{"id":"https://openalex.org/W2010936282","doi":"https://doi.org/10.1002/ptr.1239","title":"Smooth muscle contraction induced by Indigofera dendroides leaf extracts may involve calcium mobilization via potential sensitive channels","display_name":"Smooth muscle contraction induced by Indigofera dendroides leaf extracts may involve calcium mobilization via potential sensitive channels","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W2010936282","doi":"https://doi.org/10.1002/ptr.1239","mag":"2010936282","pmid":"https://pubmed.ncbi.nlm.nih.gov/12916079"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.1239","doi":"https://doi.org/10.1002/ptr.1239","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1239","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000906257","display_name":"Samson Amos","orcid":"https://orcid.org/0000-0003-2780-2276","observed_orcids":["https://orcid.org/0000-0003-2780-2276"]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"S. Amos","raw_affiliation_strings":["Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria. samsonamos@yahoo.co.uk","Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria. samsonamos@yahoo.co.uk","institution_ids":["https://openalex.org/I4210104694"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111895934","display_name":"Lucy Binda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"L. Binda","raw_affiliation_strings":["Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112345844","display_name":"Oluyemisi Folashade Kunle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"O. F. Kunle","raw_affiliation_strings":["Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Plant Research and Traditional Medicine, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I. Okafor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"I. Okafor","raw_affiliation_strings":["Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014716440","display_name":"Martins Ochubiojo Emeje","orcid":"https://orcid.org/0000-0002-0202-5426","observed_orcids":["https://orcid.org/0000-0002-0202-5426"]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"M. Emeje","raw_affiliation_strings":["Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071666850","display_name":"P. A. Akah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"P. A. Akah","raw_affiliation_strings":["Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110404700","display_name":"Charles O. Wambebe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"C. Wambebe","raw_affiliation_strings":["Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110168092","display_name":"K. Gamaniel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104694","display_name":"National Institute for Pharmaceutical Research and Development","ror":"https://ror.org/01c7jsk34","country_code":"NG","type":"government","lineage":["https://openalex.org/I4210104694"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"K. Gamaniel","raw_affiliation_strings":["Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria","institution_ids":["https://openalex.org/I4210104694"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000906257"],"corresponding_institution_ids":["https://openalex.org/I4210104694"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.7864,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.78258634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":"7","first_page":"792","last_page":"796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.32280001044273376,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.32280001044273376,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.30790001153945923,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.2736999988555908,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.8009999990463257},{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.781000018119812},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ileal-smooth-muscle","display_name":"ileal smooth muscle","score":0.8840000033378601},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.8510000109672546},{"id":"https://openalex.org/keywords/potassium-chloride","display_name":"potassium chloride","score":0.7639999985694885},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.6499999761581421},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.7210000157356262},{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.4959999918937683},{"id":"https://openalex.org/keywords/histamine-receptors","display_name":"histamine receptors","score":0.7089999914169312},{"id":"https://openalex.org/keywords/calcium-pools","display_name":"calcium pools","score":0.42899999022483826},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.6050000190734863},{"id":"https://openalex.org/keywords/mepyramine","display_name":"mepyramine","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pirenzepine","display_name":"pirenzepine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.8547937273979187},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.7090004086494446},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6804957389831543},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.6512001752853394},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.5460810661315918},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.5302752256393433},{"id":"https://openalex.org/C2779090179","wikidata":"https://www.wikidata.org/wiki/Q3800087","display_name":"Mepyramine","level":4,"score":0.5268634557723999},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.5152533650398254},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48824241757392883},