{"id":"https://openalex.org/W2010806617","doi":"https://doi.org/10.1021/jp106373r","title":"Cholesterol Modulates the Membrane Effects and Spatial Organization of Membrane-Penetrating Ligands for G-Protein Coupled Receptors","display_name":"Cholesterol Modulates the Membrane Effects and Spatial Organization of Membrane-Penetrating Ligands for G-Protein Coupled Receptors","publication_year":2010,"publication_date":"2010-08-30","ids":{"openalex":"https://openalex.org/W2010806617","doi":"https://doi.org/10.1021/jp106373r","mag":"2010806617","pmid":"https://pubmed.ncbi.nlm.nih.gov/20804205","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943214"},"language":"en","primary_location":{"id":"doi:10.1021/jp106373r","doi":"https://doi.org/10.1021/jp106373r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp106373r","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943214","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110654593","display_name":"George Khelashvili","orcid":"https://orcid.org/0000-0001-7235-8579","observed_orcids":["https://orcid.org/0000-0001-7235-8579"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George Khelashvili","raw_affiliation_strings":["Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York","Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085619646","display_name":"Sayan Mondal","orcid":"https://orcid.org/0000-0002-1812-0575","observed_orcids":["https://orcid.org/0000-0002-1812-0575"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sayan Mondal","raw_affiliation_strings":["Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031193521","display_name":"Olaf Sparre Andersen","orcid":"https://orcid.org/0000-0002-3026-6710","observed_orcids":["https://orcid.org/0000-0002-3026-6710"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olaf S. Andersen","raw_affiliation_strings":["Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014370221","display_name":"Harel Weinstein","orcid":"https://orcid.org/0000-0003-3473-9818","observed_orcids":["https://orcid.org/0000-0003-3473-9818"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harel Weinstein","raw_affiliation_strings":["Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110654593"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":1.5621,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.81122481,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"114","issue":"37","first_page":"12046","last_page":"12057"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.9660000205039978},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9559999704360962},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.925000011920929},{"id":"https://openalex.org/keywords/dynorphin-a","display_name":"dynorphin A","score":0.9139999747276306},{"id":"https://openalex.org/keywords/membrane-deformation","display_name":"membrane deformation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/hydrophobic-matching","display_name":"hydrophobic matching","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7333325147628784},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.7218124866485596},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7040351629257202},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.6665236949920654},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6608848571777344},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.6553934812545776},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5572510361671448},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5269059538841248},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46930769085884094},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.44219139218330383},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.41991323232650757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2741997241973877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1402645707130432},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.05874955654144287},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004134","descriptor_name":"Dimyristoylphosphatidylcholine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017473","descriptor_name":"Receptors, Opioid, kappa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021962","descriptor_name":"Membrane