{"id":"https://openalex.org/W2010822709","doi":"https://doi.org/10.1016/j.biocel.2008.11.007","title":"In vitro non-homologous DNA end joining assays\u2014The 20th anniversary","display_name":"In vitro non-homologous DNA end joining assays\u2014The 20th anniversary","publication_year":2008,"publication_date":"2008-12-07","ids":{"openalex":"https://openalex.org/W2010822709","doi":"https://doi.org/10.1016/j.biocel.2008.11.007","mag":"2010822709","pmid":"https://pubmed.ncbi.nlm.nih.gov/19110069","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2901157"},"language":"en","primary_location":{"id":"doi:10.1016/j.biocel.2008.11.007","doi":"https://doi.org/10.1016/j.biocel.2008.11.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2008.11.007","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry & Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2901157/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056222311","display_name":"El\u017cbieta Pastwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Elzbieta Pastwa","raw_affiliation_strings":["Department of Molecular Genetics, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland. epastwa@csk.umed.lodz.pl","Department of Molecular Genetics, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland. epastwa@csk.umed.lodz.pl","institution_ids":["https://openalex.org/I4210122071"]},{"raw_affiliation_string":"Department of Molecular Genetics, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063040714","display_name":"Richard Idem Somiari","orcid":"https://orcid.org/0000-0003-3466-3892","observed_orcids":["https://orcid.org/0000-0003-3466-3892"]},"institutions":[{"id":"https://openalex.org/I4210152633","display_name":"Integrated Technologies & Services International (United States)","ror":"https://ror.org/05e7vgz71","country_code":"US","type":"company","lineage":["https://openalex.org/I4210152633"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard I. Somiari","raw_affiliation_strings":["Functional Genomics & Proteomics, ITSI-Biosciences, 633 Napoleon Street, Johnstown, PA 15901, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Functional Genomics & Proteomics, ITSI-Biosciences, 633 Napoleon Street, Johnstown, PA 15901, USA","institution_ids":["https://openalex.org/I4210152633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002365628","display_name":"Mariusz Malinowski","orcid":"https://orcid.org/0000-0002-1632-8647","observed_orcids":["https://orcid.org/0000-0002-1632-8647","https://orcid.org/0009-0007-7983-0582"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Mariusz Malinowski","raw_affiliation_strings":["Department of Molecular and Medical Biophysics, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Biophysics, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049273454","display_name":"Stella Somiari","orcid":"https://orcid.org/0000-0002-7170-9098","observed_orcids":["https://orcid.org/0000-0002-7170-9098"]},"institutions":[{"id":"https://openalex.org/I1321217177","display_name":"Windber Research Institute","ror":"https://ror.org/03w8j7142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1321217177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stella B. Somiari","raw_affiliation_strings":["Cell Biology Unit, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology Unit, Windber Research Institute, 620 Seventh Street, Windber, PA 15963, USA","institution_ids":["https://openalex.org/I1321217177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007842122","display_name":"Thomas A. Winters","orcid":"https://orcid.org/0000-0003-4206-0020","observed_orcids":["https://orcid.org/0000-0003-4206-0020"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Winters","raw_affiliation_strings":["Nuclear Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5056222311"],"corresponding_institution_ids":["https://openalex.org/I4210122071"],"apc_list":{"value":3840,"currency":"USD","value_usd":3840},"apc_paid":null,"fwci":0.1537,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.10501995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"41","issue":"6","first_page":"1254","last_page":"1260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9900000095367432},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.9169999957084656},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7889999747276306},{"id":"https://openalex.org/keywords/dna-end-joining","display_name":"DNA end joining","score":0.49000000953674316},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.7139999866485596},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7239999771118164},{"id":"https://openalex.org/keywords/anticancer-drug-targets","display_name":"anticancer drug targets","score":0.8149999976158142},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8119999766349792},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/clinical-material","display_name":"clinical material","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.7667773365974426},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6552606225013733},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6191821098327637},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6033924221992493},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5773259401321411},{"id":"https://openalex.org/C145803527","wikidata":"https://www.wikidata.org/wiki/Q18032396","display_name":"DNA repair protein