{"id":"https://openalex.org/W2010868671","doi":"https://doi.org/10.1016/s0168-1702(01)00284-2","title":"Functional changes in astrocytes by human T-lymphotropic virus type-1 T-lymphocytes","display_name":"Functional changes in astrocytes by human T-lymphotropic virus type-1 T-lymphocytes","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2010868671","doi":"https://doi.org/10.1016/s0168-1702(01)00284-2","mag":"2010868671","pmid":"https://pubmed.ncbi.nlm.nih.gov/11520580"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-1702(01)00284-2","doi":"https://doi.org/10.1016/s0168-1702(01)00284-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-1702(01)00284-2","pdf_url":null,"source":{"id":"https://openalex.org/S114911520","display_name":"Virus Research","issn_l":"0168-1702","issn":["0168-1702","1872-7492"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virus Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105778461","display_name":"H. Akaoka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hideo Akaoka","raw_affiliation_strings":["Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Cedex 08, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Cedex 08, Lyon, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072098494","display_name":"Rapha\u00ebl Szymocha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Raphael Szymocha","raw_affiliation_strings":["Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009883186","display_name":"Patricia Beurton-Marduel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patricia Beurton-Marduel","raw_affiliation_strings":["Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105414400","display_name":"Arlette Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Arlette Bernard","raw_affiliation_strings":["Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111790623","display_name":"Marie\u2010Fran\u00e7oise Belin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Francoise Belin","raw_affiliation_strings":["Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006021181","display_name":"Pascale Giraudon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pascale Giraudon","raw_affiliation_strings":["Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculte de Medecine Laennec, Experimental Neurobiology and Physiopathology, INSERM U433, F69372 Lyon Cedex 08, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006021181"],"corresponding_institution_ids":["https://openalex.org/I154526488"],"apc_list":{"value":3010,"currency":"USD","value_usd":3010},"apc_paid":null,"fwci":0.3139,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.52296175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"78","issue":"1-2","first_page":"57","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/htlv-1","display_name":"HTLV-1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8059999942779541},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7699999809265137},{"id":"https://openalex.org/keywords/htlv-1-associated-myelopathy","display_name":"tropical spastic paraparesis","score":0.7239999771118164},{"id":"https://openalex.org/keywords/glutamate-uptake","display_name":"glutamate uptake","score":0.7020000219345093},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.9390000104904175},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.9810000061988831},{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/glutamate-dehydrogenase","display_name":"glutamate dehydrogenase","score":0.8389999866485596},{"id":"https://openalex.org/keywords/astrocyte-metabolism","display_name":"astrocyte metabolism","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cns-lesions","display_name":"central nervous system lesions","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7837721109390259},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7762190103530884},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7470312118530273},{"id":"https://openalex.org/C2776238826","wikidata":"https://www.wikidata.org/wiki/Q1280388","display_name":"Human T-lymphotropic virus 1","level":4,"score":0.4659586548805237},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3964877724647522},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3681015372276306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2989141047000885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28857457637786865},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2208382785320282},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2776913467","wikidata":"https://www.wikidata.org/wiki/Q7667895","display_name":"T-cell leukemia","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0168-1702(01)00284-2","doi":"https://doi.org/10.1016/s0168-1702(01)00284-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-1702(01)00284-2","pdf_url":null,"source":{"id":"https://openalex.org/S114911520","display_name":"Virus Research","issn_l":"0168-1702","issn":["0168-1702","1872-7492"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virus Research","raw_type":"journal-article"},{"id":"pmid:11520580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11520580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virus research","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-03066584v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-03066584","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Virus Research, 2001, 78 (1-2), pp.57-66. &#x27E8;10.1016/s0168-1702(01)00284-2&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309737","display_name":"Fondation pour l'Aide \u00e0 la Recherche sur la Scl\u00e9rose en Plaques","ror":"https://ror.org/04gyrp304"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W216974483","https://openalex.org/W276333667","https://openalex.org/W623287869","https://openalex.org/W1527912335","https://openalex.org/W1894558700","https://openalex.org/W1986600046","https://openalex.org/W1990477022","https://openalex.org/W1991853401","https://openalex.org/W1991941671","https://openalex.org/W1999389160","https://openalex.org/W2005599435","https://openalex.org/W2030646700","https://openalex.org/W2037374528","https://openalex.org/W2047208087","https://openalex.org/W2049163310","https://openalex.org/W2056067293","https://openalex.org/W2064898829","https://openalex.org/W2069667541","https://openalex.org/W2076146063","https://openalex.org/W2076165333","https://openalex.org/W2076758203","https://openalex.org/W2089337693","https://openalex.org/W2091741063","https://openalex.org/W2092094911","https://openalex.org/W2092635505","https://openalex.org/W2110653553","https://openalex.org/W2113416158","https://openalex.org/W2125986419","https://openalex.org/W2132758162","https://openalex.org/W2151694455","https://openalex.org/W2167211922","https://openalex.org/W4249225034"],"related_works":["https://openalex.org/W2125986419","https://openalex.org/W2335422539","https://openalex.org/W2080290248","https://openalex.org/W2132758162","https://openalex.org/W1932256759","https://openalex.org/W2129021021","https://openalex.org/W2032365782","https://openalex.org/W1986600046","https://openalex.org/W623082322","https://openalex.org/W2187921987"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
