{"id":"https://openalex.org/W2010949040","doi":"https://doi.org/10.1182/blood-2005-11-4608","title":"STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBP\u03b1","display_name":"STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBP\u03b1","publication_year":2006,"publication_date":"2006-02-03","ids":{"openalex":"https://openalex.org/W2010949040","doi":"https://doi.org/10.1182/blood-2005-11-4608","mag":"2010949040","pmid":"https://pubmed.ncbi.nlm.nih.gov/16455947"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2005-11-4608","doi":"https://doi.org/10.1182/blood-2005-11-4608","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2005-11-4608","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11370/c5588cf4-94de-40f1-8678-e0fb070175a3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109852526","display_name":"Albertus T.J. Wierenga","orcid":"https://orcid.org/0000-0002-7464-850X","observed_orcids":["https://orcid.org/0000-0002-7464-850X"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Albertus T. J. Wierenga","raw_affiliation_strings":["From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I1334819555"]},{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014983653","display_name":"Hein Schepers","orcid":"https://orcid.org/0000-0002-7731-3318","observed_orcids":["https://orcid.org/0000-0002-7731-3318"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Hein Schepers","raw_affiliation_strings":["From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I1334819555"]},{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110863459","display_name":"Malcolm A.S. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Malcolm A. S. Moore","raw_affiliation_strings":["From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I1334819555"]},{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050532707","display_name":"Edo Vellenga","orcid":"https://orcid.org/0000-0002-7741-8697","observed_orcids":["https://orcid.org/0000-0002-7741-8697"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Edo Vellenga","raw_affiliation_strings":["From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I1334819555"]},{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011506752","display_name":"Jan Jacob Schuringa","orcid":"https://orcid.org/0000-0001-8452-8555","observed_orcids":["https://orcid.org/0000-0001-8452-8555"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Jan Jacob Schuringa","raw_affiliation_strings":["From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; and Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I1334819555"]},{"raw_affiliation_string":"From the University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":4.0591,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.94160939,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"107","issue":"11","first_page":"4326","last_page":"4333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat5a","display_name":"STAT5A","score":0.8930000066757202},{"id":"https://openalex.org/keywords/c-ebpalpha","display_name":"C/EBP\u03b1","score":0.921999990940094},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.9010000228881836},{"id":"https://openalex.org/keywords/myelopoiesis","display_name":"myelopoiesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/myeloid-differentiation","display_name":"myeloid differentiation","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8149999976158142},{"id":"https://openalex.org/keywords/long-term-culture-initiating-cells","display_name":"long-term culture-initiating cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/colony-forming-cells","display_name":"colony-forming cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/transcriptional-downregulation","display_name":"transcriptional downregulation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/retroviral-transduction","display_name":"retroviral transduction","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C95862172","wikidata":"https://www.wikidata.org/wiki/Q9032597","display_name":"Myelopoiesis","level":4,"score":0.8863750100135803},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7165844440460205},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6679165959358215},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.661827027797699},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.41881993412971497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39183494448661804},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3479993939399719},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3130542039871216}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014161","descriptor_name":"Transduction, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022762","descriptor_name":"CCAAT-Enhancer-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038042","descriptor_name":"Myelopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050799","descriptor_name":"STAT5 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050799","descriptor_name":"STAT5 Transcription Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1182/blood-2005-11-4608","doi":"https://doi.org/10.1182/blood-2005-11-4608","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2005-11-4608","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:16455947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16455947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/c5588cf4-94de-40f1-8678-e0fb070175a3","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/c5588cf4-94de-40f1-8678-e0fb070175a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wierenga, ATJ, Schepers, H, Moore, MAS, Vellenga, E & Schuringa, JJ 2006, 'STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBP alpha', Blood, vol. 107, no. 11, pp. 4326-4333.