keywords/intramuscular-vaccination","display_name":"intramuscular vaccination","score":0.828000009059906},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2780924562","wikidata":"https://www.wikidata.org/wiki/Q190527","display_name":"Alum","level":2,"score":0.7191635370254517},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.7163606286048889},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.686854362487793},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.6267006397247314},{"id":"https://openalex.org/C2778814158","wikidata":"https://www.wikidata.org/wiki/Q959350","display_name":"MHC class II","level":4,"score":0.5721133351325989},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.546094536781311},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5379036664962769},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5265132188796997},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5135529041290283},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4573052227497101},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.44279932975769043},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4214330017566681},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4016862213611603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3601362705230713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33054593205451965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1408630609512329},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000534","descriptor_name":"Alum Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000949","descriptor_name":"Histocompatibility Antigens Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1300392110","doi":"https://doi.org/10.1073/pnas.1300392110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1300392110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2606079","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3607057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3607057","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3607057","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:23447566","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23447566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2606079","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3607057","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1361006016","display_name":null,"funder_award_id":"AI-18785","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2196125700","display_name":null,"funder_award_id":"AI 22295","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2900422150","display_name":"Antigen Recognition by Lymphocytes","funder_award_id":"P01AI022295","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G670264981","display_name":"CHARACTERISTICS OF T CELL RECEPTORS","funder_award_id":"R37AI018785","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7017699771","display_name":"Characteristics of T Cell Receptors","funder_award_id":"R56AI018785","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8715986517","display_name":"Characteristics of T Cell Receptors","funder_award_id":"R01AI018785","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1514540900","https://openalex.org/W1525912444","https://openalex.org/W1541731964","https://openalex.org/W1573590923","https://openalex.org/W1907513513","https://openalex.org/W1907743066","https://openalex.org/W1945887236","https://openalex.org/W1964741953","https://openalex.org/W1965763900","https://openalex.org/W1968178474","https://openalex.org/W1968789597","https://openalex.org/W1978508787","https://openalex.org/W1979256282","https://openalex.org/W1979991507","https://openalex.org/W1983221400","https://openalex.org/W1984189757","https://openalex.org/W1988338839","https://openalex.org/W2004285416","https://openalex.org/W2004829503","https://openalex.org/W2007988618","https://openalex.org/W2014161666","https://openalex.org/W2028682232","https://openalex.org/W2031182394","https://openalex.org/W2034320715","https://openalex.org/W2042045439","https://openalex.org/W2042288276","https://openalex.org/W2042816890","https://openalex.org/W2053397734","https://openalex.org/W2055456092","https://openalex.org/W2059944604","https://openalex.org/W2060004514","https://openalex.org/W2066887263","https://openalex.org/W2070530924","https://openalex.org/W2072118838","https://openalex.org/W2077577111","https://openalex.org/W2085374326","https://openalex.org/W2089712328","https://openalex.org/W2109363497","https://openalex.org/W2116933950","https://openalex.org/W2117789841","https://openalex.org/W2126384811","https://openalex.org/W2132565242","https://openalex.org/W2140649712","https://openalex.org/W2157428298","https://openalex.org/W2159567970","https://openalex.org/W2161901483","https://openalex.org/W2165748936","https://openalex.org/W2170382285"],"related_works":["https://openalex.org/W2770394555","https://openalex.org/W2313753627","https://openalex.org/W7134961098","https://openalex.org/W1968789597","https://openalex.org/W2089147775","https://openalex.org/W1548884443","https://openalex.org/W2475219939","https://openalex.org/W2118965097","https://openalex.org/W1983401173","https://openalex.org/W2042728718"],"abstract_inverted_index":{"Many":[0],"vaccines":[1,125],"include":[2],"aluminum":[3],"salts":[4],"(alum)":[5],"as":[6,170],"adjuvants":[7],"despite":[8],"little":[9],"knowledge":[10],"of":[11,26,57,62,107,165,180],"alum's":[12],"functions.":[13],"Host":[14],"DNA":[15,161,176],"rapidly":[16],"coats":[17],"injected":[18,44,117],"alum.":[19,47,93],"Here,":[20],"we":[21],"further":[22],"investigated":[23],"the":[24,80,84,119,151,178],"mechanism":[25],"alum":[27,168],"and":[28,135,141,193],"DNA's":[29],"adjuvant":[30,172],"function.":[31],"Our":[32],"data":[33,96],"show":[34,97],"that":[35,71,98,156,187],"DNase":[36,72,99,128],"coinjection":[37],"reduces":[38],"CD4":[39,143],"T-cell":[40],"priming":[41],"by":[42,121,173],"i.m.":[43,147],"antigen":[45,136],"+":[46],"This":[48],"effect":[49],"is":[50],"partially":[51],"replicated":[52],"in":[53,88,113],"mice":[54,89],"lacking":[55],"stimulator":[56],"IFN":[58],"genes,":[59],"a":[60],"mediator":[61],"cellular":[63],"responses":[64],"to":[65,83,162],"cytoplasmic":[66],"DNA.":[67],"Others":[68],"have":[69],"shown":[70],"treatment":[73],"impairs":[74],"dendritic":[75],"cell":[76],"(DC)":[77],"migration":[78,164],"from":[79,150],"peritoneal":[81],"cavity":[82],"draining":[85,116],"lymph":[86,114],"node":[87],"immunized":[90],"i.p.":[91],"with":[92],"However,":[94],"our":[95],"does":[100,129,157],"not":[101,158],"affect":[102],"accumulation":[103],"of,":[104],"or":[105],"expression":[106],"costimulatory":[108],"proteins":[109],"on,":[110],"antigen-loaded":[111],"DCs":[112,140],"nodes":[115],"muscles,":[118],"site":[120,155],"which":[122],"most":[123],"human":[124],"are":[126],"administered.":[127],"inhibit":[130],"prolonged":[131],"T-cell-DC":[132],"conjugate":[133],"formation":[134],"presentation":[137,192],"between":[138],"antigen-positive":[139],"antigen-specific":[142],"T":[144],"cells":[145],"following":[146],"injection.":[148],"Thus,":[149],"muscle,":[152],"an":[153,171],"immunization":[154],"require":[159],"host":[160,175],"promote":[163,188],"inflammatory":[166],"DCs,":[167,182],"acts":[169],"introducing":[174],"into":[177],"cytoplasm":[179],"antigen-bearing":[181],"where":[183],"it":[184],"engages":[185],"receptors":[186],"MHC":[189],"class":[190],"II":[191],"better":[194],"DC-T-cell":[195],"interactions.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
