{"id":"https://openalex.org/W2010838716","doi":"https://doi.org/10.1152/jn.00346.2009","title":"The Influence of Neuroactive Steroid Lipophilicity on GABAAReceptor Modulation: Evidence for a Low-Affinity Interaction","display_name":"The Influence of Neuroactive Steroid Lipophilicity on GABAAReceptor Modulation: Evidence for a Low-Affinity Interaction","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W2010838716","doi":"https://doi.org/10.1152/jn.00346.2009","mag":"2010838716","pmid":"https://pubmed.ncbi.nlm.nih.gov/19553485","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2724350"},"language":"en","primary_location":{"id":"doi:10.1152/jn.00346.2009","doi":"https://doi.org/10.1152/jn.00346.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00346.2009","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2724350","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089302046","display_name":"Mariangela Chisari","orcid":"https://orcid.org/0000-0002-2984-0375","observed_orcids":["https://orcid.org/0000-0002-2984-0375"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariangela Chisari","raw_affiliation_strings":["Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108515676","display_name":"Lawrence N. Eisenman","orcid":"https://orcid.org/0000-0002-0306-243X","observed_orcids":["https://orcid.org/0000-0002-0306-243X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence N. Eisenman","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109388571","display_name":"Kathiresan Krishnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathiresan Krishnan","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011756749","display_name":"Achintya K. Bandyopadhyaya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Achintya K. Bandyopadhyaya","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cunde Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cunde Wang","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111763326","display_name":"Amanda Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Taylor","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053236515","display_name":"Ann M. Benz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Benz","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088595477","display_name":"Douglas F. Covey","orcid":"https://orcid.org/0000-0002-9316-8683","observed_orcids":["https://orcid.org/0000-0002-9316-8683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas F. Covey","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081481500","display_name":"Charles F. Zorumski","orcid":"https://orcid.org/0000-0002-9704-5154","observed_orcids":["https://orcid.org/0000-0002-9704-5154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles F. Zorumski","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013396820","display_name":"Steven J. Mennerick","orcid":"https://orcid.org/0000-0003-0868-0664","observed_orcids":["https://orcid.org/0000-0003-0868-0664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Mennerick","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.343,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.87263687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"102","issue":"2","first_page":"1254","last_page":"1264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurosteroids","display_name":"neurosteroids","score":0.8370000123977661},{"id":"https://openalex.org/keywords/lipophilicity","display_name":"lipophilicity","score":0.8539999723434448},{"id":"https://openalex.org/keywords/lipid-partitioning","display_name":"lipid partitioning","score":0.6990000009536743},{"id":"https://openalex.org/keywords/low-affinity-binding","display_name":"low-affinity binding","score":0.578000009059906},{"id":"https://openalex.org/keywords/pharmacophore","display_name":"pharmacophore","score":0.593999981880188},{"id":"https://openalex.org/keywords/alfaxalone","display_name":"alfaxalone","score":0.7260000109672546},{"id":"https://openalex.org/keywords/gamma-cyclodextrin","display_name":"\u03b3-cyclodextrin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/enantioselectivity","display_name":"enantioselectivity","score":0.550000011920929},{"id":"https://openalex.org/keywords/receptor-kinetics","display_name":"receptor kinetics","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8043627142906189},{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.7779616117477417},{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.7329509258270264},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.5548673868179321},{"id":"https://openalex.org/C2776801781","wikidata":"https://www.wikidata.org/wiki/Q18344323","display_name":"Pregnanolone","level":5,"score":0.5223454236984253},{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.4257057309150696},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4230203628540039},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.42241108417510986},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39088016748428345},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.3630499243736267},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36094120144844055},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13847431540489197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09840831160545349},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011280","descriptor_name":"Pregnanolone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011280","descriptor_name":"Pregnanolone","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047408","descriptor_name":"gamma-Cyclodextrins