{"id":"https://openalex.org/W2011002613","doi":"https://doi.org/10.1016/j.tibtech.2007.03.011","title":"Protein aggregation in silico","display_name":"Protein aggregation in silico","publication_year":2007,"publication_date":"2007-04-13","ids":{"openalex":"https://openalex.org/W2011002613","doi":"https://doi.org/10.1016/j.tibtech.2007.03.011","mag":"2011002613","pmid":"https://pubmed.ncbi.nlm.nih.gov/17433843","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2680282"},"language":"en","primary_location":{"id":"doi:10.1016/j.tibtech.2007.03.011","doi":"https://doi.org/10.1016/j.tibtech.2007.03.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibtech.2007.03.011","pdf_url":null,"source":{"id":"https://openalex.org/S147849156","display_name":"Trends in biotechnology","issn_l":"0167-7799","issn":["0167-7799","0167-9430","1879-3096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC2680282","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044029964","display_name":"Troy Cellmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Troy Cellmer","raw_affiliation_strings":["National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018686820","display_name":"D. Bratko","orcid":"https://orcid.org/0000-0002-3675-5275","observed_orcids":["https://orcid.org/0000-0002-3675-5275"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dusan Bratko","raw_affiliation_strings":["Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA","Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020540558","display_name":"John M. Prausnitz","orcid":"https://orcid.org/0000-0001-9458-0648","observed_orcids":["https://orcid.org/0000-0001-9458-0648"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Prausnitz","raw_affiliation_strings":["Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA","Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109919878","display_name":"Harvey W. Blanch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harvey W. Blanch","raw_affiliation_strings":["Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109919878"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.6676,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.54523173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"25","issue":"6","first_page":"254","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.09600000083446503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":1.0},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.9900000095367432},{"id":"https://openalex.org/keywords/molecular-simulation","display_name":"molecular simulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/therapeutic-proteins","display_name":"therapeutic proteins","score":0.9649999737739563},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.6359999775886536},{"id":"https://openalex.org/keywords/formulation-stability","display_name":"formulation stability","score":0.9810000061988831},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8102560043334961},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.6854938268661499},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5906314253807068},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.5677700042724609},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5675972700119019},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.52034991979599},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.4555947780609131},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4108412265777588},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.32658660411834717},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31668493151664734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3154103457927704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1329965591430664},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12622851133346558},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.tibtech.2007.03.011","doi":"https://doi.org/10.1016/j.tibtech.2007.03.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibtech.2007.03.011","pdf_url":null,"source":{"id":"https://openalex.org/S147849156","display_name":"Trends in biotechnology","issn_l":"0167-7799","issn":["0167-7799","0167-9430","1879-3096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biotechnology","raw_type":"journal-article"},{"id":"pmid:17433843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17433843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1440694","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2680282","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2680282","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2680282","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends Biotechnol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1440694","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC2680282","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7619774194","display_name":"Experimental/Computational Study of Protein Aggregation","funder_award_id":"R01GM070919","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1581858536","https://openalex.org/W1963994022","https://openalex.org/W1968280815","https://openalex.org/W1970898345","https://openalex.org/W1971071753","https://openalex.org/W1973099019","https://openalex.org/W1976545437","https://openalex.org/W1988809070","https://openalex.org/W1991210194","https://openalex.org/W2000408345","https://openalex.org/W2005596951","https://openalex.org/W2006225923","https://openalex.org/W2010144733","https://openalex.org/W2010212854","https://openalex.org/W2010512690","https://openalex.org/W2014095962","https://openalex.org/W2014451295","https://openalex.org/W2018794627","https://openalex.org/W2019408667","https://openalex.org/W2021843093","https://openalex.org/W2022817060","https://openalex.org/W2027839322","https://openalex.org/W2033568678","https://openalex.org/W2039516928","https://openalex.org/W2045820581","https://openalex.org/W2049342852","https://openalex.org/W2051419400","https://openalex.org/W2056544504","https://openalex.org/W2057158394","https://openalex.org/W2064096073","https://openalex.org/W2068334126","https://openalex.org/W2074255526","https://openalex.org/W2080675825","https://openalex.org/W2080908359","https://openalex.org/W2085519055","https://openalex.org/W2090586240","https://openalex.org/W2095200778","https://openalex.org/W2099092270","https://openalex.org/W2099804970","https://openalex.org/W2101817300","https://openalex.org/W2102400503","https://openalex.org/W2106297709","https://openalex.org/W2110476236","https://openalex.org/W2114823344","https://openalex.org/W2118038132","https://openalex.org/W2120531463","https://openalex.org/W2120717592","https://openalex.org/W2121398756","https://openalex.org/W2124122451","https://openalex.org/W2124929769","https://openalex.org/W2132938122","https://openalex.org/W2137261793","https://openalex.org/W2140389961","https://openalex.org/W2140797187","https://openalex.org/W2145487893","https://openalex.org/W2152474890","https://openalex.org/W2153102663","https://openalex.org/W2153333215","https://openalex.org/W2158303080","https://openalex.org/W2159709470","https://openalex.org/W2161586227","https://openalex.org/W2165580849","https://openalex.org/W2166085772","https://openalex.org/W2170168709","https://openalex.org/W2324660492"],"related_works":["https://openalex.org/W2171624654","https://openalex.org/W2150543420","https://openalex.org/W3121893592","https://openalex.org/W2478184427","https://openalex.org/W7095839433","https://openalex.org/W2346371028","https://openalex.org/W4404612234","https://openalex.org/W2059027334","https://openalex.org/W4214499760","https://openalex.org/W9549410"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}