{"id":"https://openalex.org/W2010890576","doi":"https://doi.org/10.1111/j.1432-1033.1982.tb06811.x","title":"A Thermodynamic Study of Cooperative Structures in Rabbit Immunoglobulin G","display_name":"A Thermodynamic Study of Cooperative Structures in Rabbit Immunoglobulin G","publication_year":1982,"publication_date":"1982-09-01","ids":{"openalex":"https://openalex.org/W2010890576","doi":"https://doi.org/10.1111/j.1432-1033.1982.tb06811.x","mag":"2010890576","pmid":"https://pubmed.ncbi.nlm.nih.gov/7140745"},"language":"en","primary_location":{"id":"doi:10.1111/j.1432-1033.1982.tb06811.x","doi":"https://doi.org/10.1111/j.1432-1033.1982.tb06811.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1982.tb06811.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1982.tb06811.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1982.tb06811.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014612245","display_name":"V. M. Tischenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir M. TISCHENKO","raw_affiliation_strings":["Institut Prikladnio Mikrobiologii, Serpuhov, USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Prikladnio Mikrobiologii, Serpuhov, USSR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005937757","display_name":"Vladimir P. Zav'yalov","orcid":"https://orcid.org/0000-0001-5351-8741","observed_orcids":["https://orcid.org/0000-0001-5351-8741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir P. ZAV'YALOV","raw_affiliation_strings":["Institut Prikladnio Mikrobiologii, Serpuhov, USSR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Prikladnio Mikrobiologii, Serpuhov, USSR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108386976","display_name":"Gy\u00f6rgy A. MEDGYESI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gy\u00f6rgy A. MEDGYESI","raw_affiliation_strings":["Szamo\u0308ca ul. 3, H-I 125 Budapest, Hungary","Szam\u00f6ca ul. 3, H\u2010I 125 Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Szamo\u0308ca ul. 3, H-I 125 Budapest, Hungary","institution_ids":[]},{"raw_affiliation_string":"Szam\u00f6ca ul. 3, H\u2010I 125 Budapest, Hungary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014037919","display_name":"Sergey A. Potekhin","orcid":"https://orcid.org/0000-0002-1538-0275","observed_orcids":["https://orcid.org/0000-0002-1538-0275"]},"institutions":[{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergei A. POTEKHIN","raw_affiliation_strings":["Institut Belka, Akademiya Nauk S.S.S.R., Pushchino, Moskovskaya, Oblast', USSR 142292"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Belka, Akademiya Nauk S.S.S.R., Pushchino, Moskovskaya, Oblast', USSR 142292","institution_ids":["https://openalex.org/I4210137602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112756627","display_name":"Peter L. Privalov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137602","display_name":"Institute of Protein Research","ror":"https://ror.org/0489f0s93","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210137602"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Peter L. PRIVALOV","raw_affiliation_strings":["Institut Belka, Akademiya Nauk S.S.S.R., Pushchino, Moskovskaya, Oblast', USSR 142292"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Belka, Akademiya Nauk S.S.S.R., Pushchino, Moskovskaya, Oblast', USSR 142292","institution_ids":["https://openalex.org/I4210137602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8316,"has_fulltext":true,"cited_by_count":84,"citation_normalized_percentile":{"value":0.6395524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"126","issue":"3","first_page":"517","last_page":"521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.2393999993801117,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.1615000069141388,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rabbit-immunoglobulin-g","display_name":"rabbit immunoglobulin G","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cooperative-unfolding","display_name":"cooperative unfolding","score":0.5989999771118164},{"id":"https://openalex.org/keywords/fab-fragment","display_name":"Fab fragment","score":0.8759999871253967},{"id":"https://openalex.org/keywords/fc-region","display_name":"Fc fragment","score":1.0},{"id":"https://openalex.org/keywords/proteolytic-fragments","display_name":"proteolytic fragments","score":0.8050000071525574},{"id":"https://openalex.org/keywords/structural-domains","display_name":"structural