{"id":"https://openalex.org/W2010917826","doi":"https://doi.org/10.2196/resprot.4462","title":"Timing of High-Dose Rate Brachytherapy With External Beam Radiotherapy in Intermediate and High-Risk Localized Prostate CAncer (THEPCA) Patients and Its Effects on Toxicity and Quality of Life: Protocol of a Randomized Feasibility Trial","display_name":"Timing of High-Dose Rate Brachytherapy With External Beam Radiotherapy in Intermediate and High-Risk Localized Prostate CAncer (THEPCA) Patients and Its Effects on Toxicity and Quality of Life: Protocol of a Randomized Feasibility Trial","publication_year":2015,"publication_date":"2015-04-29","ids":{"openalex":"https://openalex.org/W2010917826","doi":"https://doi.org/10.2196/resprot.4462","mag":"2010917826","pmid":"https://pubmed.ncbi.nlm.nih.gov/25926023","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4430680"},"language":"en","primary_location":{"id":"doi:10.2196/resprot.4462","doi":"https://doi.org/10.2196/resprot.4462","is_oa":true,"landing_page_url":"https://doi.org/10.2196/resprot.4462","pdf_url":"https://www.researchprotocols.org/2015/2/e49/PDF","source":{"id":"https://openalex.org/S2739058702","display_name":"JMIR Research Protocols","issn_l":"1929-0748","issn":["1929-0748"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320608","host_organization_name":"JMIR Publications","host_organization_lineage":["https://openalex.org/P4310320608"],"host_organization_lineage_names":["JMIR Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Research Protocols","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.researchprotocols.org/2015/2/e49/PDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035372455","display_name":"Sreekanth Palvai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sreekanth Palvai","raw_affiliation_strings":["Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom","institution_ids":["https://openalex.org/I125671874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036211581","display_name":"Michael Harrison","orcid":"https://orcid.org/0000-0002-1163-6480","observed_orcids":["https://orcid.org/0000-0002-1163-6480"]},"institutions":[{"id":"https://openalex.org/I51216347","display_name":"Anglia Ruskin University","ror":"https://ror.org/0009t4v78","country_code":"GB","type":"education","lineage":["https://openalex.org/I51216347"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael Harrison","raw_affiliation_strings":["Anglia Ruskin - Clinical Trials Unit, Postgraduate Medical Institute, Anglia Ruskin University, Chelmsford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anglia Ruskin - Clinical Trials Unit, Postgraduate Medical Institute, Anglia Ruskin University, Chelmsford, United Kingdom","institution_ids":["https://openalex.org/I51216347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047114420","display_name":"Sharon Shibu Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sharon Shibu Thomas","raw_affiliation_strings":["Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom","institution_ids":["https://openalex.org/I125671874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080712512","display_name":"Karen E. Hayden","orcid":"https://orcid.org/0000-0003-4223-0659","observed_orcids":["https://orcid.org/0000-0003-4223-0659"]},"institutions":[{"id":"https://openalex.org/I51216347","display_name":"Anglia Ruskin University","ror":"https://ror.org/0009t4v78","country_code":"GB","type":"education","lineage":["https://openalex.org/I51216347"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen Hayden","raw_affiliation_strings":["Anglia Ruskin - Clinical Trials Unit, Postgraduate Medical Institute, Anglia Ruskin University, Chelmsford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anglia Ruskin - Clinical Trials Unit, Postgraduate Medical Institute, Anglia Ruskin University, Chelmsford, United Kingdom","institution_ids":["https://openalex.org/I51216347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100779590","display_name":"James S. A. Green","orcid":"https://orcid.org/0000-0003-4846-5192","observed_orcids":["https://orcid.org/0000-0003-4846-5192"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Green","raw_affiliation_strings":["Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom","institution_ids":["https://openalex.org/I125671874"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Oliver Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51216347","display_name":"Anglia Ruskin University","ror":"https://ror.org/0009t4v78","country_code":"GB","type":"education","lineage":["https://openalex.org/I51216347"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oliver Anderson","raw_affiliation_strings":["Anglia Ruskin - Clinical Trials Unit, Postgraduate Medical Institute, Anglia Ruskin University, Chelmsford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anglia Ruskin - Clinical Trials Unit, Postgraduate Medical Institute, Anglia Ruskin University, Chelmsford, United Kingdom","institution_ids":["https://openalex.org/I51216347"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072182090","display_name":"Lavinia Romero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lavinia Romero","raw_affiliation_strings":["Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom","institution_ids":["https://openalex.org/I125671874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060050025","display_name":"Richard