Microdomains","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/jp106373r","doi":"https://doi.org/10.1021/jp106373r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp106373r","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"pmid:20804205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20804205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2943214","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943214","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Phys Chem B","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2943214","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943214","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Phys Chem B","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2550165365","display_name":"Structure and Function of Neurotransmitter Transporters","funder_award_id":"P01DA012408","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G5823824368","display_name":"Hallucinogens and 5-HT Receptors: Mechanisms and Effects","funder_award_id":"P01DA012923","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8737628347","display_name":"Energetics of Channel-Bilayer Interactions","funder_award_id":"R01GM021342","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W82875452","https://openalex.org/W268493558","https://openalex.org/W1523492509","https://openalex.org/W1592077035","https://openalex.org/W1630241876","https://openalex.org/W1635401440","https://openalex.org/W1736189198","https://openalex.org/W1833104430","https://openalex.org/W1964809614","https://openalex.org/W1972758026","https://openalex.org/W1974409875","https://openalex.org/W1974487582","https://openalex.org/W1978310995","https://openalex.org/W1980420294","https://openalex.org/W1982372009","https://openalex.org/W1985868705","https://openalex.org/W1987970138","https://openalex.org/W1993357003","https://openalex.org/W1994197757","https://openalex.org/W1995581477","https://openalex.org/W1998518831","https://openalex.org/W1999032653","https://openalex.org/W1999458597","https://openalex.org/W1999591184","https://openalex.org/W2000787398","https://openalex.org/W2002801210","https://openalex.org/W2003452243","https://openalex.org/W2003486597","https://openalex.org/W2003636671","https://openalex.org/W2003777487","https://openalex.org/W2004296371","https://openalex.org/W2005624144","https://openalex.org/W2007483105","https://openalex.org/W2008708467","https://openalex.org/W2009393499","https://openalex.org/W2010265988","https://openalex.org/W2011754496","https://openalex.org/W2012461056","https://openalex.org/W2012945956","https://openalex.org/W2013850102","https://openalex.org/W2020360234","https://openalex.org/W2020922094","https://openalex.org/W2021882008","https://openalex.org/W2027408247","https://openalex.org/W2028479939","https://openalex.org/W2029639174","https://openalex.org/W2030487072","https://openalex.org/W2034871685","https://openalex.org/W2035687084","https://openalex.org/W2038434242","https://openalex.org/W2038758364","https://openalex.org/W2040562404","https://openalex.org/W2041566506","https://openalex.org/W2044309821","https://openalex.org/W2044449796","https://openalex.org/W2045252225","https://openalex.org/W2045740138","https://openalex.org/W2046153515","https://openalex.org/W2049848440","https://openalex.org/W2052753851","https://openalex.org/W2056951579","https://openalex.org/W2057334680","https://openalex.org/W2059918628","https://openalex.org/W2060529580","https://openalex.org/W2064602142","https://openalex.org/W2064845310","https://openalex.org/W2064919700","https://openalex.org/W2071475257","https://openalex.org/W2072030765","https://openalex.org/W2072088396","https://openalex.org/W2073059665","https://openalex.org/W2073270298","https://openalex.org/W2073894126","https://openalex.org/W2079094640","https://openalex.org/W2080105128","https://openalex.org/W2081722643","https://openalex.org/W2081995805","https://openalex.org/W2086836468","https://openalex.org/W2088406330","https://openalex.org/W2089630271","https://openalex.org/W2091203881","https://openalex.org/W2092296126","https://openalex.org/W2095426514","https://openalex.org/W2097270648","https://openalex.org/W2101934167","https://openalex.org/W2104237986","https://openalex.org/W2113456505","https://openalex.org/W2114469046","https://openalex.org/W2114481572","https://openalex.org/W2115040835","https://openalex.org/W2121936687","https://openalex.org/W2122882997","https://openalex.org/W2136558879","https://openalex.org/W2137722526","https://openalex.org/W2143213067","https://openalex.org/W2149378523","https://openalex.org/W2150981663","https://openalex