{"id":"https://openalex.org/W2011029744","doi":"https://doi.org/10.1016/s1044-0305(02)00409-9","title":"Increased proteome coverage for quantitative peptide abundance measurements based upon high performance separations and DREAMS FTICR mass spectrometry","display_name":"Increased proteome coverage for quantitative peptide abundance measurements based upon high performance separations and DREAMS FTICR mass spectrometry","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2011029744","doi":"https://doi.org/10.1016/s1044-0305(02)00409-9","mag":"2011029744","pmid":"https://pubmed.ncbi.nlm.nih.gov/12216736"},"language":"en","primary_location":{"id":"doi:10.1016/s1044-0305(02)00409-9","doi":"https://doi.org/10.1016/s1044-0305(02)00409-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1044-0305(02)00409-9","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055812269","display_name":"Ljiljana Pa\u0161a\u2010Toli\u0107","orcid":"https://orcid.org/0000-0001-9853-5457","observed_orcids":["https://orcid.org/0000-0001-9853-5457","https://orcid.org/0000-0001-8438-5267"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ljiljana Pa\u0161a-Toli\u0107","raw_affiliation_strings":["Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061641914","display_name":"Richard Harkewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Harkewicz","raw_affiliation_strings":["Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018692662","display_name":"Gordon Anderson","orcid":"https://orcid.org/0000-0002-7066-6161","observed_orcids":["https://orcid.org/0000-0002-7066-6161"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon A. Anderson","raw_affiliation_strings":["Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052412732","display_name":"Nikola Toli\u0107","orcid":"https://orcid.org/0000-0003-3950-9130","observed_orcids":["https://orcid.org/0000-0003-3950-9130"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikola Toli\u0107","raw_affiliation_strings":["Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051597447","display_name":"Yufeng Shen","orcid":"https://orcid.org/0000-0002-1299-5979","observed_orcids":["https://orcid.org/0000-0002-1299-5979"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yufeng Shen","raw_affiliation_strings":["Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684042","display_name":"Rui Zhao","orcid":"https://orcid.org/0000-0003-0045-2974","observed_orcids":["https://orcid.org/0000-0003-0045-2974","https://orcid.org/0009-0002-1572-0716"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Zhao","raw_affiliation_strings":["Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110543549","display_name":"Brian D. Thrall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Thrall","raw_affiliation_strings":["Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019155111","display_name":"Christophe Masselon","orcid":"https://orcid.org/0000-0003-0117-2480","observed_orcids":["https://orcid.org/0000-0003-0117-2480"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christophe Masselon","raw_affiliation_strings":["Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023982706","display_name":"Richard D. Smith","orcid":"https://orcid.org/0000-0002-2381-2349","observed_orcids":["https://orcid.org/0000-0002-2381-2349"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I2801280572","display_name":"Environmental Molecular Sciences Laboratory","ror":"https://ror.org/04rc0xn13","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I2801280572","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard D. Smith","raw_affiliation_strings":["Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Molecular Sciences Laboratory, PacificNorthwest National Laboratory, MSIN: K8-98, 99352, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810","https://openalex.org/I2801280572"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.9533,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.97656763,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"13","issue":"8","first_page":"954","last_page":"963"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dreams","display_name":"dreams","score":0.9340000152587891},{"id":"https://openalex.org/keywords/dynamic-range-enhancement","display_name":"dynamic range extension","score":0.878000020980835},{"id":"https://openalex.org/keywords/ft-icr-mass-spectrometry","display_name":"FT-ICR mass spectrometry","score":0.9200000166893005},{"id":"https://openalex.org/keywords/proteome-coverage","display_name":"proteome coverage","score":0.875},{"id":"https://openalex.org/keywords/15n-labeling","display_name":"15N labeling","score":0.7360000014305115},{"id":"https://openalex.org/keywords/isotopic-labeling","display_name":"isotopic labeling","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8710012435913086},{"id":"https://openalex.org/C170552419","wikidata":"https://www.wikidata.org/wiki/Q2400735","display_name":"Fourier transform ion cyclotron resonance","level":3,"score":0.7964887022972107},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7625311613082886},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.742199182510376},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5482968091964722},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.52447909116745},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5195006132125854},{"id":"https://openalex.org/C202157981","wikidata":"https://www.wikidata.org/wiki/Q7251488","display_name":"Protein mass spectrometry","level":4,"score":0.48555776476860046},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.4568740427494049},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.45570996403694153},{"id":"https://openalex.org/C13762613","wikidata":"https://www.wikidata.org/wiki/Q7824366","display_name":"Top-down proteomics","level":5,"score":0.4449795186519623},{"id":"https://openalex.org/C184185385","wikidata":"https://www.wikidata.org/wiki/Q6085263","display_name":"Isobaric