{"id":"https://openalex.org/W2010900536","doi":"https://doi.org/10.7197/cmj.v36i2.5000033144","title":"Investigation of the effects of drugs effective on PI3K-AKT signaling pathway in colorectal cancer alone and in combination","display_name":"Investigation of the effects of drugs effective on PI3K-AKT signaling pathway in colorectal cancer alone and in combination","publication_year":2014,"publication_date":"2014-06-16","ids":{"openalex":"https://openalex.org/W2010900536","doi":"https://doi.org/10.7197/cmj.v36i2.5000033144","mag":"2010900536"},"language":"en","primary_location":{"id":"doi:10.7197/cmj.v36i2.5000033144","doi":"https://doi.org/10.7197/cmj.v36i2.5000033144","is_oa":false,"landing_page_url":"https://doi.org/10.7197/cmj.v36i2.5000033144","pdf_url":null,"source":{"id":"https://openalex.org/S2765044717","display_name":"Cumhuriyet T\u0131p Dergisi/Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi dergisi","issn_l":"1300-1957","issn":["1300-1957","1305-0028"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cumhuriyet Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000600498","display_name":"Tijen Kaya Temiz","orcid":"https://orcid.org/0000-0002-0069-6576","observed_orcids":["https://orcid.org/0000-0002-0069-6576"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]},{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tijen Kaya Temiz","raw_affiliation_strings":["Cumhuriyet University School of Medicine, TR-58140 Sivas","Department of Pharmacology (Prof","Farmokoloji Anabilim Dal\u0131, Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi, TR-58140 Sivas","\u0130zmir Katip \u00c7elebi University School of Medicine, TR-35620 \u0130zmir. Department of Pharmacology (Assist"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cumhuriyet University School of Medicine, TR-58140 Sivas","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Department of Pharmacology (Prof","institution_ids":[]},{"raw_affiliation_string":"Farmokoloji Anabilim Dal\u0131, Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi, TR-58140 Sivas","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"\u0130zmir Katip \u00c7elebi University School of Medicine, TR-35620 \u0130zmir. Department of Pharmacology (Assist","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045144310","display_name":"Ahmet Altun","orcid":"https://orcid.org/0000-0003-2056-8683","observed_orcids":["https://orcid.org/0000-0003-2056-8683"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]},{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ahmet Altun","raw_affiliation_strings":["Cumhuriyet University School of Medicine, TR-58140 Sivas","Department of Pharmacology (Prof","Farmokoloji Anabilim Dal\u0131, Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi, TR-58140 Sivas","\u0130zmir Katip \u00c7elebi University School of Medicine, TR-35620 \u0130zmir. Department of Pharmacology (Assist"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cumhuriyet University School of Medicine, TR-58140 Sivas","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Department of Pharmacology (Prof","institution_ids":[]},{"raw_affiliation_string":"Farmokoloji Anabilim Dal\u0131, Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi, TR-58140 Sivas","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"\u0130zmir Katip \u00c7elebi University School of Medicine, TR-35620 \u0130zmir. Department of Pharmacology (Assist","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102716154","display_name":"Nergiz Hacer Turgut","orcid":"https://orcid.org/0000-0003-1700-2451","observed_orcids":["https://orcid.org/0000-0003-1700-2451"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]},{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Nergiz Hacer Turgut","raw_affiliation_strings":["Cumhuriyet University School of Medicine, TR-58140 Sivas","Department of Pharmacology (Prof","Farmokoloji Anabilim Dal\u0131, Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi, TR-58140 Sivas","\u0130zmir Katip \u00c7elebi University School of Medicine, TR-35620 \u0130zmir. Department of Pharmacology (Assist"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cumhuriyet University School of Medicine, TR-58140 Sivas","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Department of Pharmacology (Prof","institution_ids":[]},{"raw_affiliation_string":"Farmokoloji Anabilim Dal\u0131, Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi, TR-58140 Sivas","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"\u0130zmir Katip \u00c7elebi University School of Medicine, TR-35620 \u0130zmir. Department of Pharmacology (Assist","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112765896","display_name":"Ezgi Balc\u0131","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]},{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ezgi Balc\u0131","raw_affiliation_strings":["Cumhuriyet University School of Medicine, TR-58140 Sivas","Department of Pharmacology (Prof","Farmokoloji Anabilim Dal\u0131, Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi, TR-58140 Sivas","\u0130zmir Katip \u00c7elebi University School of Medicine, TR-35620 \u0130zmir. Department of