{"id":"https://openalex.org/W2010854915","doi":"https://doi.org/10.1021/ja077641f","title":"TMG-chitotriomycin, an Enzyme Inhibitor Specific for Insect and Fungal \u03b2-N-Acetylglucosaminidases, Produced by Actinomycete Streptomyces anulatus NBRC 13369","display_name":"TMG-chitotriomycin, an Enzyme Inhibitor Specific for Insect and Fungal \u03b2-N-Acetylglucosaminidases, Produced by Actinomycete Streptomyces anulatus NBRC 13369","publication_year":2008,"publication_date":"2008-02-29","ids":{"openalex":"https://openalex.org/W2010854915","doi":"https://doi.org/10.1021/ja077641f","mag":"2010854915","pmid":"https://pubmed.ncbi.nlm.nih.gov/18307344"},"language":"en","primary_location":{"id":"doi:10.1021/ja077641f","doi":"https://doi.org/10.1021/ja077641f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja077641f","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033717496","display_name":"Hirokazu Usuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Usuki","raw_affiliation_strings":["Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087984801","display_name":"Teruhiko Nitoda","orcid":"https://orcid.org/0009-0000-5084-2685","observed_orcids":["https://orcid.org/0009-0000-5084-2685"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teruhiko Nitoda","raw_affiliation_strings":["Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033873298","display_name":"\u7f8e\u91cc \u5e02\u5ddd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misato Ichikawa","raw_affiliation_strings":["Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111571848","display_name":"Nahoko Yamaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nahoko Yamaji","raw_affiliation_strings":["Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000378438","display_name":"Takashi Iwashita","orcid":"https://orcid.org/0000-0002-0234-9287","observed_orcids":["https://orcid.org/0000-0002-0234-9287"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Iwashita","raw_affiliation_strings":["Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112084258","display_name":"Hajime Komura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hajime Komura","raw_affiliation_strings":["Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027774777","display_name":"Hiroshi Kanzaki","orcid":"https://orcid.org/0000-0002-9506-3519","observed_orcids":["https://orcid.org/0000-0002-9506-3519"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kanzaki","raw_affiliation_strings":["Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Bioresources Chemistry, The Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan, and Suntory Institute for Bioorganic Research (SUNBOR), 1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.1909,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.74687941,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"130","issue":"12","first_page":"4146","last_page":"4152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12683","display_name":"Studies on Chitinases and Chitosanases","score":0.7681000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.09470000118017197,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.06159999966621399,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptomyces-anulatus","display_name":"Streptomyces anulatus","score":0.9430000185966492},{"id":"https://openalex.org/keywords/chitinase-inhibitors","display_name":"chitinase inhibitors","score":0.6359999775886536},{"id":"https://openalex.org/keywords/fungal-chitinase","display_name":"fungal chitinase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/selective-enzyme-inhibition","display_name":"selective enzyme inhibition","score":0.7289999723434448},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/spodoptera-litura","display_name":"Spodoptera litura","score":0.9319999814033508},{"id":"https://openalex.org/keywords/selective-pesticides","display_name":"selective pesticides","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.922183096408844},{"id":"https://openalex.org/C2776273252","wikidata":"https://www.wikidata.org/wiki/Q27294","display_name":"Spodoptera litura","level":3,"score":0.7962598204612732},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.6986535787582397},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5992199182510376},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5434397459030151},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.48090052604675293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45337459444999695},{"id":"https://openalex.org/C2780778831","wikidata":"https://www.wikidata.org/wiki/Q424099","display_name":"Chitinase","level":3,"score":0.453254759311676},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.4439375400543213},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.4397931694984436},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.18027445673942566},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.1632189154624939},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C173758957","wikidata":"https://www.wikidata.org/wiki/Q129270","display_name":"Larva","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001407","descriptor_name":"Bacillus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002236","descriptor_name":"Carbohydrate Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002688","descriptor_name":"Chitinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007313","descriptor_name":"Insecta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010407","descriptor_name":"Penicillium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013305","descriptor_name":"Streptomyces