{"id":"https://openalex.org/W2010914745","doi":"https://doi.org/10.1055/s-0028-1086639","title":"Delay and reduction of glial scar formation after spinal cord injury by systemic cyclooxygenase blockade","display_name":"Delay and reduction of glial scar formation after spinal cord injury by systemic cyclooxygenase blockade","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2010914745","doi":"https://doi.org/10.1055/s-0028-1086639","mag":"2010914745"},"language":"en","primary_location":{"id":"doi:10.1055/s-0028-1086639","doi":"https://doi.org/10.1055/s-0028-1086639","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0028-1086639","pdf_url":null,"source":{"id":"https://openalex.org/S48308836","display_name":"Aktuelle Neurologie","issn_l":"0302-4350","issn":["0302-4350","1438-9428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aktuelle Neurologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063660131","display_name":"Jan Markus Schwab","orcid":"https://orcid.org/0000-0001-6784-4919","observed_orcids":["https://orcid.org/0000-0001-6784-4919"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J.M Schwab","raw_affiliation_strings":["Berlin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berlin","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5063660131"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13848127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"35","issue":"S 01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.8510000109672546},{"id":"https://openalex.org/keywords/glial-scar","display_name":"glial scar","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.9570000171661377},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/reactive-astrogliosis","display_name":"reactive astrogliosis","score":0.8960000276565552},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.9190000295639038},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cox-1","display_name":"cyclooxygenase-1","score":0.7940000295639038},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.734000027179718},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5920000076293945},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.8982294797897339},{"id":"https://openalex.org/C2777594495","wikidata":"https://www.wikidata.org/wiki/Q5569540","display_name":"Glial scar","level":4,"score":0.8239818215370178},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6985186338424683},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6104977130889893},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6026406288146973},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5537508726119995},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.530756950378418},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.4971676170825958},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.4940343499183655},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4586939215660095},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.45715874433517456},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.32497891783714294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2773873507976532},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2659132480621338},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2611958384513855},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.24521103501319885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.062344253063201904},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0028-1086639","doi":"https://doi.org/10.1055/s-0028-1086639","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0028-1086639","pdf_url":null,"source":{"id":"https://openalex.org/S48308836","display_name":"Aktuelle Neurologie","issn_l":"0302-4350","issn":["0302-4350","1438-9428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aktuelle Neurologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2047184935","https://openalex.org/W2003454030","https://openalex.org/W2053985129","https://openalex.org/W2328475596","https://openalex.org/W2555876929","https://openalex.org/W2029533654","https://openalex.org/W1514189323","https://openalex.org/W1981554128","https://openalex.org/W2094992458","https://openalex.org/W2018677347"],"abstract_inverted_index":{"Disturbances":[0],"in":[1,18,45,66,73],"microcirculating":[2],"and":[3,33,81,129,141,154],"inflammation":[4],"promotes":[5],"glial":[6,50],"scar":[7,51,90,157],"formation":[8,52,158],"after":[9,159],"spinal":[10,63,160],"cord":[11,64,161],"injury.":[12],"Cyclooxygenases":[13],"(COX)":[14],"are":[15],"key":[16],"enzymes":[17],"the":[19,37,104,176],"conversion":[20],"of":[21,39,78,89,98,124,143,156],"arachidonic":[22],"acid":[23],"into":[24],"prostanoids":[25],"which":[26],"mediate":[27],"immunomodulation,":[28],"mitogenesis,":[29],"apoptosis,":[30],"blood":[31],"flow":[32],"inflammation.":[34],"We":[35],"investigated":[36],"impact":[38],"CNS":[40,167],"effective":[41,168],"COX":[42,169],"pathway":[43],"inhibition":[44,69],"(Indomethacin,":[46],"2mg/kg/d,":[47],"i.p.)":[48],"on":[49],"(reactive":[53],"astrogliosis,":[54],"extracellular":[55],"matrix":[56],"(ECM)":[57],"deposition)":[58],"by":[59,151,163],"immunohistochemistry":[60],"following":[61],"experimental":[62],"injury":[65,162],"rat.":[67],"Pan-COX":[68],"(COX-1,":[70],"COX-2)":[71],"resulted":[72],"significantly":[74,94,148],"(p<0.0001)":[75,95,149],"reduced":[76,96],"numbers":[77,97],"lesional":[79,125,139],"COX-1+":[80],"COX-2+":[82],"cells.":[83],"Already":[84],"at":[85,103,135],"day":[86,114,136],"3":[87],"(onset":[88],"formation),":[91],"Indomethacin":[92],"treatment":[93],"activated":[99],"vimentin+,":[100],"GFAP+":[101],"astrocytes":[102,132],"lesion":[105],"site":[106],"(16\u201cb1.1)":[107],"as":[108,171],"compared":[109],"to":[110,174],"controls":[111],"(32\u201cb2.3).":[112],"At":[113],"14":[115],"(mature":[116],"scar),":[117],"we":[118],"observed":[119],"a":[120],"persistent":[121],"decreased":[122],"number":[123],"reactive":[126],"vimentin+/GFAP+":[127],"(60%)":[128],"nestin+/GFAP+":[130],"(71%)":[131],"(p<0.0001).":[133],"Furthermore,":[134],"14,":[137],"average":[138],"length":[140],"width":[142],"fibronectin+":[144],"ECM":[145],"deposition":[146],"was":[147],"diminished":[150],"50%.":[152],"Delay":[153],"reduction":[155],"cyclooxygenase":[164],"blockade":[165],"suggests":[166],"blockers":[170],"adjuvant":[172],"candidates":[173],"prolong":[175],"therapeutic":[177],"time":[178],"frame":[179],"for":[180],"neuro-regenerative":[181],"approaches/agents.":[182]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}