{"id":"https://openalex.org/W2011028580","doi":"https://doi.org/10.1158/1078-0432.ccr-06-0992","title":"The Use of a Tropism-Modified Measles Virus in Folate Receptor\u2013Targeted Virotherapy of Ovarian Cancer","display_name":"The Use of a Tropism-Modified Measles Virus in Folate Receptor\u2013Targeted Virotherapy of Ovarian Cancer","publication_year":2006,"publication_date":"2006-10-15","ids":{"openalex":"https://openalex.org/W2011028580","doi":"https://doi.org/10.1158/1078-0432.ccr-06-0992","mag":"2011028580","pmid":"https://pubmed.ncbi.nlm.nih.gov/17062694"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-06-0992","doi":"https://doi.org/10.1158/1078-0432.ccr-06-0992","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-06-0992","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021592961","display_name":"Kosei Hasegawa","orcid":"https://orcid.org/0000-0002-1751-6527","observed_orcids":["https://orcid.org/0000-0002-1751-6527"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kosei Hasegawa","raw_affiliation_strings":["1Molecular Medicine Program,","Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Molecular Medicine Program,","institution_ids":[]},{"raw_affiliation_string":"Molecular Medicine Program, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071254876","display_name":"Takafumi Nakamura","orcid":"https://orcid.org/0000-0002-0196-0754","observed_orcids":["https://orcid.org/0000-0002-0196-0754"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takafumi Nakamura","raw_affiliation_strings":["1Molecular Medicine Program,","Mayo Clinic College of Medicine and Science;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Molecular Medicine Program,","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic College of Medicine and Science;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068461077","display_name":"Mary E. Harvey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Harvey","raw_affiliation_strings":["2Toxicology Core,","Mayo Clinic College of Medicine and Science;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Toxicology Core,","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic College of Medicine and Science;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101451857","display_name":"Yasuhiro Ikeda","orcid":"https://orcid.org/0000-0002-9874-7537","observed_orcids":["https://orcid.org/0000-0002-9874-7537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuhiro Ikeda","raw_affiliation_strings":["1Molecular Medicine Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Molecular Medicine Program,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069976109","display_name":"Ann L. Oberg","orcid":"https://orcid.org/0000-0003-2539-9807","observed_orcids":["https://orcid.org/0000-0003-2539-9807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Oberg","raw_affiliation_strings":["3Biostatistics, and","Mayo College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Biostatistics, and","institution_ids":[]},{"raw_affiliation_string":"Mayo College of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087949502","display_name":"Mariangela Figini","orcid":"https://orcid.org/0000-0001-9001-8754","observed_orcids":["https://orcid.org/0000-0001-9001-8754"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariangela Figini","raw_affiliation_strings":["5Department of Experimental Oncology, Unit of Molecular Therapies, Instituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Experimental Oncology, Unit of Molecular Therapies, Instituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037526893","display_name":"Silvana Canevari","orcid":"https://orcid.org/0000-0002-2963-3587","observed_orcids":["https://orcid.org/0000-0002-2963-3587"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvana Canevari","raw_affiliation_strings":["5Department of Experimental Oncology, Unit of Molecular Therapies, Instituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Experimental Oncology, Unit of Molecular Therapies, Instituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005798440","display_name":"Lynn C. Hartmann","orcid":"https://orcid.org/0000-0002-5931-7876","observed_orcids":["https://orcid.org/0000-0002-5931-7876"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn C. Hartmann","raw_affiliation_strings":["4Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; and","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072521252","display_name":"Kah-Whye Peng","orcid":"https://orcid.org/0000-0002-9815-7721","observed_orcids":["https://orcid.org/0000-0002-9815-7721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kah-Whye Peng","raw_affiliation_strings":["1Molecular