XRCC4","level":5,"score":0.5226858854293823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5214121341705322},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.49662214517593384},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4867301285266876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4317828416824341},{"id":"https://openalex.org/C74054111","wikidata":"https://www.wikidata.org/wiki/Q5891445","display_name":"Homology directed repair","level":5,"score":0.43007534742355347},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.4205361604690552},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3766126036643982},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35744792222976685},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3545790910720825},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35025554895401},{"id":"https://openalex.org/C104451858","wikidata":"https://www.wikidata.org/wiki/Q2714458","display_name":"Nucleotide excision repair","level":4,"score":0.29768723249435425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20590975880622864}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045643","descriptor_name":"DNA Repair Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biocel.2008.11.007","doi":"https://doi.org/10.1016/j.biocel.2008.11.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2008.11.007","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry & Cell Biology","raw_type":"journal-article"},{"id":"pmid:19110069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19110069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of biochemistry & cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2901157","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2901157/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Biochem Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2901157","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2901157/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Biochem Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1106777487","display_name":"Investigating DNA repair vulnerabilities in oncometabolite producing cancers","funder_award_id":"F31CA260794","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G267495551","display_name":"Gene-targetted  Radiotherapy","funder_award_id":"Z01CL060001","funder_id":"https://openalex.org/F4320337376","funder_display_name":"NIH Clinical Center"},{"id":"https://openalex.org/G550647324","display_name":null,"funder_award_id":"Z99CL999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320323344","display_name":"Uniwersytet \u0141\u00f3dzki","ror":"https://ror.org/05cq64r17"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1496351322","https://openalex.org/W1546251261","https://openalex.org/W1565234072","https://openalex.org/W1575933290","https://openalex.org/W1964882397","https://openalex.org/W1965531809","https://openalex.org/W1968241360","https://openalex.org/W1970225082","https://openalex.org/W1974083655","https://openalex.org/W1977106716","https://openalex.org/W1992688638","https://openalex.org/W1994813693","https://openalex.org/W2001381570","https://openalex.org/W2001749347","https://openalex.org/W2001784394","https://openalex.org/W2010711320","https://openalex.org/W2011522975","https://openalex.org/W2023574672","https://openalex.org/W2025951531","https://openalex.org/W2026956074","https://openalex.org/W2028876509","https://openalex.org/W2037639095","https://openalex.org/W2043776284","https://openalex.org/W2044179656","https://openalex.org/W2044874191","https://openalex.org/W2046770300","https://openalex.org/W2050821897","https://openalex.org/W2051148032","https://openalex.org/W2054370981","https://openalex.org/W2059678690","https://openalex.org/W2064771448","https://openalex.org/W2067488984","https://openalex.org/W2067982379","https://openalex.org/W2071721946","https://openalex.org/W2071809333","https://openalex.org/W2074779681","https://openalex.org/W2076173823","https://openalex.org/W2080419891","https://openalex.org/W2080666790","https://openalex.org/W2082910780","https://openalex.org/W2083326500","https://openalex.org/W2085414209","https://openalex.org/W2085422820","https://openalex.org/W2090808879","https://openalex.org/W2092831117","https://openalex.org/W2093351286","https://openalex.org/W2097498769","https://openalex.org/W2103883080","https://openalex.org/W2104098433","https://openalex.org/W2104191744","https://openalex.org/W2107664182","https://openalex.org/W2116718924","https://openalex.org/W2125915272","https://openalex.org/W2131418908","https://openalex.org/W2138201502","https://openalex.org/W2138277779","https://openalex.org/W2138322020","https://openalex.org/W2140010849","https://openalex.org/W2143842681","https://openalex.org/W2148760839","https://openalex.org/W2150281047","https://openalex.org/W2152370879","https://openalex.org/W2175899622","https://openalex.org/W2409661687","https://openalex.org/W4205774600","https://openalex.org/W7214215354"],"related_works":["https://openalex.org/W2291060447","https://openalex.org/W3028842059","https://openalex.org/W9740015","https://openalex.org/W2071809333","https://openalex.org/W2409661687","https://openalex.org/W1974083655","https://openalex.org/W2904099259","https://openalex.org/W2129189161","https://openalex.org/W2493211414","https://openalex.org/W2026124878"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}