Pharmacology (Assist"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cumhuriyet University School of Medicine, TR-58140 Sivas","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Department of Pharmacology (Prof","institution_ids":[]},{"raw_affiliation_string":"Farmokoloji Anabilim Dal\u0131, Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi, TR-58140 Sivas","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"\u0130zmir Katip \u00c7elebi University School of Medicine, TR-35620 \u0130zmir. Department of Pharmacology (Assist","institution_ids":["https://openalex.org/I250383648"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102716154"],"corresponding_institution_ids":["https://openalex.org/I12700597","https://openalex.org/I250383648"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"36","issue":"2","first_page":"167","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9779999852180481},{"id":"https://openalex.org/keywords/pp242","display_name":"PP242","score":0.9629999995231628},{"id":"https://openalex.org/keywords/dual-pi3k-mtor-inhibitor","display_name":"PI3K/mTOR dual inhibitor","score":0.7450000047683716},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5669999718666077},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dld-1-cells","display_name":"DLD-1 cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.4309999942779541},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8817731142044067},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7603765726089478},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.652662456035614},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6230429410934448},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5613672137260437},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5175892114639282},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5109735727310181},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46035027503967285},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4471924602985382},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43352940678596497},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4105476438999176},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32726335525512695},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3148338198661804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2710598409175873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25038331747055054},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14074069261550903},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06438973546028137}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.7197/cmj.v36i2.5000033144","doi":"https://doi.org/10.7197/cmj.v36i2.5000033144","is_oa":false,"landing_page_url":"https://doi.org/10.7197/cmj.v36i2.5000033144","pdf_url":null,"source":{"id":"https://openalex.org/S2765044717","display_name":"Cumhuriyet T\u0131p Dergisi/Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi dergisi","issn_l":"1300-1957","issn":["1300-1957","1305-0028"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cumhuriyet Medical Journal","raw_type":"journal-article"},{"id":"doi:10.7197/1305-0028.33144","doi":"https://doi.org/10.7197/1305-0028.33144","is_oa":false,"landing_page_url":"http://doi.org/10.7197/1305-0028.33144","pdf_url":null,"source":{"id":"https://openalex.org/S2765044717","display_name":"Cumhuriyet T\u0131p Dergisi/Cumhuriyet \u00dcniversitesi T\u0131p Fak\u00fcltesi dergisi","issn_l":"1300-1957","issn":["1300-1957","1305-0028"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cumhuriyet Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.gov.tr:article/56413","doi":null,"is_oa":false,"landing_page_url":"http://dergipark.gov.tr/223/issue/4230/56413","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\\n Volume: 36, Issue: 2\\n 167-177\\n \\n","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dergipark.org.tr:article/56413","doi":null,"is_oa":false,"landing_page_url":"https://dergipark.org.tr/tr/pub/cmj/issue/4230/56413","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W96531724","https://openalex.org/W1997813173","https://openalex.org/W1999429403","https://openalex.org/W2006303853","https://openalex.org/W2034320618","https://openalex.org/W2050926816","https://openalex.org/W2053206500","https://openalex.org/W2055614052","https://openalex.org/W2056183265","https://openalex.org/W2058645214","https://openalex.org/W2060942394","https://openalex.org/W2061745177","https://openalex.org/W2061918668","https://openalex.org/W2065887259","https://openalex.org/W2069453842","https://openalex.org/W2070732456","https://openalex.org/W2080100938","https://openalex.org/W2093531978","https://openalex.org/W2093579930","https://openalex.org/W2094709780","https://openalex.org/W2111101616","https://openalex.org/W2113931660","https://openalex.org/W2119581553","https://openalex.org/W2119999174","https://openalex.org/W2133475958","https://openalex.org/W2166336604","https://openalex.org/W2320907931"],"related_works":["https://openalex.org/W2578248437","https://openalex.org/W4300295558","https://openalex.org/W2346515569","https://openalex.org/W1973870621","https://openalex.org/W1