{"id":"https://openalex.org/W2010942791","doi":"https://doi.org/10.1016/0024-3205(89)90374-3","title":"Sodium diethyldithiocarbamate protects against the MPTP-induced inhibition of immune responses in mice","display_name":"Sodium diethyldithiocarbamate protects against the MPTP-induced inhibition of immune responses in mice","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2010942791","doi":"https://doi.org/10.1016/0024-3205(89)90374-3","mag":"2010942791","pmid":"https://pubmed.ncbi.nlm.nih.gov/2539542"},"language":"en","primary_location":{"id":"doi:10.1016/0024-3205(89)90374-3","doi":"https://doi.org/10.1016/0024-3205(89)90374-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(89)90374-3","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054769763","display_name":"Gerard Renoux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"G\u00e9rard Renoux","raw_affiliation_strings":["Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, France","institution_ids":["https://openalex.org/I110017253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005450777","display_name":"Kathleen Bizi\u00e8re","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Kathleen Bizi\u00e8re","raw_affiliation_strings":["Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France","institution_ids":["https://openalex.org/I110017253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011306030","display_name":"MICHELINE RENOUX","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Micheline Renoux","raw_affiliation_strings":["Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France","institution_ids":["https://openalex.org/I110017253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111597252","display_name":"R\u00e9gis Steinberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R\u00e9gis Steinberg","raw_affiliation_strings":["Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France","institution_ids":["https://openalex.org/I110017253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111552823","display_name":"J.P. Kan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Paul Kan","raw_affiliation_strings":["Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France","institution_ids":["https://openalex.org/I110017253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110861569","display_name":"Jean-Maurice Guillaumin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Maurice Guillaumin","raw_affiliation_strings":["Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immunologie, Facult\u00e9 de M\u00e9decine de Tours, 37032 Tours Cedex, France","institution_ids":["https://openalex.org/I110017253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054769763"],"corresponding_institution_ids":["https://openalex.org/I110017253"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":3.058,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.9096563,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"44","issue":"12","first_page":"771","last_page":"777"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-diethyldithiocarbamate","display_name":"sodium diethyldithiocarbamate","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.925000011920929},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.4309999942779541},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.7289999723434448},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.5979999899864197},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9259999990463257},{"id":"https://openalex.org/keywords/selegiline","display_name":"selegiline","score":0.7879999876022339},{"id":"https://openalex.org/keywords/3-methoxytyramine","display_name":"3-methoxytyramine","score":0.843999981880188},{"id":"https://openalex.org/keywords/dopac","display_name":"DOPAC","score":0.843999981880188},{"id":"https://openalex.org/keywords/homovanillic-acid","display_name":"homovanillic acid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neuroimmunomodulation","display_name":"neuroimmunomodulation","score":0.6349999904632568},{"id":"https://openalex.org/keywords/parkinson-s-disease-model","display_name":"Parkinson's disease model","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2775841634","wikidata":"https://www.wikidata.org/wiki/Q903566","display_name":"Homovanillic acid","level":4,"score":0.9524500966072083},{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.9171057939529419},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7539417743682861},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6570200324058533},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6492565870285034},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5501927137374878},{"id":"https://openalex.org/C2775905480","wikidata":"https://www.wikidata.org/wiki/Q4634071","display_name":"3,4-Dihydroxyphenylacetic acid","level":5,"score":0.4265940487384796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3606838881969452},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3568289279937744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21056172251701355},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.20998051762580872},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.2054840624332428},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19233930110931396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15314701199531555},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000090023","descriptor_name":"Metallothionein 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004050","descriptor_name":"Ditiocarb","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006719","descriptor_name":"Homovanillic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012642","descriptor_name":"Selegiline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015102","descriptor_name":"3,4-Dihydroxyphenylacetic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015198","descriptor_name":"Designer Drugs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015632","descriptor_name":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0024-3205(89)90374-3","doi":"https://doi.org/10.1016/0024-3205(89)90374-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(89)90374-3","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:2539542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2539542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W631301279","https://openalex.org/W1967727486","https://openalex.org/W1968358905","https://openalex.org/W1972788225","https://openalex.org/W1979632245","https://openalex.org/W1982099580","https://openalex.org/W1982557686","https://openalex.org/W1983111592","https://openalex.org/W1990007023","https://openalex.org/W1994791590","https://openalex.org/W2009364947","https://openalex.org/W2023211111","https://openalex.org/W2030963875","https://openalex.org/W2037206381","https://openalex.org/W2046721730","https://openalex.org/W2048953131","https://openalex.org/W2049164552","https://openalex.org/W2083301389","https://openalex.org/W2087137358","https://openalex.org/W2093395901","https://openalex.org/W2135073428","https://openalex.org/W2140588832","https://openalex.org/W2168362820","https://openalex.org/W2396309155","https://openalex.org/W2415478451","https://openalex.org/W4236818045","https://openalex.org/W4246611139","https://openalex.org/W4300882461"],"related_works":["https://openalex.org/W4236818045","https://openalex.org/W2067251552","https://openalex.org/W2078838939","https://openalex.org/W2049565473","https://openalex.org/W2052899919","https://openalex.org/W2052859400","https://openalex.org/W2403396009","https://openalex.org/W2062805042","https://openalex.org/W2032933983","https://openalex.org/W1964149279"],"abstract_inverted_index":null,"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}