domains","score":0.5019999742507935},{"id":"https://openalex.org/keywords/protein-thermodynamics","display_name":"protein thermodynamics","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.6143555641174316},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5922588109970093},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41155749559402466},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3145103454589844},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.251783549785614},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1880059540271759},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007120","descriptor_name":"Immunochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007141","descriptor_name":"Immunoglobulin Fc Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1432-1033.1982.tb06811.x","doi":"https://doi.org/10.1111/j.1432-1033.1982.tb06811.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1982.tb06811.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1982.tb06811.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:7140745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7140745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1432-1033.1982.tb06811.x","doi":"https://doi.org/10.1111/j.1432-1033.1982.tb06811.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1432-1033.1982.tb06811.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1432-1033.1982.tb06811.x","source":{"id":"https://openalex.org/S4210214924","display_name":"European Journal of Biochemistry","issn_l":"0014-2956","issn":["0014-2956","0945-5795","1432-1033"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010890576.pdf","grobid_xml":"https://content.openalex.org/works/W2010890576.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W144754746","https://openalex.org/W1552541935","https://openalex.org/W1786523947","https://openalex.org/W1847276374","https://openalex.org/W1980802782","https://openalex.org/W1986510280","https://openalex.org/W2009444140","https://openalex.org/W2017367781","https://openalex.org/W2029255999","https://openalex.org/W2037514444","https://openalex.org/W2047116345","https://openalex.org/W2054032387","https://openalex.org/W2066461480","https://openalex.org/W2081065702","https://openalex.org/W2093572741","https://openalex.org/W2159392498","https://openalex.org/W2315333381","https://openalex.org/W2335055254","https://openalex.org/W2397839015","https://openalex.org/W2413292330","https://openalex.org/W2600349519"],"related_works":["https://openalex.org/W2010408573","https://openalex.org/W2149532677","https://openalex.org/W1966148155","https://openalex.org/W2411269961","https://openalex.org/W1979780600","https://openalex.org/W1967693680","https://openalex.org/W2055244071","https://openalex.org/W1551214592","https://openalex.org/W1982224344","https://openalex.org/W2081764549"],"abstract_inverted_index":{"The":[0,37,56],"intramolecular":[1],"melting":[2],"of":[3,25,66,94,122,126,130,137],"rabbit":[4],"immunoglobulin":[5],"G":[6],"and":[7,39,102,107,133],"its":[8],"proteolytic":[9],"fragments":[10,41,104,128],"has":[11],"been":[12,34],"studied":[13],"by":[14,118],"scanning":[15],"microcalorimetry":[16],"in":[17,42,50,75,151],"the":[18,26,30,51,85,92,123,135,143,152],"acidic":[19],"pH":[20,52],"region.":[21],"By":[22],"thermodynamic":[23],"analysis":[24],"heat":[27],"capacity":[28],"function":[29],"following":[31],"conclusions":[32],"have":[33],"made.":[35],"1.":[36],"Fab":[38,57],"Fc":[40,101,153],"IgG":[43],"molecules":[44],"are":[45,69,78,140],"thermodynamically":[46],"practically":[47],"independent":[48],"subunits":[49],"region":[53],"studied.":[54],"2.":[55],"fragment":[58,77],"exhibits":[59],"three":[60],"cooperative":[61,82,98,109,144,149],"transitions":[62,68,113],"at":[63],"melting.":[64],"Two":[65],"these":[67,97,127],"explained":[70,116],"assuming":[71,119],"that":[72,120,134],"equivalent":[73,138],"domains":[74,125],"this":[76],"paired,":[79],"forming":[80,147],"two":[81,108,131],"blocks,":[83],"while":[84],"third":[86],"transition":[87],"seems":[88],"to":[89,91],"correspond":[90],"disruption":[93],"contacts":[95],"between":[96],"blocks.":[99],"3.":[100],"pFc'":[103],"exhibit":[105],"four":[106,148],"transitions,":[110],"respectively.":[111],"These":[112],"can":[114],"be":[115],"only":[117],"each":[121],"structural":[124],"consists":[129],"subparts":[132,139],"pairs":[136],"merged":[141],"into":[142],"blocks":[145,150],"thus":[146],"fragment.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}