{"id":"https://openalex.org/W2010919880","doi":"https://doi.org/10.1016/0003-2697(85)90333-1","title":"A high-pressure liquid chromatographic method for plasma phenylacetic acid, a putative marker for depressive disorders","display_name":"A high-pressure liquid chromatographic method for plasma phenylacetic acid, a putative marker for depressive disorders","publication_year":1985,"publication_date":"1985-02-01","ids":{"openalex":"https://openalex.org/W2010919880","doi":"https://doi.org/10.1016/0003-2697(85)90333-1","mag":"2010919880","pmid":"https://pubmed.ncbi.nlm.nih.gov/4003753"},"language":"en","primary_location":{"id":"doi:10.1016/0003-2697(85)90333-1","doi":"https://doi.org/10.1016/0003-2697(85)90333-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-2697(85)90333-1","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108753892","display_name":"Fabian Gusovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabian Gusovsky","raw_affiliation_strings":["Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111659801","display_name":"JAN A. FAWCETT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Fawcett","raw_affiliation_strings":["Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079865921","display_name":"Javaid I. Javaid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javaid I. Javaid","raw_affiliation_strings":["Illinois State Psychiatric Institute, Chicago, Illinois 60612 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illinois State Psychiatric Institute, Chicago, Illinois 60612 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072392241","display_name":"Helen Jeffriess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Jeffriess","raw_affiliation_strings":["Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077370882","display_name":"HECTOR C. SABELLI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hector Sabelli","raw_affiliation_strings":["Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":0.7218,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.70175439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"145","issue":"1","first_page":"101","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.2175000011920929,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenylacetic-acid","display_name":"phenylacetic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7059999704360962},{"id":"https://openalex.org/keywords/depressive-disorders","display_name":"depressive disorders","score":0.9160000085830688},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hplc-determination","display_name":"HPLC determination","score":0.5979999899864197},{"id":"https://openalex.org/keywords/acid-hydrolysis","display_name":"acid hydrolysis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/perchloric-acid-protein-precipitation","display_name":"perchloric acid protein precipitation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/benzene-extraction","display_name":"benzene extraction","score":0.8809999823570251}],"concepts":[{"id":"https://openalex.org/C2778990612","wikidata":"https://www.wikidata.org/wiki/Q410842","display_name":"Phenylacetic acid","level":2,"score":0.8157827854156494},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7384642958641052},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.489940345287323},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4445400536060333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1672733724117279},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06648501753807068},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010648","descriptor_name":"Phenylacetates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0003-2697(85)90333-1","doi":"https://doi.org/10.1016/0003-2697(85)90333-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0003-2697(85)90333-1","pdf_url":null,"source":{"id":"https://openalex.org/S7858788","display_name":"Analytical Biochemistry","issn_l":"0003-2697","issn":["0003-2697","1096-0309"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Biochemistry","raw_type":"journal-article"},{"id":"pmid:4003753","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4003753","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W75082916","https://openalex.org/W1998016111","https://openalex.org/W2015092881","https://openalex.org/W2023275921","https://openalex.org/W2044240568","https://openalex.org/W2050445876","https://openalex.org/W2052362839","https://openalex.org/W2057501720","https://openalex.org/W2058860879","https://openalex.org/W2065686973","https://openalex.org/W2069623562","https://openalex.org/W4298371400"],"related_works":["https://openalex.org/W2062590867","https://openalex.org/W2053321097","https://openalex.org/W4313396075","https://openalex.org/W2039358667","https://openalex.org/W2069623562","https://openalex.org/W1965020540","https://openalex.org/W1980827436","https://openalex.org/W2011527411","https://openalex.org/W2128824617","https://openalex.org/W1989723577"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}