{"id":"https://openalex.org/W2010919598","doi":"https://doi.org/10.1074/jbc.m111.228981","title":"Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain","display_name":"Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain","publication_year":2011,"publication_date":"2011-03-19","ids":{"openalex":"https://openalex.org/W2010919598","doi":"https://doi.org/10.1074/jbc.m111.228981","mag":"2010919598","pmid":"https://pubmed.ncbi.nlm.nih.gov/21454483","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3091211"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.228981","doi":"https://doi.org/10.1074/jbc.m111.228981","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.228981","pdf_url":"http://www.jbc.org/article/S0021925820514208/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820514208/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049815773","display_name":"Brittany L. Cross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany Cross","raw_affiliation_strings":["Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725291","display_name":"Lihong Chen","orcid":"https://orcid.org/0000-0002-2302-6890","observed_orcids":["https://orcid.org/0000-0002-2302-6890"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lihong Chen","raw_affiliation_strings":["From the Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612 and","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101699735","display_name":"Qian Cheng","orcid":"https://orcid.org/0000-0002-3674-1025","observed_orcids":["https://orcid.org/0000-0002-3674-1025"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Cheng","raw_affiliation_strings":["From the Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612 and","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028354954","display_name":"Baozong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baozong Li","raw_affiliation_strings":["From the Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612 and","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079178970","display_name":"Zhi-Min Yuan","orcid":"https://orcid.org/0000-0003-4812-251X","observed_orcids":["https://orcid.org/0000-0003-4812-251X"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhi-Min Yuan","raw_affiliation_strings":["the Department of Radiation Oncology, University of Texas Health Science Center, San Antonio, Texas 78229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Radiation Oncology, University of Texas Health Science Center, San Antonio, Texas 78229","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101498583","display_name":"Jiandong Chen","orcid":"https://orcid.org/0000-0001-6178-8370","observed_orcids":["https://orcid.org/0000-0001-6178-8370","https://orcid.org/0000-0002-2644-3315"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jiandong Chen","raw_affiliation_strings":["From the Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Molecular Oncology Department, Moffitt Cancer Center, Tampa, Florida 33612 and","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101498583"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.1181,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.92419665,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"286","issue":"18","first_page":"16018","last_page":"16029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/p53-dna-binding","display_name":"p53 DNA binding","score":0.9480000138282776},{"id":"https://openalex.org/keywords/suv39h1","display_name":"SUV39H1","score":0.9330000281333923},{"id":"https://openalex.org/keywords/nutlin","display_name":"nutlin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.7009999752044678},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8519999980926514},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.7717907428741455},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.53879314661026},{"id":"https://openalex.org/C33987129","wikidata":"https://www.wikidata.org/wiki/Q13479514","display_name":"DNA-binding domain","level":4,"score":0.5178030729293823},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.4578307271003723},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.44297534227371216},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.43382781744003296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4277375042438507},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4257945418357849},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.4208359718322754},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4192587435245514},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41731947660446167},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4155574440956116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4075341820716858},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.33645156025886536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3340030312538147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07655090093612671}],"mesh":[{"descriptor_ui":"D000069286","descriptor_name":"Bortezomib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001897","descriptor_name":"Boronic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008780","descriptor_name":"Methyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011719","descriptor_name":"Pyrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051736","descriptor_name":"Proto-Oncogene