{"id":"https://openalex.org/W2010957709","doi":"https://doi.org/10.1126/science.1188063","title":"Reprogramming of T Cells to Natural Killer\u2013Like Cells upon Bcl11b Deletion","display_name":"Reprogramming of T Cells to Natural Killer\u2013Like Cells upon Bcl11b Deletion","publication_year":2010,"publication_date":"2010-06-10","ids":{"openalex":"https://openalex.org/W2010957709","doi":"https://doi.org/10.1126/science.1188063","mag":"2010957709","pmid":"https://pubmed.ncbi.nlm.nih.gov/20538915","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3628452"},"language":"en","primary_location":{"id":"doi:10.1126/science.1188063","doi":"https://doi.org/10.1126/science.1188063","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1188063","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3628452","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100432789","display_name":"Peng Li","orcid":"https://orcid.org/0000-0003-4530-2400","observed_orcids":["https://orcid.org/0000-0003-4530-2400"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peng Li","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103168721","display_name":"Shannon Burke","orcid":"https://orcid.org/0000-0002-2876-7946","observed_orcids":["https://orcid.org/0000-0002-2876-7946"]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shannon Burke","raw_affiliation_strings":["Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK","Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK","institution_ids":["https://openalex.org/I1302113299"]},{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018855600","display_name":"Juexuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Juexuan Wang","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025178810","display_name":"Xiongfeng Chen","orcid":"https://orcid.org/0000-0002-7445-3673","observed_orcids":["https://orcid.org/0000-0002-7445-3673"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiongfeng Chen","raw_affiliation_strings":["SAIC-Frederick, National Cancer Institute\u2013Frederick, Frederick, MD 21701, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SAIC-Frederick, National Cancer Institute\u2013Frederick, Frederick, MD 21701, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108413777","display_name":"Mariaestela Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mariaestela Ortiz","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110658284","display_name":"Song-Choon Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Song-Choon Lee","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086793017","display_name":"Dong Lu","orcid":"https://orcid.org/0000-0002-9919-6378","observed_orcids":["https://orcid.org/0000-0002-9919-6378"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dong Lu","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091468568","display_name":"Lia S. Campos","orcid":"https://orcid.org/0000-0001-9776-5517","observed_orcids":["https://orcid.org/0000-0001-9776-5517"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lia Campos","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065695073","display_name":"David Goulding","orcid":"https://orcid.org/0000-0002-1529-8415","observed_orcids":["https://orcid.org/0000-0002-1529-8415"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Goulding","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008489368","display_name":"Bee Ling Ng","orcid":"https://orcid.org/0000-0002-8338-4390","observed_orcids":["https://orcid.org/0000-0002-8338-4390"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bee Ling Ng","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115010691","display_name":"Gordon Dougan","orcid":"https://orcid.org/0000-0003-0022-965X","observed_orcids":["https://orcid.org/0000-0003-0022-965X","https://orcid.org/0009-0005-7776-0117"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gordon Dougan","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029251605","display_name":"Brian J.P. Huntly","orcid":"https://orcid.org/0000-0003-0312-161X","observed_orcids":["https://orcid.org/0000-0003-0312-161X"]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian Huntly","raw_affiliation_strings":["Cambridge Institute for Medical Research, Wellcome Trust\u2013MRC Building, Hills Road, Cambridge CB2 0XY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge Institute for Medical Research, Wellcome Trust\u2013MRC Building, Hills Road, Cambridge CB2 0XY, UK","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017318024","display_name":"Berthold G\u00f6ttgens","orcid":"https://orcid.org/0000-0001-6302-5705","observed_orcids":["https://orcid.org/0000-0001-6302-5705"]},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bertie Gottgens","raw_affiliation_strings":["Cambridge Institute for Medical Research, Wellcome Trust\u2013MRC Building, Hills Road, Cambridge CB2 0XY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cambridge Institute for Medical Research, Wellcome Trust\u2013MRC Building, Hills Road, Cambridge CB2 0XY, UK","institution_ids":["https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108403260","display_name":"Nancy A. Jenkins","orcid":"https://orcid.org/0009-0005-1155-9314","observed_orcids":["https://orcid.org/0009-0005-1155-9314","https://orcid.org/0000-0003-1653-6574"]},"institutions":[{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Nancy A. Jenkins","raw_affiliation_strings":["Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos 