{"id":"https://openalex.org/W2010930241","doi":"https://doi.org/10.1002/1529-0131(200102)44:2<389::aid-anr58>3.0.co;2-r","title":"The DNA mismatch repair enzyme PMS1 is a myositis-specific autoantigen","display_name":"The DNA mismatch repair enzyme PMS1 is a myositis-specific autoantigen","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2010930241","doi":"https://doi.org/10.1002/1529-0131(200102)44:2<389::aid-anr58>3.0.co;2-r","mag":"2010930241","pmid":"https://pubmed.ncbi.nlm.nih.gov/11229471"},"language":"en","primary_location":{"id":"doi:10.1002/1529-0131(200102)44:2<389::aid-anr58>3.0.co;2-r","doi":"https://doi.org/10.1002/1529-0131(200102)44:2<389::aid-anr58>3.0.co;2-r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1529-0131(200102)44:2<389::aid-anr58>3.0.co;2-r","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004540531","display_name":"Livia A Casciola-Rosen","orcid":"https://orcid.org/0000-0002-4172-1539","observed_orcids":["https://orcid.org/0000-0002-4172-1539"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Livia A. Casciola-Rosen","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA","Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026688859","display_name":"Ann F. Pluta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann F. Pluta","raw_affiliation_strings":["University of Maryland , Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland , Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056507445","display_name":"Paul H. Pl\u00f6tz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul H. Plotz","raw_affiliation_strings":["NATIONAL INSTITUTES OF HEALTH, BETHESDA, MARYLAND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NATIONAL INSTITUTES OF HEALTH, BETHESDA, MARYLAND","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021990512","display_name":"Amy E. Cox","orcid":"https://orcid.org/0009-0003-4609-8445","observed_orcids":["https://orcid.org/0009-0003-4609-8445"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy E. Cox","raw_affiliation_strings":["Johns Hopkins University, School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054053445","display_name":"Steven M. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Morris","raw_affiliation_strings":["Johns Hopkins University, School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068528030","display_name":"Fredrick M. Wigley","orcid":"https://orcid.org/0000-0003-0762-6981","observed_orcids":["https://orcid.org/0000-0003-0762-6981"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fredrick M. Wigley","raw_affiliation_strings":["Johns Hopkins University, School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108470332","display_name":"Michelle Petri","orcid":"https://orcid.org/0000-0003-1441-5373","observed_orcids":["https://orcid.org/0000-0003-1441-5373"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Petri","raw_affiliation_strings":["Johns Hopkins University, School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004999384","display_name":"Allan C. Gelber","orcid":"https://orcid.org/0000-0001-8463-311X","observed_orcids":["https://orcid.org/0000-0001-8463-311X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan C. Gelber","raw_affiliation_strings":["Johns Hopkins University, School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008833389","display_name":"Antony Rosen","orcid":"https://orcid.org/0000-0002-8374-4763","observed_orcids":["https://orcid.org/0000-0002-8374-4763"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antony Rosen","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5469,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.92566655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"44","issue":"2","first_page":"389","last_page":"396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pms1","display_name":"PMS1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.902999997138977},{"id":"https://openalex.org/keywords/autoimmune-myositis","display_name":"autoimmune myositis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.9210000038146973},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":0.8690000176429749},{"id":"https://openalex.org/keywords/dna-repair-proteins","display_name":"DNA repair proteins","score":0.6430000066757202},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/dna-dependent-protein-kinase","display_name":"DNA-dependent protein kinase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mi-2","display_name":"Mi-2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/disease-specificity","display_name":"disease specificity","score":0.5440000295639038},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9290000200271606},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7664306163787842},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6145460605621338},{"id":"https://openalex.org/C2780380082","wikidata":"https://www.wikidata.org/wiki/Q12646460","display_name":"Granzyme B","level":4,"score":0.5436498522758484},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.49361979961395264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47170042991638184},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3803540766239166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35941797494888306},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3182070255279541},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.08875840902328491}],"mesh":[{"descriptor_ui":"D000070956","descriptor_name":"MutL Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009220","descriptor_name":"Myositis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020137","descriptor_name":"Base Pair Mismatch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/1529-0131(200102)44:2<389::aid-anr58>3.0.co;2-r","doi":"https://doi.org/10.1002/1529-0131(200102)44:2<389::aid-anr58>3.0.co;2-r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1529-0131(200102)44:2<389::aid-anr58>3.0.co;2-r","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"doi:10.1002/1529-0131(200102)44:2<389::aid-anr58>3.3.co;2-i","doi":"https://doi.org/10.1002/1529-0131(200102)44:2<389::aid-anr58>3.3.