{"id":"https://openalex.org/W2011027702","doi":"https://doi.org/10.1007/s11458-008-0087-z","title":"Design of parallel microfluidic gradient-generating networks for studying cellular response to chemical stimuli","display_name":"Design of parallel microfluidic gradient-generating networks for studying cellular response to chemical stimuli","publication_year":2008,"publication_date":"2008-08-23","ids":{"openalex":"https://openalex.org/W2011027702","doi":"https://doi.org/10.1007/s11458-008-0087-z","mag":"2011027702"},"language":"en","primary_location":{"id":"doi:10.1007/s11458-008-0087-z","doi":"https://doi.org/10.1007/s11458-008-0087-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11458-008-0087-z","pdf_url":null,"source":{"id":"https://openalex.org/S124099097","display_name":"Frontiers of Chemistry in China","issn_l":"1673-3495","issn":["1673-3495","1673-3614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers of Chemistry in China","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lihui Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihui Wang","raw_affiliation_strings":["Department of Pathology, Dalian Medical University, Dalian, 116044, China","Department of Pathology, Dalian Medical University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010630057","display_name":"Dayu Liu","orcid":"https://orcid.org/0000-0002-6538-8718","observed_orcids":["https://orcid.org/0000-0002-6538-8718"]},"institutions":[{"id":"https://openalex.org/I180585399","display_name":"Dalian Institute of Chemical Physics","ror":"https://ror.org/00prkya54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I180585399","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dayu Liu","raw_affiliation_strings":["Biomedical Engineering Center, Improve Medical Instrument\u2019s Co., Ltd., Guangzhou, 510370, China","Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China","Biomedical Engineering Center, Improve Medical Instrument\u2019s Co., Ltd., Guangzhou, China","Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Center, Improve Medical Instrument\u2019s Co., Ltd., Guangzhou, 510370, China","institution_ids":[]},{"raw_affiliation_string":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China","institution_ids":["https://openalex.org/I180585399","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Biomedical Engineering Center, Improve Medical Instrument\u2019s Co., Ltd., Guangzhou, China","institution_ids":[]},{"raw_affiliation_string":"Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China","institution_ids":["https://openalex.org/I180585399","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063446205","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0001-9234-035X","observed_orcids":["https://orcid.org/0000-0001-9234-035X"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Wang","raw_affiliation_strings":["Department of Pathology, Dalian Medical University, Dalian, 116044, China","Department of Pathology, Dalian Medical University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102339374","display_name":"Jie Sun","orcid":"https://orcid.org/0000-0002-2682-4724","observed_orcids":["https://orcid.org/0000-0002-2682-4724"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Sun","raw_affiliation_strings":["Department of Pathology, Dalian Medical University, Dalian, 116044, China","Department of Pathology, Dalian Medical University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061541496","display_name":"Lianhong Li","orcid":"https://orcid.org/0000-0001-8990-9349","observed_orcids":["https://orcid.org/0000-0001-8990-9349"]},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lianhong Li","raw_affiliation_strings":["Department of Pathology, Dalian Medical University, Dalian, 116044, China","Department of Pathology, Dalian Medical University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, 116044, China","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"Department of Pathology, Dalian Medical University, Dalian, China","institution_ids":["https://openalex.org/I191996457"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061541496"],"corresponding_institution_ids":["https://openalex.org/I191996457"],"apc_list":null,"apc_paid":null,"fwci":0.442,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.66296029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"3","issue":"4","first_page":"384","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.777999997138977},{"id":"https://openalex.org/keywords/laminar-flow","display_name":"laminar flow","score":0.847000002861023},{"id":"https://openalex.org/keywords/drug-concentration-gradient","display_name":"drug concentration gradient","score":0.8149999976158142},{"id":"https://openalex.org/keywords/lab-on-a-chip","display_name":"lab-on-a-chip","score":0.8610000014305115},{"id":"https://openalex.org/keywords/reduced-glutathione","display_name":"reduced glutathione","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8560000061988831},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.7850000262260437},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9449999928474426},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/high-content-drug-screening","display_name":"high-content drug screening","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7676594257354736},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5878257155418396},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5326036810874939},{"id":"https://openalex.org/C2988198817","wikidata":"https://www.wikidata.org/wiki/Q633261","display_name":"Microfluidic chip","level":3,"score":0.5234802961349487},{"id":"https://openalex.org/C36248471","wikidata":"https://www.wikidata.org/wiki/Q7445669","display_name":"Seeding","level":2,"score":0.48154905438423157},{"id":"https://openalex.org/C3018453882","wikidata":"https://www.wikidata.org/wiki/Q17104113","display_name":"Concentration gradient","level":2,"score":0.4682798385620117},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4628194272518158},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.45571374893188477},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44644901156425476},{"id":"https://openalex.org/C50712719","wikidata":"https://www.wikidata.org/wiki/Q446473","display_name":"Syringe driver","level":3,"score":0.4318270683288574},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4063633680343628},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35650813579559326},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.18604940176010132},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11099898815155029},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07085058093070984},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0},{"id":"https://openalex.org/C2778571141","wikidata":"https://www.wikidata.org/wiki/Q273318","display_name":"Syringe","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s11458-008-0087-z","doi":"https://doi.org/10.1007/s11458-008-0087-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11458-008-0087-z","pdf_url":null,"source":{"id":"https://openalex.org/S124099097","display_name":"Frontiers of Chemistry in China","issn_l":"1673-3495","issn":["1673-3495","1673-3614"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers of Chemistry in China","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1504784308","https://openalex.org/W1597455536","https://openalex.org/W1969435013","https://openalex.org/W1974679842","https://openalex.org/W1976136445","https://openalex.org/W1983480912","https://openalex.org/W1988572643","https://openalex.org/W2033117797","https://openalex.org/W2041634752","https://openalex.org/W2046993362","https://openalex.org/W2062279417","https://openalex.org/W2064880903","https://openalex.org/W2066757217","https://openalex.org/W2080328815","https://openalex.org/W2091357581","https://openalex.org/W2115151855","https://openalex.org/W2117741956","https://openalex.org/W2127967852"],"related_works":["https://openalex.org/W7065346817","https://openalex.org/W2069046600","https://openalex.org/W1994189867","https://openalex.org/W4396927833","https://openalex.org/W3044128171","https://openalex.org/W6965035198","https://openalex.org/W6908969792","https://openalex.org/W2980951990","https://openalex.org/W3124126281","https://openalex.org/W4411568390"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
