{"id":"https://openalex.org/W2010985136","doi":"https://doi.org/10.1089/108076801750295326","title":"Evaluation of Intraocular Pharmacokinetics and Toxicity of Prinomastat (AG3340) in the Rabbit","display_name":"Evaluation of Intraocular Pharmacokinetics and Toxicity of Prinomastat (AG3340) in the Rabbit","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W2010985136","doi":"https://doi.org/10.1089/108076801750295326","mag":"2010985136","pmid":"https://pubmed.ncbi.nlm.nih.gov/11436949"},"language":"en","primary_location":{"id":"doi:10.1089/108076801750295326","doi":"https://doi.org/10.1089/108076801750295326","is_oa":false,"landing_page_url":"https://doi.org/10.1089/108076801750295326","pdf_url":null,"source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039407742","display_name":"Lingyun Cheng","orcid":"https://orcid.org/0000-0002-0748-5173","observed_orcids":["https://orcid.org/0000-0002-0748-5173"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lingyun Cheng","raw_affiliation_strings":["Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California","Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, La Jolla 90093-0946, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, La Jolla 90093-0946, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028537072","display_name":"Maria E. Rivero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria E. Rivero","raw_affiliation_strings":["Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070848769","display_name":"Claudio Renato Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudio R. Garcia","raw_affiliation_strings":["Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105413949","display_name":"Charles D. McDermott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles D. McDermott","raw_affiliation_strings":["Agouron Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agouron Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060396124","display_name":"Kelly Keefe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly S. Keefe","raw_affiliation_strings":["Navy Hospital, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Navy Hospital, San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074276009","display_name":"Clayton A. Wiley","orcid":"https://orcid.org/0000-0002-2697-7691","observed_orcids":["https://orcid.org/0000-0002-2697-7691"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clayton A. Wiley","raw_affiliation_strings":["Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019172815","display_name":"Kelly A. Soules","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly A. Soules","raw_affiliation_strings":["Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109562166","display_name":"Germaine Bergeron-Lynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Germaine Bergeron-Lynn","raw_affiliation_strings":["Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075568801","display_name":"Sylvia Vekich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvia Vekich","raw_affiliation_strings":["Agouron Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agouron Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042162801","display_name":"Kanyin Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kanyin Zhang","raw_affiliation_strings":["Agouron Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agouron Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057559814","display_name":"Krzysztof Appelt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krzysztof Appelt","raw_affiliation_strings":["Agouron Pharmaceuticals, Inc., San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agouron Pharmaceuticals, Inc., San Diego, California","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101974690","display_name":"William R. Freeman","orcid":"https://orcid.org/0000-0001-6382-1218","observed_orcids":["https://orcid.org/0000-0001-6382-1218","https://orcid.org/0000-0001-9979-2500"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Freeman","raw_affiliation_strings":["Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shiley Eye Center, University of California, San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7123,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.83458875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"17","issue":"3","first_page":"295","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.5756999850273132,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.16699999570846558,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prinomastat","display_name":"prinomastat","score":0.9950000047683716},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-inhibitors","display_name":"matrix metalloproteinase inhibitors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/ocular-toxicity","display_name":"ocular toxicity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.9959999918937683},{"id":"https://openalex.org/keywords/subtenon-injection","display_name":"subtenon injection","score":0.9980000257492065},{"id":"https://openalex.org/keywords/choroid","display_name":"choroid","score":0.7749999761581421},{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.968999981880188},{"id":"https://openalex.org/keywords/rabbit-eye","display_name":"rabbit