Proteins c-mdm2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m111.228981","doi":"https://doi.org/10.1074/jbc.m111.228981","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.228981","pdf_url":"http://www.jbc.org/article/S0021925820514208/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2351917","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3091211","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3091211","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3091211","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21454483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21454483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.228981","doi":"https://doi.org/10.1074/jbc.m111.228981","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.228981","pdf_url":"http://www.jbc.org/article/S0021925820514208/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G283277140","display_name":"Function and regulation of MDMX","funder_award_id":"R01CA109636","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3039817217","display_name":null,"funder_award_id":"CA 109636","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G339021324","display_name":null,"funder_award_id":"CA 118210","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G371726913","display_name":"Targeting Signal Transduction Pathways for Cancer Drug Discovery","funder_award_id":"P01CA118210","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G739547486","display_name":null,"funder_award_id":"CA141244","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000867105","display_name":"Allosteric Regulation of MDMX by Protein Disorder","funder_award_id":"R01CA141244","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000876523","display_name":"Moffitt Cancer Center Support Grant","funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010919598.pdf","grobid_xml":"https://content.openalex.org/works/W2010919598.grobid-xml"},"referenced_works_count":293,"referenced_works":["https://openalex.org/W16338948","https://openalex.org/W47313401","https://openalex.org/W65126192","https://openalex.org/W152231097","https://openalex.org/W172433167","https://openalex.org/W1487724525","https://openalex.org/W1491121534","https://openalex.org/W1495933836","https://openalex.org/W1497251274","https://openalex.org/W1520947267","https://openalex.org/W1533075742","https://openalex.org/W1538028541","https://openalex.org/W1544032942","https://openalex.org/W1544851750","https://openalex.org/W1545495395","https://openalex.org/W1548972556","https://openalex.org/W1563774067","https://openalex.org/W1565881767","https://openalex.org/W1584759442","https://openalex.org/W1591222350","https://openalex.org/W1591281137","https://openalex.org/W1592021885","https://openalex.org/W1598779357","https://openalex.org/W1644206514","https://openalex.org/W1650797637","https://openalex.org/W1746080159","https://openalex.org/W1823168351","https://openalex.org/W1824671129","https://openalex.org/W1831428880","https://openalex.org/W1906462579","https://openalex.org/W1937607074","https://openalex.org/W1963795701","https://openalex.org/W1965363596","https://openalex.org/W1965581435","https://openalex.org/W1965641462","https://openalex.org/W1967632402","https://openalex.org/W1968149863","https://openalex.org/W1969044026","https://openalex.org/W1970329931","https://openalex.org/W1970796703","https://openalex.org/W1971283175","https://openalex.org/W1971849102","https://openalex.org/W1971850308","https://openalex.org/W1973073454","https://openalex.org/W1973821009","https://openalex.org/W1973886069","https://openalex.org/W1974279777","https://openalex.org/W1977548232","https://openalex.org/W1978345721","https://openalex.org/W1978406914","https://openalex.org/W1978902916","https://openalex.org/W1979319210","https://openalex.org/W1981000558","https://openalex.org/W1983751803","https://openalex.org/W1984862663","https://openalex.org/W1984948591","https://openalex.org/W1985469910","https://openalex.org/W1989168159","https://openalex.org/W1990085600","https://openalex.org/W1990952117","https://openalex.org/W1991154912","https://openalex.org/W1991429659","https://openalex.org/W1991494214","https://openalex.org/W1991510903","https://openalex.org/W1991906934","https://openalex.org/W1993864973","https://openalex.org/W1994017669","https://openalex.org/W1994169350","https://openalex.org/W1994655355","https://openalex.org/W1995095999","https://openalex.org/W1995290136","https://openalex.org/W1995741673","https://openalex.org/W1995856480","https://openalex.org/W1996675458","https://