{"id":"https://openalex.org/W2010935118","doi":"https://doi.org/10.1021/bi301496p","title":"Structural and Mechanistic Characterization of l -Histidinol Phosphate Phosphatase from the Polymerase and Histidinol Phosphatase Family of Proteins","display_name":"Structural and Mechanistic Characterization of l -Histidinol Phosphate Phosphatase from the Polymerase and Histidinol Phosphatase Family of Proteins","publication_year":2013,"publication_date":"2013-01-17","ids":{"openalex":"https://openalex.org/W2010935118","doi":"https://doi.org/10.1021/bi301496p","mag":"2010935118","pmid":"https://pubmed.ncbi.nlm.nih.gov/23327428","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3570733"},"language":"en","primary_location":{"id":"doi:10.1021/bi301496p","doi":"https://doi.org/10.1021/bi301496p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi301496p","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3570733","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077929697","display_name":"Swapnil V. Ghodge","orcid":"https://orcid.org/0000-0002-5201-9665","observed_orcids":["https://orcid.org/0000-0002-5201-9665"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swapnil V. Ghodge","raw_affiliation_strings":["Department of Chemistry, P.O. Box 30012, Texas A&M University, College Station, Texas 77843-3012, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, P.O. Box 30012, Texas A&M University, College Station, Texas 77843-3012, United States","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077718436","display_name":"Alexander A. Fedorov","orcid":"https://orcid.org/0000-0002-7911-3301","observed_orcids":["https://orcid.org/0000-0002-7911-3301"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Fedorov","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061121659","display_name":"E.V. Fedorov","orcid":"https://orcid.org/0000-0003-2121-7092","observed_orcids":["https://orcid.org/0000-0003-2121-7092"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena V. Fedorov","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063750114","display_name":"B. Hillerich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandan Hillerich","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101445333","display_name":"Ronald D. Seidel III","orcid":"https://orcid.org/0000-0001-6928-5268","observed_orcids":["https://orcid.org/0000-0001-6928-5268"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Seidel","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006013523","display_name":"Steven C. Almo","orcid":"https://orcid.org/0000-0003-2591-5234","observed_orcids":["https://orcid.org/0000-0003-2591-5234"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven C. Almo","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park\rAvenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park#R#Avenue, Bronx, New York 10461, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002277619","display_name":"Frank Michael Raushel","orcid":"https://orcid.org/0000-0002-5918-3089","observed_orcids":["https://orcid.org/0000-0002-5918-3089"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frank M. Raushel","raw_affiliation_strings":["Department of Chemistry, P.O. Box 30012, Texas A&M University, College Station, Texas 77843-3012, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, P.O. Box 30012, Texas A&M University, College Station, Texas 77843-3012, United States","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002277619","https://openalex.org/A5006013523"],"corresponding_institution_ids":["https://openalex.org/I129975664","https://openalex.org/I91045830"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.804,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.84176665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"52","issue":"6","first_page":"1101","last_page":"1112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amidohydrolase-superfamily","display_name":"amidohydrolase superfamily","score":0.9340000152587891},{"id":"https://openalex.org/keywords/manganese-substitution","display_name":"manganese substitution","score":0.5220000147819519},{"id":"https://openalex.org/keywords/solvent-isotope-effect","display_name":"solvent isotope effect","score":0.7580000162124634},{"id":"https://openalex.org/keywords/viscous-effects","display_name":"viscosity effects","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lactococcus-lactis","display_name":"Lactococcus lactis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/enzyme-crystal-structure","display_name":"enzyme crystal structure","score":0.5839999914169312},{"id":"https://openalex.org/keywords/substrate-recognition","display_name":"substrate recognition","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2779485144","wikidata":"https://www.wikidata.org/wiki/Q4746164","display_name":"Amidohydrolase","level":3,"score":0.8925313949584961},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7014279365539551},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.6819440126419067},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5884231328964233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5830032825469971},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.5519711375236511},{"id":"https://openalex.org/C2780011460","wikidata":"https://www.wikidata.org/wiki/Q133598","display_name":"Lactococcus lactis","level":4,"score":0.49903273582458496},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4653495252132416},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.42354488372802734},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.41489213705062866},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35332971811294556},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1625581979751587},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.08475691080093384},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001149","descriptor_name":"Arsenates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006642","descriptor_name":"Histidinol-Phosphatase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006642","descriptor_name":"Histidinol-Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006642","descriptor_name":"Histidinol-Phosphatase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013294","descriptor_name":"Lactococcus