eye","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8504441976547241},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6689319610595703},{"id":"https://openalex.org/C2776694393","wikidata":"https://www.wikidata.org/wiki/Q271762","display_name":"Choroid","level":3,"score":0.6683752536773682},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6199987530708313},{"id":"https://openalex.org/C2779113765","wikidata":"https://www.wikidata.org/wiki/Q681562","display_name":"Electroretinography","level":3,"score":0.5717649459838867},{"id":"https://openalex.org/C2779742858","wikidata":"https://www.wikidata.org/wiki/Q180609","display_name":"Intravitreal administration","level":3,"score":0.5602115392684937},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4917192757129669},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.41780656576156616},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40329694747924805},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.3681565523147583},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.18883955478668213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10399609804153442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05392104387283325},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014065","descriptor_name":"Tonometry, Ocular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/108076801750295326","doi":"https://doi.org/10.1089/108076801750295326","is_oa":false,"landing_page_url":"https://doi.org/10.1089/108076801750295326","pdf_url":null,"source":{"id":"https://openalex.org/S192126995","display_name":"Journal of Ocular Pharmacology and Therapeutics","issn_l":"1080-7683","issn":["1080-7683","1557-7732","8756-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ocular Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:11436949","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11436949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1802017290","display_name":"Studies of Retinopathy of AIDS in the HAART Era","funder_award_id":"R01EY007366","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W106891798","https://openalex.org/W119546037","https://openalex.org/W167631909","https://openalex.org/W170946976","https://openalex.org/W1504137704","https://openalex.org/W1507115169","https://openalex.org/W1538850399","https://openalex.org/W1963504975","https://openalex.org/W1967004211","https://openalex.org/W1980480613","https://openalex.org/W1981427921","https://openalex.org/W1981841536","https://openalex.org/W1991095880","https://openalex.org/W1993794032","https://openalex.org/W2000000541","https://openalex.org/W2018586410","https://openalex.org/W2037141117","https://openalex.org/W2043578399","https://openalex.org/W2108340827","https://openalex.org/W2119571293","https://openalex.org/W2137893922","https://openalex.org/W2151131974","https://openalex.org/W2168277472"],"related_works":["https://openalex.org/W2075044031","https://openalex.org/W2348664412","https://openalex.org/W2017934171","https://openalex.org/W2043238105","https://openalex.org/W1971634822","https://openalex.org/W2123709249","https://openalex.org/W2092960458","https://openalex.org/W2006867403","https://openalex.org/W3110317260","https://openalex.org/W1982823939"],"abstract_inverted_index":{"To":[0],"determine":[1],"the":[2,57,74,125,163],"ocular":[3],"pharmacokinetics,":[4],"physiological":[5],"and":[6,27,105,127,132,147],"histological":[7],"effects":[8],"of":[9,17,20,30,33,40,46,61,68,122,139],"prinomastat":[10,31,47,64,123,140],"(a":[11],"matrix":[12],"metalloprotease":[13],"inhibitor),":[14],"a":[15,171],"total":[16],"seventy-seven":[18],"eyes":[19],"New":[21],"Zealand":[22],"White":[23],"rabbits":[24],"received":[25],"intravitreous":[26],"subtenon":[28,58],"injections":[29],"or":[32,48],"acidified":[34,49,69],"water":[35,50,70],"vehicle":[36],"as":[37],"control,":[38],"Doses":[39],"0.5":[41,66],"mg":[42,63],"in":[43,65,73,124,162,183],"0.05":[44],"mL":[45,67],"were":[51,71,79,129,141],"used":[52],"for":[53,165],"intravitreal":[54,119,173,178],"injection.":[55],"For":[56],"injections,":[59],"doses":[60],"5":[62],"administered":[72],"superotemporal":[75],"quadrant.":[76],"Intraocular":[77],"pharmacokinetics":[78],"determined":[80],"by":[81,100],"analyzing":[82],"vitreous":[83,126],"samples":[84],"at":[85,144,152,166],"different":[86],"postinjection":[87],"time":[88],"points":[89],"using":[90],"Liquid":[91],"Chromatography-Mass":[92],"Spectroscopy/Mass":[93],"Spectroscopy":[94],"(LC-MS/MS).":[95],"The":[96,136],"toxicity":[97,108],"was":[98,109],"evaluated":[99],"biomicroscopy,":[101],"electroretinography":[102],"(ERG),":[103],"pneumatonometry,":[104],"histology.":[106],"No":[107],"found":[110],"with":[111],"either":[112],"administration":[113],"method.":[114],"At":[115],"day":[116],"14":[117],"after":[118,170],"injection,":[120,174],"levels":[121,138],"choroid":[128,164],"1.4":[130],"ng/mg":[131,143,151],"7.8":[133],"ng/mg,":[134],"respectively.":[135],"retinal":[137],"22":[142],"24":[145],"hr":[146],"dropped":[148],"below":[149],"1":[150],"48":[153],"hr.":[154],"Prinomastat":[155],"remained":[156],"well":[157],"above":[158],"minimum":[159],"effective":[160],"concentration":[161],"least":[167],"four":[168],"weeks":[169],"single":[172],"suggesting":[175],"that":[176],"local":[177],"injection":[179],"may":[180],"have":[181],"potential":[182],"treating":[184],"choroidal":[185],"neovascularization.":[186]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
