{"id":"https://openalex.org/W2010805909","doi":"https://doi.org/10.1021/ol034640t","title":"Simple Mimetics of a Nuclear Localization Signal (NLS)","display_name":"Simple Mimetics of a Nuclear Localization Signal (NLS)","publication_year":2003,"publication_date":"2003-06-17","ids":{"openalex":"https://openalex.org/W2010805909","doi":"https://doi.org/10.1021/ol034640t","mag":"2010805909","pmid":"https://pubmed.ncbi.nlm.nih.gov/12841749"},"language":"en","primary_location":{"id":"doi:10.1021/ol034640t","doi":"https://doi.org/10.1021/ol034640t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol034640t","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091055050","display_name":"Seung Bum Park","orcid":"https://orcid.org/0000-0003-1753-1433","observed_orcids":["https://orcid.org/0000-0003-1753-1433"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seung Bum Park","raw_affiliation_strings":["University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607","University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058650905","display_name":"Thai H. Ho","orcid":"https://orcid.org/0000-0003-0023-2939","observed_orcids":["https://orcid.org/0000-0003-0023-2939"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thai H. Ho","raw_affiliation_strings":["University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029536011","display_name":"Brian M. Reedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian M. Reedy","raw_affiliation_strings":["University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091725897","display_name":"Michael D. Connolly","orcid":"https://orcid.org/0000-0002-1817-8136","observed_orcids":["https://orcid.org/0000-0002-1817-8136"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Connolly","raw_affiliation_strings":["University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021060084","display_name":"Robert F. Standaert","orcid":"https://orcid.org/0000-0002-5684-1322","observed_orcids":["https://orcid.org/0000-0002-5684-1322"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert F. Standaert","raw_affiliation_strings":["University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Illinois at Chicago, Department of Chemistry (M/C 111), 845 West Taylor Street, Room 4500, Chicago, Illinois 60607","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6712,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.62118086,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"14","first_page":"2437","last_page":"2440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.6265000104904175,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.05889999866485596,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-localization-signal","display_name":"nuclear localization signal","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hiv-1-matrix-protein","display_name":"HIV-1 matrix protein","score":0.9919999837875366},{"id":"https://openalex.org/keywords/karyopherin-alpha","display_name":"karyopherin alpha","score":0.9100000262260437},{"id":"https://openalex.org/keywords/nuclear-import-receptor","display_name":"nuclear import receptor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/resorcinol","display_name":"resorcinol","score":0.6970000267028809},{"id":"https://openalex.org/keywords/linker-length","display_name":"linker length","score":0.6359999775886536},{"id":"https://openalex.org/keywords/competitive-binding-assay","display_name":"competitive binding assay","score":0.5759999752044678},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8101580142974854},{"id":"https://openalex.org/C186435350","wikidata":"https://www.wikidata.org/wiki/Q1050365","display_name":"NLS","level":4,"score":0.8090908527374268},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.8011010885238647},{"id":"https://openalex.org/C2777336224","wikidata":"https://www.wikidata.org/wiki/Q3193641","display_name":"Karyopherin","level":5,"score":0.7917472124099731},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.6888973712921143},{"id":"https://openalex.org/C133882971","wikidata":"https://www.wikidata.org/wiki/Q24205524","display_name":"Importin","level":5,"score":0.6342595219612122},{"id":"https://openalex.org/C59157529","wikidata":"https://www.wikidata.org/wiki/Q994741","display_name":"Nuclear transport","level":4,"score":0.5547399520874023},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.4709245562553406},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4574526846408844},{"id":"https://openalex.org/C105686024","wikidata":"https://www.wikidata.org/wiki/Q906755","display_name":"Nuclear matrix","level":4,"score":0.445911705493927},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4153936803340912},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3814200460910797},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3706141710281372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21141046285629272},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.1573880910873413},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.09012719988822937},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08713376522064209},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.08320370316505432},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D018716","descriptor_name":"Molecular Mimicry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019913","descriptor_name":"Nuclear Localization Signals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/ol034640t","doi":"https://doi.org/10.1021/ol034640t","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ol034640t","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:12841749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12841749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6796854563","display_name":"MOLECULAR RECOGNITION IN NUCLEAR PROTEIN TRANSPORT","funder_award_id":"R01GM057543","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1505502740","https://openalex.org/W1560988201","https://openalex.org/W1965274591","https://openalex.org/W1972651910","https://openalex.org/W1980115889","https://openalex.org/W1986045651","https://openalex.org/W2002041526","https://openalex.org/W2019167088","https://openalex.org/W2021057156","https://openalex.org/W2024735180","https://openalex.org/W2032382139","https://openalex.org/W2051334762","https://openalex.org/W2053796273","https://openalex.org/W2061659653","https://openalex.org/W2078818397","https://openalex.org/W2082389145","https://openalex.org/W2086272269","https://openalex.org/W2087979658","https://openalex.org/W2120226363","https://openalex.org/W2156891333","https://openalex.org/W2162166182"],"related_works":["https://openalex.org/W2264086704","https://openalex.org/W2050332537","https://openalex.org/W2032382139","https://openalex.org/W2005282433","https://openalex.org/W7098793315","https://openalex.org/W2046318163","https://openalex.org/W2186507212","https://openalex.org/W4239599953","https://openalex.org/W2052099400","https://openalex.org/W3007225749"],"abstract_inverted_index":{"[reaction:":[0],"see":[1],"text]":[2],"Molecular":[3],"modeling":[4],"was":[5],"used":[6],"to":[7,62,74],"design":[8],"mimetics":[9,42],"of":[10,23,37,45],"the":[11,63,71],"HIV-1":[12],"matrix":[13],"protein":[14],"nuclear":[15,64],"localization":[16],"signal":[17],"(NLS)":[18],"in":[19,35,56],"which":[20],"a":[21,29,57],"scaffold":[22],"two":[24],"resorcinol":[25],"units":[26],"joined":[27],"by":[28],"diamide":[30],"linker":[31,73],"presents":[32],"3-aminopropyl":[33],"ethers":[34],"place":[36],"lysine":[38],"side":[39],"chains.":[40],"Prospective":[41],"with":[43],"linkers":[44],"6,":[46],"8,":[47],"10,":[48],"or":[49],"12":[50],"atoms":[51],"were":[52],"synthesized":[53],"and":[54,77],"compared":[55],"competition":[58],"assay":[59],"for":[60],"binding":[61],"import":[65],"receptor":[66],"subunit":[67],"karyopherin":[68],"alpha,":[69],"showing":[70],"10-atom":[72],"be":[75],"best":[76],"shorter":[78],"ones":[79],"ineffective.":[80]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}