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.47278663516044617},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.4708145558834076},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4675518274307251},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.4474944770336151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4393613636493683},{"id":"https://openalex.org/C2779995051","wikidata":"https://www.wikidata.org/wiki/Q412127","display_name":"Gallopamil","level":4,"score":0.4392204284667969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40437328815460205},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.33663469552993774},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.29154330492019653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2213945984840393},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1260053813457489},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029883","descriptor_name":"Indigofera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/ptr.1239","doi":"https://doi.org/10.1002/ptr.1239","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1239","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},{"id":"pmid:12916079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12916079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy research : PTR","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.cedarville.edu:pharmaceutical_sciences_publications-1116","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.cedarville.edu/pharmaceutical_sciences_publications/114","pdf_url":null,"source":{"id":"https://openalex.org/S4377196552","display_name":"DigitalCommons-Cedarville (Cedarville University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169138485","host_organization_name":"Cedarville University","host_organization_lineage":["https://openalex.org/I169138485"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutical Sciences Faculty Publications","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W113642746","https://openalex.org/W1535207151","https://openalex.org/W1844605916","https://openalex.org/W1975310638","https://openalex.org/W1986292963","https://openalex.org/W2011042327","https://openalex.org/W2012275063","https://openalex.org/W2030982179","https://openalex.org/W2042464457","https://openalex.org/W2061229425","https://openalex.org/W2063100823","https://openalex.org/W2070310062","https://openalex.org/W2080688803","https://openalex.org/W2091584761","https://openalex.org/W2093342959","https://openalex.org/W2126562474","https://openalex.org/W2217037112","https://openalex.org/W2347149315","https://openalex.org/W2401414712","https://openalex.org/W2409212570"],"related_works":["https://openalex.org/W2401414712","https://openalex.org/W2059123247","https://openalex.org/W1993351414","https://openalex.org/W2112717118","https://openalex.org/W2941000779","https://openalex.org/W2084884769","https://openalex.org/W2196770928","https://openalex.org/W1116778660","https://openalex.org/W2022898054","https://openalex.org/W2770857847"],"abstract_inverted_index":{"The":[0,33,84,154,195],"contractile":[1,34,159],"effects":[2,35],"of":[3,7,10,36,72,95,139,157,169,180,193],"the":[4,8,17,50,64,96,158,166,191],"aqueous":[5],"extract":[6,69],"leaves":[9],"Indigofera":[11],"dendroides":[12],"(ID)":[13],"were":[14,47,104,125,174,201],"studied":[15],"on":[16,49],"gastrointestinal":[18,140],"motility":[19,141],"in":[20,82,137,150,190],"mice":[21],"and":[22,30,43,99,146,171,185,229],"isolated":[23],"smooth":[24,53],"muscle":[25,54],"preparations":[26],"obtained":[27],"from":[28,219,234],"rats":[29],"guinea":[31,97],"pigs.":[32],"10(-6)":[37],"M":[38],"acetylcholine,":[39],"80":[40],"mM":[41],"KCl":[42,145],"1.6":[44],"mg/ml":[45],"ID":[46,88,147,186,230],"measured":[48],"rat":[51,100],"ileal":[52],"exposed":[55],"to":[56,62,161,177],"calcium-free":[57,181],"buffer":[58],"or":[59,118,223,237],"physiological":[60],"solution,":[61],"determine":[63],"calcium":[65,207],"pools":[66],"mobilized":[67],"by":[68,107,128,204],"for":[70],"activation":[71],"contraction.":[73],"Acute":[74],"toxicity":[75],"test":[76],"(LD(50))":[77],"was":[78,142],"also":[79,213],"carried":[80],"out":[81],"mice.":[83],"result":[85],"showed":[86],"that":[87,198,215],"(0.05-3.2":[89],"mg/ml)":[90],"produced":[91,148],"a":[92],"concentration-dependent":[93],"contraction":[94],"pig":[98],"ileum.":[101],"These":[102],"responses":[103,160],"not":[105,202],"blocked":[106,126],"mepyramine":[108],"(2.49":[109],"x":[110,115,121,131],"10(-9)":[111,116,132],"M),":[112,117,123],"verapamil":[113],"(8.14":[114],"pirenzepine":[119],"(4.7":[120],"10(-7)":[122],"but":[124],"completely":[127],"atropine":[129],"(2.92":[130],"M).":[133],"A":[134],"significant":[135],"increase":[136],"propulsion":[138],"observed.":[143],"Acetylcholine,":[144],"contractions":[149,173,189,200],"Ca(2+)":[151],"free":[152],"media.":[153],"phasic":[155],"components":[156],"Ach":[162,216],"as":[163,165],"well":[164],"tonic":[167],"component":[168],"K(+)":[170,184,228],"ID-induced":[172,199],"relatively":[175],"resistant":[176],"short":[178],"periods":[179],"exposure.":[182],"Ach,":[183],"still":[187],"caused":[188],"presence":[192],"verapamil.":[194],"data":[196],"revealed":[197],"mediated":[203],"histaminergic":[205],"receptors,":[206],"channels,":[208],"M1":[209],"muscarinic":[210],"receptors.":[211],"It":[212],"suggests":[214],"mobilize":[217,232],"Ca":[218,233],"some":[220,235],"tightly":[221],"bound":[222],"intracellular":[224],"pool,":[225],"whereas":[226],"high":[227],"may":[231],"superficial":[236],"loosely-bound":[238],"pool.":[239]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}