{"id":"https://openalex.org/W2010979263","doi":"https://doi.org/10.5604/17322693.1094726","title":"SMAD family proteins: the current knowledge on their expression and potential role in neoplastic diseases","display_name":"SMAD family proteins: the current knowledge on their expression and potential role in neoplastic diseases","publication_year":2014,"publication_date":"2014-03-20","ids":{"openalex":"https://openalex.org/W2010979263","doi":"https://doi.org/10.5604/17322693.1094726","mag":"2010979263","pmid":"https://pubmed.ncbi.nlm.nih.gov/24662798"},"language":"pl","primary_location":{"id":"doi:10.5604/17322693.1094726","doi":"https://doi.org/10.5604/17322693.1094726","is_oa":true,"landing_page_url":"https://doi.org/10.5604/17322693.1094726","pdf_url":null,"source":{"id":"https://openalex.org/S2754756021","display_name":"Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej","issn_l":"0032-5449","issn":["0032-5449","1732-2693"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317397","host_organization_name":"Index Copernicus International S.A.","host_organization_lineage":["https://openalex.org/P4310317397"],"host_organization_lineage_names":["Index Copernicus International S.A."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5604/17322693.1094726","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028601682","display_name":"Magdalena Witkowska","orcid":"https://orcid.org/0000-0002-3942-0753","observed_orcids":["https://orcid.org/0000-0002-3942-0753"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Witkowska","raw_affiliation_strings":["Zak\u0142ad Hematologii Do\u015bwiadczalnej, Uniwersytetu Medycznego w \u0141odzi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zak\u0142ad Hematologii Do\u015bwiadczalnej, Uniwersytetu Medycznego w \u0141odzi","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060741746","display_name":"Piotr Smolewski","orcid":"https://orcid.org/0000-0003-2700-3343","observed_orcids":["https://orcid.org/0000-0003-2700-3343"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Smolewski","raw_affiliation_strings":["Zak\u0142ad Hematologii Do\u015bwiadczalnej, Uniwersytetu Medycznego w \u0141odzi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zak\u0142ad Hematologii Do\u015bwiadczalnej, Uniwersytetu Medycznego w \u0141odzi","institution_ids":["https://openalex.org/I4210122071"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210122071"],"apc_list":null,"apc_paid":null,"fwci":0.4165,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.53153747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"68","issue":null,"first_page":"301","last_page":"309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/smad-proteins","display_name":"Smad proteins","score":0.9679999947547913},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.7739999890327454},{"id":"https://openalex.org/keywords/smad2","display_name":"Smad2","score":1.0},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.5680000185966492},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7450000047683716},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.7450000047683716},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.8429999947547913},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8930000066757202},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.8902904987335205},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6023535132408142},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5662757158279419},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4814162254333496},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4407828450202942},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41283711791038513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39388421177864075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35959869623184204},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.3459446430206299},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2178400158882141},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19516292214393616},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16592609882354736}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051785","descriptor_name":"Smad Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.5604/17322693.1094726","doi":"https://doi.org/10.5604/17322693.1094726","is_oa":true,"landing_page_url":"https://doi.org/10.5604/17322693.1094726","pdf_url":null,"source":{"id":"https://openalex.org/S2754756021","display_name":"Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej","issn_l":"0032-5449","issn":["0032-5449","1732-2693"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317397","host_organization_name":"Index Copernicus International S.A.","host_organization_lineage":["https://openalex.org/P4310317397"],"host_organization_lineage_names":["Index Copernicus International S.A."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej","raw_type":"journal-article"},{"id":"pmid:24662798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24662798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postepy higieny i medycyny doswiadczalnej (Online)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5604/17322693.1094726","doi":"https://doi.org/10.5604/17322693.1094726","is_oa":true,"landing_page_url":"https://doi.org/10.5604/17322693.1094726","pdf_url":null,"source":{"id":"https://openalex.org/S2754756021","display_name":"Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej","issn_l":"0032-5449","issn":["0032-5449","1732-2693"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310317397","host_organization_name":"Index Copernicus International S.A.","host_organization_lineage":["https://openalex.org/P4310317397"],"host_organization_lineage_names":["Index Copernicus International S.A."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386222707","https://openalex.org/W2979862721","https://openalex.org/W1970240733","https://openalex.org/W2065317999","https://openalex.org/W2077528068","https://openalex.org/W2966432621","https://openalex.org/W1618973455","https://openalex.org/W2792793299","https://openalex.org/W2062537719","https://openalex.org/W7132948665"],"abstract_inverted_index":{"Transforming":[0],"growth":[1],"factor":[2,212],"beta":[3],"(TGF-\u03b2)":[4],"plays":[5],"a":[6,48,68,103],"crucial":[7],"role":[8],"and":[9,22,32,132,174,196],"takes":[10],"part":[11],"in":[12,15,20,28,77,94,102,114,148,151,160,183,188,213],"many":[13],"processes":[14],"the":[16,56,62,78,83,86,95,144,163,200],"human":[17],"body":[18],"both":[19,191],"physiology":[21],"pathology.":[23],"This":[24,64],"cytokine":[25],"is":[26,47],"involved":[27],"angiogenesis,":[29],"regulates":[30],"apoptosis":[31],"stimulates":[33],"divisions":[34],"of":[35,51,85,97,105,146,154,162,169,176,190,202,215],"cells,":[36],"such":[37,117],"as":[38,118],"hepatocytes,":[39],"lymphocytes":[40],"or":[41,122,137],"hematopoietic":[42],"cells.":[43],"SMAD":[44,98,149,205],"proteins":[45,99,150],"family":[46],"unique":[49],"group":[50],"particles":[52],"responsible":[53],"for":[54,112,127],"transducting":[55],"signal":[57,69],"induced":[58],"by":[59],"TGF-\u03b2":[60],"into":[61],"nucleus.":[63],"molecules,":[65],"after":[66],"receiving":[67],"from":[70],"activated":[71],"TGF-\u03b2,":[72],"act":[73],"on":[74],"transcription":[75],"factors":[76],"nucleus,":[79],"leading":[80],"directly":[81],"to":[82,90],"expression":[84,109,207],"corresponding":[87],"genes.":[88],"According":[89],"current":[91],"knowledge,":[92],"disturbances":[93],"functioning":[96],"are":[100],"present":[101],"number":[104],"diseases.":[106,217],"The":[107,139],"reduced":[108],"was":[110,186],"observed,":[111],"example":[113],"cardiovascular":[115],"diseases":[116,126],"primary":[119],"pulmonary":[120],"hypertension":[121],"myocardial":[123],"infarction,":[124],"autoimmune":[125],"instance":[128],"systemic":[129],"lupus":[130],"erythematosus":[131],"multiple":[133],"sclerosis,":[134],"Alzheimer's":[135],"disease":[136],"osteoporosis.":[138],"latest":[140],"clinical":[141],"data":[142],"showed":[143],"presence":[145],"mutations":[147],"cancerogenesis.":[152],"Mutation":[153],"SMAD-4":[155],"protein":[156,185,206],"can":[157],"be":[158,209],"detected":[159],"half":[161],"patients":[164,170,177,192],"with":[165,171,178,193],"pancreatic":[166],"cancer,":[167],"20%":[168],"colorectal":[172,194],"cancer":[173,195],"10%":[175],"lung":[179,197],"cancer.":[180,198],"However,":[181],"mutation":[182],"SMAD-2":[184],"observed":[187],"7%":[189],"On":[199],"basis":[201],"numerous":[203],"works,":[204],"would":[208],"valuable":[210],"prognostic":[211],"some":[214],"neoplastic":[216]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