Medicine Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Molecular Medicine Program,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1797,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.91744104,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"20","first_page":"6170","last_page":"6178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measles-virus","display_name":"measles virus","score":0.9350000023841858},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.949999988079071},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8009999990463257},{"id":"https://openalex.org/keywords/folate-receptor-alpha","display_name":"folate receptor alpha","score":0.890999972820282},{"id":"https://openalex.org/keywords/viral-tropism","display_name":"viral tropism","score":0.7269999980926514},{"id":"https://openalex.org/keywords/single-chain-antibody","display_name":"single-chain antibody","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cd46","display_name":"CD46","score":0.8259999752044678},{"id":"https://openalex.org/keywords/simultaneous-localization-and-mapping","display_name":"SLAM","score":0.9190000295639038},{"id":"https://openalex.org/keywords/viral-attachment-protein","display_name":"viral attachment protein","score":0.5260000228881836},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.44999998807907104},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.800000011920929},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/bioluminescence-imaging","display_name":"bioluminescence imaging","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9356241822242737},{"id":"https://openalex.org/C2778199166","wikidata":"https://www.wikidata.org/wiki/Q573943","display_name":"Measles virus","level":4,"score":0.901199460029602},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6762303709983826},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6723806262016296},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6578196883201599},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.58708655834198},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.5782002806663513},{"id":"https://openalex.org/C2780355102","wikidata":"https://www.wikidata.org/wiki/Q1753162","display_name":"Mononegavirales","level":5,"score":0.5517157316207886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4923146963119507},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.4652612507343292},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.4444003999233246},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4261378049850464},{"id":"https://openalex.org/C2776438120","wikidata":"https://www.wikidata.org/wiki/Q79793","display_name":"Measles","level":3,"score":0.4090285301208496},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3954959809780121},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3489767909049988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32126304507255554},{"id":"https://openalex.org/C2780813555","wikidata":"https://www.wikidata.org/wiki/Q911129","display_name":"Paramyxoviridae","level":4,"score":0.238386869430542},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.19705864787101746},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.13676512241363525},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008459","descriptor_name":"Measles virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008459","descriptor_name":"Measles virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008459","descriptor_name":"Measles virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058973","descriptor_name":"Folate Receptors, GPI-Anchored","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058973","descriptor_name":"Folate Receptors, GPI-Anchored","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058973","descriptor_name":"Folate Receptors, GPI-Anchored","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-06-0992","doi":"https://doi.org/10.1158/1078-0432.ccr-06-0992","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-06-0992","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:17062694","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17062694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1581511516","https://openalex.org/W1591890160","https://openalex.org/W1733042088","https://openalex.org/W1852614201","https://openalex.org/W1960032085","https://openalex.org/W1964034932","https://openalex.org/W1970589770","https://openalex.org/W1970832325","https://openalex.org/W1971341208","https://openalex.org/W1976971356","https://openalex.org/W1985911140","https://openalex.org/W1995751033","https://openalex.org/W1997888721","https://openalex.org/W2006769300","https