{"id":"https://openalex.org/W2010873140","doi":"https://doi.org/10.1117/12.698012","title":"Cellular immunological effects of laser irradiation and immunoadjuvant application","display_name":"Cellular immunological effects of laser irradiation and immunoadjuvant application","publication_year":2007,"publication_date":"2007-02-08","ids":{"openalex":"https://openalex.org/W2010873140","doi":"https://doi.org/10.1117/12.698012","mag":"2010873140"},"language":"en","primary_location":{"id":"doi:10.1117/12.698012","doi":"https://doi.org/10.1117/12.698012","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.698012","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001447073","display_name":"Wei R. Chen","orcid":"https://orcid.org/0000-0002-7133-5794","observed_orcids":["https://orcid.org/0000-0002-7133-5794"]},"institutions":[{"id":"https://openalex.org/I139325414","display_name":"University of Central Oklahoma","ror":"https://ror.org/02n455404","country_code":"US","type":"education","lineage":["https://openalex.org/I139325414"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei R. Chen","raw_affiliation_strings":["Univ. of Central Oklahoma (United States)","University of Central Oklahoma*"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Central Oklahoma (United States)","institution_ids":["https://openalex.org/I139325414"]},{"raw_affiliation_string":"University of Central Oklahoma*","institution_ids":["https://openalex.org/I139325414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085373804","display_name":"Abdiwahab Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139325414","display_name":"University of Central Oklahoma","ror":"https://ror.org/02n455404","country_code":"US","type":"education","lineage":["https://openalex.org/I139325414"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdiwahab Mohamed","raw_affiliation_strings":["Univ. of Central Oklahoma (United States)","University of Central Oklahoma*"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Central Oklahoma (United States)","institution_ids":["https://openalex.org/I139325414"]},{"raw_affiliation_string":"University of Central Oklahoma*","institution_ids":["https://openalex.org/I139325414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024471347","display_name":"Mark F. Naylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark F. Naylor","raw_affiliation_strings":["Univ. of Oklahoma College of Medicine (United States)","University of Oklahoma College of Medicine, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Oklahoma College of Medicine (United States)","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"University of Oklahoma College of Medicine, United States","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028000024","display_name":"Kenneth E. Bartels","orcid":"https://orcid.org/0000-0002-8694-9609","observed_orcids":["https://orcid.org/0000-0002-8694-9609"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth E. Bartels","raw_affiliation_strings":["Oklahoma State Univ. (United States)","Oklahoma State University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma State Univ. (United States)","institution_ids":["https://openalex.org/I115475287"]},{"raw_affiliation_string":"Oklahoma State University,","institution_ids":["https://openalex.org/I115475287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072467920","display_name":"Jerry W. Ritchey","orcid":"https://orcid.org/0000-0003-0307-4673","observed_orcids":["https://orcid.org/0000-0003-0307-4673"]},"institutions":[{"id":"https://openalex.org/I115475287","display_name":"Oklahoma State University","ror":"https://ror.org/01g9vbr38","country_code":"US","type":"education","lineage":["https://openalex.org/I115475287"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry W. Ritchey","raw_affiliation_strings":["Oklahoma State Univ. (United States)","Oklahoma State University,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma State Univ. (United States)","institution_ids":["https://openalex.org/I115475287"]},{"raw_affiliation_string":"Oklahoma State University,","institution_ids":["https://openalex.org/I115475287"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Liu","raw_affiliation_strings":["Univ. of Oklahoma (United States)","University of Oklahoma"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Oklahoma (United States)","institution_ids":["https://openalex.org/I8692664"]},{"raw_affiliation_string":"University of Oklahoma","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112541359","display_name":"Robert E. Nordquist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119755","display_name":"Advanced Cancer Therapeutics","ror":"https://ror.org/02mx1bf53","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210119755"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Nordquist","raw_affiliation_strings":["Advanced Cancer Therapies L.L.C. (United States)","Advanced Cancer Therapies L.L.