992894966","https://openalex.org/W2326082736","https://openalex.org/W2020016981","https://openalex.org/W2591449775","https://openalex.org/W3008402902","https://openalex.org/W2756187670"],"abstract_inverted_index":{"AbstractAim.":[0],"This":[1,157],"study":[2,158],"was":[3,96,107],"designed":[4],"to":[5,45,85,109,153,201],"determine":[6,110],"the":[7,18,26,80,111,114,122,132,141,147,188],"agent":[8,11,176],"and/or":[9],"possible":[10],"combinations":[12,148],"that":[13,160],"may":[14],"be":[15,183,199],"effective":[16],"in":[17,50,116],"treatment":[19,172],"of":[20,32,53,113,146,167],"colorectal":[21,54,90,99,117],"cancer.":[22,91],"For":[23],"this":[24,74],"reason":[25],"single":[27,175],"and":[28,37,63,77,136,180],"combined":[29,168],"antiproliferative":[30,66,87],"effects":[31,67,81,112],"NVPBEZ-235,":[33,61,208,243,262,315,392],"API-1,":[34,209,244,393],"LY":[35,210,245,283,394],"294002":[36,246,284],"PP242":[38,64,212,396],"which":[39,68],"target":[40],"PI3K/AKT":[41,162,191,206,390],"pathway":[42,163,192],"well":[43],"known":[44,84],"have":[46,65,69,86],"an":[47],"important":[48],"role":[49],"pathophysiological":[51],"mechanisms":[52],"cancer":[55,75],"were":[56,124,149],"investigated.":[57],"We":[58],"investigated":[59],"whether":[60],"API-1":[62,263],"not":[70,150],"been":[71],"studied":[72],"on":[73,89],"type":[76],"also":[78],"compared":[79,152],"with":[82,173],"LY294002":[83,139,327],"effect":[88,135],"Method.":[92],"DLD-1":[93,288],"cell":[94,103,118],"line":[95],"used":[97,108],"as":[98],"cells.":[100],"Real":[101],"time":[102],"analysis":[104],"(xCELLigence":[105],"system)":[106],"agents":[115,123,189],"proliferation.":[119],"Results.":[120],"When":[121],"applied":[125],"alone,":[126],"PI3K/mTOR":[127,317],"dual":[128,316],"inhibitor":[129,138],"NVP-BEZ":[130,194,319,377],"had":[131,140],"strongest":[133],"cytotoxic":[134,143],"PI3K":[137,325],"lowest":[142],"effect.":[144],"None":[145],"superior":[151],"alone":[154],"applications.":[155],"Conclusion.":[156],"indicates":[159],"when":[161],"is":[164],"targeted,":[165],"instead":[166],"treatment,":[169],"targeted":[170,196],"specific":[171],"a":[174],"having":[177],"higher":[178],"affinity":[179],"effectiveness":[181],"would":[182],"more":[184],"appropriate.":[185],"Also":[186],"among":[187],"effecting":[190],"especially,":[193],"for":[195],"therapy":[197],"can":[198],"alternative":[200],"conventional":[202],"treatments.Keywords:":[203],"Colorectal":[204],"cancer,":[205],"pathway,":[207],"294002,":[211,395],"\u00d6zetAma\u00e7.":[213],"Bu":[214,228,343],"\u00e7al\u0131\u015fma":[215,344],"kolorektal":[216,230,274,291,301],"kanser":[217,259,275],"tedavisinde":[218],"etkili":[219],"madde":[220,223,360],"ve/veya":[221],"olas\u0131":[222],"kombinasyonlar\u0131n\u0131":[224],"belirlemek":[225,306],"i\u00e7in":[226,307,383],"tasarlanm\u0131\u015ft\u0131r.":[227],"nedenle":[229],"kanserin":[231],"patofizyolojik":[232],"mekanizmalar\u0131nda":[233],"\u00f6nemli":[234],"bir":[235,278,359,384],"rol":[236],"oynad\u0131\u011f\u0131":[237],"bilinen":[238,282],"PI3K/Akt":[239,345,372],"yola\u011f\u0131n\u0131":[240,373],"hedef":[241,347],"alan":[242],"ve":[247,250,264,324,355],"PP242\u2019nin":[248,265],"tek":[249,311,334,358],"kombinasyon":[251],"halinde":[252],"anti-proliferatif":[253,266,277],"etkileri":[254,273],"ara\u015ft\u0131r\u0131ld\u0131.":[255,270],"Daha":[256],"\u00f6nce":[257],"bu":[258,272],"tipinde":[260],"\u00e7al\u0131\u015f\u0131lmayan":[261],"etkilerinin":[267],"olup":[268],"olmad\u0131\u011f\u0131":[269],"Ayr\u0131ca":[271,370],"\u00fczerinde":[276],"etkiye":[279,323],"sahip":[280],"oldu\u011fu":[281],"ile":[285,337,361],"kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131.":[286],"Y\u00f6ntem.":[287],"h\u00fccre":[289,292,297,302],"hatt\u0131":[290],"olarak":[293],"kullan\u0131ld\u0131.":[294,308],"Ger\u00e7ek":[295],"zamanl\u0131":[296],"analizi":[298],"(XCELLigence":[299],"sistemi)":[300],"\u00e7o\u011falmas\u0131nda":[303],"ajanlar\u0131n":[304],"etkilerini":[305],"Bulgular.":[309],"Maddeler":[310],"ba\u015f\u0131na":[312,335],"uyguland\u0131\u011f\u0131":[313],"zaman":[314],"inhibit\u00f6r\u00fc":[318,326],"en":[320,328],"g\u00fc\u00e7l\u00fc":[321],"sitotoksik":[322],"d\u00fc\u015f\u00fck":[329],"sitotoksisiteye":[330],"sahipti.":[331],"Kombinasyonlar\u0131n":[332],"hi\u00e7biri,":[333],"uygulamalar\u0131":[336],"kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda":[338],"daha":[339,352,366],"\u00fcst\u00fcn":[340],"de\u011fildi.":[341],"Sonu\u00e7.":[342],"yola\u011f\u0131":[346],"al\u0131nd\u0131\u011f\u0131nda,":[348],"kombine":[349],"tedavi":[350],"yerine":[351],"y\u00fcksek":[353],"afinitesi":[354],"etkinli\u011fi":[356],"olan":[357],"hedefe":[362,378],"y\u00f6nelik":[363,379],"spesifik":[364],"tedavinin":[365],"uygun":[367],"olaca\u011f\u0131n\u0131":[368],"g\u00f6stermektedir.":[369],"\u00f6zellikle":[371],"etkileyen":[374],"maddeler":[375],"aras\u0131nda":[376],"tedavide":[380],"geleneksel":[381],"tedaviler":[382],"alternatif":[385],"olabilir.Anahtar":[386],"s\u00f6zc\u00fckler:":[387],"Kolorektal":[388],"kanser,":[389],"yola\u011f\u0131,":[391]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}