138673, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos 138673, Singapore","institution_ids":["https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110080713","display_name":"Neal G. Copeland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75573869","display_name":"Institute of Molecular and Cell Biology","ror":"https://ror.org/04xpsrn94","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I75573869"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Neal G. Copeland","raw_affiliation_strings":["Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos 138673, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos 138673, Singapore","institution_ids":["https://openalex.org/I75573869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068894624","display_name":"Francesco Colucci","orcid":"https://orcid.org/0000-0001-5193-6376","observed_orcids":["https://orcid.org/0000-0001-5193-6376"]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Francesco Colucci","raw_affiliation_strings":["Centre for Trophoblast Research, Physiology Building, Downing Street, University of Cambridge, Cambridge CB2 3EG, UK","Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Trophoblast Research, Physiology Building, Downing Street, University of Cambridge, Cambridge CB2 3EG, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK","institution_ids":["https://openalex.org/I1302113299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015985377","display_name":"Pentao Liu","orcid":"https://orcid.org/0000-0001-5774-9678","observed_orcids":["https://orcid.org/0000-0001-5774-9678"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Pentao Liu","raw_affiliation_strings":["Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK","institution_ids":["https://openalex.org/I2802476451"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015985377"],"corresponding_institution_ids":["https://openalex.org/I2802476451"],"apc_list":null,"apc_paid":null,"fwci":13.7512,"has_fulltext":false,"cited_by_count":389,"citation_normalized_percentile":{"value":0.99378079,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"329","issue":"5987","first_page":"85","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.11159999668598175,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bcl11b","display_name":"BCL11B","score":0.9940000176429749},{"id":"https://openalex.org/keywords/t-cell-development","display_name":"T cell development","score":0.9480000138282776},{"id":"https://openalex.org/keywords/nk-like-cells","display_name":"NK-like cells","score":0.6769999861717224},{"id":"https://openalex.org/keywords/lineage-commitment","display_name":"lineage commitment","score":0.5490000247955322},{"id":"https://openalex.org/keywords/thymus-development","display_name":"thymus development","score":0.5809999704360962},{"id":"https://openalex.org/keywords/zinc-finger-transcription-factor","display_name":"zinc finger transcription factor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/t-cell-progenitors","display_name":"T cell progenitors","score":0.6949999928474426},{"id":"https://openalex.org/keywords/antitumor-cytotoxicity","display_name":"tumor cytotoxicity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/nk-cell-expansion","display_name":"NK cell expansion","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7403916120529175},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.715540885925293},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5303709506988525},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5289062857627869},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5078838467597961},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.5066216588020325},{"id":"https://openalex.org/C28651165","wikidata":"https://www.wikidata.org/wiki/Q4259786","display_name":"Lymphokine-activated killer cell","level":5,"score":0.4999103546142578},{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.49869251251220703},{"id":"https://openalex.org/C2778102761","wikidata":"https://www.wikidata.org/wiki/Q332181","display_name":"Natural killer cell","level":4,"score":0.4871901869773865},{"id":"https://openalex.org/C139563560","wikidata":"https://www.wikidata.org/wiki/Q224930","display_name":"Natural killer T cell","level":4,"score":0.4549039304256439},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.4449284076690674},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.43060582876205444},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.39711958169937134},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3738028407096863},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3665724992752075},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36402127146720886},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25809454917907715},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09593716263771057}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016693","descriptor_name":"Receptors, Antigen, T-Cell, alpha-beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019674","descriptor_name":"Genes, T-Cell Receptor beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038041","descriptor_name":"Lymphopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054504","descriptor_name":"Precursor Cells, T-Lymphoid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D054504","descriptor_name":"Precursor Cells, T-Lymphoid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055879","descriptor_name":"Gene