{"id":"https://openalex.org/W2010920735","doi":"https://doi.org/10.1016/s0140-6736(11)60959-8","title":"Safety and efficacy of zoledronic acid in multiple myeloma","display_name":"Safety and efficacy of zoledronic acid in multiple myeloma","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W2010920735","doi":"https://doi.org/10.1016/s0140-6736(11)60959-8","mag":"2010920735","pmid":"https://pubmed.ncbi.nlm.nih.gov/21704866"},"language":"en","primary_location":{"id":"doi:10.1016/s0140-6736(11)60959-8","doi":"https://doi.org/10.1016/s0140-6736(11)60959-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0140-6736(11)60959-8","pdf_url":"http://www.thelancet.com/article/S0140673611609598/pdf","source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thelancet.com/article/S0140673611609598/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020157236","display_name":"Tetsuya E. Tanimoto","orcid":"https://orcid.org/0000-0002-9818-8587","observed_orcids":["https://orcid.org/0000-0002-9818-8587"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsuya Tanimoto","raw_affiliation_strings":["Cancer Institute, Japanese Foundation for Cancer Research, Koto Ward, Tokyo 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute, Japanese Foundation for Cancer Research, Koto Ward, Tokyo 135-8550, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040861552","display_name":"Tetsutaro Matayoshi","orcid":"https://orcid.org/0000-0002-3834-4269","observed_orcids":["https://orcid.org/0000-0002-3834-4269"]},"institutions":[{"id":"https://openalex.org/I32915989","display_name":"University of the Ryukyus","ror":"https://ror.org/02z1n9q24","country_code":"JP","type":"education","lineage":["https://openalex.org/I32915989"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsutaro Matayoshi","raw_affiliation_strings":["University of the Ryukyus, Okinawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of the Ryukyus, Okinawa, Japan","institution_ids":["https://openalex.org/I32915989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017994748","display_name":"Fumiharu Yagasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132452","display_name":"Saitama International Medical Center","ror":"https://ror.org/03ftky336","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210132452"]},{"id":"https://openalex.org/I8588240","display_name":"Saitama Medical University","ror":"https://ror.org/04zb31v77","country_code":"JP","type":"education","lineage":["https://openalex.org/I8588240"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumiharu Yagasaki","raw_affiliation_strings":["Saitama Medical University International Medical Centre, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saitama Medical University International Medical Centre, Saitama, Japan","institution_ids":["https://openalex.org/I4210132452","https://openalex.org/I8588240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044544485","display_name":"Kengo Takeuchi","orcid":"https://orcid.org/0000-0002-1599-5800","observed_orcids":["https://orcid.org/0000-0002-1599-5800"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kengo Takeuchi","raw_affiliation_strings":["Cancer Institute, Japanese Foundation for Cancer Research, Koto Ward, Tokyo 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute, Japanese Foundation for Cancer Research, Koto Ward, Tokyo 135-8550, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049518445","display_name":"Masahiro Kami","orcid":"https://orcid.org/0000-0002-5130-3832","observed_orcids":["https://orcid.org/0000-0002-5130-3832"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Kami","raw_affiliation_strings":["Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5020157236"],"corresponding_institution_ids":["https://openalex.org/I42570316"],"apc_list":{"value":7890,"currency":"USD","value_usd":7890},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"377","issue":"9784","first_page":"2178","last_page":"2178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zoledronic-acid","display_name":"zoledronic acid","score":0.9549999833106995},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9959999918937683},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/skeletal-related-events","display_name":"skeletal-related events","score":0.7910000085830688},{"id":"https://openalex.org/keywords/thromboembolic-events","display_name":"thromboembolic events","score":0.8939999938011169},{"id":"https://openalex.org/keywords/thromboprophylaxis","display_name":"thromboprophylaxis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6380000114440918},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intensive-chemotherapy","display_name":"intensive chemotherapy","score":0.4690000116825104},{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.800000011920929},{"id":"https://openalex.org/keywords/lenalidomide","display_name":"lenalidomide","score":0.996999979019165},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8009999990463257},{"id":"https://openalex.org/keywords/thrombosis-risk-factors","display_name":"thrombosis risk factors","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2776326535","wikidata":"https://www.wikidata.org/wiki/Q218507","display_name":"Zoledronic acid","level":2,"score":0.9561832547187805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8546867370605469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6552045941352844},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.6299784779548645},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6262974143028259},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.47133612632751465},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46832019090652466},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.43317556381225586},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4208487570285797},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3633708655834198},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3351748585700989},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0895395278930664},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077211","descriptor_name":"Zoledronic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004002","descriptor_name":"Clodronic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004002","descriptor_name":"Clodronic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010020","descriptor_name":"Osteonecrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010020","descriptor_name":"Osteonecrosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017751","descriptor_name":"Safety Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0140-6736(11)60959-8","doi":"https://doi.org/10.1016/s0140-6736(11)60959-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0140-6736(11)60959-8","pdf_url":"http://www.thelancet.com/article/S0140673611609598/pdf","source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},{"id":"pmid:21704866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21704866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lancet (London, England)","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1016/s0140-6736(11)60959-8","doi":"https://doi.org/10.1016/s0140-6736(11)60959-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0140-6736(11)60959-8","pdf_url":"http://www.thelancet.com/article/S0140673611609598/pdf","source":{"id":"https://openalex.org/S49861241","display_name":"The Lancet","issn_l":"0099-5355","issn":["0099-5355","0140-6736","1474-547X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010920735.pdf","grobid_xml":"https://content.openalex.org/works/W2010920735.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W75633284","https://openalex.org/W2069449301","https://openalex.org/W2088348963","https://openalex.org/W2097331346","https://openalex.org/W2103011422","https://openalex.org/W2109113725","https://openalex.org/W2126134029","https://openalex.org/W2134071321"],"related_works":["https://openalex.org/W2161604858","https://openalex.org/W2103011422","https://openalex.org/W2323729928","https://openalex.org/W1983807890","https://openalex.org/W1603354012","https://openalex.org/W2334657571","https://openalex.org/W2050323584","https://openalex.org/W2952958610","https://openalex.org/W4231472492","https://openalex.org/W2035607339"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