openalex.org/W1997646834","https://openalex.org/W1997897157","https://openalex.org/W1997926119","https://openalex.org/W1999258680","https://openalex.org/W1999478182","https://openalex.org/W2000011855","https://openalex.org/W2001205304","https://openalex.org/W2001258296","https://openalex.org/W2001480633","https://openalex.org/W2002689109","https://openalex.org/W2006095114","https://openalex.org/W2006313701","https://openalex.org/W2006482335","https://openalex.org/W2006565381","https://openalex.org/W2007010211","https://openalex.org/W2007249806","https://openalex.org/W2007658328","https://openalex.org/W2007935491","https://openalex.org/W2008715871","https://openalex.org/W2008797552","https://openalex.org/W2009183786","https://openalex.org/W2009486080","https://openalex.org/W2011727075","https://openalex.org/W2012053348","https://openalex.org/W2015519364","https://openalex.org/W2016160656","https://openalex.org/W2016479508","https://openalex.org/W2016533385","https://openalex.org/W2017673293","https://openalex.org/W2017721333","https://openalex.org/W2018383450","https://openalex.org/W2018385269","https://openalex.org/W2018537155","https://openalex.org/W2019029225","https://openalex.org/W2020132558","https://openalex.org/W2020808779","https://openalex.org/W2023297626","https://openalex.org/W2024894759","https://openalex.org/W2024996523","https://openalex.org/W2026211921","https://openalex.org/W2027544528","https://openalex.org/W2027931017","https://openalex.org/W2028044172","https://openalex.org/W2028867134","https://openalex.org/W2029635647","https://openalex.org/W2030239546","https://openalex.org/W2030262696","https://openalex.org/W2030674197","https://openalex.org/W2032076692","https://openalex.org/W2033950216","https://openalex.org/W2034177818","https://openalex.org/W2034269086","https://openalex.org/W2034562270","https://openalex.org/W2035122577","https://openalex.org/W2036179093","https://openalex.org/W2036587414","https://openalex.org/W2039382131","https://openalex.org/W2039463309","https://openalex.org/W2039944287","https://openalex.org/W2041968244","https://openalex.org/W2042461504","https://openalex.org/W2043033879","https://openalex.org/W2043912950","https://openalex.org/W2044230130","https://openalex.org/W2045086385","https://openalex.org/W2047330128","https://openalex.org/W2047596219","https://openalex.org/W2048440069","https://openalex.org/W2049133549","https://openalex.org/W2049436772","https://openalex.org/W2049763628","https://openalex.org/W2050745715","https://openalex.org/W2051152566","https://openalex.org/W2051182140","https://openalex.org/W2051409222","https://openalex.org/W2052516738","https://openalex.org/W2052556036","https://openalex.org/W2054749109","https://openalex.org/W2056495027","https://openalex.org/W2056530510","https://openalex.org/W2056872792","https://openalex.org/W2057061154","https://openalex.org/W2058947924","https://openalex.org/W2059985270","https://openalex.org/W2060584880","https://openalex.org/W2060763507","https://openalex.org/W2060972565","https://openalex.org/W2061497413","https://openalex.org/W2062552623","https://openalex.org/W2062612693","https://openalex.org/W2063060712","https://openalex.org/W2063779563","https://openalex.org/W2065395316","https://openalex.org/W2065643866","https://openalex.org/W2065886319","https://openalex.org/W2065891752","https://openalex.org/W2068196972","https://openalex.org/W2068624303","https://openalex.org/W2069717852","https://openalex.org/W2069900557","https://openalex.org/W2070854644","https://openalex.org/W2071133966","https://openalex.org/W2071555702","https://openalex.org/W2071581430","https://openalex.org/W2072319696","https://openalex.org/W2072677280","https://openalex.org/W2073576377","https://openalex.org/W2074222004","https://openalex.org/W2074297667","https://openalex.org/W2076059928","https://openalex.org/W2077085480","https://openalex.org/W2077858999","https://openalex.org/W2078131820","https://openalex.org/W2078731043","https://openalex.org/W2080633751","https://openalex.org/W2081288740","https://openalex.org/W2081519294","https://openalex.org/W2082541302","https://openalex.org/W2082979850","https://openalex.org/W2084374650","https://openalex.org/W2084733813","https://openalex.org/W2085195718","https://openalex.org/W2085267622","https://openalex.org/W2088603230","https://openalex.org/W2090025028","https://openalex.org/W2091312754","https://openalex.org/W2091942447","https://openalex.org/W2092108176","https://openalex.org/W2094550394","https://openalex.org/W2095424116","https://openalex.org/W2095441674","https://openalex.org/W2096207943","https://openalex.org/W2096276671","https://openalex.org/W2097081350","https://openalex.org/W2098810873","https://openalex.org/W2098911357","https://openalex.org/W2098935972","https://openalex.org/W2098995242","https://openalex.org/W2099791897","https://openalex.org/W2100448419","https://openalex.org/W2100589388","https://openalex.org/W2102930268","https://openalex.org/W