Knock-In Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1126/science.1188063","doi":"https://doi.org/10.1126/science.1188063","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1188063","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:20538915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20538915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2627797","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3628452","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3628452","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3628452","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},{"id":"pmh:oai:hub.hku.hk:10722/249147","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/249147","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2627797","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3628452","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2847826333","display_name":null,"funder_award_id":"077186","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7551492885","display_name":null,"funder_award_id":"G0900729/1","funder_id":"https://openalex.org/F4320320333","funder_display_name":"National Centre for the Replacement, Refinement and Reduction of Animals in Research"},{"id":"https://openalex.org/G8585449075","display_name":null,"funder_award_id":"076962","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320333","display_name":"National Centre for the Replacement, Refinement and Reduction of Animals in Research","ror":"https://ror.org/02w0kg036"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1534334488","https://openalex.org/W1570366622","https://openalex.org/W1973632024","https://openalex.org/W1980060543","https://openalex.org/W2002766208","https://openalex.org/W2016857233","https://openalex.org/W2020713861","https://openalex.org/W2025322183","https://openalex.org/W2028735719","https://openalex.org/W2029358883","https://openalex.org/W2036806857","https://openalex.org/W2051038219","https://openalex.org/W2057698592","https://openalex.org/W2076617145","https://openalex.org/W2088513299","https://openalex.org/W2102625414","https://openalex.org/W2108715505","https://openalex.org/W2118376550","https://openalex.org/W2127944870","https://openalex.org/W2136394465","https://openalex.org/W2141778874","https://openalex.org/W2143731593","https://openalex.org/W2147195750","https://openalex.org/W2149011343","https://openalex.org/W2155926744","https://openalex.org/W4313347834"],"related_works":["https://openalex.org/W2022969625","https://openalex.org/W2170505338","https://openalex.org/W1556609966","https://openalex.org/W147011334","https://openalex.org/W4246424575","https://openalex.org/W4402574926","https://openalex.org/W2150556723","https://openalex.org/W2438638271","https://openalex.org/W2590083701","https://openalex.org/W4413399701"],"abstract_inverted_index":{"One":[0],"Two":[1],"T":[2,3,82,93,99,108,113,123,139,188,205],"cells":[4,94,124,149,155,163,182,189,206,215],"develop":[5],"in":[6,81,85,91,145,156,168,204],"the":[7,36,71,78,98,146],"thymus,":[8],"where":[9],"they":[10,21,175],"proceed":[11],"through":[12],"several":[13],"developmental":[14,28],"stages,":[15],"losing":[16],"alternative":[17],"lineage":[18,109],"potential":[19],"as":[20,77],"progress.":[22],"The":[23],"molecular":[24],"regulation":[25],"of":[26,70,89,142,148,202,212],"this":[27],"process,":[29],"however,":[30],"is":[31],"not":[32,177,185],"fully":[33],"understood":[34],"(see":[35],"Perspective":[37],"by":[38],"Di":[39],"Santo":[40],").":[41],"P.":[42],"Li":[43,54],"et":[44,55,62],"al.":[45,56,63],"(p.":[46,57,64],"85":[47],",":[48],"published":[49],"online":[50],"10":[51],"June),":[52],"L.":[53],"89":[58],"),":[59],"and":[60,125,129,137,159,170,183],"Ikawa":[61],"93":[65],")":[66],"now":[67],"identify":[68],"expression":[69],"zinc":[72],"finger":[73],"transcription":[74],"factor":[75],"Bcl11b":[76,90,111,143,203],"earliest":[79],"checkpoint":[80],"cell":[83,100,114],"development":[84],"mice.":[86],"Genetic":[87],"deletion":[88,201],"developing":[92,136],"inhibited":[95],"commitment":[96],"to":[97,117,193],"lineage.":[101],"Under":[102],"conditions":[103],"that":[104,150],"should":[105],"have":[106],"stimulated":[107],"differentiation,":[110],"-deficient":[112],"progenitors":[115],"failed":[116],"up-regulate":[118],"genes":[119],"associated":[120],"with":[121],"lineage-committed":[122],"maintained":[126],"stem":[127],"cell\u2013":[128],"progenitor":[130],"cell\u2013associated":[131],"gene":[132],"expression.":[133],"In":[134],"both":[135,157],"committed":[138],"cells,":[140,200],"loss":[141],"resulted":[144],"generation":[147],"resembled":[151],"natural":[152],"killer":[153],"(NK)":[154],"phenotype":[158],"function.":[160],"These":[161],"NK-like":[162],"could":[164],"be":[165],"expanded":[166],"easily":[167],"vitro":[169],"possessed":[171],"antitumor":[172,218],"cytotoxicity,":[173],"but":[174],"did":[176],"exhibit":[178],"cytotoxicity":[179],"against":[180],"normal":[181],"were":[184],"tumorigenic.":[186],"Because":[187],"are":[190],"much":[191],"easier":[192],"obtain":[194],"from":[195],"human":[196],"patients":[197],"than":[198],"NK":[199,214],"may":[207],"thus":[208],"provide":[209],"a":[210],"source":[211],"easy-to-grow":[213],"for":[216],"cell-based":[217],"therapies.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":30},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":29},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}