://openalex.org/W2009193838","https://openalex.org/W2009994985","https://openalex.org/W2010397777","https://openalex.org/W2010680800","https://openalex.org/W2013919931","https://openalex.org/W2017056242","https://openalex.org/W2025036947","https://openalex.org/W2025064244","https://openalex.org/W2027042410","https://openalex.org/W2029195580","https://openalex.org/W2029647918","https://openalex.org/W2039934078","https://openalex.org/W2042288895","https://openalex.org/W2052150582","https://openalex.org/W2054622725","https://openalex.org/W2058221032","https://openalex.org/W2060417225","https://openalex.org/W2060726255","https://openalex.org/W2079267696","https://openalex.org/W2088003991","https://openalex.org/W2088311855","https://openalex.org/W2089644478","https://openalex.org/W2089645494","https://openalex.org/W2090732350","https://openalex.org/W2093780636","https://openalex.org/W2102883003","https://openalex.org/W2105678378","https://openalex.org/W2122124363","https://openalex.org/W2131816598","https://openalex.org/W2140284740","https://openalex.org/W2151577023","https://openalex.org/W2154885678","https://openalex.org/W2156164027","https://openalex.org/W2161051851","https://openalex.org/W2167813852","https://openalex.org/W2254792577","https://openalex.org/W2322528816","https://openalex.org/W2331980852","https://openalex.org/W3102414871"],"related_works":["https://openalex.org/W2001397790","https://openalex.org/W2174387488","https://openalex.org/W138586086","https://openalex.org/W2384093552","https://openalex.org/W4366091465","https://openalex.org/W4319761902","https://openalex.org/W2118430699","https://openalex.org/W2026891347","https://openalex.org/W2393354963","https://openalex.org/W4381377592"],"abstract_inverted_index":{"PURPOSE:":[0],"Attenuated":[1],"measles":[2,41,52,70,78,127,238],"viruses":[3],"are":[4,36],"promising":[5],"experimental":[6],"anticancer":[7],"agents":[8],"currently":[9],"being":[10],"evaluated":[11,131],"in":[12,132,146,201],"a":[13,87,96,229,236],"phase":[14],"I":[15],"dose":[16],"escalation":[17],"trial":[18],"for":[19,92,232,240],"ovarian":[20,65,103,206,214],"cancer":[21,66,207,215],"patients.":[22],"Virus":[23],"attachment,":[24],"entry,":[25],"and":[26,32,44,55,86,122,150,191,209,221,235],"subsequent":[27],"intercellular":[28],"fusion":[29],"between":[30],"infected":[31],"uninfected":[33],"neighboring":[34],"cells":[35],"mediated":[37],"via":[38],"the":[39,109,168,198],"two":[40,202],"receptors":[42,83],"(CD46":[43],"SLAM).":[45],"To":[46],"minimize":[47],"potential":[48],"toxicity":[49],"due":[50],"to":[51,62,158,162,167,197,223],"virus-associated":[53],"immunosuppression":[54],"infection":[56,129],"of":[57,77,101,115,126,153,183,204],"nontarget":[58],"tissues,":[59],"we":[60],"sought":[61],"develop":[63],"an":[64],"exclusive":[67],"fully":[68],"retargeted":[69],"virus.":[71],"EXPERIMENTAL":[72],"DESIGN":[73],"AND":[74],"RESULTS:":[75],"Interactions":[76],"virus":[79,116,128,163,200,218,239],"with":[80],"its":[81],"natural":[82],"were":[84],"ablated,":[85],"single-chain":[88],"antibody":[89],"(scFv)":[90],"specific":[91],"alpha-folate":[93],"receptor":[94],"(FRalpha),":[95],"target":[97],"overexpressed":[98],"on":[99,108,120,176],"90%":[100],"nonmucinous":[102],"cancer,":[104],"was":[105,118,130,140,155,195,219],"genetically":[106],"engineered":[107],"viral":[110],"attachment":[111],"protein":[112],"(MV-alphaFR).":[113],"Specificity":[114],"tropism":[117],"tested":[119],"tumor":[121,188],"normal":[123,177],"cells.":[124,179],"Biodistribution":[125],"measles-susceptible":[133],"CD46":[134],"transgenic":[135],"mice,":[136],"whereas":[137],"antitumor":[138,181],"activity":[139,152,182],"monitored":[141],"noninvasively":[142],"by":[143,187],"bioluminescence":[144],"imaging":[145],"xenograft":[147],"models.":[148],"Tropism":[149],"fusogenic":[151],"MV-alphaFR":[154,171],"redirected":[156],"exclusively":[157],"FRalpha":[159],"without":[160],"compromise":[161],"infectivity.":[164],"In":[165],"contrast":[166],"parental":[169,199],"virus,":[170],"has":[172],"no":[173],"background":[174],"infectivity":[175],"human":[178,205],"The":[180],"MV-alphaFR,":[184],"as":[185],"assessed":[186],"volume":[189],"reduction":[190],"overall":[192],"survival":[193],"increase,":[194],"equal":[196],"models":[203],"(s.c.":[208],"i.p.).":[210],"CONCLUSIONS:":[211],"A":[212],"FR-exclusive":[213],"targeted":[216],"oncolytic":[217],"generated":[220],"shown":[222],"be":[224],"therapeutically":[225],"effective,":[226],"thus":[227],"introducing":[228],"new":[230],"modality":[231],"FR":[233],"targeting":[234],"candidate":[237],"clinical":[241],"testing.":[242]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}