.org/W2159718916","https://openalex.org/W2159910988","https://openalex.org/W2168269595","https://openalex.org/W2171832928","https://openalex.org/W2246457688","https://openalex.org/W2264936970","https://openalex.org/W2411751083","https://openalex.org/W3048187409","https://openalex.org/W4234782700"],"related_works":["https://openalex.org/W2589191033","https://openalex.org/W2500682855","https://openalex.org/W2557616111","https://openalex.org/W2107345283","https://openalex.org/W4378213118","https://openalex.org/W2012461056","https://openalex.org/W3100271906","https://openalex.org/W2491156807","https://openalex.org/W2546702170","https://openalex.org/W2060126179"],"abstract_inverted_index":{"The":[0,152],"ligands":[1],"of":[2,28,34,52,74,166,200,235,246,256,274,311],"certain":[3],"G-protein":[4],"coupled":[5],"receptors":[6],"(GPCRs)":[7],"are":[8,42,297],"membrane":[9,119,154,248,257,288],"soluble":[10],"and":[11,21,50,78,93,146,161,231,319,325],"reach":[12],"their":[13,320,326],"target":[14],"from":[15,103],"the":[16,26,38,48,57,61,104,118,143,159,169,173,198,232,236,268,272,275,282,304,309,312],"lipid":[17,35,276,316],"bilayer.":[18],"Lipid":[19],"composition":[20],"dynamics":[22,51,71],"will":[23],"therefore":[24],"modulate":[25],"activity":[27],"these":[29,177],"receptors,":[30],"but":[31,204],"specific":[32,295],"roles":[33],"components,":[36],"including":[37],"ubiquitous":[39],"cholesterol":[40,129],"(Chol),":[41],"not":[43,205],"clear.":[44],"We":[45],"have":[46,186],"probed":[47],"organization":[49],"such":[53],"a":[54,108,148,163,220,253],"lipid-bilayer-penetrating":[55],"ligand,":[56],"endogenous":[58],"ligand":[59,214],"for":[60],"\u03ba-opioid":[62],"receptor":[63],"(KOR)":[64],"dynorphin":[65],"A":[66,138,243],"(1-17)":[67],"(DynA),":[68],"using":[69],"molecular":[70],"(MD)":[72],"simulations":[73],"DynA":[75,82,123,201,227],"in":[76,107,147,189,202,206,240,281,285],"cholesterol-depleted":[77],"cholesterol-enriched":[79,241],"model":[80],"membranes.":[81,175],"is":[83,131,238,250,261],"found":[84],"to":[85,117,142,179,225,229,299,315],"penetrate":[86],"deep":[87],"inside":[88,124,168],"fluid":[89],"dimyristoylphosphatidylcholine":[90],"(DMPC)":[91],"bilayers,":[92],"resides":[94],"with":[95,115,127,133,191,210,252,267,322],"its":[96,134],"N-terminal":[97],"helix":[98],"at":[99,111],"\u223c6":[100],"\u00c5":[101],"away":[102],"bilayer":[105],"midplane,":[106],"tilted":[109],"orientation,":[110],"an":[112],"\u223c50\u00b0":[113],"angle":[114],"respect":[116],"normal.":[120],"In":[121],"contrast,":[122],"DMPC/Chol":[125,174,283],"membranes":[126],"20%":[128],"(DMPC/Chol)":[130],"situated":[132],"helical":[135],"segment":[136],"\u223c5":[137],"higher,":[139],"i.e.,":[140],"closer":[141],"lipid/water":[144],"interface":[145],"relatively":[149],"vertical":[150],"orientation.":[151],"DMPC":[153],"shows":[155],"greater":[156],"thinning":[157],"around":[158,290],"insertion":[160],"permits":[162],"stronger":[164],"influx":[165],"water":[167],"hydrocarbon":[170],"core":[171],"than":[172],"Relating":[176],"results":[178],"data":[180,270],"about":[181],"key":[182],"GPCR":[183,193,213,323],"residues":[184],"that":[185,197,260],"been":[187],"implicated":[188],"interactions":[190,321],"membrane-inserting":[192],"ligands,":[194],"we":[195],"conclude":[196],"position":[199],"DMPC/Chol,":[203],"pure":[207],"DMPC,":[208],"correlates":[209],"generally":[211],"proposed":[212],"entry":[215],"pathways.":[216],"Our":[217],"predictions":[218],"provide":[219],"possible":[221],"mechanistic":[222],"explanation":[223],"as":[224],"why":[226],"binding":[228],"KOR,":[230],"subsequent":[233],"activation":[234],"receptor,":[237],"facilitated":[239],"environments.":[242],"quantitative":[244],"description":[245],"DynA-induced":[247],"deformations":[249,258],"obtained":[251],"continuum":[254],"theory":[255],"(CTMD)":[259],"based":[262],"on":[263],"hydrophobic":[264],"matching.":[265],"Comparison":[266],"MD":[269],"reveals":[271],"significance":[273],"tail":[277],"packing":[278],"energy":[279,301],"contribution":[280],"mixtures":[284,318],"predicting":[286],"equilibrium":[287],"shape":[289],"DynA.":[291],"On":[292],"this":[293,300],"basis,":[294],"corrections":[296],"introduced":[298],"term":[302],"within":[303],"CTMD":[305,313],"framework,":[306],"thereby":[307],"extending":[308],"applicability":[310],"framework":[314],"raft":[317],"proteins":[324],"ligands.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}