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Cancer Therapies L.L.C. (United States)","institution_ids":["https://openalex.org/I4210119755"]},{"raw_affiliation_string":"Advanced Cancer Therapies L.L.C","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.1071,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.97571744,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"6438","issue":null,"first_page":"64380B","last_page":"64380B"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4108999967575073,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4108999967575073,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.19380000233650208,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.18310000002384186,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laser-irradiation","display_name":"laser irradiation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/immunoadjuvant","display_name":"immunoadjuvant","score":0.9470000267028809},{"id":"https://openalex.org/keywords/indocyanine-green","display_name":"indocyanine green","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.5460000038146973},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.9440000057220459},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6079999804496765},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8679999709129333},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2909935589","wikidata":"https://www.wikidata.org/wiki/Q967453","display_name":"Immunoadjuvant","level":3,"score":0.9787337183952332},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.7090824842453003},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7037075757980347},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5583034753799438},{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.5290588140487671},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.5189768671989441},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47382888197898865},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4695513844490051},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.426258385181427},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41446346044540405},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4034785032272339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22633743286132812},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1791720688343048},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.095298171043396},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.698012","doi":"https://doi.org/10.1117/12.698012","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.698012","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2033458284","https://openalex.org/W2043356328","https://openalex.org/W2157180829","https://openalex.org/W2160860777","https://openalex.org/W2055606593","https://openalex.org/W2164024619","https://openalex.org/W1997254998","https://openalex.org/W2030538619","https://openalex.org/W2093046212","https://openalex.org/W2092748567"],"abstract_inverted_index":{"Immune":[0],"system":[1],"is":[2,11,247],"critical":[3],"in":[4,104,118,168,191],"the":[5,12,49,64,71,93,129,142,147,169,200,223,230,233,251],"fight":[6],"against":[7],"cancer.":[8],"Particular":[9],"important":[10,167],"responses":[13],"through":[14],"immune":[15,77,197],"cells":[16,198],"that":[17,136,159],"regulate":[18],"immunological":[19],"functions.":[20],"Certain":[21],"cytokines":[22],"enhance":[23,76],"cancer":[24,37,72],"immunity":[25,38],"(such":[26,39],"as":[27,40,55],"IL12":[28,58],"and":[29,32,84,151,175,213,229,244],"interferon":[30],"gamma)":[31],"others":[33],"interfere":[34],"or":[35,145],"impede":[36],"IL10).":[41],"The":[42,208,238],"clinical":[43],"outcome":[44],"can":[45],"be":[46],"linked":[47],"to":[48,57,113,171,176,199,218,232,249],"balance":[50],"of":[51,70,81,87,95,149,180,187,196,210,240,253],"these":[52],"cytokines,":[53],"such":[54],"IL10":[56],"ratio.":[59],"Effective":[60],"treatments":[61],"often":[62],"reduce":[63],"IL10:IL12":[65,155],"ratio,":[66],"indicating":[67,203],"higher":[68],"levels":[69],"fighting":[73],"IL12.":[74],"To":[75],"responses,":[78,224],"a":[79,98,204],"combination":[80,148,209],"laser":[82,103,130,150,211],"irradiation":[83],"concurrent":[85],"use":[86],"immunostimulants":[88],"has":[89,110,215],"been":[90,111,216,236],"applied":[91],"for":[92],"treatment":[94,170,186,201,212,234,256],"tumors.":[96],"In":[97],"recent":[99],"study,":[100],"an":[101,166],"805-nm":[102],"conjunction":[105],"with":[106,141,146],"indocyanine":[107],"green":[108],"(ICG)":[109],"used":[112,217],"treat":[114,219],"EMT6":[115],"mammary":[116,189],"tumors":[117,190,228],"mice.":[119,181],"An":[120],"immunoadjuvant,":[121],"glycated":[122],"chitosan":[123],"(GC),":[124],"was":[125],"intratumoral":[126],"injected":[127],"after":[128,184,245],"irradiation.":[131],"Our":[132],"preliminary":[133],"results":[134],"showed":[135,194],"tumor-bearing":[137],"mice":[138],"treated":[139,226],"either":[140],"immunoadjuvant":[143,152],"alone":[144],"had":[153],"lower":[154],"ratios":[156],"than":[157],"animals":[158],"received":[160],"no":[161],"treatment.":[162],"This":[163],"may":[164],"play":[165],"decrease":[172],"tumor":[173],"size":[174],"increase":[177],"survival":[178],"times":[179],"Cellular":[182],"activities":[183],"laser-ICG-GC":[185],"DBMA-4":[188],"rats":[192],"also":[193],"infiltration":[195],"sites,":[202],"possible":[205],"induced":[206],"immunity.":[207],"immunotherapy":[214],"late-stage":[220],"melanoma":[221],"patients;":[222],"both":[225],"primary":[227],"metastases,":[231],"have":[235],"promising.":[237],"histology":[239],"two":[241],"patients,":[242],"before":[243],"treatment,":[246],"presented":[248],"show":[250],"effects":[252],"this":[254],"novel":[255],"method.":[257]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}