lactis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013294","descriptor_name":"Lactococcus lactis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/bi301496p","doi":"https://doi.org/10.1021/bi301496p","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi301496p","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:23327428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23327428","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2903735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3570733","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3570733","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3570733","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2903735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3570733","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1553095488","display_name":"COLLABORATIVE CENTER FOR AN ENZYME FUNCTION INITIATIVE","funder_award_id":"U54GM093342","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2501434638","display_name":null,"funder_award_id":"GM71790","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4797540902","display_name":null,"funder_award_id":"GM93342","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6696541873","display_name":"DECIPHERING ENZYME SPECIFICITY","funder_award_id":"P01GM071790","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1539796472","https://openalex.org/W1941046107","https://openalex.org/W1964445220","https://openalex.org/W1972373490","https://openalex.org/W1973741311","https://openalex.org/W1977797772","https://openalex.org/W1985203726","https://openalex.org/W2001641653","https://openalex.org/W2015967099","https://openalex.org/W2030517878","https://openalex.org/W2039478231","https://openalex.org/W2063091148","https://openalex.org/W2071822446","https://openalex.org/W2072067365","https://openalex.org/W2084575458","https://openalex.org/W2088933990","https://openalex.org/W2094476648","https://openalex.org/W2100262865","https://openalex.org/W2100750044","https://openalex.org/W2106246537","https://openalex.org/W2113561798","https://openalex.org/W2114622716","https://openalex.org/W2115668755","https://openalex.org/W2118818078","https://openalex.org/W2120772351","https://openalex.org/W2122851202","https://openalex.org/W2127321587","https://openalex.org/W2131367352","https://openalex.org/W2133790733","https://openalex.org/W2144081223","https://openalex.org/W2154714625","https://openalex.org/W2155142785","https://openalex.org/W2160216877","https://openalex.org/W2161855013","https://openalex.org/W2180229411","https://openalex.org/W2312222238","https://openalex.org/W2323630730","https://openalex.org/W2323794435","https://openalex.org/W4301020220"],"related_works":["https://openalex.org/W2306004890","https://openalex.org/W2697845168","https://openalex.org/W1964445220","https://openalex.org/W2302163325","https://openalex.org/W2294908787","https://openalex.org/W1816148094","https://openalex.org/W2049616674","https://openalex.org/W2000268615","https://openalex.org/W2063091148","https://openalex.org/W2018657772"],"abstract_inverted_index":{"L-Histidinol":[0],"phosphate":[1,9],"phosphatase":[2,29],"(HPP)":[3],"catalyzes":[4],"the":[5,15,19,25,53,65,94,108,115,138,177,184,193,203,209],"hydrolysis":[6,63],"of":[7,21,32,47,56,60,68,89,102,107,117,124,133,160,171,187,206],"L-histidinol":[8,11,166,172],"to":[10,52,191],"and":[12,27,39,91,97,130,135,143,151,168,173,183,199],"inorganic":[13],"phosphate,":[14,167],"penultimate":[16],"step":[17],"in":[18,83,93,114,127,137,176],"biosynthesis":[20],"L-histidine.":[22],"HPP":[23,69,74,161,204],"from":[24,75],"polymerase":[26],"histidinol":[28],"(PHP)":[30],"family":[31,67,205],"proteins":[33],"possesses":[34],"a":[35,40,87,99,121,131,169],"trinuclear":[36],"active":[37,95,139,178],"site":[38,96],"distorted":[41],"(\u03b2/\u03b1)(7)-barrel":[42],"protein":[43,109],"fold.":[44],"This":[45],"group":[46],"enzymes":[48,70,207],"is":[49],"closely":[50],"related":[51],"amidohydrolase":[54,210],"superfamily":[55],"enzymes.":[57],"The":[58],"mechanism":[59],"phosphomonoester":[61],"bond":[62],"by":[64,202],"PHP":[66],"was":[71,81],"addressed.":[72],"Recombinant":[73],"Lactococcus":[76],"lactis":[77,79],"subsp.":[78],"that":[80,147],"expressed":[82],"Escherichia":[84],"coli":[85],"contained":[86],"mixture":[88,132],"iron":[90],"zinc":[92,134],"had":[98],"catalytic":[100,128,185],"efficiency":[101,129],"~10(3)":[103],"M(-1)":[104],"s(-1).":[105],"Expression":[106],"under":[110],"iron-free":[111],"conditions":[112],"resulted":[113],"production":[116],"an":[118],"enzyme":[119],"with":[120,164],"2":[122],"order":[123],"magnitude":[125],"improvement":[126],"manganese":[136],"site.":[140,179],"Solvent":[141],"isotope":[142],"viscosity":[144],"effects":[145],"demonstrated":[146],"proton":[148],"transfer":[149],"steps":[150,154],"product":[152],"dissociation":[153],"are":[155],"not":[156],"rate-limiting.":[157],"X-ray":[158],"structures":[159,182],"were":[162,189],"determined":[163],"sulfate,":[165],"complex":[170],"arsenate":[174],"bound":[175],"These":[180],"crystal":[181],"properties":[186],"variants":[188],"used":[190],"identify":[192],"structural":[194],"elements":[195],"required":[196],"for":[197],"catalysis":[198],"substrate":[200],"recognition":[201],"within":[208],"superfamily.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
