{"id":"https://openalex.org/W2010963009","doi":"https://doi.org/10.3109/03008207.2014.898066","title":"Physicochemical properties of collagen solutions cross-linked by glutaraldehyde","display_name":"Physicochemical properties of collagen solutions cross-linked by glutaraldehyde","publication_year":2014,"publication_date":"2014-02-24","ids":{"openalex":"https://openalex.org/W2010963009","doi":"https://doi.org/10.3109/03008207.2014.898066","mag":"2010963009","pmid":"https://pubmed.ncbi.nlm.nih.gov/24564765"},"language":"en","primary_location":{"id":"doi:10.3109/03008207.2014.898066","doi":"https://doi.org/10.3109/03008207.2014.898066","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03008207.2014.898066","pdf_url":null,"source":{"id":"https://openalex.org/S3113591","display_name":"Connective Tissue Research","issn_l":"0300-8207","issn":["0300-8207","1026-7433","1607-8438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective Tissue Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101728614","display_name":"Zhenhua Tian","orcid":"https://orcid.org/0000-0001-9977-5276","observed_orcids":["https://orcid.org/0000-0001-9977-5276"]},"institutions":[{"id":"https://openalex.org/I4405271128","display_name":"Key Laboratory of Leather Chemistry and Engineering of Ministry of Education","ror":"https://ror.org/01xsqhy43","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271128"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenhua Tian","raw_affiliation_strings":["The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education and","The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education and","institution_ids":["https://openalex.org/I4405271128"]},{"raw_affiliation_string":"The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education","institution_ids":["https://openalex.org/I4405271128"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111488815","display_name":"Conghu Li","orcid":"https://orcid.org/0000-0003-0453-9532","observed_orcids":["https://orcid.org/0000-0003-0453-9532"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Conghu Li","raw_affiliation_strings":["National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University ChengduPR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University ChengduPR China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051831435","display_name":"Lian Duan","orcid":"https://orcid.org/0000-0002-5927-2604","observed_orcids":["https://orcid.org/0000-0002-5927-2604"]},"institutions":[{"id":"https://openalex.org/I4405271128","display_name":"Key Laboratory of Leather Chemistry and Engineering of Ministry of Education","ror":"https://ror.org/01xsqhy43","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271128"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lian Duan","raw_affiliation_strings":["The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education","institution_ids":["https://openalex.org/I4405271128"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100650479","display_name":"Guoying Li","orcid":"https://orcid.org/0000-0001-5751-4019","observed_orcids":["https://orcid.org/0000-0001-5751-4019"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4405271128","display_name":"Key Laboratory of Leather Chemistry and Engineering of Ministry of Education","ror":"https://ror.org/01xsqhy43","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405271128"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guoying Li","raw_affiliation_strings":["The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education; National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University ChengduPR China","National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University\nChengduPR China","The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education; National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University ChengduPR China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4405271128"]},{"raw_affiliation_string":"National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University\nChengduPR China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education","institution_ids":["https://openalex.org/I4405271128"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100650479"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4405271128"],"apc_list":null,"apc_paid":null,"fwci":1.2142,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.71514115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"55","issue":"3","first_page":"239","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11511","display_name":"Dyeing and Modifying Textile Fibers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-solutions","display_name":"collagen solutions","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glutaraldehyde-crosslinking","display_name":"glutaraldehyde crosslinking","score":0.9909999966621399},{"id":"https://openalex.org/keywords/molecular-weight","display_name":"molecular weight","score":0.7649999856948853},{"id":"https://openalex.org/keywords/rheological-properties","display_name":"rheological properties","score":0.734000027179718},{"id":"https://openalex.org/keywords/thermal-denaturation","display_name":"thermal denaturation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/gelation","display_name":"gelation","score":0.5519999861717224},{"id":"https://openalex.org/keywords/fiber-diameter","display_name":"fiber diameter","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.8339778184890747},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8178374767303467},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6206200122833252},{"id":"https://openalex.org/C2776923230","wikidata":"https://www.wikidata.org/wiki/Q16955798","display_name":"Denaturation (fissile