{"id":"https://openalex.org/W2011008667","doi":"https://doi.org/10.1111/j.1471-0528.1997.tb10647.x","title":"Counselling implications of chromosomal abnormalities other than trisomy 21 detected through a maternal serum screening programme","display_name":"Counselling implications of chromosomal abnormalities other than trisomy 21 detected through a maternal serum screening programme","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2011008667","doi":"https://doi.org/10.1111/j.1471-0528.1997.tb10647.x","mag":"2011008667","pmid":"https://pubmed.ncbi.nlm.nih.gov/8988695"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-0528.1997.tb10647.x","doi":"https://doi.org/10.1111/j.1471-0528.1997.tb10647.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-0528.1997.tb10647.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210173111","display_name":"BJOG An International Journal of Obstetrics & Gynaecology","issn_l":"0306-5456","issn":["0306-5456","1365-215X","1470-0328","1471-0528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJOG: An International Journal of Obstetrics & Gynaecology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045064606","display_name":"Eamonn G. Sheridan","orcid":"https://orcid.org/0000-0002-7237-6280","observed_orcids":["https://orcid.org/0000-0002-7237-6280"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"E. Sheridan","raw_affiliation_strings":["St Jame's Hospital, Leeds, UK","St James's Hospital, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jame's Hospital, Leeds, UK","institution_ids":["https://openalex.org/I2801331674"]},{"raw_affiliation_string":"St James's Hospital, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026704601","display_name":"Jeffrey J. Williams","orcid":"https://orcid.org/0000-0001-7173-6910","observed_orcids":["https://orcid.org/0000-0001-7173-6910"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Williams","raw_affiliation_strings":["St James's Hospital, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James's Hospital, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007700545","display_name":"Allan Caine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Caine","raw_affiliation_strings":["St James's Hospital, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James's Hospital, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110015231","display_name":"R. Morgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Morgan","raw_affiliation_strings":["St James's Hospital, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James's Hospital, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084494844","display_name":"Gerald Mason","orcid":"https://orcid.org/0000-0003-0389-3986","observed_orcids":["https://orcid.org/0000-0003-0389-3986"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Mason","raw_affiliation_strings":["The General Infirmary at Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The General Infirmary at Leeds","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108957662","display_name":"R F Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. F. Mueller","raw_affiliation_strings":["St James's Hospital, Leeds"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James's Hospital, Leeds","institution_ids":["https://openalex.org/I2801331674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045064606"],"corresponding_institution_ids":["https://openalex.org/I2801331674"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.445,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.61333192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"104","issue":"1","first_page":"42","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.8140000104904175},{"id":"https://openalex.org/keywords/down-syndrome","display_name":"Down syndrome","score":0.6740000247955322},{"id":"https://openalex.org/keywords/maternal-serum-screening","display_name":"maternal serum screening","score":0.972000002861023},{"id":"https://openalex.org/keywords/amniocentesis","display_name":"amniocentesis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/genetic-counseling","display_name":"genetic counseling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.5120000243186951},{"id":"https://openalex.org/keywords/structural-chromosomal-abnormalities","display_name":"structural chromosomal abnormalities","score":0.7009999752044678},{"id":"https://openalex.org/keywords/numerical-chromosome-abnormalities","display_name":"numerical chromosomal abnormalities","score":0.8220000267028809},{"id":"https://openalex.org/keywords/familial-chromosomal-abnormality","display_name":"familial chromosomal abnormality","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2777966818","wikidata":"https://www.wikidata.org/wiki/Q473768","display_name":"Amniocentesis","level":5,"score":0.8921997547149658},{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.8272871971130371},{"id":"https://openalex.org/C50965678","wikidata":"https://www.wikidata.org/wiki/Q2724302","display_name":"Abnormality","level":2,"score":0.6487941145896912},{"id":"https://openalex.org/C80227256","wikidata":"https://www.wikidata.org/wiki/Q1124169","display_name":"Genetic counseling","level":2,"score":0.6330173015594482},{"id":"https://openalex.org/C2908755955","wikidata":"https://www.wikidata.org/wiki/Q744962","display_name":"Chromosomal Abnormality","level":5,"score":0.6249725818634033},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.556006908416748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5235354900360107},{"id":"https://openalex.org/C2780189214","wikidata":"https://www.wikidata.org/wiki/Q744962","display_name":"Chromosome abnormality","level":5,"score":0.5158954858779907},{"id":"https://openalex.org/C2779954681","wikidata":"https://www.wikidata.org/wiki/Q47715","display_name":"Down