{"id":"https://openalex.org/W2010930835","doi":"https://doi.org/10.2147/ijn.s28753","title":"Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering","display_name":"Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W2010930835","doi":"https://doi.org/10.2147/ijn.s28753","mag":"2010930835","pmid":"https://pubmed.ncbi.nlm.nih.gov/22403490","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3292420"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s28753","doi":"https://doi.org/10.2147/ijn.s28753","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s28753","pdf_url":"https://www.dovepress.com/getfile.php?fileID=12122","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=12122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006317320","display_name":"Jui\u2010Yang Lai","orcid":"https://orcid.org/0000-0002-9227-8549","observed_orcids":["https://orcid.org/0000-0002-9227-8549"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jui-Yang Lai","raw_affiliation_strings":["Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China. jylai@mail.cgu.edu.tw","Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China. jylai@mail.cgu.edu.tw","institution_ids":["https://openalex.org/I173093425"]},{"raw_affiliation_string":"Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100971469","display_name":"Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Li","raw_affiliation_strings":["Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110627569","display_name":"Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Cho","raw_affiliation_strings":["Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China","institution_ids":["https://openalex.org/I173093425"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113568849","display_name":"Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Yu","raw_affiliation_strings":["Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan, Taiwan, Republic of China","institution_ids":["https://openalex.org/I173093425"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100971469","https://openalex.org/A5110627569","https://openalex.org/A5113568849"],"corresponding_institution_ids":["https://openalex.org/I173093425"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":3.5766,"has_fulltext":true,"cited_by_count":131,"citation_normalized_percentile":{"value":0.93741299,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"7","issue":null,"first_page":"1101","last_page":"1101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.21439999341964722,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.13379999995231628,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/keratocytes","display_name":"keratocytes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/carbodiimide-cross-linking","display_name":"carbodiimide crosslinking","score":0.9459999799728394},{"id":"https://openalex.org/keywords/gelatin-hydrogel","display_name":"gelatin hydrogel","score":0.843999981880188},{"id":"https://openalex.org/keywords/young-s-modulus","display_name":"Young's modulus","score":0.722000002861023},{"id":"https://openalex.org/keywords/protease-resistance","display_name":"protease resistance","score":0.968999981880188},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5529999732971191},{"id":"https://openalex.org/keywords/cell-material-interactions","display_name":"cell-material interactions","score":0.5860000252723694},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2778823387","wikidata":"https://www.wikidata.org/wiki/Q179254","display_name":"Gelatin","level":2,"score":0.8628295660018921},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.6691266894340515},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.662894070148468},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6428930759429932},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.6074889898300171},{"id":"https://openalex.org/C45206210","wikidata":"https://www.wikidata.org/wiki/Q2415817","display_name":"Nanoscopic scale","level":2,"score":0.5174568295478821},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.4982719421386719},{"id":"https://openalex.org/C6648577","wikidata":"https://www.wikidata.org/wiki/Q622669","display_name":"Porosity","level":2,"score":0.4718758165836334},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4636467695236206},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.41611456871032715},{"id":"https://openalex.org/C2776735749","wikidata":"https://www.wikidata.org/wiki/Q4862650","display_name":"Chondroitin","level":3,"score":0.4160751700401306},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36620473861694336},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.32716092467308044},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2079206109046936},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.17621329426765442},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.17521393299102783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11448872089385986},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09624013304710388},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07107535004615784},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002234","descriptor_name":"Carbodiimides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002809","descriptor_name":"Chondroitin Sulfates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003319","descriptor_name":"Corneal Stroma","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005780","descriptor_name":"Gelatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054457","descriptor_name":"Tissue Scaffolds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055119","descriptor_name":"Elastic Modulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060527","descriptor_name":"Corneal Keratocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D060527","descriptor_name":"Corneal Keratocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D060527","descriptor_name":"Corneal Keratocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2147/ijn.s28753","doi":"https://doi.org/10.2147/ijn.s28753","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s28753","pdf_url":"https://www.dovepress.com/getfile.php?fileID=12122","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3292420","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3292420","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmid:22403490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22403490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.272.4256","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.272.4256","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/cd/ad/Int_J_Nanomedicine_2012_Feb_23_7_1101-1114.