materials)","level":2,"score":0.46630918979644775},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.4397292733192444},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.373968243598938},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.3558582067489624},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34211891889572144},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3214743435382843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005976","descriptor_name":"Glutaral","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066329","descriptor_name":"Protein Aggregates","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/03008207.2014.898066","doi":"https://doi.org/10.3109/03008207.2014.898066","is_oa":false,"landing_page_url":"https://doi.org/10.3109/03008207.2014.898066","pdf_url":null,"source":{"id":"https://openalex.org/S3113591","display_name":"Connective Tissue Research","issn_l":"0300-8207","issn":["0300-8207","1026-7433","1607-8438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective Tissue Research","raw_type":"journal-article"},{"id":"pmid:24564765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24564765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connective tissue research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W69618648","https://openalex.org/W168812328","https://openalex.org/W610541947","https://openalex.org/W1486093947","https://openalex.org/W1565433405","https://openalex.org/W1798260218","https://openalex.org/W1973922820","https://openalex.org/W1977573449","https://openalex.org/W1980354709","https://openalex.org/W1987313449","https://openalex.org/W1991549119","https://openalex.org/W2003898295","https://openalex.org/W2007651974","https://openalex.org/W2008341851","https://openalex.org/W2008499420","https://openalex.org/W2012458424","https://openalex.org/W2018376286","https://openalex.org/W2033993336","https://openalex.org/W2034494561","https://openalex.org/W2035083579","https://openalex.org/W2039394702","https://openalex.org/W2039638056","https://openalex.org/W2039653102","https://openalex.org/W2040176815","https://openalex.org/W2046559036","https://openalex.org/W2049650477","https://openalex.org/W2068850000","https://openalex.org/W2075584791","https://openalex.org/W2076495102","https://openalex.org/W2080082741","https://openalex.org/W2082947497","https://openalex.org/W2086645341","https://openalex.org/W2087906874","https://openalex.org/W2091139873","https://openalex.org/W2100837269","https://openalex.org/W2101889508","https://openalex.org/W2102261777","https://openalex.org/W2102436727","https://openalex.org/W2112936654","https://openalex.org/W2126017645","https://openalex.org/W2147834652","https://openalex.org/W2150847291","https://openalex.org/W2153532131","https://openalex.org/W2159185781","https://openalex.org/W2160858701","https://openalex.org/W2405163130"],"related_works":["https://openalex.org/W2281911929","https://openalex.org/W2372963937","https://openalex.org/W4402971597","https://openalex.org/W3206080091","https://openalex.org/W3086127238","https://openalex.org/W2073495819","https://openalex.org/W2007251146","https://openalex.org/W2100261886","https://openalex.org/W2040176815","https://openalex.org/W2031987339"],"abstract_inverted_index":{"The":[0],"physicochemical":[1,64,217],"properties":[2,65,218],"of":[3,12,30,33,70,85,105,112,132,146,174,182,219],"collagen":[4,59,133,149,164,190,196,221,231],"solutions":[5,60,222],"(5":[6],"mg/ml)":[7],"cross-linked":[8,87,163],"by":[9,96,160],"various":[10],"amounts":[11,75],"glutaraldehyde":[13],"(GTA)":[14],"[GTA/collagen":[15,76,166],"(w/w)":[16,77,167],"=":[17,168],"0-0.5]":[18],"under":[19],"acidic":[20],"condition":[21],"(pH":[22],"4.00)":[23],"were":[24,117],"examined.":[25],"Based":[26],"on":[27,67],"the":[28,31,58,68,80,86,100,106,110,120,130,140,144,153,162,183,188,195,216,220,228,234],"results":[29],"determination":[32],"residual":[34,81,154],"amino":[35,82,155],"group":[36,83,156],"content,":[37],"sodium":[38],"dodecyl":[39],"sulphate-polyacrylamide":[40],"gel":[41,202],"electrophoresis,":[42],"dynamic":[43],"rheological":[44],"measurements,":[45],"differential":[46],"scanning":[47],"calorimetry":[48],"and":[49,109,115,129,176],"atomic":[50],"force":[51],"microscopy":[52],"(AFM),":[53],"it":[54],"was":[55,135,198,213],"proved":[56],"that":[57,194,215],"possessed":[61],"strikingly":[62],"different":[63,238],"depending":[66],"amount":[69],"GTA.":[71],"At":[72],"low":[73],"GTA":[74,141,147],"\u2264":[78],"0.1],":[79],"contents":[84],"collagens":[88],"decreased":[89,159],"largely":[90],"from":[91,233],"100%":[92],"to":[93,148,187],"32.76%,":[94],"accompanied":[95],"an":[97],"increase":[98],"in":[99,209,225],"molecular":[101],"weight.":[102],"Additionally,":[103],"increases":[104],"fiber":[107],"diameter":[108],"values":[111],"G',":[113],"G\u2033":[114],"\u03b7*":[116],"measured,":[118],"while":[119],"thermal":[121],"denaturation":[122],"temperature":[123],"(Td)":[124],"did":[125],"not":[126],"change":[127],"visibly":[128],"fluidity":[131],"samples":[134],"still":[136],"retained":[137],"with":[138,203,227],"increasing":[139],"amount.":[142],"When":[143],"ratio":[145],"exceeded":[150],"0.1,":[151],"although":[152],"content":[157],"only":[158],"~8.2%,":[161],"solution":[165,197],"0.3]":[169],"displayed":[170],"a":[171,177,201],"clear":[172],"loss":[173],"flow":[175],"sudden":[178],"rise":[179],"(~2.0":[180],"\u00b0C)":[181],"Td":[184],"value":[185],"compared":[186],"uncross-linked":[189],"solution,":[191],"probably":[192],"illustrating":[193],"converted":[199],"into":[200],"mature":[204],"network":[205],"structure-containing":[206],"nuclei":[207],"observed":[208],"AFM":[210],"image.":[211],"It":[212],"conjectured":[214],"might":[223],"be":[224],"connection":[226],"cross-linking":[229],"between":[230],"molecules":[232],"same":[235],"aggregate":[236],"or":[237],"aggregates.":[239]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}