Lodge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Lodge","raw_affiliation_strings":["Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom","institution_ids":["https://openalex.org/I125671874"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Patricia Burns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patricia Burns","raw_affiliation_strings":["Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom","institution_ids":["https://openalex.org/I125671874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101475991","display_name":"Imtiaz Ahmed","orcid":"https://orcid.org/0000-0001-8020-0069","observed_orcids":["https://orcid.org/0000-0001-8020-0069"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Imtiaz Ahmed","raw_affiliation_strings":["Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southend University Hospital National Health Service Foundation Trust, National Health Service, Essex, United Kingdom","institution_ids":["https://openalex.org/I125671874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101475991"],"corresponding_institution_ids":["https://openalex.org/I125671874"],"apc_list":{"value":1900,"currency":"USD","value_usd":1900},"apc_paid":{"value":1900,"currency":"USD","value_usd":1900},"fwci":0.2983,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.5953847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"4","issue":"2","first_page":"e49","last_page":"e49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/localized-prostate-cancer","display_name":"localized prostate cancer","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hdr-brachytherapy","display_name":"high-dose-rate brachytherapy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/treatment-sequencing","display_name":"treatment sequencing","score":0.7570000290870667},{"id":"https://openalex.org/keywords/genitourinary-toxicity","display_name":"genitourinary toxicity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":1.0},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7400000095367432},{"id":"https://openalex.org/keywords/intermediate-and-high-risk-prostate-cancer","display_name":"intermediate- and high-risk prostate cancer","score":0.859000027179718},{"id":"https://openalex.org/keywords/prostate-specific-antigen-recurrence","display_name":"prostate-specific antigen recurrence","score":0.6060000061988831},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7689999938011169},{"id":"https://openalex.org/keywords/feasibility-trial","display_name":"feasibility trial","score":0.6859999895095825},{"id":"https://openalex.org/keywords/acute-and-late-toxicity","display_name":"acute and late toxicity","score":0.47200000286102295},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.3179999887943268}],"concepts":[{"id":"https://openalex.org/C2777416452","wikidata":"https://www.wikidata.org/wiki/Q896687","display_name":"Brachytherapy","level":3,"score":0.899719774723053},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8253973722457886},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7709144353866577},{"id":"https://openalex.org/C2775908122","wikidata":"https://www.wikidata.org/wiki/Q3070621","display_name":"External beam radiotherapy","level":4,"score":0.7693490982055664},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7064505815505981},{"id":"https://openalex.org/C133507102","wikidata":"https://www.wikidata.org/wiki/Q4712977","display_name":"Genitourinary system","level":2,"score":0.5261489748954773},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5100348591804504},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45116499066352844},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4233860969543457},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4151570200920105},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36693882942199707},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3457731008529663},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.259221613407135}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.2196/resprot.4462","doi":"https://doi.org/10.2196/resprot.4462","is_oa":true,"landing_page_url":"https://doi.org/10.2196/resprot.4462","pdf_url":"https://www.researchprotocols.org/2015/2/e49/PDF","source":{"id":"https://openalex.org/S2739058702","display_name":"JMIR Research Protocols","issn_l":"1929-0748","issn":["1929-0748"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320608","host_organization_name":"JMIR Publications","host_organization_lineage":["https://openalex.org/P4310320608"],"host_organization_lineage_names":["JMIR Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Research Protocols","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3405307","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4430680","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25926023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25926023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR research protocols","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4430680","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4430680/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Res Protoc","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2196/resprot.4462","doi":"https://doi.org/10.2196/resprot.4462","is_oa":true,"landing_page_url":"https://doi.org/10.2196/resprot.4462","pdf_url":"https://www.researchprotocols.org/2015/2/e49/PDF","source":{"id":"https://openalex.org/S2739058702","display_name":"JMIR Research Protocols","issn_l":"1929-0748","issn":["1929-0748"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320608","host_organization_name":"JMIR Publications","host_organization_lineage":["https://openalex.org/P4310320608"],"host_organization_lineage_names":["JMIR Publications"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JMIR Research Protocols","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010917826.pdf","grobid_xml":"https://content.openalex.org/works/W2010917826.