syndrome","level":2,"score":0.5148026347160339},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.48927614092826843},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.44934001564979553},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.4373660683631897},{"id":"https://openalex.org/C2776352029","wikidata":"https://www.wikidata.org/wiki/Q4686351","display_name":"Advanced maternal age","level":4,"score":0.4181000292301178},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.38875195384025574},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.38434603810310364},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.3639093339443207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30655282735824585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2419174611568451},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.18957751989364624},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08197048306465149},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07205229997634888}],"mesh":[{"descriptor_ui":"D000649","descriptor_name":"Amniocentesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002882","descriptor_name":"Chromosomes, Human, Pair 13","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003376","descriptor_name":"Counseling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007446","descriptor_name":"Chromosome Inversion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014314","descriptor_name":"Trisomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-0528.1997.tb10647.x","doi":"https://doi.org/10.1111/j.1471-0528.1997.tb10647.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-0528.1997.tb10647.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210173111","display_name":"BJOG An International Journal of Obstetrics & Gynaecology","issn_l":"0306-5456","issn":["0306-5456","1365-215X","1470-0328","1471-0528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJOG: An International Journal of Obstetrics & Gynaecology","raw_type":"journal-article"},{"id":"pmid:8988695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8988695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of obstetrics and gynaecology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W10463031","https://openalex.org/W171613887","https://openalex.org/W1495912443","https://openalex.org/W1969701730","https://openalex.org/W1979096773","https://openalex.org/W1979713583","https://openalex.org/W1993382464","https://openalex.org/W1998129468","https://openalex.org/W1999157526","https://openalex.org/W2003986175","https://openalex.org/W2011245539","https://openalex.org/W2027657108","https://openalex.org/W2030645242","https://openalex.org/W2044504499","https://openalex.org/W2066839254","https://openalex.org/W2085809389","https://openalex.org/W2090302910","https://openalex.org/W2118636042","https://openalex.org/W2151812794","https://openalex.org/W2221860284","https://openalex.org/W2270319053"],"related_works":["https://openalex.org/W2352034868","https://openalex.org/W4233893319","https://openalex.org/W2491985224","https://openalex.org/W2182820886","https://openalex.org/W2372162220","https://openalex.org/W7222358669","https://openalex.org/W2045310812","https://openalex.org/W2371546431","https://openalex.org/W2410517995","https://openalex.org/W2064328073"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"identify":[2],"counselling":[3,136,182],"requirements,":[4],"we":[5],"reviewed":[6],"the":[7,33,59,78,90,123,178,220],"frequency":[8,105],"and":[9,52,95,104,157,174,228],"type":[10],"of":[11,32,36,40,70,93,106,142,166,177,222],"non-trisomy":[12],"21":[13,156,214],"chromosome":[14],"abnormalities":[15],"found":[16,217],"at":[17,56,218],"amniocentesis":[18],"after":[19],"maternal":[20,43,49,73,188],"serum":[21,44,50,74,189],"screening":[22,45,51,75,190],"for":[23,77,132],"Down's":[24],"syndrome.":[25],"DESIGN:":[26],"The":[27,48,84,102],"study":[28],"involved":[29],"a":[30,41,68,71,148,208],"review":[31],"cytogenetic":[34,85,108],"results":[35,86,109],"amniocenteses":[37,53,64,144],"performed":[38,55,66],"because":[39],"raised":[42,72],"risk.":[46],"SETTING:":[47],"were":[54,65,87,110,116,145,172],"hospitals":[57],"in":[58,112,118,175,192],"Yorkshire":[60],"region.":[61],"SAMPLE:":[62],"1715":[63,143],"as":[67],"result":[69],"risk":[76],"period":[79],"1990":[80],"to":[81,120,196],"1993.":[82],"METHODS:":[83],"classified":[88],"into":[89],"main":[91],"categories":[92],"numerical":[94],"structural":[96],"chromosomal":[97,149,162,209],"abnormalities.":[98],"MAIN":[99],"OUTCOME":[100],"MEASURES:":[101],"nature":[103,221],"abnormal":[107,124],"identified":[111,146],"which":[113,133,223],"parental":[114,170,226],"samples":[115,227],"required":[117,173],"order":[119],"determine":[121],"if":[122],"finding":[125],"was":[126,137,183],"de":[127],"novo":[128],"or":[129],"familial":[130],"and/or":[131],"specialist":[134,180,229],"genetic":[135,181],"required.":[138,184],"RESULTS:":[139],"Sixty-nine":[140],"pregnancies":[141],"with":[147,154,160],"abnormality":[150,210],"(4.0%):":[151],"35":[152],"(2.0%)":[153,159],"trisomy":[155,213],"34":[158,168,179],"another":[161],"abnormality.":[163],"For":[164],"20":[165],"these":[167],"abnormalities,":[169],"karyotypes":[171],"29":[176],"CONCLUSIONS:":[185],"Women":[186],"undergoing":[187],"and,":[191],"particular,":[193],"those":[194],"proceeding":[195],"amniocentesis,":[197,219],"should":[198],"be":[199,216],"informed":[200],"that":[201,207],"there":[202],"is":[203],"an":[204],"equal":[205],"chance":[206],"other":[211],"than":[212],"will":[215],"usually":[224],"requires":[225],"counselling.":[230]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}