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1529-0131(200102)44:2<389::aid-anr58>3.3.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:11229471","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11229471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8100000023841858,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1022260038","display_name":null,"funder_award_id":"AR 44684","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G1294676937","display_name":"Rheumatic Disease Sera: Probes of Disease Mechanisms","funder_award_id":"R01AR044684","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3593991805","display_name":null,"funder_award_id":"AR43727","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6269278073","display_name":null,"funder_award_id":"DE12354","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W179381085","https://openalex.org/W184510336","https://openalex.org/W1567517848","https://openalex.org/W1832181040","https://openalex.org/W1968334728","https://openalex.org/W1970184435","https://openalex.org/W1980510932","https://openalex.org/W1981112371","https://openalex.org/W1992159506","https://openalex.org/W1999158929","https://openalex.org/W2002012875","https://openalex.org/W2003096758","https://openalex.org/W2016557482","https://openalex.org/W2028397246","https://openalex.org/W2028921539","https://openalex.org/W2043681988","https://openalex.org/W2046690135","https://openalex.org/W2053827853","https://openalex.org/W2055597783","https://openalex.org/W2067028787","https://openalex.org/W2075271539","https://openalex.org/W2077060586","https://openalex.org/W2082558653","https://openalex.org/W2085382985","https://openalex.org/W2100915449","https://openalex.org/W2102512189","https://openalex.org/W2110451932","https://openalex.org/W2113400076","https://openalex.org/W2123883912","https://openalex.org/W2132103243","https://openalex.org/W2140582776","https://openalex.org/W2146203649","https://openalex.org/W2238822973","https://openalex.org/W2314311014","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1923837980","https://openalex.org/W2423989695","https://openalex.org/W2561147690","https://openalex.org/W593594756","https://openalex.org/W2069359556","https://openalex.org/W2164521943","https://openalex.org/W7096802783","https://openalex.org/W2303895490","https://openalex.org/W2104077617","https://openalex.org/W2000618386"],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,216],"specificity":[2,54],"of":[3,55,77,107,135,190,207,226,262],"the":[4,52,75,237,260],"autoantibody":[5],"response":[6,34,222,268],"in":[7,35,61,81,105,133,143,176,231,251,266],"different":[8],"autoimmune":[9,33,139,152,257],"diseases":[10,153],"makes":[11],"autoantibodies":[12,41,78,212],"useful":[13],"for":[14,31,255],"diagnostic":[15],"purposes.":[16],"It":[17],"also":[18,170],"focuses":[19],"attention":[20],"on":[21],"tissue-":[22,243],"and":[23,92,179,187,234,236,244],"event-specific":[24,245],"circumstances":[25],"that":[26,242],"may":[27,42],"select":[28],"unique":[29,200],"molecules":[30,254],"an":[32,57,220,256,270],"specific":[36],"diseases.":[37],"Defining":[38],"additional":[39],"phenotype-specific":[40],"identify":[43],"such":[44],"circumstances.":[45],"This":[46],"study":[47],"was":[48,122],"undertaken":[49],"to":[50,73,79,110,129,223],"investigate":[51],"disease":[53],"PMS1,":[56,116],"autoantigen":[58],"previously":[59],"identified":[60,123],"some":[62],"sera":[63,82,101,145],"from":[64,83,93,146],"patients":[65,84,137,148],"with":[66,85,138,149],"myositis.":[67],"METHODS:":[68],"We":[69],"used":[70],"immunoprecipitation":[71],"analysis":[72],"determine":[74],"frequency":[76],"PMS1":[80,130,169,211],"myositis,":[86],"systemic":[87,151],"lupus":[88],"erythematosus,":[89],"or":[90],"scleroderma":[91],"healthy":[94],"controls.":[95],"Additional":[96,157],"antigens":[97],"recognized":[98,171],"by":[99,112,196],"PMS1-positive":[100],"were":[102,131,163,193],"further":[103],"characterized":[104],"terms":[106],"their":[108],"susceptibility":[109],"cleavage":[111,265],"apoptotic":[113],"proteases.":[114],"RESULTS:":[115],"a":[117,125,224,249],"DNA":[118,177,232],"mismatch":[119,158],"repair":[120,159,178,233],"enzyme,":[121],"as":[124],"myositis-specific":[126],"autoantigen.":[127],"Autoantibodies":[128],"found":[132],"4":[134],"53":[136],"myositis":[140,214,238],"(7.5%),":[141],"but":[142],"no":[144],"94":[147],"other":[150,173,205],"(P":[154],"=":[155],"0.016).":[156],"enzymes":[160],"(PMS2,":[161],"MLH1)":[162],"targeted,":[164],"apparently":[165],"independently.":[166],"Sera":[167],"recognizing":[168],"several":[172],"proteins":[174],"involved":[175],"remodeling,":[180],"including":[181],"poly(ADP-ribose)":[182],"polymerase,":[183],"DNA-dependent":[184],"protein":[185],"kinase,":[186],"Mi-2.":[188],"All":[189],"these":[191,253],"autoantigens":[192],"efficiently":[194],"cleaved":[195],"granzyme":[197,227,263],"B,":[198],"generating":[199],"fragments":[201],"not":[202],"observed":[203],"during":[204],"forms":[206],"cell":[208],"death.":[209],"CONCLUSION:":[210],"are":[213],"specific.":[215],"striking":[217],"correlation":[218],"between":[219],"immune":[221],"group":[225],"B":[228,264],"substrates":[229],"(functioning":[230],"remodeling)":[235],"phenotype":[239],"strongly":[240],"implies":[241],"biochemical":[246],"events":[247],"play":[248],"role":[250,261],"selecting":[252],"response.":[258],"Understanding":[259],"this":[267],"is":[269],"important":[271],"priority.":[272]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}