{"id":"https://openalex.org/W2010991470","doi":"https://doi.org/10.3171/jns.2005.103.1.0136","title":"Angiogenesis in the brain during development: the effects of vascular endothelial growth factor and angiopoietin-2 in an animal model","display_name":"Angiogenesis in the brain during development: the effects of vascular endothelial growth factor and angiopoietin-2 in an animal model","publication_year":2005,"publication_date":"2005-07-01","ids":{"openalex":"https://openalex.org/W2010991470","doi":"https://doi.org/10.3171/jns.2005.103.1.0136","mag":"2010991470","pmid":"https://pubmed.ncbi.nlm.nih.gov/16121984"},"language":"en","primary_location":{"id":"doi:10.3171/jns.2005.103.1.0136","doi":"https://doi.org/10.3171/jns.2005.103.1.0136","is_oa":false,"landing_page_url":"https://doi.org/10.3171/jns.2005.103.1.0136","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112083792","display_name":"George Edward Vates","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Edward Vates","raw_affiliation_strings":["Department of Neurology, Center for Cerebrovascular Research, University of California, San Francisco, California, USA. edward_vates@urmc.rochester.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Center for Cerebrovascular Research, University of California, San Francisco, California, USA. edward_vates@urmc.rochester.edu","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014880968","display_name":"Tomoki N Hashimoto","orcid":"https://orcid.org/0000-0002-6046-9148","observed_orcids":["https://orcid.org/0000-0002-6046-9148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoki Hashimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109184964","display_name":"William L. Young","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William L. Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029728124","display_name":"Michael T. Lawton","orcid":"https://orcid.org/0000-0002-1887-3980","observed_orcids":["https://orcid.org/0000-0002-1887-3980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael T. Lawton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2332,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.47888579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"103","issue":"1","first_page":"136","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11402","display_name":"Vascular Malformations Diagnosis and Treatment","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":1.0},{"id":"https://openalex.org/keywords/quail-embryo","display_name":"quail embryo","score":0.8420000076293945},{"id":"https://openalex.org/keywords/optic-tectum","display_name":"optic tectum","score":0.8970000147819519},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.7590000033378601},{"id":"https://openalex.org/keywords/arteriovenous-malformation","display_name":"arteriovenous malformation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7761964797973633},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.754278302192688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7364011406898499},{"id":"https://openalex.org/C2777882087","wikidata":"https://www.wikidata.org/wiki/Q6072584","display_name":"Quail","level":2,"score":0.6475729942321777},{"id":"https://openalex.org/C2779094623","wikidata":"https://www.wikidata.org/wiki/Q539710","display_name":"Angiopoietin","level":4,"score":0.6097075343132019},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.5188640356063843},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.48356911540031433},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4652130901813507},{"id":"https://openalex.org/C15215337","wikidata":"https://www.wikidata.org/wiki/Q18032325","display_name":"Vascular endothelial growth factor B","level":5,"score":0.4495656192302704},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3757008910179138},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.35966014862060547},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3409624695777893},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3291153907775879},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.32824403047561646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32209211587905884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16730937361717224},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D003370","descriptor_name":"Coturnix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3171/jns.2005.103.1.0136","doi":"https://doi.org/10.3171/jns.2005.103.1.0136","is_oa":false,"landing_page_url":"https://doi.org/10.3171/jns.2005.103.1.0136","pdf_url":null,"source":{"id":"https://openalex.org/S1995308","display_name":"Journal of neurosurgery","issn_l":"0022-3085","issn":["0022-3085","1933-0693"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316861","host_organization_name":"American