labeling","level":5,"score":0.4380122423171997},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15475445985794067}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005583","descriptor_name":"Fourier Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011492","descriptor_name":"Protein Hydrolysates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017357","descriptor_name":"Cyclotrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1044-0305(02)00409-9","doi":"https://doi.org/10.1016/s1044-0305(02)00409-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1044-0305(02)00409-9","pdf_url":null,"source":{"id":"https://openalex.org/S60743949","display_name":"Journal of the American Society for Mass Spectrometry","issn_l":"1044-0305","issn":["1044-0305","1879-1123"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:12216736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12216736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society for Mass Spectrometry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5514325754","display_name":null,"funder_award_id":"CA86340","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1519199376","https://openalex.org/W1519955500","https://openalex.org/W1520694472","https://openalex.org/W1597678601","https://openalex.org/W1964952922","https://openalex.org/W1968746767","https://openalex.org/W1969416735","https://openalex.org/W1970156673","https://openalex.org/W1975938671","https://openalex.org/W1982535455","https://openalex.org/W1988287443","https://openalex.org/W1990616595","https://openalex.org/W1994802428","https://openalex.org/W1997898173","https://openalex.org/W2002895604","https://openalex.org/W2003347556","https://openalex.org/W2007805022","https://openalex.org/W2010966256","https://openalex.org/W2012942725","https://openalex.org/W2023166002","https://openalex.org/W2025386864","https://openalex.org/W2027961368","https://openalex.org/W2031999503","https://openalex.org/W2032659860","https://openalex.org/W2032961810","https://openalex.org/W2041507541","https://openalex.org/W2048747277","https://openalex.org/W2052124028","https://openalex.org/W2053697292","https://openalex.org/W2054380340","https://openalex.org/W2061802503","https://openalex.org/W2067493178","https://openalex.org/W2073292063","https://openalex.org/W2078492636","https://openalex.org/W2084151531","https://openalex.org/W2088392539","https://openalex.org/W2093538680","https://openalex.org/W2111208057","https://openalex.org/W2133636765","https://openalex.org/W2138222961","https://openalex.org/W2151238743","https://openalex.org/W2170949754","https://openalex.org/W2950008142","https://openalex.org/W4213265720","https://openalex.org/W4249877820","https://openalex.org/W4251700885"],"related_works":["https://openalex.org/W1978740119","https://openalex.org/W1964952922","https://openalex.org/W2054380340","https://openalex.org/W2153867541","https://openalex.org/W1994491274","https://openalex.org/W2041051086","https://openalex.org/W2072823039","https://openalex.org/W3136224420","https://openalex.org/W2005348030","https://openalex.org/W2883984615"],"abstract_inverted_index":{"A":[0],"primary":[1],"challenge":[2,41],"in":[3,109,148,173,215,222,250],"proteome":[4,45],"measurements":[5,150,208],"is":[6,63,92,218],"to":[7,10,58,74,113,193],"be":[8],"able":[9],"detect,":[11],"identify,":[12],"and":[13,36,135,178,201],"quantify":[14],"the":[15,66,70,76,114,121,156,187,194,204,212,216,230],"extremely":[16],"complex":[17],"mixtures":[18],"of":[19,24,31,69,79,89,97,105,124,158,166,189,198,211,229,235],"proteins.":[20],"The":[21,87,181],"relative":[22],"abundances":[23],"interest":[25],"span":[26],"at":[27],"least":[28],"six":[29],"orders":[30],"magnitude":[32],"for":[33,42,144,151,206,245],"mammalian":[34,152],"proteomes,":[35],"this":[37,125],"constitutes":[38],"an":[39],"intractable":[40],"high":[43,128,136],"throughput":[44],"studies.":[46],"We":[47,154,225],"have":[48],"recently":[49],"described":[50],"a":[51,110,159,163,251],"new":[52],"approach,":[53],"Dynamic":[54],"Range":[55],"Enhancement":[56],"Applied":[57],"Mass":[59],"Spectrometry":[60],"(DREAMS),":[61],"which":[62],"based":[64],"upon":[65],"selective":[67,95],"ejection":[68,96],"most":[71],"abundant":[72,99],"species":[73,108],"expand":[75],"dynamic":[77],"range":[78],"Fourier":[80],"transform":[81],"ion":[82,116],"cyclotron":[83],"resonanace":[84],"(FTICR)":[85],"measurements.":[86],"basis":[88,205],"our":[90],"approach":[91,126,232],"on-the-fly":[93],"data-dependent":[94],"highly":[98],"species,":[100],"followed":[101],"by":[102],"prolonged":[103],"accumulation":[104],"remaining":[106],"low-abundance":[107],"quadrupole":[111],"external":[112],"FTICR":[115,141,182],"trap.":[117],"Here":[118],"we":[119],"report":[120],"initial":[122],"implementation":[123,228],"with":[127],"efficiency":[129],"capillary":[130],"reverse":[131],"phase":[132],"LC":[133],"separations":[134],"magnetic":[137],"field":[138],"electrospray":[139],"ionization":[140],"mass":[142,183],"spectrometry":[143],"obtaining":[145],"enhanced":[146],"coverage":[147],"quantitative":[149,243],"proteomes.":[153],"describe":[155],"analysis":[157,185],"sample":[160],"derived":[161],"from":[162,168],"tryptic":[164],"digest":[165],"proteins":[167],"mouse":[169],"B16":[170],"cells":[171],"cultured":[172],"both":[174],"natural":[175],"isotopic":[176],"abundance":[177],"15N-labeled":[179],"media.":[180],"spectrometric":[184],"allows":[186,233],"assignment":[188,234],"peptide":[190,239,248],"pairs":[191,249],"(corresponding":[192],"two":[195,213],"distinctive":[196],"versions":[197],"each":[199],"peptide),":[200],"thus":[202,241],"provides":[203],"quantiative":[207],"when":[209],"one":[210],"proteomes":[214],"mixture":[217],"perturbed":[219],"or":[220],"altered":[221],"some":[223],"fashion.":[224],"show":[226],"that":[227],"DREAMS":[231],"approximately":[236,246],"80%":[237],"more":[238],"pairs,":[240],"providing":[242],"information":[244],"18,000":[247],"single":[252],"analysis.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