griseus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013402","descriptor_name":"Sugar Alcohols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013402","descriptor_name":"Sugar Alcohols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018411","descriptor_name":"Spodoptera","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D048828","descriptor_name":"beta-N-Acetyl-Galactosaminidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja077641f","doi":"https://doi.org/10.1021/ja077641f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja077641f","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:18307344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18307344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1591752816","https://openalex.org/W1772341111","https://openalex.org/W1966139125","https://openalex.org/W1989430502","https://openalex.org/W1993042746","https://openalex.org/W1994493971","https://openalex.org/W1996487921","https://openalex.org/W2001865803","https://openalex.org/W2004629418","https://openalex.org/W2004765042","https://openalex.org/W2015486246","https://openalex.org/W2068348723","https://openalex.org/W2077783230","https://openalex.org/W2079169243","https://openalex.org/W2081270646","https://openalex.org/W2090727689","https://openalex.org/W2098303032","https://openalex.org/W2103996248","https://openalex.org/W2111963823","https://openalex.org/W2113376388","https://openalex.org/W2113964973","https://openalex.org/W2123199112","https://openalex.org/W2152594018","https://openalex.org/W2155614702","https://openalex.org/W2166606816","https://openalex.org/W2326670661","https://openalex.org/W2413095012","https://openalex.org/W2431194848","https://openalex.org/W2474485065","https://openalex.org/W2951960937","https://openalex.org/W2952299998"],"related_works":["https://openalex.org/W2060265916","https://openalex.org/W4200018279","https://openalex.org/W1998436145","https://openalex.org/W2156345372","https://openalex.org/W1986982404","https://openalex.org/W4398206823","https://openalex.org/W2067756129","https://openalex.org/W2015486246","https://openalex.org/W373038627","https://openalex.org/W1990259368"],"abstract_inverted_index":{"A":[0],"novel":[1],"beta-N-acetylglucosaminidase":[2],"(GlcNAcase)":[3],"inhibitor":[4,95],"named":[5],"TMG-chitotriomycin":[6,70],"(1)":[7,71],"was":[8,26,41],"isolated":[9],"from":[10],"the":[11,29,34,50,66,92,110,119,128,133],"culture":[12],"filtrate":[13],"of":[14,39,49,59,65,77,85,113,118,136,149],"Streptomyces":[15],"anulatus":[16],"NBRC13369.":[17],"The":[18,37,145],"strain":[19],"produced":[20],"1":[21,40,137,150],"only":[22],"when":[23],"colloidal":[24],"chitin":[25],"used":[27],"as":[28],"sole":[30],"carbon":[31],"source":[32],"in":[33],"production":[35],"medium.":[36],"structure":[38],"determined":[42],"by":[43],"spectral":[44],"and":[45,61,74,79,87,158],"constitutive":[46],"sugar":[47,112],"analyses":[48],"corresponding":[51],"alditol":[52],"derivatives":[53],"to":[54,154,159],"be":[55,103,152],"an":[56],"equilibrated":[57],"mixture":[58],"alpha-d-N,N,N-triMeGlcNH2-(1,4)-beta-d-GlcNAc-(1,4)-beta-d-GlcNAc-(1,4)-d-GlcNAc":[60],"its":[62,141],"C-2":[63],"epimer":[64],"reducing":[67,134],"end":[68,135],"residue.":[69],"showed":[72,115],"potent":[73],"selective":[75,161],"inhibition":[76,84,117],"insect":[78,120],"fungal":[80],"GlcNAcases":[81],"with":[82],"no":[83,116],"mammalian":[86],"plant":[88],"GlcNAcases.":[89,100],"In":[90],"contrast,":[91],"known":[93],"GlcNAcase":[94],"nagstatin":[96],"potently":[97],"inhibited":[98],"all":[99],"It":[101],"should":[102],"emphasized":[104],"that":[105,127],"synthesized":[106],"d-N,N,N-triMeGlcNH2,":[107],"which":[108],"is":[109,138],"component":[111],"1,":[114],"Spodoptera":[121],"litura":[122],"GlcNAcase.":[123],"These":[124],"results":[125],"suggest":[126],"(GlcNAc)3":[129],"unit":[130],"positioned":[131],"at":[132],"essential":[139],"for":[140],"enzyme":[142],"inhibitory":[143,147],"activity.":[144],"unique":[146],"spectrum":[148],"will":[151],"useful":[153],"study":[155],"chitinolytic":[156],"systems":[157],"develop":[160],"fungicides":[162],"or":[163],"pesticides.":[164]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}