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1993681878","https://openalex.org/W2014233043","https://openalex.org/W2024413350","https://openalex.org/W2041203398","https://openalex.org/W2047608066","https://openalex.org/W2056643793","https://openalex.org/W2062313368","https://openalex.org/W2097532477","https://openalex.org/W2130514725","https://openalex.org/W2135238404","https://openalex.org/W2152182740","https://openalex.org/W2274851081"],"related_works":["https://openalex.org/W3135099534","https://openalex.org/W4390457477","https://openalex.org/W7034290372","https://openalex.org/W2551999381","https://openalex.org/W2146085853","https://openalex.org/W4251101708","https://openalex.org/W1948738671","https://openalex.org/W1995180099","https://openalex.org/W2590540865","https://openalex.org/W4414557419"],"abstract_inverted_index":{"BACKGROUND:":[0],"Prostate":[1,169],"cancer":[2,7,30,64,205],"is":[3,65,83,146,172],"the":[4,11,26,34,55,66,87,120,140,158,222,232,243,249,297,342,351,358],"most":[5],"common":[6],"in":[8,10,25,40,99,118,142,168,180,228,245,338],"males":[9],"UK":[12],"and":[13,49,70,73,94,129,184,198,224,240,284,296,310,325],"affects":[14],"around":[15],"105":[16],"men":[17],"for":[18],"every":[19],"100,000.":[20],"The":[21,76,96,287],"role":[22],"of":[23,28,54,58,61,68,89,122,126,163,191,203,213,221,231,282,305,327,353],"radiotherapy":[24,44,47,51,59],"management":[27],"prostate":[29,63,187,204],"significantly":[31],"changed":[32],"over":[33,199],"last":[35],"few":[36],"decades":[37],"with":[38,166,182,200,237],"developments":[39],"brachytherapy,":[41],"external":[42],"beam":[43],"(EBRT),":[45],"intensity-modulated":[46],"(IMRT),":[48],"image-guided":[50],"(IGRT).":[52],"One":[53],"challenging":[56],"factors":[57],"treatment":[60,144,215,354],"localized":[62,186],"development":[67],"acute":[69,127],"late":[71],"genitourinary":[72,128,283,294,306],"gastrointestinal":[74,130,285,312],"toxicities.":[75,286],"recent":[77],"European":[78],"guidelines":[79],"suggest":[80],"that":[81,350],"there":[82],"no":[84],"consensus":[85],"regarding":[86],"timing":[88],"high-dose":[90],"rate":[91],"(HDR)":[92],"brachytherapy":[93,150,165,239,260],"EBRT.":[95,113,123,262],"schedules":[97],"vary":[98],"different":[100],"institutions":[101],"where":[102],"an":[103,155],"HDR":[104,117,149,164,238,259,273],"boost":[105],"can":[106],"be":[107,209,235,291,301,336,365],"given":[108],"either":[109],"before":[110,261,272],"or":[111,151],"after":[112],"Few":[114],"centers":[115],"deliver":[116],"between":[119],"fractions":[121],"OBJECTIVE:":[124],"Assessment":[125],"toxicities":[131,307,313],"at":[132,279,389],"various":[133],"time":[134],"points":[135],"to":[136,211,316,367],"better":[137],"understand":[138],"if":[139],"order":[141,244],"which":[143,246],"modality":[145,355],"delivered":[147],"(ie,":[148],"EBRT":[152,167,271],"first)":[153],"has":[154],"effect":[156],"on":[157],"toxicity":[159,295,360],"profile.":[160],"METHODS:":[161],"Timing":[162],"CAncer":[170],"(THEPCA)":[171],"a":[173,369],"single-center,":[174],"open,":[175],"randomized":[176,210,372],"controlled":[177,373],"feasibility":[178,333,346],"trial":[179,334,347],"patients":[181,193,256,268],"intermediate":[183],"high-risk":[185],"cancer.":[188],"A":[189],"group":[190],"50":[192],"aged":[194],"18":[195],"years":[196],"old":[197],"histological":[201],"diagnosis":[202],"(stages":[206],"T1b-T3BNOMO),":[207],"will":[208,234,251,257,269,277,290,300,335],"one":[212],"two":[214],"arms":[216,230],"(ratio":[217],"1:1),":[218],"following":[219],"explanation":[220],"study":[223,233],"informed":[225],"consent.":[226],"Patients":[227],"both":[229],"treated":[236],"EBRT,":[241],"however,":[242],"they":[247],"receive":[248,258,270],"treatments":[250],"vary.":[252],"In":[253,263],"Arm":[254,264],"A,":[255],"B":[265],"(control":[266],"arm),":[267],"brachytherapy.":[274],"Study":[275],"outcomes":[276],"look":[278],"prospective":[280],"assessment":[281],"primary":[288],"endpoint":[289],"grade":[292],"3":[293],"secondary":[298],"endpoints":[299],"all":[302],"other":[303],"grades":[304],"(grades":[308,314],"1":[309,315],"2),":[311],"4),":[317],"prostate-specific":[318],"antigen":[319],"(PSA)":[320],"recurrence-free":[321],"survival,":[322,324],"overall":[323],"quality":[326],"life.":[328],"RESULTS:":[329],"Results":[330],"from":[331,344],"this":[332,345],"available":[337],"mid-2016.":[339],"CONCLUSIONS:":[340],"If":[341],"results":[343],"show":[348],"evidence":[349],"sequence":[352],"does":[356],"affect":[357],"patients'":[359],"profiles,":[361],"then":[362],"funding":[363],"would":[364],"sought":[366],"conduct":[368],"large,":[370],"multicenter,":[371],"trial.":[374],"TRIAL":[375],"REGISTRATION:":[376],"International":[377],"Standard":[378],"Randomized":[379],"Controlled":[380],"Trial":[381],"Number":[382],"(ISRCTN):":[383],"15835424;":[384],"http://www.isrctn.com/ISRCTN15835424":[385],"(Archived":[386],"by":[387],"WebCite":[388],"http://www.webcitation.org/6Xz7jfg1u).":[390]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
