{"id":"https://openalex.org/W2010945407","doi":"https://doi.org/10.1001/jama.1982.03330230052032","title":"Virilizing Adrenocortical Carcinoma","display_name":"Virilizing Adrenocortical Carcinoma","publication_year":1982,"publication_date":"1982-12-17","ids":{"openalex":"https://openalex.org/W2010945407","doi":"https://doi.org/10.1001/jama.1982.03330230052032","mag":"2010945407","pmid":"https://pubmed.ncbi.nlm.nih.gov/7143691"},"language":"en","primary_location":{"id":"doi:10.1001/jama.1982.03330230052032","doi":"https://doi.org/10.1001/jama.1982.03330230052032","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.1982.03330230052032","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111901599","display_name":"Arthur Bauman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Arthur Bauman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111901599"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7859,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.83787993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"248","issue":"23","first_page":"3140","last_page":"3140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.3411000072956085,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.08910000324249268,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/congenital-adrenal-hyperplasia","display_name":"congenital adrenal hyperplasia","score":0.953000009059906},{"id":"https://openalex.org/keywords/21-hydroxylase-deficiency","display_name":"21-hydroxylase deficiency","score":0.9739999771118164},{"id":"https://openalex.org/keywords/salt-losing-congenital-adrenal-hyperplasia","display_name":"salt-losing congenital adrenal hyperplasia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/adrenal-cortex-neoplasms","display_name":"adrenal cortex neoplasms","score":0.7319999933242798},{"id":"https://openalex.org/keywords/masculinization","display_name":"masculinization","score":0.7070000171661377},{"id":"https://openalex.org/keywords/urinary-17-ketosteroids","display_name":"urinary 17-ketosteroids","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.5109999775886536},{"id":"https://openalex.org/keywords/clitoromegaly","display_name":"clitoromegaly","score":0.6700000166893005},{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":0.5659999847412109},{"id":"https://openalex.org/keywords/hyponatremia","display_name":"hyponatremia","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.925547182559967},{"id":"https://openalex.org/C2781371012","wikidata":"https://www.wikidata.org/wiki/Q1081574","display_name":"Labia majora","level":3,"score":0.8824194669723511},{"id":"https://openalex.org/C2776016352","wikidata":"https://www.wikidata.org/wiki/Q873072","display_name":"Clitoris","level":2,"score":0.8130083084106445},{"id":"https://openalex.org/C2778242168","wikidata":"https://www.wikidata.org/wiki/Q794086","display_name":"Hypokalemia","level":2,"score":0.6301467418670654},{"id":"https://openalex.org/C2777767042","wikidata":"https://www.wikidata.org/wiki/Q366868","display_name":"Congenital adrenal hyperplasia","level":2,"score":0.6268414258956909},{"id":"https://openalex.org/C2776631543","wikidata":"https://www.wikidata.org/wiki/Q1433654","display_name":"Virilization","level":4,"score":0.608989953994751},{"id":"https://openalex.org/C2777977426","wikidata":"https://www.wikidata.org/wiki/Q19065","display_name":"Adrenal cortex","level":2,"score":0.46845006942749023},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.4519984722137451},{"id":"https://openalex.org/C2781399356","wikidata":"https://www.wikidata.org/wiki/Q918285","display_name":"Adrenocortical carcinoma","level":2,"score":0.4519467353820801},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4287453293800354},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3756796419620514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3652607798576355},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.25765687227249146},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2291426658630371},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22777333855628967},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.21244847774505615},{"id":"https://openalex.org/C2776316342","wikidata":"https://www.wikidata.org/wiki/Q2192288","display_name":"Vulva","level":2,"score":0.0876135528087616}],"mesh":[{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000312","descriptor_name":"Adrenal Hyperplasia, Congenital","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014770","descriptor_name":"Virilism","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014770","descriptor_name":"Virilism","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015068","descriptor_name":"17-Ketosteroids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1001/jama.1982.03330230052032","doi":"https://doi.org/10.1001/jama.1982.03330230052032","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.1982.03330230052032","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"journal-article"},{"id":"doi:10.1001/jama.248.23.3140","doi":"https://doi.org/10.1001/jama.248.23.3140","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.248.23.3140","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA: The Journal of the American Medical Association","raw_type":"journal-article"},{"id":"pmid:7143691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7143691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAMA","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1607274231","https://openalex.org/W1989538539","https://openalex.org/W2067244949","https://openalex.org/W2067443764","https://openalex.org/W2099764659","https://openalex.org/W2329409914"],"related_works":["https://openalex.org/W4231459851","https://openalex.org/W1607274231","https://openalex.org/W2034120276","https://openalex.org/W2412266656","https://openalex.org/W4300035060","https://openalex.org/W1835530353","https://openalex.org/W3022089655","https://openalex.org/W1975616431","https://openalex.org/W7096995556","https://openalex.org/W7129733539"],"abstract_inverted_index":{"CONGENITAL":[0],"adrenal":[1,67],"hyperplasia":[2],"(CAH)":[3],"is":[4,18,38],"an":[5],"uncommon":[6],"disorder,":[7],"but":[8],"the":[9,27,30,36,66,80,101,106,134],"incidence":[10],"of":[11,23,32,50,65,71,88,96,104],"virilizing":[12,63],"adrenocortical":[13],"neoplasms,":[14],"benign":[15],"and":[16,113,122,133],"malignant,":[17],"even":[19],"less":[20],"common.1The":[21],"occurrence":[22],"both":[24],"conditions":[25],"in":[26,143],"same":[28],"patient2-5raises":[29],"question":[31],"whether":[33],"or":[34],"not":[35],"association":[37],"coincidental.":[39],"The":[40,128],"patient":[41,107],"described":[42],"herein":[43],"was":[44,77],"born":[45],"with":[46,92],"a":[47,55,62,72,144],"salt-losing":[48],"form":[49],"CAH,":[51],"probably":[52],"caused":[53],"by":[54],"severe":[56],"21-hydroxylase":[57],"deficiency;":[58],"despite":[59],"adequate":[60],"control,":[61],"carcinoma":[64],"cortex":[68],"developed.":[69],"Report":[70],"Case":[73],"An":[74],"11-year-old":[75],"girl":[76],"admitted":[78],"to":[79],"White":[81],"Plains":[82],"(NY)":[83],"Hospital":[84],"Medical":[85],"Center":[86],"because":[87],"progressive":[89],"virilization":[90],"associated":[91],"strikingly":[93],"increasing":[94],"levels":[95],"urinary":[97],"17-ketosteroids":[98],"(17-KS).":[99],"During":[100],"first":[102],"week":[103],"life,":[105],"had":[108,109,118,130,140],"persistent":[110],"vomiting,":[111],"weakness,":[112],"convulsions.":[114],"Serum":[115],"sodium":[116],"level":[117],"been":[119,131],"126":[120],"mEq/L,":[121],"serum":[123],"potassium":[124],"level,":[125],"9.2":[126],"mEq/L.":[127],"clitoris":[129],"enlarged":[132],"labia":[135],"majora":[136],"fused.":[137],"A":[138],"cystourethrogram":[139],"shown":[141],"dye":[142],"vaginal":[145]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}