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/c5588cf4-94de-40f1-8678-e0fb070175a3","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/c5588cf4-94de-40f1-8678-e0fb070175a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood, 107(11), 4326 - 4333. AMER SOC HEMATOLOGY","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pure.rug.nl:openaire/c5588cf4-94de-40f1-8678-e0fb070175a3","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/c5588cf4-94de-40f1-8678-e0fb070175a3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wierenga, ATJ, Schepers, H, Moore, MAS, Vellenga, E & Schuringa, JJ 2006, 'STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBP alpha', Blood, vol. 107, no. 11, pp. 4326-4333.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320321026","display_name":"Ministry of Earth Sciences","ror":"https://ror.org/013cf5k59"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320323105","display_name":"Universitair Medisch Centrum Groningen","ror":"https://ror.org/03cv38k47"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1489323849","https://openalex.org/W1917578864","https://openalex.org/W1977354830","https://openalex.org/W1980568348","https://openalex.org/W1981860701","https://openalex.org/W1987598864","https://openalex.org/W1992852437","https://openalex.org/W1993600035","https://openalex.org/W1996590957","https://openalex.org/W2008735841","https://openalex.org/W2012185449","https://openalex.org/W2016730049","https://openalex.org/W2018902760","https://openalex.org/W2020936923","https://openalex.org/W2029315929","https://openalex.org/W2047398915","https://openalex.org/W2049145190","https://openalex.org/W2049629344","https://openalex.org/W2053953456","https://openalex.org/W2056777862","https://openalex.org/W2057360098","https://openalex.org/W2070793750","https://openalex.org/W2081773938","https://openalex.org/W2083331687","https://openalex.org/W2083483484","https://openalex.org/W2088583545","https://openalex.org/W2090786449","https://openalex.org/W2096340973","https://openalex.org/W2100088478","https://openalex.org/W2103054294","https://openalex.org/W2106515248","https://openalex.org/W2117437672","https://openalex.org/W2126317027","https://openalex.org/W2127621383","https://openalex.org/W2129321368","https://openalex.org/W2137105120","https://openalex.org/W2144664431","https://openalex.org/W2148379964","https://openalex.org/W2152895316","https://openalex.org/W2160509246","https://openalex.org/W2162564085","https://openalex.org/W2167731274","https://openalex.org/W2172276903","https://openalex.org/W2316179291","https://openalex.org/W2403474134"],"related_works":["https://openalex.org/W7006163244","https://openalex.org/W2460138841","https://openalex.org/W2581439623","https://openalex.org/W2505506459","https://openalex.org/W2480079090","https://openalex.org/W2151041687","https://openalex.org/W2994279254","https://openalex.org/W7100073366","https://openalex.org/W2076096857","https://openalex.org/W2126602106"],"abstract_inverted_index":{"Previously,":[0],"we":[1],"demonstrated":[2],"that":[3,38,185,207],"enforced":[4],"activation":[5],"of":[6,11,68,90,100,115,119,129,163,182,188,209],"signal":[7],"transducer":[8],"and":[9,26,44,126,168,219],"activator":[10],"transcription":[12],"5":[13],"(STAT5A)":[14],"in":[15,23,81,92,96,165,201],"human":[16],"cord":[17],"blood":[18],"(CB)-derived":[19],"stem/progenitor":[20],"cells":[21,54,84,94,108,173,190],"results":[22],"enhanced":[24],"self-renewal":[25,218],"impaired":[27],"myelopoiesis.":[28,101,220],"The":[29,102],"present":[30],"study":[31],"identifies":[32],"C/EBPalpha":[33,56,91,120,164,198,210],"as":[34,57,117,149],"a":[35,71,86,97,122,212],"critical":[36],"component":[37],"is":[39,211],"down-regulated":[40,61],"by":[41,109,147],"STAT5.":[42],"Microarray":[43],"reverse":[45],"transcriptase-polymerase":[46],"chain":[47],"reaction":[48],"(RT-PCR)":[49],"analysis":[50],"on":[51,106,112,217],"STAT5A(1*6)-transduced":[52],"CD34(+)":[53,83,107],"identified":[55],"the":[58,65,78,113,127,186],"most":[59],"prominently":[60],"gene.":[62],"To":[63],"determine":[64],"cell-biological":[66],"relevance":[67],"these":[69,154],"observations,":[70],"4-OHT-inducible":[72],"C/EBPalpha-ER":[73],"protein":[74],"was":[75,192,199],"co-expressed":[76,200],"with":[77,151],"STAT5A(1*6)":[79,93,110,148,166,202],"mutant":[80],"CB":[82],"using":[85],"retroviral":[87],"approach.":[88],"Re-expression":[89],"resulted":[95],"marked":[98],"restoration":[99],"proliferative":[103],"advantage":[104],"imposed":[105],"depended":[111],"down-modulation":[114,208],"C/EBPalpha,":[116],"reintroduction":[118],"induced":[121],"quick":[123],"cell-cycle":[124],"arrest":[125],"onset":[128],"myeloid":[130],"differentiation.":[131],"Long-term":[132],"culture-initiating":[133],"cell":[134],"(LTC-IC)":[135],"frequencies":[136,157],"were":[137,158],"elevated":[138,155],"from":[139,178],"0.8%":[140],"+/-":[141,145],"0.6%":[142],"to":[143],"7.8%":[144],"1.9%":[146],"compared":[150],"controls,":[152],"but":[153],"LTC-IC":[156],"strongly":[159],"reduced":[160,193],"upon":[161],"re-introduction":[162],"cells,":[167],"no":[169],"second":[170],"cobble-stone":[171],"area-forming":[172],"(CAFCs)":[174],"could":[175],"be":[176],"generated":[177],"double-transduced":[179],"cells.":[180,203],"Enumeration":[181],"progenitors":[183],"revealed":[184],"number":[187],"colony-forming":[189],"(CFCs)":[191],"more":[194],"than":[195],"20-fold":[196],"when":[197],"Our":[204],"data":[205],"indicate":[206],"prerequisite":[213],"for":[214],"STAT5-induced":[215],"effects":[216]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