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047408","descriptor_name":"gamma-Cyclodextrins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/jn.00346.2009","doi":"https://doi.org/10.1152/jn.00346.2009","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.00346.2009","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2002091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2724350","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:19553485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19553485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2724350","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2724350/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurophysiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2002091","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2724350","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2632464076","display_name":"Axonal Signaling in the Hippocampus","funder_award_id":"R01NS054174","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3642697844","display_name":"Anesthetics: Cellular and Molecular Actions","funder_award_id":"P01GM047969","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W163176627","https://openalex.org/W563356271","https://openalex.org/W1561736958","https://openalex.org/W1566202711","https://openalex.org/W1941659122","https://openalex.org/W1967751978","https://openalex.org/W1970595032","https://openalex.org/W1971486313","https://openalex.org/W1976707885","https://openalex.org/W1980872418","https://openalex.org/W1981503496","https://openalex.org/W1996056304","https://openalex.org/W1997828916","https://openalex.org/W2015285475","https://openalex.org/W2016408696","https://openalex.org/W2017227716","https://openalex.org/W2020165167","https://openalex.org/W2028724208","https://openalex.org/W2048706813","https://openalex.org/W2057387160","https://openalex.org/W2083418663","https://openalex.org/W2084846774","https://openalex.org/W2086482387","https://openalex.org/W2106615190","https://openalex.org/W2128156437","https://openalex.org/W2136019568","https://openalex.org/W2143178821","https://openalex.org/W2161403274","https://openalex.org/W2306036017","https://openalex.org/W2309683846","https://openalex.org/W2400172421","https://openalex.org/W4406057306"],"related_works":["https://openalex.org/W2076224060","https://openalex.org/W1561736958","https://openalex.org/W2040064014","https://openalex.org/W2002110177","https://openalex.org/W2607356885","https://openalex.org/W2017227716","https://openalex.org/W7100531778","https://openalex.org/W1984437374","https://openalex.org/W2017144728","https://openalex.org/W7098863230"],"abstract_inverted_index":{"Anesthetic":[0],"steroids":[1,102],"with":[2],"actions":[3],"at":[4,82,190],"gamma-aminobutyric":[5],"acid":[6],"type":[7],"A":[8,128],"receptors":[9],"(GABA(A)Rs)":[10],"may":[11,56],"access":[12],"transmembrane":[13],"domain":[14],"binding":[15,202],"site(s)":[16],"directly":[17],"from":[18],"the":[19,24,31,34,118,123,134,151,221],"plasma":[20],"cell":[21],"membrane.":[22],"Accordingly,":[23],"effective":[25],"concentration":[26],"in":[27,78,161],"lipid":[28,61,216],"phase":[29],"and":[30,51,80,93,142,183,213,223],"ability":[32],"of":[33,53,74,90,110,125,133,146,150,163,168,225],"steroid":[35,177,227],"to":[36,45,185,220],"meet":[37],"pharmacophore":[38,174,211],"requirements":[39,175],"for":[40,176],"activity":[41],"will":[42],"both":[43,207],"contribute":[44,219],"observed":[46],"steady-state":[47],"potency.":[48],"Furthermore,":[49],"onset":[50],"offset":[52,96,99],"receptor":[54],"effects":[55],"be":[57],"rate":[58],"limited":[59],"by":[60,106,122,159],"partitioning.":[62],"Here":[63],"we":[64],"show":[65],"that":[66,114,200],"several":[67],"GABA-active":[68],"steroids,":[69],"including":[70],"naturally":[71],"occurring":[72],"neurosteroids,":[73],"different":[75],"lipophilicity":[76],"differ":[77],"kinetics":[79,182],"potency":[81,89,222],"GABA(A)Rs.":[83,191],"The":[84,166],"hydrophobicity":[85],"ranking":[86],"predicted":[87,94],"relative":[88],"GABA(A)R":[91,164],"potentiation":[92,162],"current":[95],"kinetics.":[97],"Kinetic":[98],"differences":[100,116,156,160],"among":[101,117],"were":[103,157],"largely":[104],"eliminated":[105],"gamma-cyclodextrin,":[107],"a":[108,147],"scavenger":[109],"unbound":[111],"steroid,":[112],"suggesting":[113],"affinity":[115,203],"analogues":[119],"are":[120],"dwarfed":[121],"contributions":[124],"nonspecific":[126,140,214],"accumulation.":[127],"7-nitrobenz-2-oxa-1,3-diazole":[129],"(NBD)-tagged":[130],"fluorescent":[131,148],"analogue":[132,149],"low-lipophilicity":[135],"alphaxalone":[136],"(C17-NBD-alphaxalone)":[137],"exhibited":[138,179],"faster":[139],"accumulation":[141],"departitioning":[143],"than":[144],"those":[145],"high-lipophilicity":[152],"(3alpha,5alpha)-3-hydroxypregnan-20-one":[153],"(C17-NBD-3alpha5alphaA).":[154],"These":[155],"paralleled":[158],"function.":[165],"enantiomer":[167],"C17-NBD-3alpha5alphaA,":[169,186],"which":[170,198],"does":[171],"not":[172],"satisfy":[173],"potentiation,":[178],"identical":[180],"fluorescence":[181],"distribution":[184],"but":[187],"was":[188],"inactive":[189],"Simple":[192],"simulations":[193],"supported":[194],"our":[195],"major":[196],"findings,":[197],"suggest":[199],"neurosteroid":[201],"is":[204],"low.":[205],"Therefore":[206],"specific":[208],"(e.g.,":[209,215],"fulfilling":[210],"requirements)":[212],"solubility)":[217],"properties":[218],"longevity":[224],"anesthetic":[226],"action.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}