{"id":"https://openalex.org/W2010902079","doi":"https://doi.org/10.1016/j.yrtph.2012.03.004","title":"Assessment of diurnal systemic dose of agrochemicals in regulatory toxicity testing \u2013 An integrated approach without additional animal use","display_name":"Assessment of diurnal systemic dose of agrochemicals in regulatory toxicity testing \u2013 An integrated approach without additional animal use","publication_year":2012,"publication_date":"2012-03-16","ids":{"openalex":"https://openalex.org/W2010902079","doi":"https://doi.org/10.1016/j.yrtph.2012.03.004","mag":"2010902079","pmid":"https://pubmed.ncbi.nlm.nih.gov/22440553"},"language":"en","primary_location":{"id":"doi:10.1016/j.yrtph.2012.03.004","doi":"https://doi.org/10.1016/j.yrtph.2012.03.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2012.03.004","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025473377","display_name":"Shakil Ahmed Saghir","orcid":"https://orcid.org/0000-0002-9929-1981","observed_orcids":["https://orcid.org/0000-0002-9929-1981"]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shakil A. Saghir","raw_affiliation_strings":["The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI 48674, USA. ssaghir@dow.com","The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI 48674, USA. ssaghir@dow.com","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113668123","display_name":"Michael J. Bartels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Bartels","raw_affiliation_strings":["The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000546472","display_name":"David L. Rick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Rick","raw_affiliation_strings":["The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058045163","display_name":"Alene T. McCoy","orcid":"https://orcid.org/0000-0001-7721-6123","observed_orcids":["https://orcid.org/0000-0001-7721-6123"]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alene T. McCoy","raw_affiliation_strings":["The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046965017","display_name":"Reza J. Rasoulpour","orcid":"https://orcid.org/0000-0003-0247-0105","observed_orcids":["https://orcid.org/0000-0003-0247-0105"]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reza J. Rasoulpour","raw_affiliation_strings":["The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111879697","display_name":"Robert G. Ellis\u2010Hutchings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Ellis-Hutchings","raw_affiliation_strings":["The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072531528","display_name":"Mary Sue Marty","orcid":"https://orcid.org/0000-0002-5404-8515","observed_orcids":["https://orcid.org/0000-0002-5404-8515"]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Sue Marty","raw_affiliation_strings":["The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090645239","display_name":"Claire Terry","orcid":"https://orcid.org/0000-0003-0421-8309","observed_orcids":["https://orcid.org/0000-0003-0421-8309"]},"institutions":[{"id":"https://openalex.org/I4387152393","display_name":"Dow Agrosciences (United Kingdom)","ror":"https://ror.org/033x3yk48","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210111170","https://openalex.org/I4210133143","https://openalex.org/I4387152393"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Terry","raw_affiliation_strings":["Dow AgroSciences, LLC, Milton Park, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow AgroSciences, LLC, Milton Park, UK","institution_ids":["https://openalex.org/I4387152393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075582649","display_name":"Jason P. Bailey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason P. Bailey","raw_affiliation_strings":["Dow AgroSciences, LLC, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow AgroSciences, LLC, Indianapolis, IN, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006710775","display_name":"Richard Billington","orcid":"https://orcid.org/0000-0001-7288-8916","observed_orcids":["https://orcid.org/0000-0001-7288-8916"]},"institutions":[{"id":"https://openalex.org/I4387152393","display_name":"Dow Agrosciences (United Kingdom)","ror":"https://ror.org/033x3yk48","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210111170","https://openalex.org/I4210133143","https://openalex.org/I4387152393"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Billington","raw_affiliation_strings":["Dow AgroSciences, LLC, Milton Park, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dow AgroSciences, LLC, Milton Park, UK","institution_ids":["https://openalex.org/I4387152393"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065907492","display_name":"James S. Bus","orcid":"https://orcid.org/0000-0002-1420-4384","observed_orcids":["https://orcid.org/0000-0002-1420-4384"]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James S. Bus","raw_affiliation_strings":["The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Toxicology & Environmental Research and Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]},{"raw_affiliation_string":"The Dow Chemical Company, Toxicology and Environmental Research & Consulting, Midland, MI, USA","institution_ids":["https://openalex.org/I4210133143"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5025473377"],"corresponding_institution_ids":["https://openalex.org/I4210133143"],"apc_list":{"value":4210,"currency":"USD","value_usd":4210},"apc_paid":null,"fwci":5.2682,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.94808762,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"63","issue":"2","first_page":"321","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":0.8413000106811523,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.041200000792741776,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agrochemicals","display_name":"agrochemicals","score":0.8970000147819519},{"id":"https://openalex.org/keywords/dose-selection","display_name":"dose selection","score":0.5130000114440918},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.7699999809265137},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.6039999723434448},{"id":"https://openalex.org/keywords/reproductive-toxicity","display_name":"reproductive toxicity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/2-4-d","display_name":"2,4-D","score":0.8629999756813049},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.593999981880188},{"id":"https://openalex.org/keywords/human-risk-assessment","display_name":"human risk assessment","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7181345820426941},{"id":"https://openalex.org/C207581243","wikidata":"https://www.wikidata.org/wiki/Q2746959","display_name":"Agrochemical","level":3,"score":0.6159021854400635},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.5597248673439026},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.5003726482391357},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48529499769210815},{"id":"https://openalex.org/C179335377","wikidata":"https://www.wikidata.org/wiki/Q5266825","display_name":"Developmental toxicity","level":4,"score":0.4421662390232086},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.4301300644874573},{"id":"https://openalex.org/C2777495288","wikidata":"https://www.wikidata.org/wiki/Q1755926","display_name":"No-observed-adverse-effect level","level":3,"score":0.42673683166503906},{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.4236447811126709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38957148790359497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.327323853969574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14714336395263672},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09583193063735962},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09513062238693237},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C118518473","wikidata":"https://www.wikidata.org/wiki/Q11451","display_name":"Agriculture","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016573","descriptor_name":"Agrochemicals","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016573","descriptor_name":"Agrochemicals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D016573","descriptor_name":"Agrochemicals","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017408","descriptor_name":"Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020714","descriptor_name":"Maximum Tolerated Dose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023401","descriptor_name":"Animal Use Alternatives","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D023401","descriptor_name":"Animal Use Alternatives","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.yrtph.2012.03.004","doi":"https://doi.org/10.1016/j.yrtph.2012.03.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.yrtph.2012.03.004","pdf_url":null,"source":{"id":"https://openalex.org/S87719511","display_name":"Regulatory Toxicology and Pharmacology","issn_l":"0273-2300","issn":["0273-2300","1096-0295"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:22440553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22440553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regulatory toxicology and pharmacology : RTP","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5365999937057495}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W99970865","https://openalex.org/W1483263499","https://openalex.org/W1966174785","https://openalex.org/W1982026267","https://openalex.org/W1986750010","https://openalex.org/W1991029540","https://openalex.org/W2010006276","https://openalex.org/W2017300930","https://openalex.org/W2018910398","https://openalex.org/W2045363877","https://openalex.org/W2046114394","https://openalex.org/W2063909696","https://openalex.org/W2075805572","https://openalex.org/W2120914195","https://openalex.org/W2122946550","https://openalex.org/W2126230571","https://openalex.org/W2128464247","https://openalex.org/W2137367013","https://openalex.org/W2138786323","https://openalex.org/W2146976723","https://openalex.org/W2168864272","https://openalex.org/W2170847288","https://openalex.org/W2488748284","https://openalex.org/W4229791719","https://openalex.org/W4256036191"],"related_works":["https://openalex.org/W2191126535","https://openalex.org/W2159399841","https://openalex.org/W7135101766","https://openalex.org/W1991029540","https://openalex.org/W4210967530","https://openalex.org/W7151367959","https://openalex.org/W2105263575","https://openalex.org/W2030740188","https://openalex.org/W815969226","https://openalex.org/W2532082818"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2016-06-24T00:00:00"}
