{"id":"https://openalex.org/W2010859896","doi":"https://doi.org/10.1002/ajh.21020","title":"Oral decitabine reactivates expression of the methylated \u03b3\u2010globin gene in Papio anubis","display_name":"Oral decitabine reactivates expression of the methylated \u03b3\u2010globin gene in Papio anubis","publication_year":2007,"publication_date":"2007-08-15","ids":{"openalex":"https://openalex.org/W2010859896","doi":"https://doi.org/10.1002/ajh.21020","mag":"2010859896","pmid":"https://pubmed.ncbi.nlm.nih.gov/17696208"},"language":"en","primary_location":{"id":"doi:10.1002/ajh.21020","doi":"https://doi.org/10.1002/ajh.21020","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajh.21020","pdf_url":null,"source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063034363","display_name":"Donald Lavelle","orcid":"https://orcid.org/0000-0002-0275-7168","observed_orcids":["https://orcid.org/0000-0002-0275-7168"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald Lavelle","raw_affiliation_strings":["Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA. dlavelle@uic.edu","Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","Jesse Brown VA Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA. dlavelle@uic.edu","institution_ids":["https://openalex.org/I4210135737"]},{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071485813","display_name":"Janet Chin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Chin","raw_affiliation_strings":["Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","Jesse Brown VA Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078192093","display_name":"Kestis Vaitkus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kestis Vaitkus","raw_affiliation_strings":["Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","Jesse Brown VA Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020548821","display_name":"Sanjeev Redkar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149223","display_name":"SuperGen (United States)","ror":"https://ror.org/049922318","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210149223","https://openalex.org/I4387155454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjeev Redkar","raw_affiliation_strings":["SuperGen, Inc., Dublin, California","SuperGen, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SuperGen, Inc., Dublin, California","institution_ids":["https://openalex.org/I4210149223"]},{"raw_affiliation_string":"SuperGen, Inc","institution_ids":["https://openalex.org/I4210149223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042902495","display_name":"Pasit Phiasivongsa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149223","display_name":"SuperGen (United States)","ror":"https://ror.org/049922318","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210149223","https://openalex.org/I4387155454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pasit Phiasivongsa","raw_affiliation_strings":["SuperGen, Inc., Dublin, California","SuperGen, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SuperGen, Inc., Dublin, California","institution_ids":["https://openalex.org/I4210149223"]},{"raw_affiliation_string":"SuperGen, Inc","institution_ids":["https://openalex.org/I4210149223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067015301","display_name":"Chunlin Tang","orcid":"https://orcid.org/0000-0002-5740-4036","observed_orcids":["https://orcid.org/0000-0002-5740-4036"]},"institutions":[{"id":"https://openalex.org/I4210149223","display_name":"SuperGen (United States)","ror":"https://ror.org/049922318","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210149223","https://openalex.org/I4387155454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunlin Tang","raw_affiliation_strings":["SuperGen, Inc., Dublin, California","SuperGen, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SuperGen, Inc., Dublin, California","institution_ids":["https://openalex.org/I4210149223"]},{"raw_affiliation_string":"SuperGen, Inc","institution_ids":["https://openalex.org/I4210149223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082279784","display_name":"Roselle Will","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149223","display_name":"SuperGen (United States)","ror":"https://ror.org/049922318","country_code":"US","type":"company","lineage":["https://openalex.org/I114030911","https://openalex.org/I4210149223","https://openalex.org/I4387155454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roselle Will","raw_affiliation_strings":["SuperGen, Inc., Dublin, California","SuperGen, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SuperGen, Inc., Dublin, California","institution_ids":["https://openalex.org/I4210149223"]},{"raw_affiliation_string":"SuperGen, Inc","institution_ids":["https://openalex.org/I4210149223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037254989","display_name":"Maria Hankewych","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Hankewych","raw_affiliation_strings":["Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","Jesse Brown VA Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008871897","display_name":"Bryan P. Roxas","orcid":"https://orcid.org/0000-0002-0139-2232","observed_orcids":["https://orcid.org/0000-0002-0139-2232"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Roxas","raw_affiliation_strings":["Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","Jesse Brown VA Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022953205","display_name":"Mahipal Singh","orcid":"https://orcid.org/0000-0002-1369-9370","observed_orcids":["https://orcid.org/0000-0002-1369-9370"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahipal Singh","raw_affiliation_strings":["Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","Jesse Brown VA Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049987484","display_name":"Yogen Saunthararajah","orcid":"https://orcid.org/0000-0002-9757-1031","observed_orcids":["https://orcid.org/0000-0002-9757-1031"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yogen Saunthararajah","raw_affiliation_strings":["Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","University of Illinois at Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112289071","display_name":"Joseph DeSimone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210135737","display_name":"Jesse Brown VA Medical Center","ror":"https://ror.org/049qtwc86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210135737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph DeSimone","raw_affiliation_strings":["Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","Jesse Brown VA Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Illinois at Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Jesse Brown