2107739085","https://openalex.org/W2108483542","https://openalex.org/W2109998141","https://openalex.org/W2112450780","https://openalex.org/W2112706571","https://openalex.org/W2114103020","https://openalex.org/W2114261502","https://openalex.org/W2114825009","https://openalex.org/W2115124693","https://openalex.org/W2115986380","https://openalex.org/W2116326380","https://openalex.org/W2116755440","https://openalex.org/W2116998164","https://openalex.org/W2117834752","https://openalex.org/W2118733942","https://openalex.org/W2119121049","https://openalex.org/W2119239003","https://openalex.org/W2119363024","https://openalex.org/W2121421904","https://openalex.org/W2121673811","https://openalex.org/W2124560610","https://openalex.org/W2124788978","https://openalex.org/W2125553533","https://openalex.org/W2127217324","https://openalex.org/W2128306207","https://openalex.org/W2129540887","https://openalex.org/W2130603065","https://openalex.org/W2132279561","https://openalex.org/W2134507382","https://openalex.org/W2134609748","https://openalex.org/W2134872883","https://openalex.org/W2135426193","https://openalex.org/W2135451553","https://openalex.org/W2136558899","https://openalex.org/W2141224144","https://openalex.org/W2143206501","https://openalex.org/W2143351237","https://openalex.org/W2145034349","https://openalex.org/W2146502962","https://openalex.org/W2148200419","https://openalex.org/W2149581245","https://openalex.org/W2149597711","https://openalex.org/W2150123812","https://openalex.org/W2150611871","https://openalex.org/W2150710841","https://openalex.org/W2150833695","https://openalex.org/W2151439322","https://openalex.org/W2152711948","https://openalex.org/W2155033951","https://openalex.org/W2158005145","https://openalex.org/W2158689768","https://openalex.org/W2158795036","https://openalex.org/W2160919785","https://openalex.org/W2162264777","https://openalex.org/W2162888470","https://openalex.org/W2163565167","https://openalex.org/W2164115530","https://openalex.org/W2164489545","https://openalex.org/W2164821454","https://openalex.org/W2166164324","https://openalex.org/W2166213130","https://openalex.org/W2166269098","https://openalex.org/W2166440816","https://openalex.org/W2166633890","https://openalex.org/W2168979257","https://openalex.org/W2170494099","https://openalex.org/W2170939558","https://openalex.org/W2172142216","https://openalex.org/W2223661640","https://openalex.org/W2314477394","https://openalex.org/W2319962899","https://openalex.org/W2332575792","https://openalex.org/W2402021172","https://openalex.org/W2411092595","https://openalex.org/W2413004485","https://openalex.org/W2468433074","https://openalex.org/W2750896950"],"related_works":["https://openalex.org/W7019926803","https://openalex.org/W2320317513","https://openalex.org/W3088623310","https://openalex.org/W2165179185","https://openalex.org/W2006482335","https://openalex.org/W2062552623","https://openalex.org/W4283718250","https://openalex.org/W2790029974","https://openalex.org/W2138282644","https://openalex.org/W1978902916"],"abstract_inverted_index":{"MDM2":[0,12,21,32,55,74,95,124,144,170],"regulates":[1],"p53":[2,6,23,35,60,65,78,100,121,133,155],"predominantly":[3],"by":[4,123,153],"promoting":[5],"ubiquitination.":[7],"However,":[8],"ubiquitination-independent":[9,118],"mechanisms":[10],"of":[11,54,120],"have":[13],"also":[14,98],"been":[15],"implicated.":[16],"Here":[17],"we":[18,140],"show":[19,141],"that":[20,142],"inhibits":[22],"DNA":[24,66,84,156],"binding":[25,33,71,85,92,157],"activity":[26],"in":[27,30],"vitro":[28],"and":[29,63,82,104,125,136,158,169],"vivo.":[31],"promotes":[34],"to":[36,43,58,72,93,108,132],"adopt":[37],"a":[38,162],"mutant-like":[39],"conformation,":[40],"losing":[41],"reactivity":[42],"antibody":[44],"Pab1620,":[45],"while":[46],"exposing":[47],"the":[48,73,94,143,149],"Pab240":[49],"epitope.":[50],"The":[51],"acidic":[52,75,96],"domain":[53,76,97],"is":[56],"required":[57],"induce":[59],"conformational":[61],"change":[62],"inhibit":[64],"binding.":[67],"Alternate":[68],"reading":[69],"frame":[70],"restores":[77,99],"wild":[79,101],"type":[80,102],"conformation":[81,103],"rescues":[83],"activity.":[86],"Furthermore,":[87,139],"histone":[88],"methyl":[89],"transferase":[90],"SUV39H1":[91],"allows":[105],"p53-MDM2-SUV39H1":[106],"complex":[107],"bind":[109],"DNA.":[110],"These":[111],"results":[112],"provide":[113],"further":[114],"evidence":[115],"for":[116,164],"an":[117],"mechanism":[119],"regulation":[122],"reveal":[126],"how":[127],"MDM2-interacting":[128],"repressors":[129],"gain":[130],"access":[131],"target":[134],"promoters":[135],"repress":[137],"transcription.":[138],"inhibitor":[145,151],"Nutlin":[146],"cooperates":[147],"with":[148],"proteasome":[150,168],"Bortezomib":[152],"stimulating":[154],"transcriptional":[159],"activity,":[160],"providing":[161],"rationale":[163],"combination":[165],"therapy":[166],"using":[167],"inhibitors.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}