Association of Neurological Surgeons","host_organization_lineage":["https://openalex.org/P4310316861"],"host_organization_lineage_names":["American Association of Neurological Surgeons"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurosurgery","raw_type":"journal-article"},{"id":"pmid:16121984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16121984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5333695870","display_name":"RADIATION ARTERIOPATHY IN A TRANSGENIC AV FISTULA MODEL","funder_award_id":"K08NS002220","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W28772129","https://openalex.org/W72663156","https://openalex.org/W168998846","https://openalex.org/W1229236830","https://openalex.org/W1516410466","https://openalex.org/W1679229092","https://openalex.org/W1773027464","https://openalex.org/W1783580437","https://openalex.org/W1844495809","https://openalex.org/W1957871175","https://openalex.org/W1977729430","https://openalex.org/W1978851591","https://openalex.org/W1980414520","https://openalex.org/W1984827993","https://openalex.org/W1986313393","https://openalex.org/W1996430165","https://openalex.org/W2007314087","https://openalex.org/W2008648745","https://openalex.org/W2012390831","https://openalex.org/W2013295961","https://openalex.org/W2021659118","https://openalex.org/W2022653793","https://openalex.org/W2024601523","https://openalex.org/W2024842181","https://openalex.org/W2032686344","https://openalex.org/W2041502432","https://openalex.org/W2042427065","https://openalex.org/W2046416427","https://openalex.org/W2051487747","https://openalex.org/W2056244148","https://openalex.org/W2058671832","https://openalex.org/W2060109867","https://openalex.org/W2064254592","https://openalex.org/W2064255351","https://openalex.org/W2065530550","https://openalex.org/W2066888615","https://openalex.org/W2076654705","https://openalex.org/W2078348571","https://openalex.org/W2079530892","https://openalex.org/W2082256624","https://openalex.org/W2084450090","https://openalex.org/W2088206853","https://openalex.org/W2088355263","https://openalex.org/W2093062161","https://openalex.org/W2110863171","https://openalex.org/W2113343160","https://openalex.org/W2125510640","https://openalex.org/W2132623819","https://openalex.org/W2132700647","https://openalex.org/W2145150521","https://openalex.org/W2149132223","https://openalex.org/W2152215024","https://openalex.org/W2154184667","https://openalex.org/W2162212032","https://openalex.org/W2169612004","https://openalex.org/W2186809187","https://openalex.org/W2188958531","https://openalex.org/W2331626896","https://openalex.org/W2380603540","https://openalex.org/W2407288812","https://openalex.org/W2470199831","https://openalex.org/W4240796153"],"related_works":["https://openalex.org/W2148443137","https://openalex.org/W2415982111","https://openalex.org/W2121903406","https://openalex.org/W2610371543","https://openalex.org/W2031548543","https://openalex.org/W2077097365","https://openalex.org/W2024873964","https://openalex.org/W2086841438","https://openalex.org/W63901502","https://openalex.org/W2146230262"],"abstract_inverted_index":{"OBJECT:":[0],"The":[1],"goal":[2],"of":[3,11,23,48,58,93,104,111,134,148],"this":[4],"study":[5],"was":[6],"to":[7,70],"examine":[8],"the":[9,21,27,49,55,72,78,91,96,101],"roles":[10],"vascular":[12],"endothelial":[13,75,81],"growth":[14,82],"factor":[15,83],"(VEGF)":[16],"and":[17,64,84,100,113,120,126],"angiopoietin-2":[18],"(Ang-2)":[19],"in":[20,26,29,77],"formation":[22],"blood":[24,94,122],"vessels":[25,123],"brain":[28,121,149],"a":[30,39,46,109,145],"developmental":[31],"animal":[32],"model":[33,147],"not":[34],"routinely":[35],"used":[36,69],"for":[37],"such":[38],"study.":[40],"METHODS:":[41],"Either":[42],"VEGF,":[43],"Ang-2,":[44],"or":[45,117],"combination":[47,110],"two":[50],"factors":[51],"were":[52,68],"injected":[53],"into":[54,140],"optic":[56],"tectum":[57],"4-day-old":[59],"quail":[60],"embryos.":[61],"Immunohistochemical":[62],"analysis":[63],"laser":[65],"confocal":[66],"microscopy":[67],"observe":[71],"effects":[73,89],"on":[74,90],"cells":[76],"brain.":[79],"Vascular":[80],"Ang-2":[85,114],"had":[86],"very":[87],"different":[88],"development":[92],"vessels;":[95],"former":[97],"caused":[98,115],"expansion":[99],"latter":[102],"retraction":[103],"these":[105,135],"vessels.":[106],"Treatment":[107],"with":[108,128],"VEGF":[112],"retroorbital":[116],"intraventricular":[118],"hemorrhage,":[119],"appeared":[124],"enlarged":[125],"dysmorphic,":[127],"dramatically":[129],"extended":[130],"filopodia.":[131],"CONCLUSIONS:":[132],"Some":[133],"observations":[136],"may":[137,143],"provide":[138],"insight":[139],"how":[141],"one":[142],"develop":[144],"better":[146],"arteriovenous":[150],"malformations.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