VA Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4210135737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063034363"],"corresponding_institution_ids":["https://openalex.org/I39422238","https://openalex.org/I4210135737"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":1.1968,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.75128769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"82","issue":"11","first_page":"981","last_page":"985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.6586999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.2800000011920929,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.8960000276565552},{"id":"https://openalex.org/keywords/gamma-globin-gene","display_name":"gamma-globin gene","score":0.796999990940094},{"id":"https://openalex.org/keywords/promoter-demethylation","display_name":"promoter demethylation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/fetal-hemoglobin-reactivation","display_name":"fetal hemoglobin reactivation","score":0.906000018119812},{"id":"https://openalex.org/keywords/epsilon-globin-gene","display_name":"epsilon-globin gene","score":0.7649999856948853},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.972000002861023},{"id":"https://openalex.org/keywords/baboons","display_name":"baboons","score":0.5550000071525574},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.6800000071525574},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.9758331775665283},{"id":"https://openalex.org/C2779200787","wikidata":"https://www.wikidata.org/wiki/Q414030","display_name":"Cladribine","level":2,"score":0.5522704124450684},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4983692169189453},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.4713396728038788},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.46528545022010803},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.43265485763549805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4319833517074585},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4021332263946533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.393669992685318},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29701656103134155},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2611251771450043},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21674907207489014},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17699003219604492},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.11597901582717896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11168751120567322}],"mesh":[{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D005319","descriptor_name":"Fetal Hemoglobin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005319","descriptor_name":"Fetal Hemoglobin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015254","descriptor_name":"DNA Modification Methylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D048530","descriptor_name":"Papio anubis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ajh.21020","doi":"https://doi.org/10.1002/ajh.21020","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ajh.21020","pdf_url":null,"source":{"id":"https://openalex.org/S199810014","display_name":"American Journal of Hematology","issn_l":"0361-8609","issn":["0361-8609","1096-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hematology","raw_type":"journal-article"},{"id":"pmid:17696208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17696208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2363599411","display_name":null,"funder_award_id":"HL02015","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W163413690","https://openalex.org/W1966474816","https://openalex.org/W1970950268","https://openalex.org/W1972933434","https://openalex.org/W1976961324","https://openalex.org/W1984807040","https://openalex.org/W1992274074","https://openalex.org/W1996043889","https://openalex.org/W2004172747","https://openalex.org/W2005486326","https://openalex.org/W2023213476","https://openalex.org/W2033274941","https://openalex.org/W2038091872","https://openalex.org/W2040257851","https://openalex.org/W2049340909","https://openalex.org/W2061578142","https://openalex.org/W2067098123","https://openalex.org/W2069145367","https://openalex.org/W2080201494","https://openalex.org/W2081105579","https://openalex.org/W2087409930","https://openalex.org/W2092901978","https://openalex.org/W2099166288","https://openalex.org/W2103374204","https://openalex.org/W2106584820","https://openalex.org/W2109895173","https://openalex.org/W2145750252","https://openalex.org/W2146683645","https://openalex.org/W2155577690","https://openalex.org/W2163916327","https://openalex.org/W2404368999"],"related_works":["https://openalex.org/W2614212280","https://openalex.org/W2136714188","https://openalex.org/W2593225494","https://openalex.org/W2565710648","https://openalex.org/W2053921820","https://openalex.org/W2558265656","https://openalex.org/W2581221643","https://openalex.org/W2114229226","https://openalex.org/W2549764875","https://openalex.org/W2080201494"],"abstract_inverted_index":{"The":[0,43,112],"silencing":[1],"of":[2,11,22,25,31,47,59,77,80,109,114,134,160,170,186],"tumor":[3],"suppressor":[4],"genes":[5,27],"associated":[6],"with":[7,69,85,94],"increased":[8],"DNA":[9,32,120],"methylation":[10],"the":[12,60,132,145,176],"promoter":[13,105],"regions":[14],"is":[15,38],"a":[16,39,137],"frequent":[17],"observation":[18],"in":[19,64,67,83,149,189],"many":[20],"forms":[21],"cancer.":[23],"Reactivation":[24],"these":[26,89,161,187],"using":[28,119],"pharmacological":[29],"inhibitors":[30,122],"methyltransferase":[33,121],"such":[34,125],"as":[35],"5-aza-2'-deoxycytidine":[36],"(decitabine)":[37],"worthwhile":[40],"therapeutic":[41],"goal.":[42],"effectiveness":[44],"and":[45,50,56,66,107,136,178,182],"tolerability":[46],"low-dose":[48,78,90],"intravenous":[49],"subcutaneous":[51,168],"decitabine":[52,135,141,171],"regimens":[53,79,91],"to":[54,74,103,128,143],"demethylate":[55],"reactivate":[57,144],"expression":[58,108],"methylated":[61,146],"gamma-globin":[62,147,179],"gene":[63,148,180],"baboons":[65,150,190],"patients":[68,84],"sickle":[70],"cell":[71],"disease":[72],"led":[73],"successful":[75],"trials":[76],"this":[81],"drug":[82],"myelodysplastic":[86],"syndrome.":[87],"Since":[88],"are":[92,98],"well-tolerated":[93],"minimal":[95],"toxicity,":[96],"they":[97],"suitable":[99],"for":[100],"chronic":[101,126],"dosing":[102],"maintain":[104],"hypomethylation":[106],"target":[110],"genes.":[111],"development":[113],"an":[115],"orally":[116],"administered":[117,152],"therapy":[118],"would":[123],"facilitate":[124],"approaches":[127],"therapy.":[129],"We":[130],"tested":[131],"ability":[133],"new":[138],"salt":[139],"derivative,":[140],"mesylate,":[142],"when":[151],"orally.":[153],"Our":[154],"results":[155],"demonstrate":[156],"that":[157],"oral":[158],"administration":[159],"drugs":[162],"at":[163],"doses":[164,169],"17-34":[165],"times":[166],"optimal":[167],"reactivates":[172],"fetal":[173],"hemoglobin,":[174],"demethylates":[175],"epsilon-":[177],"promoters,":[181],"increases":[183],"histone":[184],"acetylation":[185],"promoters":[188],"(Papio":[191],"anubis).":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}