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:6cd19175535243dfb88b4b82f59270a7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6cd19175535243dfb88b4b82f59270a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol 2012, Iss default, Pp 1101-1114 (2012)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/9335","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/nanoscale-modification-of-porous-gelatin-scaffolds-with-chondroitin-su-peer-reviewed-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s28753","doi":"https://doi.org/10.2147/ijn.s28753","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s28753","pdf_url":"https://www.dovepress.com/getfile.php?fileID=12122","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322767","display_name":"Chang Gung Medical Foundation","ror":"https://ror.org/02verss31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010930835.pdf","grobid_xml":"https://content.openalex.org/works/W2010930835.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W19536194","https://openalex.org/W129868507","https://openalex.org/W1513962827","https://openalex.org/W1552936131","https://openalex.org/W1972429192","https://openalex.org/W1981013532","https://openalex.org/W1982627594","https://openalex.org/W1987429432","https://openalex.org/W1990212229","https://openalex.org/W1990552062","https://openalex.org/W1995231071","https://openalex.org/W2004906401","https://openalex.org/W2005013534","https://openalex.org/W2005690903","https://openalex.org/W2006438089","https://openalex.org/W2008704253","https://openalex.org/W2009930793","https://openalex.org/W2010787542","https://openalex.org/W2019326461","https://openalex.org/W2022717979","https://openalex.org/W2024268683","https://openalex.org/W2024366939","https://openalex.org/W2024964552","https://openalex.org/W2029231378","https://openalex.org/W2034140478","https://openalex.org/W2037227485","https://openalex.org/W2037802341","https://openalex.org/W2040450375","https://openalex.org/W2043627720","https://openalex.org/W2053868595","https://openalex.org/W2055644152","https://openalex.org/W2056292710","https://openalex.org/W2057159803","https://openalex.org/W2060002764","https://openalex.org/W2063877586","https://openalex.org/W2084651465","https://openalex.org/W2087257666","https://openalex.org/W2090672743","https://openalex.org/W2092535047","https://openalex.org/W2103044471","https://openalex.org/W2113089828","https://openalex.org/W2122230709","https://openalex.org/W2125906494","https://openalex.org/W2143953113","https://openalex.org/W2152848521","https://openalex.org/W2153055548","https://openalex.org/W2154659743","https://openalex.org/W2167356135"],"related_works":["https://openalex.org/W7096454495","https://openalex.org/W7097714291","https://openalex.org/W2025215630","https://openalex.org/W2350557959","https://openalex.org/W2299570015","https://openalex.org/W1968356058","https://openalex.org/W1899646534","https://openalex.org/W2353230976","https://openalex.org/W1552936131","https://openalex.org/W160357853"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"reflect":[2],"the":[3,18,34,37,41,91,101,119,127,198,214,218,224],"importance":[4],"of":[5,21,43,67,93,129,152,159,177,187,209,229,239],"using":[6,75],"naturally":[7],"occurring":[8],"biopolymers":[9],"as":[10,48,113],"three-dimensional":[11],"corneal":[12,54,61,200,254],"keratocyte":[13,62],"scaffolds":[14,63,178],"and":[15,84,157,167,174,202,206,226],"suggest":[16],"that":[17,90,217],"porous":[19,46,68,146],"structure":[20],"gelatin":[22,47,69,147,231],"materials":[23,70],"may":[24,248],"play":[25],"an":[26,49],"important":[27],"role":[28],"in":[29,122,126,253],"controlling":[30],"nutrient":[31],"uptake.":[32],"In":[33,111,212],"current":[35],"study,":[36],"authors":[38,59,215],"further":[39],"consider":[40],"application":[42],"carbodiimide":[44,76],"cross-linked":[45],"alternative":[50],"to":[51,108],"collagen":[52],"for":[53,251],"stromal":[55,255],"tissue":[56,256],"engineering.":[57,257],"The":[58,172,190],"developed":[60],"by":[64,115],"nanoscale":[65],"modification":[66,220],"with":[71,138,180,185,197,235],"chondroitin":[72],"sulfate":[73],"(CS)":[74],"chemistry.":[77],"Scanning":[78],"electron":[79],"microscopy/energy":[80],"dispersive":[81],"X-ray":[82],"spectroscopy":[83,88],"Fourier":[85],"transform":[86],"infrared":[87],"showed":[89,203],"amount":[92,158],"covalently":[94],"incorporated":[95],"polysaccharide":[96],"was":[97,104,125],"significantly":[98],"increased":[99,105],"when":[100],"CS":[102,120,142,182,237],"concentration":[103],"from":[106,192],"0%":[107],"1.25%":[109],"(w/v).":[110],"addition,":[112],"demonstrated":[114],"dimethylmethylene":[116],"blue":[117],"assays,":[118],"content":[121,238],"these":[123],"samples":[124,191],"range":[128],"0.078-0.149":[130],"nmol":[131,243],"per":[132,244],"10":[133,245],"mg":[134,246],"scaffold.":[135],"When":[136],"compared":[137],"their":[139],"counterparts":[140],"without":[141],"treatment,":[143],"various":[144],"CS-modified":[145],"membranes":[148,234],"exhibited":[149],"higher":[150],"levels":[151],"water":[153],"content,":[154],"light":[155],"transmittance,":[156],"permeated":[160],"nutrients":[161],"but":[162],"possessed":[163],"lower":[164],"Young's":[165],"modulus":[166],"resistance":[168],"against":[169],"protease":[170],"digestion.":[171],"hydrophilic":[173],"mechanical":[175],"properties":[176],"modified":[179],"0.25%":[181],"were":[183,195],"comparable":[184],"those":[186],"native":[188],"corneas.":[189],"this":[193],"group":[194],"biocompatible":[196],"rabbit":[199],"keratocytes":[201],"enhanced":[204],"proliferative":[205],"biosynthetic":[207],"capacity":[208],"cultured":[210],"cells.":[211],"summary,":[213],"found":[216],"nanoscale-level":[219],"has":[221],"influence":[222],"on":[223],"characteristics":[225],"cell-material":[227],"interactions":[228],"CS-containing":[230],"hydrogels.":[232],"Porous":[233],"a":[236],"0.112":[240],"\u00b1":[241],"0.003":[242],"scaffold":[247],"hold":[249],"potential":[250],"use":[252]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}